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ME2 (malic enzyme 2)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4200
Gene nameGene Name - the full gene name approved by the HGNC.
Malic enzyme 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ME2
SynonymsGene synonyms aliases
ODS1
ChromosomeChromosome number
18
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q21.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been s
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049487 hsa-miR-92a-3p CLASH 23622248
MIRT1139632 hsa-miR-1228 CLIP-seq
MIRT1139633 hsa-miR-124 CLIP-seq
MIRT1139634 hsa-miR-1247 CLIP-seq
MIRT1139635 hsa-miR-1827 CLIP-seq
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004470 Function Malic enzyme activity IBA 21873635
GO:0004470 Function Malic enzyme activity IMP 23334421
GO:0004471 Function Malate dehydrogenase (decarboxylating) (NAD+) activity IEA
GO:0004473 Function Malate dehydrogenase (decarboxylating) (NADP+) activity IBA 21873635
GO:0005739 Component Mitochondrion IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P23368
Protein name NAD-dependent malic enzyme, mitochondrial (NAD-ME) (EC 1.1.1.38) (Malic enzyme 2)
Protein function NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate.
PDB 1DO8 , 1EFK , 1EFL , 1GZ3 , 1GZ4 , 1PJ2 , 1PJ3 , 1PJ4 , 1PJL , 1QR6 , 7BSJ , 7BSK , 7BSL , 7XDE , 7XDF , 7XDG , 9AYI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00390 malic
89 270
Malic enzyme, N-terminal domain
Domain
PF03949 Malic_M
280 535
Malic enzyme, NAD binding domain
Domain
Sequence
Sequence length 584
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Pyruvate metabolism
Carbon metabolism
  Citric acid cycle (TCA cycle)
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 17258816
Unknown
Disease name Disease term dbSNP ID References
Bipolar disorder Bipolar Disorder 17258816
Manic disorder Manic, Manic Disorder 17258816
Nonorganic psychosis Nonorganic psychosis 17258816
Psychosis Psychotic Disorders 17258816

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