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MAN2A1 (mannosidase alpha class 2A member 1)

Gene

Mannosidase alpha class 2A member 1

MAN2A1

AMan II, GOLIM7, MANA2, MANII

5

5q21.3

This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a syste

Show/Hide all(208)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002612	hsa-miR-124-3p	Microarray	18668037
MIRT002612	hsa-miR-124-3p	Microarray	15685193
MIRT045458	hsa-miR-149-5p	CLASH	23622248
MIRT044543	hsa-miR-320a	CLASH	23622248
MIRT621073	hsa-miR-4521	HITS-CLIP	23824327
MIRT621075	hsa-miR-576-3p	HITS-CLIP	23824327
MIRT621074	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT621073	hsa-miR-4521	HITS-CLIP	23824327
MIRT556352	hsa-miR-532-5p	PAR-CLIP	21572407
MIRT556351	hsa-miR-5697	PAR-CLIP	21572407
MIRT556350	hsa-miR-2682-3p	PAR-CLIP	21572407
MIRT556349	hsa-miR-6781-3p	PAR-CLIP	21572407
MIRT556348	hsa-miR-4633-5p	PAR-CLIP	21572407
MIRT556347	hsa-miR-1297	PAR-CLIP	21572407
MIRT556346	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT556345	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT556344	hsa-miR-4465	PAR-CLIP	21572407
MIRT556343	hsa-miR-188-3p	PAR-CLIP	21572407
MIRT556346	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT556345	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT727258	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT727259	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT727257	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT621073	hsa-miR-4521	HITS-CLIP	23824327
MIRT621075	hsa-miR-576-3p	HITS-CLIP	23824327
MIRT621074	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT621073	hsa-miR-4521	HITS-CLIP	23824327
MIRT556352	hsa-miR-532-5p	PAR-CLIP	21572407
MIRT556351	hsa-miR-5697	PAR-CLIP	21572407
MIRT556350	hsa-miR-2682-3p	PAR-CLIP	21572407
MIRT556349	hsa-miR-6781-3p	PAR-CLIP	21572407
MIRT556348	hsa-miR-4633-5p	PAR-CLIP	21572407
MIRT556347	hsa-miR-1297	PAR-CLIP	21572407
MIRT556346	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT556345	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT556344	hsa-miR-4465	PAR-CLIP	21572407
MIRT556343	hsa-miR-188-3p	PAR-CLIP	21572407
MIRT1127210	hsa-miR-1179	CLIP-seq
MIRT1127211	hsa-miR-1183	CLIP-seq
MIRT1127212	hsa-miR-1193	CLIP-seq
MIRT1127213	hsa-miR-1246	CLIP-seq
MIRT1127214	hsa-miR-1267	CLIP-seq
MIRT1127215	hsa-miR-1305	CLIP-seq
MIRT1127216	hsa-miR-137	CLIP-seq
MIRT1127217	hsa-miR-218	CLIP-seq
MIRT1127218	hsa-miR-25	CLIP-seq
MIRT1127219	hsa-miR-3134	CLIP-seq
MIRT1127220	hsa-miR-3163	CLIP-seq
MIRT1127221	hsa-miR-3165	CLIP-seq
MIRT1127222	hsa-miR-32	CLIP-seq
MIRT1127223	hsa-miR-3202	CLIP-seq
MIRT1127224	hsa-miR-323-5p	CLIP-seq
MIRT1127225	hsa-miR-335	CLIP-seq
MIRT1127226	hsa-miR-363	CLIP-seq
