MCM4 (minichromosome maintenance complex component 4)

Gene

• Entrez ID: 4173
• Gene name: Minichromosome maintenance complex component 4
• Gene symbol: MCM4
• Synonyms: CDC21, CDC54, IMD54, NKCD, NKGCD, P1-CDC21, hCdc21
• Chromosome: 8
• Chromosome location: 8q11.21
• Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of t

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016612	hsa-miR-193b-3p	Microarray	20304954
MIRT016612	hsa-miR-193b-3p	Proteomics	21512034
MIRT023946	hsa-miR-1-3p	Proteomics	18668040
MIRT025322	hsa-miR-34a-5p	Proteomics	21566225
MIRT025322	hsa-miR-34a-5p	Proteomics	21566225
MIRT030629	hsa-miR-24-3p	qRT-PCR;Microarray	19748357
MIRT052176	hsa-let-7b-5p	CLASH	23622248
MIRT052176	hsa-let-7b-5p	CLASH	23622248
MIRT047147	hsa-miR-183-5p	CLASH	23622248
MIRT044489	hsa-miR-320a	CLASH	23622248
MIRT042917	hsa-miR-324-3p	CLASH	23622248
MIRT042917	hsa-miR-324-3p	CLASH	23622248
MIRT042917	hsa-miR-324-3p	CLASH	23622248
MIRT038934	hsa-miR-31-3p	CLASH	23622248
MIRT037991	hsa-miR-501-3p	CLASH	23622248
MIRT642991	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT642990	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT642989	hsa-miR-1281	HITS-CLIP	23824327
MIRT642988	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT642987	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT642986	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT642985	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT642984	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT642983	hsa-miR-4284	HITS-CLIP	23824327
MIRT642982	hsa-miR-1206	HITS-CLIP	23824327
MIRT642981	hsa-miR-5571-3p	HITS-CLIP	23824327
MIRT549863	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT549862	hsa-miR-216b-5p	PAR-CLIP	21572407
MIRT549861	hsa-miR-3675-3p	PAR-CLIP	21572407
MIRT549860	hsa-miR-517-5p	PAR-CLIP	21572407
MIRT549859	hsa-miR-1251-5p	PAR-CLIP	21572407
MIRT549858	hsa-miR-539-5p	PAR-CLIP	21572407
MIRT225201	hsa-miR-633	PAR-CLIP	21572407
MIRT526159	hsa-miR-1285-5p	PAR-CLIP	22012620
MIRT244619	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT363888	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT363885	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT363886	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT526158	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT526157	hsa-miR-372-5p	PAR-CLIP	22012620
MIRT526156	hsa-miR-1301-5p	PAR-CLIP	22012620
MIRT526155	hsa-miR-6502-5p	PAR-CLIP	22012620
MIRT526154	hsa-miR-6822-3p	PAR-CLIP	22012620
MIRT244620	hsa-miR-5590-5p	PAR-CLIP	22012620
