Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
4218 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
RAB8A, member RAS oncogene family |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
RAB8A |
SynonymsGene synonyms aliases
|
MEL, RAB8 |
ChromosomeChromosome number
|
19 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
19p13.11 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endo |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000139 |
Component |
Golgi membrane |
TAS |
|
GO:0003924 |
Function |
GTPase activity |
IDA |
17646400 |
GO:0005515 |
Function |
Protein binding |
IPI |
15207266, 15837803, 16541104, 16902405, 17646400, 18329369, 19864458, 20308558, 20388642, 20643351, 21273506, 21378754, 22011575, 22159412, 22543976, 22854040, 26258637, 26824392, 27103069, 27173435, 29125462, 32017888 |
GO:0005525 |
Function |
GTP binding |
IDA |
20937701 |
GO:0005768 |
Component |
Endosome |
IBA |
21873635 |
GO:0005813 |
Component |
Centrosome |
IDA |
24421332, 25849865 |
GO:0005814 |
Component |
Centriole |
IEA |
|
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005886 |
Component |
Plasma membrane |
IBA |
21873635 |
GO:0005929 |
Component |
Cilium |
IDA |
17646400, 24421332 |
GO:0005929 |
Component |
Cilium |
IDA |
21844891 |
GO:0006904 |
Process |
Vesicle docking involved in exocytosis |
IBA |
21873635 |
GO:0006904 |
Process |
Vesicle docking involved in exocytosis |
IDA |
17574030 |
GO:0006914 |
Process |
Autophagy |
IEA |
|
GO:0007409 |
Process |
Axonogenesis |
ISS |
|
GO:0008021 |
Component |
Synaptic vesicle |
IBA |
21873635 |
GO:0009306 |
Process |
Protein secretion |
IBA |
21873635 |
GO:0010506 |
Process |
Regulation of autophagy |
IMP |
27103069 |
GO:0014069 |
Component |
Postsynaptic density |
IEA |
|
GO:0017157 |
Process |
Regulation of exocytosis |
IBA |
21873635 |
GO:0019003 |
Function |
GDP binding |
IDA |
20937701 |
GO:0019901 |
Function |
Protein kinase binding |
IEA |
|
GO:0030140 |
Component |
Trans-Golgi network transport vesicle |
IBA |
21873635 |
GO:0030496 |
Component |
Midbody |
IDA |
22159412 |
GO:0030670 |
Component |
Phagocytic vesicle membrane |
IEA |
|
GO:0031267 |
Function |
Small GTPase binding |
ISS |
|
GO:0031489 |
Function |
Myosin V binding |
IPI |
24006491 |
GO:0032588 |
Component |
Trans-Golgi network membrane |
TAS |
|
GO:0032869 |
Process |
Cellular response to insulin stimulus |
IBA |
21873635 |
GO:0032869 |
Process |
Cellular response to insulin stimulus |
ISS |
|
GO:0043025 |
Component |
Neuronal cell body |
IEA |
|
GO:0043197 |
Component |
Dendritic spine |
IBA |
21873635 |
GO:0043687 |
Process |
Post-translational protein modification |
TAS |
|
GO:0045335 |
Component |
Phagocytic vesicle |
IDA |
21255211 |
GO:0048169 |
Process |
Regulation of long-term neuronal synaptic plasticity |
IEA |
|
GO:0048210 |
Process |
Golgi vesicle fusion to target membrane |
IBA |
21873635 |
GO:0048210 |
Process |
Golgi vesicle fusion to target membrane |
IDA |
17574030 |
GO:0051223 |
Process |
Regulation of protein transport |
IEA |
|
GO:0055038 |
Component |
Recycling endosome membrane |
IDA |
19864458, 21951725 |
GO:0055038 |
Component |
Recycling endosome membrane |
TAS |
|
GO:0060271 |
Process |
Cilium assembly |
IDA |
17574030 |
GO:0060271 |
Process |
Cilium assembly |
IMP |
17646400, 21844891 |
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19056867, 20458337 |
GO:0072659 |
Process |
Protein localization to plasma membrane |
IBA |
21873635 |
GO:0072659 |
Process |
Protein localization to plasma membrane |
ISS |
|
GO:0097730 |
Component |
Non-motile cilium |
IDA |
17574030, 24648492 |
GO:0098887 |
Process |
Neurotransmitter receptor transport, endosome to postsynaptic membrane |
IEA |
|
GO:0098969 |
Process |
Neurotransmitter receptor transport to postsynaptic membrane |
IBA |
21873635 |
GO:0098978 |
Component |
Glutamatergic synapse |
IEA |
|
GO:0099003 |
Process |
Vesicle-mediated transport in synapse |
IEA |
|
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
P61006 |
Protein name |
Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel) |
Protein function |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r |
PDB |
3QBT
,
3TNF
,
4LHV
,
4LHW
,
4LHX
,
4LHY
,
4LHZ
,
4LI0
,
5SZI
,
6RIR
,
6SQ2
,
6STF
,
6STG
,
6WHE
,
6YX5
,
6ZSI
,
6ZSJ
,
7BWT
,
7LWB
,
9IKQ
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00071 |
Ras |
10 → 171 |
Ras family |
Domain |
|
Sequence |
|
Sequence length |
207 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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