MIRT1127227	hsa-miR-367	CLIP-seq
MIRT1127228	hsa-miR-3691-5p	CLIP-seq
MIRT1127229	hsa-miR-3692	CLIP-seq
MIRT1127230	hsa-miR-3974	CLIP-seq
MIRT1127231	hsa-miR-421	CLIP-seq
MIRT1127232	hsa-miR-4324	CLIP-seq
MIRT1127233	hsa-miR-4325	CLIP-seq
MIRT1127234	hsa-miR-4428	CLIP-seq
MIRT1127235	hsa-miR-4434	CLIP-seq
MIRT1127236	hsa-miR-4436b-5p	CLIP-seq
MIRT1127237	hsa-miR-4476	CLIP-seq
MIRT1127238	hsa-miR-4490	CLIP-seq
MIRT1127239	hsa-miR-4516	CLIP-seq
MIRT1127240	hsa-miR-4533	CLIP-seq
MIRT1127241	hsa-miR-4536	CLIP-seq
MIRT1127242	hsa-miR-4659a-3p	CLIP-seq
MIRT1127243	hsa-miR-4659b-3p	CLIP-seq
MIRT1127244	hsa-miR-4666-3p	CLIP-seq
MIRT1127245	hsa-miR-4684-3p	CLIP-seq
MIRT1127246	hsa-miR-4693-5p	CLIP-seq
MIRT1127247	hsa-miR-4711-5p	CLIP-seq
MIRT1127248	hsa-miR-4747-5p	CLIP-seq
MIRT1127249	hsa-miR-4760-3p	CLIP-seq
MIRT1127250	hsa-miR-4789-3p	CLIP-seq
MIRT1127251	hsa-miR-485-3p	CLIP-seq
MIRT1127252	hsa-miR-485-5p	CLIP-seq
MIRT1127253	hsa-miR-490-3p	CLIP-seq
MIRT1127254	hsa-miR-493	CLIP-seq
MIRT1127255	hsa-miR-499-3p	CLIP-seq
MIRT1127256	hsa-miR-499a-3p	CLIP-seq
MIRT1127257	hsa-miR-511	CLIP-seq
MIRT1127258	hsa-miR-548c-3p	CLIP-seq
MIRT1127259	hsa-miR-548m	CLIP-seq
MIRT1127260	hsa-miR-550b	CLIP-seq
MIRT1127261	hsa-miR-579	CLIP-seq
MIRT1127262	hsa-miR-626	CLIP-seq
MIRT1127263	hsa-miR-636	CLIP-seq
MIRT1127264	hsa-miR-649	CLIP-seq
MIRT1127265	hsa-miR-876-3p	CLIP-seq
MIRT1127266	hsa-miR-92a	CLIP-seq
MIRT1127267	hsa-miR-92b	CLIP-seq
MIRT1127211	hsa-miR-1183	CLIP-seq
MIRT1921677	hsa-miR-135a	CLIP-seq
MIRT1921678	hsa-miR-135b	CLIP-seq
MIRT1921679	hsa-miR-3119	CLIP-seq
MIRT1127246	hsa-miR-4693-5p	CLIP-seq
MIRT1127260	hsa-miR-550b	CLIP-seq
MIRT1127211	hsa-miR-1183	CLIP-seq
MIRT1921677	hsa-miR-135a	CLIP-seq
MIRT1921678	hsa-miR-135b	CLIP-seq
MIRT1921679	hsa-miR-3119	CLIP-seq
MIRT1127246	hsa-miR-4693-5p	CLIP-seq
MIRT1127260	hsa-miR-550b	CLIP-seq
MIRT1127211	hsa-miR-1183	CLIP-seq
MIRT1921677	hsa-miR-135a	CLIP-seq
MIRT1921678	hsa-miR-135b	CLIP-seq
MIRT1921679	hsa-miR-3119	CLIP-seq
MIRT1127246	hsa-miR-4693-5p	CLIP-seq
MIRT1127260	hsa-miR-550b	CLIP-seq
MIRT1127211	hsa-miR-1183	CLIP-seq
MIRT1921677	hsa-miR-135a	CLIP-seq
MIRT1921678	hsa-miR-135b	CLIP-seq
MIRT1921679	hsa-miR-3119	CLIP-seq
MIRT1127246	hsa-miR-4693-5p	CLIP-seq
MIRT1127260	hsa-miR-550b	CLIP-seq
MIRT1127215	hsa-miR-1305	CLIP-seq
MIRT2036052	hsa-miR-3187-3p	CLIP-seq
MIRT2036053	hsa-miR-3923	CLIP-seq
MIRT1127231	hsa-miR-421	CLIP-seq
MIRT2036054	hsa-miR-4263	CLIP-seq
MIRT2036055	hsa-miR-4435	CLIP-seq
MIRT2036056	hsa-miR-4529-5p	CLIP-seq
MIRT2036057	hsa-miR-4701-5p	CLIP-seq
MIRT2036058	hsa-miR-4775	CLIP-seq
MIRT1127250	hsa-miR-4789-3p	CLIP-seq
MIRT2036059	hsa-miR-548s	CLIP-seq
MIRT2036060	hsa-miR-576-5p	CLIP-seq