MIRT642991	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT642990	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT642989	hsa-miR-1281	HITS-CLIP	23824327
MIRT642988	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT642987	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT642986	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT642985	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT642984	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT642983	hsa-miR-4284	HITS-CLIP	23824327
MIRT642982	hsa-miR-1206	HITS-CLIP	23824327
MIRT642981	hsa-miR-5571-3p	HITS-CLIP	23824327
MIRT549863	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT549862	hsa-miR-216b-5p	PAR-CLIP	21572407
MIRT549861	hsa-miR-3675-3p	PAR-CLIP	21572407
MIRT549860	hsa-miR-517-5p	PAR-CLIP	21572407
MIRT549859	hsa-miR-1251-5p	PAR-CLIP	21572407
MIRT549858	hsa-miR-539-5p	PAR-CLIP	21572407
MIRT225201	hsa-miR-633	PAR-CLIP	21572407
MIRT526159	hsa-miR-1285-5p	PAR-CLIP	22012620
MIRT244619	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT363888	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT363885	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT363886	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT526158	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT526157	hsa-miR-372-5p	PAR-CLIP	22012620
MIRT526156	hsa-miR-1301-5p	PAR-CLIP	22012620
MIRT526155	hsa-miR-6502-5p	PAR-CLIP	22012620
MIRT526154	hsa-miR-6822-3p	PAR-CLIP	22012620
MIRT244620	hsa-miR-5590-5p	PAR-CLIP	22012620
MIRT1137681	hsa-miR-103a	CLIP-seq
MIRT1137682	hsa-miR-107	CLIP-seq
MIRT1137683	hsa-miR-1178	CLIP-seq
MIRT1137684	hsa-miR-1244	CLIP-seq
MIRT1137685	hsa-miR-1278	CLIP-seq
MIRT1137686	hsa-miR-1283	CLIP-seq
MIRT1137687	hsa-miR-1285	CLIP-seq
MIRT1137688	hsa-miR-1286	CLIP-seq
MIRT1137689	hsa-miR-1301	CLIP-seq
MIRT1137690	hsa-miR-142-3p	CLIP-seq
MIRT1137691	hsa-miR-1909	CLIP-seq
MIRT1137692	hsa-miR-197	CLIP-seq
MIRT1137693	hsa-miR-1976	CLIP-seq
MIRT1137694	hsa-miR-3135	CLIP-seq
MIRT1137695	hsa-miR-3187-5p	CLIP-seq
MIRT1137696	hsa-miR-3545-3p	CLIP-seq
MIRT1137697	hsa-miR-3614-3p	CLIP-seq
MIRT1137698	hsa-miR-3663-5p	CLIP-seq
MIRT1137699	hsa-miR-3667-3p	CLIP-seq
MIRT1137700	hsa-miR-3667-5p	CLIP-seq
MIRT1137701	hsa-miR-371-5p	CLIP-seq
MIRT1137702	hsa-miR-3929	CLIP-seq
MIRT1137703	hsa-miR-3944-5p	CLIP-seq
MIRT1137704	hsa-miR-4270	CLIP-seq
MIRT1137705	hsa-miR-4279	CLIP-seq
MIRT1137706	hsa-miR-4297	CLIP-seq
MIRT1137707	hsa-miR-4327	CLIP-seq
MIRT1137708	hsa-miR-433	CLIP-seq
MIRT1137709	hsa-miR-4419b	CLIP-seq
MIRT1137710	hsa-miR-4436a	CLIP-seq
MIRT1137711	hsa-miR-4441	CLIP-seq
