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MFAP2 (microfibril associated protein 2)

Gene

4237

Microfibril associated protein 2

MFAP2

MAGP, MAGP-1, MAGP1

1p36.13

Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different isoforms have been found for

Show/Hide all(123)

miRTarBase ID	miRNA	Experiments	Reference
MIRT515930	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT515929	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT515928	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT515927	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT515926	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT515925	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT515924	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT515923	hsa-miR-302e	HITS-CLIP	23824327
MIRT515922	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT515921	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT515920	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT515919	hsa-miR-520b	HITS-CLIP	23824327
MIRT515918	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT515917	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT515916	hsa-miR-520e	HITS-CLIP	23824327
MIRT515914	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT667426	hsa-miR-4454	HITS-CLIP	23824327
MIRT667425	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT667424	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT515910	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT515930	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT515929	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT515928	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT515927	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT515926	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT515925	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT515924	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT515923	hsa-miR-302e	PAR-CLIP	23446348
MIRT515922	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT515921	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT515920	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT515919	hsa-miR-520b	PAR-CLIP	23446348
MIRT515918	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT515917	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT515916	hsa-miR-520e	PAR-CLIP	23446348
MIRT515915	hsa-miR-2114-5p	PAR-CLIP	23446348
MIRT515914	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT515913	hsa-miR-6128	PAR-CLIP	23446348
MIRT515912	hsa-miR-3135b	PAR-CLIP	23446348
MIRT515911	hsa-miR-1287-5p	PAR-CLIP	23446348
MIRT515910	hsa-miR-18a-3p	PAR-CLIP	23446348
MIRT515930	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT515929	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT515928	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT515927	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT515926	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT515925	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT515924	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT515923	hsa-miR-302e	HITS-CLIP	23824327
MIRT515922	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT515921	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT515920	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT515919	hsa-miR-520b	HITS-CLIP	23824327
MIRT515918	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT515917	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT515916	hsa-miR-520e	HITS-CLIP	23824327
MIRT515914	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT667426	hsa-miR-4454	HITS-CLIP	23824327
MIRT667425	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT667424	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT515910	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT515930	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT515929	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT515928	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT515927	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT515926	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT515925	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT515924	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT515923	hsa-miR-302e	PAR-CLIP	23446348
MIRT515922	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT515921	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT515920	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT515919	hsa-miR-520b	PAR-CLIP	23446348
MIRT515918	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT515917	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT515916	hsa-miR-520e	PAR-CLIP	23446348
MIRT515915	hsa-miR-2114-5p	PAR-CLIP	23446348
MIRT515914	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT515913	hsa-miR-6128	PAR-CLIP	23446348
MIRT515912	hsa-miR-3135b	PAR-CLIP	23446348
MIRT515911	hsa-miR-1287-5p	PAR-CLIP	23446348
MIRT515910	hsa-miR-18a-3p	PAR-CLIP	23446348
MIRT2041426	hsa-miR-1285	CLIP-seq
MIRT2041427	hsa-miR-3184	CLIP-seq
MIRT2041428	hsa-miR-3187-5p	CLIP-seq
MIRT2041429	hsa-miR-423-5p	CLIP-seq
MIRT2041430	hsa-miR-4463	CLIP-seq
MIRT2041431	hsa-miR-4494	CLIP-seq
MIRT2041432	hsa-miR-4688	CLIP-seq
MIRT2041433	hsa-miR-4771	CLIP-seq
MIRT2041434	hsa-miR-486-3p	CLIP-seq
MIRT2041435	hsa-miR-612	CLIP-seq
MIRT2390837	hsa-miR-1207-3p	CLIP-seq
MIRT2390838	hsa-miR-342-5p	CLIP-seq
MIRT2390839	hsa-miR-4447	CLIP-seq
MIRT2390840	hsa-miR-4472	CLIP-seq
MIRT2390841	hsa-miR-4525	CLIP-seq
MIRT2390842	hsa-miR-4651	CLIP-seq
MIRT2390843	hsa-miR-4664-5p	CLIP-seq
MIRT2390844	hsa-miR-4731-5p	CLIP-seq
MIRT2390845	hsa-miR-608	CLIP-seq
MIRT2570088	hsa-miR-1915	CLIP-seq
MIRT2570089	hsa-miR-361-3p	CLIP-seq
MIRT2570090	hsa-miR-4446-3p	CLIP-seq
MIRT2570091	hsa-miR-4685-5p	CLIP-seq
MIRT2041426	hsa-miR-1285	CLIP-seq
MIRT2684873	hsa-miR-188-3p	CLIP-seq
MIRT2041427	hsa-miR-3184	CLIP-seq
MIRT2041428	hsa-miR-3187-5p	CLIP-seq
MIRT2684874	hsa-miR-34a	CLIP-seq
MIRT2684875	hsa-miR-34c-5p	CLIP-seq
MIRT2570089	hsa-miR-361-3p	CLIP-seq
MIRT2041429	hsa-miR-423-5p	CLIP-seq
MIRT2041430	hsa-miR-4463	CLIP-seq
MIRT2041431	hsa-miR-4494	CLIP-seq
MIRT2684876	hsa-miR-449a	CLIP-seq
MIRT2684877	hsa-miR-449b	CLIP-seq
MIRT2041432	hsa-miR-4688	CLIP-seq
MIRT2041433	hsa-miR-4771	CLIP-seq
MIRT2041434	hsa-miR-486-3p	CLIP-seq
MIRT2684878	hsa-miR-491-5p	CLIP-seq
MIRT2041435	hsa-miR-612	CLIP-seq
MIRT2684879	hsa-miR-661	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001527	Component	Microfibril	IBA	21873635
GO:0001527	Component	Microfibril	IDA	24353434
GO:0005201	Function	Extracellular matrix structural constituent	RCA	25037231, 28327460, 28675934
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	TAS
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0048048	Process	Embryonic eye morphogenesis	IBA	21873635
GO:0048048	Process	Embryonic eye morphogenesis	IEP	25406291
GO:0048050	Process	Post-embryonic eye morphogenesis	IEP	25406291
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	25037231, 28327460, 28675934
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	24458361

MIM	HGNC	e!Ensembl
156790	7033	ENSG00000117122

Protein

UniProt ID

P55001

Protein name

Microfibrillar-associated protein 2 (MFAP-2) (Microfibril-associated glycoprotein 1) (MAGP) (MAGP-1)

Protein function

Component of the elastin-associated microfibrils.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05507	MAGP	1 → 151	Microfibril-associated glycoprotein (MAGP)	Family
PF01549	ShK	152 → 183	ShK domain-like	Domain

Sequence

MRAAYLFLLFLPAGLLAQGQYDLDPLPPFPDHVQYTHYSDQIDNPDYYDYQEVTPRPSEE
QFQFQSQQQVQQEVIPAPTPEPGNAELEPTEPGPLDCREEQYPCTRLYSIHRPCKQCLNE
VCFYSLRRVYVINKEICVRTVCAHEELLRADLCRDKFSKCGVMASSGLCQSVAASCARSC
GSC

Sequence length

183

Interactions

View interactions

	Reactome
			Elastic fibre formation Molecules associated with elastic fibres

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	30804561

Show/Hide Unknown Diseases (2)

Unknown
Disease name	Disease term	dbSNP ID	References
Corpus luteum cyst	Corpus Luteum Cyst		21239663
Ovarian cysts	Ovarian Cysts		21239663

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