MIRT2036061	hsa-miR-588	CLIP-seq
MIRT2036062	hsa-miR-590-3p	CLIP-seq
MIRT2266380	hsa-miR-1229	CLIP-seq
MIRT2266381	hsa-miR-128	CLIP-seq
MIRT1127216	hsa-miR-137	CLIP-seq
MIRT2266382	hsa-miR-2117	CLIP-seq
MIRT1127217	hsa-miR-218	CLIP-seq
MIRT1127218	hsa-miR-25	CLIP-seq
MIRT2266383	hsa-miR-27a	CLIP-seq
MIRT2266384	hsa-miR-27b	CLIP-seq
MIRT1127222	hsa-miR-32	CLIP-seq
MIRT2266385	hsa-miR-342-3p	CLIP-seq
MIRT1127226	hsa-miR-363	CLIP-seq
MIRT1127227	hsa-miR-367	CLIP-seq
MIRT2266386	hsa-miR-4273	CLIP-seq
MIRT1127242	hsa-miR-4659a-3p	CLIP-seq
MIRT1127243	hsa-miR-4659b-3p	CLIP-seq
MIRT2266387	hsa-miR-4676-5p	CLIP-seq
MIRT1127245	hsa-miR-4684-3p	CLIP-seq
MIRT1127247	hsa-miR-4711-5p	CLIP-seq
MIRT1127249	hsa-miR-4760-3p	CLIP-seq
MIRT2266388	hsa-miR-575	CLIP-seq
MIRT1127261	hsa-miR-579	CLIP-seq
MIRT1127263	hsa-miR-636	CLIP-seq
MIRT1127266	hsa-miR-92a	CLIP-seq
MIRT1127267	hsa-miR-92b	CLIP-seq
MIRT1127216	hsa-miR-137	CLIP-seq
MIRT1127217	hsa-miR-218	CLIP-seq
MIRT1127263	hsa-miR-636	CLIP-seq
MIRT1127216	hsa-miR-137	CLIP-seq
MIRT1127217	hsa-miR-218	CLIP-seq
MIRT1127263	hsa-miR-636	CLIP-seq
MIRT1127210	hsa-miR-1179	CLIP-seq
MIRT2565681	hsa-miR-1206	CLIP-seq
MIRT1127214	hsa-miR-1267	CLIP-seq
MIRT1127224	hsa-miR-323-5p	CLIP-seq
MIRT1127232	hsa-miR-4324	CLIP-seq
MIRT2565682	hsa-miR-452	CLIP-seq
MIRT1127241	hsa-miR-4536	CLIP-seq
MIRT1127242	hsa-miR-4659a-3p	CLIP-seq
MIRT1127243	hsa-miR-4659b-3p	CLIP-seq
MIRT1127244	hsa-miR-4666-3p	CLIP-seq
MIRT2565683	hsa-miR-4676-3p	CLIP-seq
MIRT1127245	hsa-miR-4684-3p	CLIP-seq
MIRT2565684	hsa-miR-4698	CLIP-seq
MIRT1127247	hsa-miR-4711-5p	CLIP-seq
MIRT1127249	hsa-miR-4760-3p	CLIP-seq
MIRT1127251	hsa-miR-485-3p	CLIP-seq
MIRT1127252	hsa-miR-485-5p	CLIP-seq
MIRT1127253	hsa-miR-490-3p	CLIP-seq
MIRT1127257	hsa-miR-511	CLIP-seq
MIRT2565685	hsa-miR-561	CLIP-seq
MIRT1127261	hsa-miR-579	CLIP-seq
MIRT1127262	hsa-miR-626	CLIP-seq
MIRT1127264	hsa-miR-649	CLIP-seq
MIRT2565686	hsa-miR-653	CLIP-seq
MIRT1127265	hsa-miR-876-3p	CLIP-seq
MIRT1127210	hsa-miR-1179	CLIP-seq
MIRT2565681	hsa-miR-1206	CLIP-seq
MIRT1127214	hsa-miR-1267	CLIP-seq
MIRT1127224	hsa-miR-323-5p	CLIP-seq
MIRT1127232	hsa-miR-4324	CLIP-seq
MIRT1127241	hsa-miR-4536	CLIP-seq
MIRT1127242	hsa-miR-4659a-3p	CLIP-seq
MIRT1127243	hsa-miR-4659b-3p	CLIP-seq
MIRT1127244	hsa-miR-4666-3p	CLIP-seq
MIRT1127245	hsa-miR-4684-3p	CLIP-seq
MIRT1127247	hsa-miR-4711-5p	CLIP-seq
MIRT1127249	hsa-miR-4760-3p	CLIP-seq
MIRT1127251	hsa-miR-485-3p	CLIP-seq
MIRT1127252	hsa-miR-485-5p	CLIP-seq
MIRT1127253	hsa-miR-490-3p	CLIP-seq
MIRT1127257	hsa-miR-511	CLIP-seq
MIRT1127261	hsa-miR-579	CLIP-seq
MIRT1127262	hsa-miR-626	CLIP-seq
MIRT1127264	hsa-miR-649	CLIP-seq
MIRT1127265	hsa-miR-876-3p	CLIP-seq