MIRT1137712	hsa-miR-4457	CLIP-seq
MIRT1137713	hsa-miR-4467	CLIP-seq
MIRT1137714	hsa-miR-4478	CLIP-seq
MIRT1137715	hsa-miR-4503	CLIP-seq
MIRT1137716	hsa-miR-4635	CLIP-seq
MIRT1137717	hsa-miR-4680-5p	CLIP-seq
MIRT1137718	hsa-miR-4699-3p	CLIP-seq
MIRT1137719	hsa-miR-4714-3p	CLIP-seq
MIRT1137720	hsa-miR-4722-3p	CLIP-seq
MIRT1137721	hsa-miR-4735-5p	CLIP-seq
MIRT1137722	hsa-miR-4740-3p	CLIP-seq
MIRT1137723	hsa-miR-4775	CLIP-seq
MIRT1137724	hsa-miR-502-5p	CLIP-seq
MIRT1137725	hsa-miR-5047	CLIP-seq
MIRT1137726	hsa-miR-5096	CLIP-seq
MIRT1137727	hsa-miR-513a-3p	CLIP-seq
MIRT1137728	hsa-miR-513b	CLIP-seq
MIRT1137729	hsa-miR-587	CLIP-seq
MIRT1137730	hsa-miR-590-3p	CLIP-seq
MIRT1137731	hsa-miR-612	CLIP-seq
MIRT1137732	hsa-miR-640	CLIP-seq
MIRT1137733	hsa-miR-645	CLIP-seq
MIRT1137734	hsa-miR-661	CLIP-seq
MIRT1137681	hsa-miR-103a	CLIP-seq
MIRT1137682	hsa-miR-107	CLIP-seq
MIRT1137735	hsa-miR-1273f	CLIP-seq
MIRT1137736	hsa-miR-143	CLIP-seq
MIRT1137737	hsa-miR-3166	CLIP-seq
MIRT1137703	hsa-miR-3944-5p	CLIP-seq
MIRT1137713	hsa-miR-4467	CLIP-seq
MIRT1137718	hsa-miR-4699-3p	CLIP-seq
MIRT1137738	hsa-miR-4708-5p	CLIP-seq
MIRT1137739	hsa-miR-4770	CLIP-seq
MIRT1137740	hsa-miR-4771	CLIP-seq
MIRT2039107	hsa-miR-1228	CLIP-seq
MIRT1137687	hsa-miR-1285	CLIP-seq
MIRT1137689	hsa-miR-1301	CLIP-seq
MIRT2039108	hsa-miR-216a	CLIP-seq
MIRT2039109	hsa-miR-216b	CLIP-seq
MIRT2039110	hsa-miR-3065-3p	CLIP-seq
MIRT1137694	hsa-miR-3135	CLIP-seq
MIRT1137695	hsa-miR-3187-5p	CLIP-seq
MIRT1137707	hsa-miR-4327	CLIP-seq
MIRT1137725	hsa-miR-5047	CLIP-seq
MIRT1137731	hsa-miR-612	CLIP-seq
MIRT1137734	hsa-miR-661	CLIP-seq
MIRT1137681	hsa-miR-103a	CLIP-seq
MIRT1137682	hsa-miR-107	CLIP-seq
MIRT2269132	hsa-miR-122	CLIP-seq
MIRT2039107	hsa-miR-1228	CLIP-seq
MIRT1137684	hsa-miR-1244	CLIP-seq
MIRT2269133	hsa-miR-1251	CLIP-seq
MIRT1137685	hsa-miR-1278	CLIP-seq
MIRT1137686	hsa-miR-1283	CLIP-seq
MIRT1137688	hsa-miR-1286	CLIP-seq
MIRT1137691	hsa-miR-1909	CLIP-seq
MIRT1137693	hsa-miR-1976	CLIP-seq
MIRT2039108	hsa-miR-216a	CLIP-seq
MIRT2039109	hsa-miR-216b	CLIP-seq
MIRT2269134	hsa-miR-24	CLIP-seq
MIRT2269135	hsa-miR-2467-5p	CLIP-seq
MIRT2039110	hsa-miR-3065-3p	CLIP-seq
MIRT2269136	hsa-miR-3135b	CLIP-seq
MIRT1137737	hsa-miR-3166	CLIP-seq
MIRT2269137	hsa-miR-3188	CLIP-seq
MIRT2269138	hsa-miR-338-3p	CLIP-seq
MIRT2269139	hsa-miR-342-3p	CLIP-seq
MIRT2269140	hsa-miR-3647-3p	CLIP-seq
MIRT2269141	hsa-miR-3652	CLIP-seq
MIRT1137699	hsa-miR-3667-3p	CLIP-seq
MIRT1137703	hsa-miR-3944-5p	CLIP-seq
MIRT2269142	hsa-miR-3975	CLIP-seq
MIRT1137704	hsa-miR-4270	CLIP-seq
MIRT1137705	hsa-miR-4279	CLIP-seq
