MARK3 (microtubule affinity regulating kinase 3)

Gene

• Entrez ID: 4140
• Gene name: Microtubule affinity regulating kinase 3
• Gene symbol: MARK3
• Synonyms: CTAK1, KP78, PAR1A, Par-1a, VIPB
• Chromosome: 14
• Chromosome location: 14q32.32-q32.33
• Summary: The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs376395495	C>G,T	Pathogenic	Coding sequence variant, intron variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT043531	hsa-miR-331-3p	CLASH	23622248
MIRT1132648	hsa-miR-1228	CLIP-seq
MIRT1132649	hsa-miR-1270	CLIP-seq
MIRT1132650	hsa-miR-1912	CLIP-seq
MIRT1132651	hsa-miR-302f	CLIP-seq
MIRT1132652	hsa-miR-3612	CLIP-seq
MIRT1132653	hsa-miR-4255	CLIP-seq
MIRT1132654	hsa-miR-4302	CLIP-seq
MIRT1132655	hsa-miR-4683	CLIP-seq
MIRT1132656	hsa-miR-4717-3p	CLIP-seq
MIRT1132657	hsa-miR-4775	CLIP-seq
MIRT1132658	hsa-miR-4802-3p	CLIP-seq
MIRT1132659	hsa-miR-483-5p	CLIP-seq
MIRT1132660	hsa-miR-499-3p	CLIP-seq
MIRT1132661	hsa-miR-499a-3p	CLIP-seq
MIRT1132662	hsa-miR-570	CLIP-seq
MIRT1132663	hsa-miR-587	CLIP-seq
MIRT1132664	hsa-miR-620	CLIP-seq
MIRT1132665	hsa-miR-650	CLIP-seq
MIRT1132666	hsa-miR-873	CLIP-seq
MIRT1132667	hsa-miR-1273f	CLIP-seq
MIRT1132668	hsa-miR-329	CLIP-seq
MIRT1132669	hsa-miR-362-3p	CLIP-seq
MIRT1132670	hsa-miR-3675-5p	CLIP-seq
MIRT1132671	hsa-miR-4431	CLIP-seq
MIRT1132672	hsa-miR-1321	CLIP-seq
MIRT1132673	hsa-miR-140-3p	CLIP-seq
MIRT1132674	hsa-miR-199a-5p	CLIP-seq
MIRT1132675	hsa-miR-199b-5p	CLIP-seq
MIRT1132676	hsa-miR-2115	CLIP-seq
MIRT1132677	hsa-miR-3064-5p	CLIP-seq
MIRT1132678	hsa-miR-30a	CLIP-seq
MIRT1132679	hsa-miR-30b	CLIP-seq
MIRT1132680	hsa-miR-30c	CLIP-seq
MIRT1132681	hsa-miR-30d	CLIP-seq
MIRT1132682	hsa-miR-30e	CLIP-seq
MIRT1132683	hsa-miR-3162-5p	CLIP-seq
MIRT1132684	hsa-miR-3545-3p	CLIP-seq
MIRT1132685	hsa-miR-3607-3p	CLIP-seq
MIRT1132686	hsa-miR-4280	CLIP-seq
MIRT1132687	hsa-miR-4708-5p	CLIP-seq
MIRT1132688	hsa-miR-4739	CLIP-seq
MIRT1132689	hsa-miR-4742-3p	CLIP-seq
MIRT1132690	hsa-miR-4756-5p	CLIP-seq
MIRT1132691	hsa-miR-495	CLIP-seq
MIRT1132692	hsa-miR-516a-3p	CLIP-seq
MIRT1132693	hsa-miR-548aa	CLIP-seq
MIRT1132694	hsa-miR-604	CLIP-seq
MIRT1132695	hsa-miR-647	CLIP-seq
MIRT1132696	hsa-miR-649	CLIP-seq
MIRT2037801	hsa-miR-1207-5p	CLIP-seq
MIRT2037802	hsa-miR-1266	CLIP-seq
MIRT2037803	hsa-miR-1284	CLIP-seq
MIRT1132672	hsa-miR-1321	CLIP-seq
MIRT2037804	hsa-miR-137	CLIP-seq
MIRT2037805	hsa-miR-1909	CLIP-seq
MIRT2037806	hsa-miR-191	CLIP-seq
MIRT2037807	hsa-miR-1915	CLIP-seq
MIRT1132674	hsa-miR-199a-5p	CLIP-seq
MIRT1132675	hsa-miR-199b-5p	CLIP-seq
MIRT1132676	hsa-miR-2115	CLIP-seq
MIRT1132683	hsa-miR-3162-5p	CLIP-seq
MIRT2037808	hsa-miR-3664-3p	CLIP-seq
MIRT1132653	hsa-miR-4255	CLIP-seq
MIRT1132686	hsa-miR-4280	CLIP-seq
MIRT1132654	hsa-miR-4302	CLIP-seq
MIRT1132671	hsa-miR-4431	CLIP-seq
MIRT2037809	hsa-miR-4436b-3p	CLIP-seq
MIRT2037810	hsa-miR-4488	CLIP-seq
MIRT2037811	hsa-miR-4518	CLIP-seq
MIRT2037812	hsa-miR-4697-5p	CLIP-seq
MIRT1132687	hsa-miR-4708-5p	CLIP-seq
MIRT2037813	hsa-miR-4726-3p	CLIP-seq
MIRT1132688	hsa-miR-4739	CLIP-seq
MIRT1132690	hsa-miR-4756-5p	CLIP-seq
MIRT2037814	hsa-miR-4761-3p	CLIP-seq
MIRT2037815	hsa-miR-4763-3p	CLIP-seq
MIRT2037816	hsa-miR-4774-3p	CLIP-seq
MIRT2037817	hsa-miR-4795-3p	CLIP-seq
MIRT1132692	hsa-miR-516a-3p	CLIP-seq
MIRT1132662	hsa-miR-570	CLIP-seq
MIRT1132663	hsa-miR-587	CLIP-seq
MIRT2037818	hsa-miR-656	CLIP-seq
MIRT1132666	hsa-miR-873	CLIP-seq
MIRT1132648	hsa-miR-1228	CLIP-seq
MIRT2267840	hsa-miR-1238	CLIP-seq
MIRT1132649	hsa-miR-1270	CLIP-seq
MIRT1132667	hsa-miR-1273f	CLIP-seq
MIRT2267841	hsa-miR-182	CLIP-seq
MIRT1132650	hsa-miR-1912	CLIP-seq
MIRT2267842	hsa-miR-29a	CLIP-seq
MIRT2267843	hsa-miR-29b	CLIP-seq
MIRT2267844	hsa-miR-29c	CLIP-seq
MIRT2267845	hsa-miR-3189-3p	CLIP-seq
MIRT2267846	hsa-miR-342-3p	CLIP-seq
MIRT1132652	hsa-miR-3612	CLIP-seq
MIRT1132670	hsa-miR-3675-5p	CLIP-seq
MIRT2267847	hsa-miR-409-3p	CLIP-seq
MIRT2267848	hsa-miR-4307	CLIP-seq
MIRT1132655	hsa-miR-4683	CLIP-seq
MIRT2267849	hsa-miR-4691-5p	CLIP-seq
MIRT2267850	hsa-miR-4695-3p	CLIP-seq
MIRT1132656	hsa-miR-4717-3p	CLIP-seq
MIRT1132658	hsa-miR-4802-3p	CLIP-seq
MIRT1132659	hsa-miR-483-5p	CLIP-seq
MIRT1132664	hsa-miR-620	CLIP-seq
MIRT1132665	hsa-miR-650	CLIP-seq
MIRT1132648	hsa-miR-1228	CLIP-seq
MIRT1132649	hsa-miR-1270	CLIP-seq
MIRT1132667	hsa-miR-1273f	CLIP-seq
MIRT1132650	hsa-miR-1912	CLIP-seq
MIRT1132652	hsa-miR-3612	CLIP-seq
MIRT1132670	hsa-miR-3675-5p	CLIP-seq
MIRT1132655	hsa-miR-4683	CLIP-seq
MIRT1132656	hsa-miR-4717-3p	CLIP-seq
MIRT1132658	hsa-miR-4802-3p	CLIP-seq
MIRT1132659	hsa-miR-483-5p	CLIP-seq
MIRT1132664	hsa-miR-620	CLIP-seq
MIRT1132665	hsa-miR-650	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0000226	Process	Microtubule cytoskeleton organization	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	9543386, 16980613
GO:0004674	Function	Protein serine/threonine kinase activity	NAS	28386764
GO:0005515	Function	Protein binding	IPI	9543386, 12556533, 14676191, 15161933, 15778465, 16169070, 16189514, 16306228, 16959763, 16980613, 17979178, 22046132, 23666762, 24255178, 25852190, 28087714, 28514442
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	23666762
GO:0005737	Component	Cytoplasm	NAS	9543386
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	21145462
GO:0006468	Process	Protein phosphorylation	IMP	23666762
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	9543386
GO:0030425	Component	Dendrite	IDA	23666762
GO:0032092	Process	Positive regulation of protein binding	IDA	9543386
GO:0035331	Process	Negative regulation of hippo signaling	IDA	28087714
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0036289	Process	Peptidyl-serine autophosphorylation	IDA	9543386
GO:0048156	Function	Tau protein binding	NAS	28386764
GO:0050321	Function	Tau-protein kinase activity	IBA	21873635
GO:0050321	Function	Tau-protein kinase activity	IMP	23666762
GO:0050321	Function	Tau-protein kinase activity	NAS	28386764
GO:0070062	Component	Extracellular exosome	HDA	18570454
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA