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA	21873635
GO:0000139	Component	Golgi membrane	TAS
GO:0001701	Process	In utero embryonic development	IEA
GO:0001889	Process	Liver development	IEA
GO:0004559	Function	Alpha-mannosidase activity	IBA	21873635
GO:0004572	Function	Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	IEA
GO:0005797	Component	Golgi medial cisterna	IDA	21525244
GO:0005801	Component	Cis-Golgi network	IEA
GO:0006013	Process	Mannose metabolic process	IEA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006491	Process	N-glycan processing	IBA	21873635
GO:0006517	Process	Protein deglycosylation	IBA	21873635
GO:0007005	Process	Mitochondrion organization	IEA
GO:0007033	Process	Vacuole organization	IEA
GO:0007585	Process	Respiratory gaseous exchange by respiratory system	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IEA
GO:0016799	Function	Hydrolase activity, hydrolyzing N-glycosyl compounds	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048286	Process	Lung alveolus development	IEA
GO:0050769	Process	Positive regulation of neurogenesis	IEA
GO:0060042	Process	Retina morphogenesis in camera-type eye	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145

MIM	HGNC	e!Ensembl
154582	6824	ENSG00000112893

Protein

UniProt ID

Protein name

Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)

Protein function

Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01074	Glyco_hydro_38N	167 → 497	Glycosyl hydrolases family 38 N-terminal domain	Domain
PF09261	Alpha-mann_mid	502 → 606	Alpha mannosidase middle domain	Domain
PF07748	Glyco_hydro_38C	760 → 964	Glycosyl hydrolases family 38 C-terminal domain	Domain

Sequence

MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLER
LLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFAS
QSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGW
LKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIEN
GQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYL
LNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTC
GPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLL
APLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRD
KGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAH
KYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIG
NSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDR
ISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKI
LESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMT
KEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTC
FFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQ
IQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQ
DDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPM
ANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFS
SKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFR
IQLR

Sequence length

1144

Interactions

View interactions

	KEGG		Reactome
	N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways		Intra-Golgi traffic Reactions specific to the complex N-glycan synthesis pathway

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	30285260, 25056061, 29483656, 26198764, 31268507, 28991256

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Diabetic retinopathy	Diabetic Retinopathy		30487263

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