MIRT2269143	hsa-miR-4282	CLIP-seq
MIRT2269144	hsa-miR-4430	CLIP-seq
MIRT1137710	hsa-miR-4436a	CLIP-seq
MIRT2269145	hsa-miR-4438	CLIP-seq
MIRT1137711	hsa-miR-4441	CLIP-seq
MIRT1137715	hsa-miR-4503	CLIP-seq
MIRT2269146	hsa-miR-4505	CLIP-seq
MIRT2269147	hsa-miR-4530	CLIP-seq
MIRT2269148	hsa-miR-4634	CLIP-seq
MIRT2269149	hsa-miR-4649-3p	CLIP-seq
MIRT2269150	hsa-miR-4663	CLIP-seq
MIRT1137717	hsa-miR-4680-5p	CLIP-seq
MIRT1137718	hsa-miR-4699-3p	CLIP-seq
MIRT1137719	hsa-miR-4714-3p	CLIP-seq
MIRT1137720	hsa-miR-4722-3p	CLIP-seq
MIRT1137722	hsa-miR-4740-3p	CLIP-seq
MIRT1137740	hsa-miR-4771	CLIP-seq
MIRT2269151	hsa-miR-4797-5p	CLIP-seq
MIRT2269152	hsa-miR-485-5p	CLIP-seq
MIRT2269153	hsa-miR-491-3p	CLIP-seq
MIRT2269154	hsa-miR-5095	CLIP-seq
MIRT2269155	hsa-miR-539	CLIP-seq
MIRT2269156	hsa-miR-541	CLIP-seq
MIRT2269157	hsa-miR-570	CLIP-seq
MIRT2269158	hsa-miR-628-5p	CLIP-seq
MIRT2269159	hsa-miR-654-5p	CLIP-seq
MIRT2269160	hsa-miR-944	CLIP-seq
MIRT2269132	hsa-miR-122	CLIP-seq
MIRT2039107	hsa-miR-1228	CLIP-seq
MIRT2039108	hsa-miR-216a	CLIP-seq
MIRT2039109	hsa-miR-216b	CLIP-seq
MIRT2269135	hsa-miR-2467-5p	CLIP-seq
MIRT2039110	hsa-miR-3065-3p	CLIP-seq
MIRT2269136	hsa-miR-3135b	CLIP-seq
MIRT2269137	hsa-miR-3188	CLIP-seq
MIRT2269141	hsa-miR-3652	CLIP-seq
MIRT2269142	hsa-miR-3975	CLIP-seq
MIRT2269144	hsa-miR-4430	CLIP-seq
MIRT2269148	hsa-miR-4634	CLIP-seq
MIRT2269149	hsa-miR-4649-3p	CLIP-seq
MIRT2269150	hsa-miR-4663	CLIP-seq
MIRT2269152	hsa-miR-485-5p	CLIP-seq
MIRT2269158	hsa-miR-628-5p	CLIP-seq
MIRT1137683	hsa-miR-1178	CLIP-seq
MIRT1137691	hsa-miR-1909	CLIP-seq
MIRT1137697	hsa-miR-3614-3p	CLIP-seq
MIRT1137699	hsa-miR-3667-3p	CLIP-seq
MIRT1137704	hsa-miR-4270	CLIP-seq
MIRT1137706	hsa-miR-4297	CLIP-seq
MIRT1137711	hsa-miR-4441	CLIP-seq
MIRT1137712	hsa-miR-4457	CLIP-seq
MIRT1137724	hsa-miR-502-5p	CLIP-seq
MIRT1137728	hsa-miR-513b	CLIP-seq
MIRT2568388	hsa-miR-1225-3p	CLIP-seq
MIRT2039107	hsa-miR-1228	CLIP-seq
MIRT2568389	hsa-miR-1233	CLIP-seq
MIRT2269133	hsa-miR-1251	CLIP-seq
MIRT1137687	hsa-miR-1285	CLIP-seq
MIRT1137689	hsa-miR-1301	CLIP-seq
MIRT2568390	hsa-miR-199a-5p	CLIP-seq
MIRT2568391	hsa-miR-199b-5p	CLIP-seq
MIRT2039108	hsa-miR-216a	CLIP-seq
MIRT2039109	hsa-miR-216b	CLIP-seq
MIRT2568392	hsa-miR-219-5p	CLIP-seq
MIRT2039110	hsa-miR-3065-3p	CLIP-seq
MIRT1137694	hsa-miR-3135	CLIP-seq
MIRT1137695	hsa-miR-3187-5p	CLIP-seq
MIRT2568393	hsa-miR-3622a-3p	CLIP-seq
MIRT2568394	hsa-miR-3622b-3p	CLIP-seq
MIRT2269140	hsa-miR-3647-3p	CLIP-seq
MIRT1137700	hsa-miR-3667-5p	CLIP-seq
MIRT1137701	hsa-miR-371-5p	CLIP-seq
