MARK1 (microtubule affinity regulating kinase 1)

Gene

• Entrez ID: 4139
• Gene name: Microtubule affinity regulating kinase 1
• Gene symbol: MARK1
• Synonyms: MARK, Par-1c, Par1c
• Chromosome: 1
• Chromosome location: 1q41

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT656421	hsa-miR-1283	HITS-CLIP	23824327
MIRT656420	hsa-miR-3616-5p	HITS-CLIP	23824327
MIRT656419	hsa-miR-573	HITS-CLIP	23824327
MIRT656421	hsa-miR-1283	HITS-CLIP	23824327
MIRT656420	hsa-miR-3616-5p	HITS-CLIP	23824327
MIRT656419	hsa-miR-573	HITS-CLIP	23824327
MIRT737308	hsa-miR-486-5p	Luciferase reporter assay, Western blotting, qRT-PCR	32547110
MIRT656421	hsa-miR-1283	HITS-CLIP	23824327
MIRT656420	hsa-miR-3616-5p	HITS-CLIP	23824327
MIRT656419	hsa-miR-573	HITS-CLIP	23824327
MIRT656421	hsa-miR-1283	HITS-CLIP	23824327
MIRT656420	hsa-miR-3616-5p	HITS-CLIP	23824327
MIRT656419	hsa-miR-573	HITS-CLIP	23824327
MIRT1132532	hsa-miR-101	CLIP-seq
MIRT1132533	hsa-miR-128	CLIP-seq
MIRT1132534	hsa-miR-144	CLIP-seq
MIRT1132535	hsa-miR-221	CLIP-seq
MIRT1132536	hsa-miR-222	CLIP-seq
MIRT1132537	hsa-miR-27a	CLIP-seq
MIRT1132538	hsa-miR-27b	CLIP-seq
MIRT1132539	hsa-miR-300	CLIP-seq
MIRT1132540	hsa-miR-381	CLIP-seq
MIRT1132541	hsa-miR-3922-5p	CLIP-seq
MIRT1132542	hsa-miR-3973	CLIP-seq
MIRT1132543	hsa-miR-4307	CLIP-seq
MIRT1132544	hsa-miR-4503	CLIP-seq
MIRT1132545	hsa-miR-4666-3p	CLIP-seq
MIRT1132546	hsa-miR-4680-3p	CLIP-seq
MIRT1132547	hsa-miR-4724-5p	CLIP-seq
MIRT1132548	hsa-miR-4781-3p	CLIP-seq
MIRT1132549	hsa-miR-499-3p	CLIP-seq
MIRT1132550	hsa-miR-499a-3p	CLIP-seq
MIRT1132551	hsa-miR-513a-3p	CLIP-seq
MIRT1132552	hsa-miR-520g	CLIP-seq
MIRT1132553	hsa-miR-520h	CLIP-seq
MIRT1132554	hsa-miR-567	CLIP-seq
MIRT1132555	hsa-miR-570	CLIP-seq
MIRT1132556	hsa-miR-582-5p	CLIP-seq
MIRT2037758	hsa-miR-1305	CLIP-seq
MIRT2037759	hsa-miR-3671	CLIP-seq
MIRT2037760	hsa-miR-4795-3p	CLIP-seq
MIRT2267825	hsa-miR-3924	CLIP-seq
MIRT2267826	hsa-miR-542-3p	CLIP-seq
MIRT1132532	hsa-miR-101	CLIP-seq
MIRT1132534	hsa-miR-144	CLIP-seq
MIRT2431020	hsa-miR-299-5p	CLIP-seq
MIRT1132551	hsa-miR-513a-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IBA	21873635
GO:0000226	Process	Microtubule cytoskeleton organization	ISS
GO:0000287	Function	Magnesium ion binding	IDA	14976552
GO:0001764	Process	Neuron migration	ISS
GO:0001786	Function	Phosphatidylserine binding	IDA	21145462
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	14976552
GO:0004674	Function	Protein serine/threonine kinase activity	NAS	28386764
GO:0005515	Function	Protein binding	IPI	23666762, 32296183, 32814053
GO:0005524	Function	ATP binding	IDA	14976552
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IDA	21145462
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	23666762
GO:0005737	Component	Cytoplasm	ISS
GO:0005856	Component	Cytoskeleton	ISS
GO:0005886	Component	Plasma membrane	IDA	21145462
GO:0006468	Process	Protein phosphorylation	IDA	14976552
GO:0006468	Process	Protein phosphorylation	IMP	23666762
GO:0007010	Process	Cytoskeleton organization	ISS
GO:0010975	Process	Regulation of neuron projection development	ISS
GO:0015630	Component	Microtubule cytoskeleton	TAS	9108484
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	NAS	10542369
GO:0030425	Component	Dendrite	IDA	23666762
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0035556	Process	Intracellular signal transduction	IDA	14976552
GO:0048156	Function	Tau protein binding	NAS	28386764
GO:0050321	Function	Tau-protein kinase activity	IBA	21873635
GO:0050321	Function	Tau-protein kinase activity	IMP	23666762
GO:0050321	Function	Tau-protein kinase activity	ISS
GO:0050321	Function	Tau-protein kinase activity	NAS	28386764
GO:0050773	Process	Regulation of dendrite development	ISS
GO:0051654	Process	Establishment of mitochondrion localization	ISS
GO:0070300	Function	Phosphatidic acid binding	IDA	21145462
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA

Other IDs

• MIM: 606511
• HGNC: 6896
• e!Ensembl: ENSG00000116141

Protein

• UniProt ID: Q9P0L2
• Protein name: Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)
• Protein function: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell p
• PDB: 2HAK, 3OSE, 6C9D
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	60 → 311	Protein kinase domain	Domain
  PF00627	UBA	331 → 367	UBA/TS-N domain	Domain
  PF02149	KA1	751 → 795	Kinase associated domain 1	Domain

• Sequence:

  MSARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNY
  RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV
  KLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVH
  RDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDV
  WSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRG
  SLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDE
  VMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQR
  RFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGP
  ERKKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSV
  ASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPD
  RTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKF
  VRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMRE
  IRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSI
  AFKNIASKIANELKL

• Sequence length: 795

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	18492799
Gastric cancer	Gastric Adenocarcinoma, Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	16367923

Unknown
Disease name	Disease term	dbSNP ID	References
Ovarian serous adenocarcinoma	Ovarian Serous Adenocarcinoma
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		16367923