Other IDs

• MIM: 602678
• HGNC: 6897
• e!Ensembl: ENSG00000075413

Protein

• UniProt ID: P27448
• Protein name: MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)
• Protein function: Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMe
• PDB: 2QNJ, 3FE3, 7P1L, 8UOH, 8UOI, 8UOJ, 8UOK, 8UOL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	56 → 307	Protein kinase domain	Domain
  PF00627	UBA	327 → 363	UBA/TS-N domain	Domain
  PF02149	KA1	709 → 753	Kinase associated domain 1	Domain

• Sequence:

  MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK
  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE
  VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
  AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
  VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ
  IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT
  YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSD
  HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK
  ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS
  THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG
  STNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRF
  TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL
  PRLSLNGVRFKRISGTSIAFKNIASKIANELKL

• Sequence length: 753

Pathways

Reactome:

RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Cornea plana	Cornea plana	rs121917858, rs121917860, rs121917862, rs121917863, rs386833985, rs386833986, rs757611751
Visual impairment and progressive phthisis bulbi	VISUAL IMPAIRMENT AND PROGRESSIVE PHTHISIS BULBI	rs376395495	29771303

Unknown
Disease name	Disease term	dbSNP ID	References
Hyperopia	Hyperopia
Phthisis bulbi	Phthisis bulbi
Ptosis	Blepharoptosis, Ptosis	rs139920573