MIRT2568395	hsa-miR-4307	CLIP-seq
MIRT1137707	hsa-miR-4327	CLIP-seq
MIRT2568396	hsa-miR-4445	CLIP-seq
MIRT2568397	hsa-miR-4459	CLIP-seq
MIRT2568398	hsa-miR-4537	CLIP-seq
MIRT2568399	hsa-miR-4676-5p	CLIP-seq
MIRT2568400	hsa-miR-4684-5p	CLIP-seq
MIRT1137719	hsa-miR-4714-3p	CLIP-seq
MIRT1137722	hsa-miR-4740-3p	CLIP-seq
MIRT2568401	hsa-miR-4782-3p	CLIP-seq
MIRT2269151	hsa-miR-4797-5p	CLIP-seq
MIRT1137725	hsa-miR-5047	CLIP-seq
MIRT2568402	hsa-miR-508-3p	CLIP-seq
MIRT2269156	hsa-miR-541	CLIP-seq
MIRT2568403	hsa-miR-542-3p	CLIP-seq
MIRT2568404	hsa-miR-567	CLIP-seq
MIRT2568405	hsa-miR-575	CLIP-seq
MIRT1137731	hsa-miR-612	CLIP-seq
MIRT2269159	hsa-miR-654-5p	CLIP-seq
MIRT1137734	hsa-miR-661	CLIP-seq
MIRT2568406	hsa-miR-665	CLIP-seq
MIRT2568388	hsa-miR-1225-3p	CLIP-seq
MIRT2039107	hsa-miR-1228	CLIP-seq
MIRT2568389	hsa-miR-1233	CLIP-seq
MIRT2269133	hsa-miR-1251	CLIP-seq
MIRT1137687	hsa-miR-1285	CLIP-seq
MIRT1137689	hsa-miR-1301	CLIP-seq
MIRT1137693	hsa-miR-1976	CLIP-seq
MIRT2568390	hsa-miR-199a-5p	CLIP-seq
MIRT2568391	hsa-miR-199b-5p	CLIP-seq
MIRT2039108	hsa-miR-216a	CLIP-seq
MIRT2039109	hsa-miR-216b	CLIP-seq
MIRT2568392	hsa-miR-219-5p	CLIP-seq
MIRT2039110	hsa-miR-3065-3p	CLIP-seq
MIRT1137694	hsa-miR-3135	CLIP-seq
MIRT1137695	hsa-miR-3187-5p	CLIP-seq
MIRT2568393	hsa-miR-3622a-3p	CLIP-seq
MIRT2568394	hsa-miR-3622b-3p	CLIP-seq
MIRT2269140	hsa-miR-3647-3p	CLIP-seq
MIRT1137700	hsa-miR-3667-5p	CLIP-seq
MIRT1137701	hsa-miR-371-5p	CLIP-seq
MIRT1137705	hsa-miR-4279	CLIP-seq
MIRT2568395	hsa-miR-4307	CLIP-seq
MIRT1137707	hsa-miR-4327	CLIP-seq
MIRT2269145	hsa-miR-4438	CLIP-seq
MIRT2568396	hsa-miR-4445	CLIP-seq
MIRT2568397	hsa-miR-4459	CLIP-seq
MIRT1137715	hsa-miR-4503	CLIP-seq
MIRT2568398	hsa-miR-4537	CLIP-seq
MIRT2684736	hsa-miR-4632	CLIP-seq
MIRT2568399	hsa-miR-4676-5p	CLIP-seq
MIRT2568400	hsa-miR-4684-5p	CLIP-seq
MIRT1137719	hsa-miR-4714-3p	CLIP-seq
MIRT1137720	hsa-miR-4722-3p	CLIP-seq
MIRT1137721	hsa-miR-4735-5p	CLIP-seq
MIRT1137722	hsa-miR-4740-3p	CLIP-seq
MIRT2568401	hsa-miR-4782-3p	CLIP-seq
MIRT2684737	hsa-miR-4795-3p	CLIP-seq
MIRT2269151	hsa-miR-4797-5p	CLIP-seq
MIRT1137725	hsa-miR-5047	CLIP-seq
MIRT2568402	hsa-miR-508-3p	CLIP-seq
MIRT2269154	hsa-miR-5095	CLIP-seq
MIRT2269156	hsa-miR-541	CLIP-seq
MIRT2568403	hsa-miR-542-3p	CLIP-seq
MIRT2568404	hsa-miR-567	CLIP-seq
MIRT2568405	hsa-miR-575	CLIP-seq
MIRT1137731	hsa-miR-612	CLIP-seq
MIRT2684738	hsa-miR-629	CLIP-seq
MIRT2269159	hsa-miR-654-5p	CLIP-seq
MIRT1137734	hsa-miR-661	CLIP-seq
MIRT2568406	hsa-miR-665	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MYCN	Activation	17826980

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	TAS
GO:0000727	Process	Double-strand break repair via break-induced replication	IBA	21873635
GO:0000781	Component	Chromosome, telomeric region	HDA	19135898
GO:0003678	Function	DNA helicase activity	IDA	9305914
GO:0003688	Function	DNA replication origin binding	IBA	21873635
GO:0003697	Function	Single-stranded DNA binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	12364596, 15232106, 16902406, 17296731, 22190034, 22540012, 23764002, 24299456, 24407287, 25036637, 28514442
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	NAS	8265339
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006260	Process	DNA replication	NAS	9465298
GO:0006260	Process	DNA replication	TAS
GO:0006267	Process	Pre-replicative complex assembly involved in nuclear cell cycle DNA replication	IBA	21873635
GO:0006268	Process	DNA unwinding involved in DNA replication	IBA	21873635
GO:0006271	Process	DNA strand elongation involved in DNA replication	IBA	21873635
GO:0016020	Component	Membrane	HDA	19946888
GO:0042555	Component	MCM complex	IBA	21873635
GO:0042555	Component	MCM complex	IDA	17296731
GO:0071162	Component	CMG complex	ISS
GO:1902975	Process	Mitotic DNA replication initiation	IBA	21873635

Other IDs

• MIM: 602638
• HGNC: 6947
• e!Ensembl: ENSG00000104738

Protein

• UniProt ID: P33991
• Protein name: DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)
• Protein function: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the mol
• PDB: 6XTX, 6XTY, 7PFO, 7PLO, 7W1Y, 7W68, 8B9D, 8RWV, 8S09, 8S0A, 8S0B, 8S0D, 8S0E, 8S0F, 8W0E, 8W0F, 8W0G, 8W0I, 9CAQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14551	MCM_N	163 → 264	MCM N-terminal domain	Domain
  PF17207	MCM_OB	270 → 398	MCM OB domain	Domain
  PF00493	MCM	445 → 670	MCM P-loop domain	Domain
  PF17855	MCM_lid	685 → 769	MCM AAA-lid domain	Domain

• Sequence:

  MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQ
  SPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGS
  AQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKE
  EENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMA
  VNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQ
  EAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPED
  MPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIH
  YRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGI
  LLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSA
  VGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAK
  AGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDR
  RLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKI
  GSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGI
  VDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMF
  EEALRALADDDFLTVTGKTVRLL

• Sequence length: 863

Pathways

KEGG:

DNA replication
Cell cycle

Reactome:

Activation of ATR in response to replication stress
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291, rs886041382, rs1057518991, rs1057518699, rs753254213, rs748294403, rs762552974, rs1135401795, rs1553121073, rs1553122926, rs1364690005, rs1554086554, rs1554210415, rs1554168326, rs1554776342, rs1553873247, rs1567860112, rs779009256, rs1557447255, rs1564568350, rs780011005, rs1597464953, rs1200336864, rs1569513017, rs1587459606, rs1570332505, rs748888652, rs1575155995, rs2087029320, rs1589669105, rs1601769604, rs1184981709, rs749201074
Immunodeficiency with natural-killer cell deficiency and adrenal insufficiency	Primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency	rs1563829725
Lymphoproliferative disorder	Lymphoproliferative Disorders	rs121908191, rs398122933, rs397514667, rs397514260, rs397514261, rs748418658, rs781593353
Microcephaly	Microcephaly	rs397704721, rs267607176, rs267607177, rs397704725, rs267606717, rs267606718, rs199422202, rs121434311, rs199422203, rs199422126, rs387906274, rs121434305, rs199422125, rs199422135, rs189678019, rs199422184, rs137852994, rs137852995, rs137852996, rs137852997, rs145489194, rs80338860, rs137852494, rs121918609, rs199422207, rs199422206, rs29001566, rs864321658, rs199422138, rs199422139, rs199422141, rs199422144, rs199422147, rs199422151, rs199422152, rs199422153, rs199422157, rs199422159, rs199422160, rs199422161, rs140602858, rs199422164, rs199422165, rs148294838, rs199422134, rs199422168, rs199422172, rs199422173, rs199422131, rs199422177, rs199422180, rs199422185, rs199422186, rs199422187, rs143931757, rs199422189, rs199422192, rs199422194, rs199422195, rs199422196, rs199422197, rs199422199, rs753597039, rs1488084787, rs387906961, rs755862917, rs387907082, rs587776899, rs387907083, rs587776900, rs587776901, rs387907084, rs863223322, rs764201220, rs202247811, rs763915472, rs587776986, rs587777036, rs398122971, rs374351172, rs373278668, rs398122976, rs121909123, rs587783393, rs730882076, rs587783211, rs144716013, rs606231255, rs587783215, rs587783216, rs587783220, rs587783221, rs587783225, rs587783227, rs587783228, rs587783230, rs587783238, rs587783239, rs587783240, rs587783245, rs587783247, rs587783248, rs587783258, rs587783259, rs587783263, rs587783265, rs587783268, rs587783269, rs587783272, rs587783275, rs587783277, rs587783278, rs587783280, rs587783282, rs587783283, rs587783285, rs587783287, rs587783288, rs587783289, rs587783292, rs587783295, rs587784452, rs587783741, rs587783735, rs587783392, rs587783390, rs587783387, rs587783410, rs202058504, rs587783423, rs587783421, rs587783414, rs587784553, rs587784558, rs587784546, rs587784549, rs587784554, rs587784412, rs876661307, rs869025200, rs747831095, rs748529285, rs797045316, rs797045315, rs797045314, rs759632528, rs797045313, rs797045311, rs754282058, rs797045441, rs797045454, rs797045430, rs869312853, rs797046109, rs767399782, rs863225127, rs863225464, rs863225465, rs780270096, rs864321621, rs864321620, rs775277800, rs879253817, rs869312824, rs761447719, rs753406334, rs147622433, rs199422137, rs879255522, rs879255524, rs879255523, rs886037892, rs886037893, rs886037894, rs886037895, rs199422169, rs886041709, rs886041282, rs138228629, rs759188041, rs769688376, rs1057517688, rs1057519087, rs1057518268, rs933106143, rs201362977, rs754909135, rs1057520873, rs1060499758, rs1060499757, rs199422146, rs748016594, rs1085307120, rs763715733, rs1064795945, rs763800571, rs1554728351, rs1553227021, rs555866170, rs1553895368, rs1334947797, rs769818500, rs1321892596, rs1553227645, rs1404276011, rs1553228275, rs1554471681, rs1554496609, rs1555420891, rs1555418825, rs587784548, rs1555723585, rs199736219, rs745997770, rs765275884, rs1553924800, rs1554730137, rs1229568621, rs1482100822, rs979186313, rs758157294, rs1555294652, rs1555299107, rs1553264033, rs1553259539, rs1553254322, rs1553259528, rs981349334, rs1553264036, rs1553253022, rs754267846, rs776034810, rs1342429887, rs752140135, rs1006898944, rs571640983, rs1477524771, rs763909256, rs199910503, rs1553223496, rs759663956, rs1553446603, rs1555139372, rs1555143325, rs1350194762, rs1555141158, rs1553225179, rs769481947, rs769364943, rs748011724, rs1334301723, rs746341112, rs149225624, rs765113367, rs1567024512, rs142865061, rs772050241, rs201721894, rs1557966012, rs1379578836, rs1568334868, rs1185537869, rs1602333390, rs1163303148, rs774338373, rs770540184, rs1571600045, rs1571601267, rs1571602991, rs1588472215, rs1599841026, rs1558328287, rs1571600860, rs1571596976, rs1309880692, rs1435239428, rs1588634016, rs1751797979, rs1810830776, rs1815354949, rs1949984655, rs886039658, rs1943461045, rs777711720, rs2031759596, rs1555710223, rs1221031683, rs774069989, rs2058919680, rs1170413397, rs1213710245, rs1599851667, rs1599760058, rs1971033478, rs746967357

Unknown
Disease name	Disease term	dbSNP ID	References
Adrenal hypoplasia, x-linked	X-linked Adrenal Hypoplasia		22354170
Natural killer cell and glucocorticoid deficiency with dna repair defect	Natural Killer Cell Deficiency, Familial Isolated		22354170, 22405088, 16532402