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MXD1 (MAX dimerization protein 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4084
Gene nameGene Name - the full gene name approved by the HGNC.
MAX dimerization protein 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
MXD1
SynonymsGene synonyms aliases
BHLHC58, MAD, MAD1
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p13.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006866 hsa-miR-138-5p Luciferase reporter assay, Microarray 22921398
MIRT017596 hsa-miR-335-5p Microarray 18185580
MIRT053155 hsa-miR-19a-3p qRT-PCR, Western blot 24675462
MIRT053210 hsa-miR-125b-5p Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 23099851
MIRT053155 hsa-miR-19a-3p Luciferase reporter assay, qRT-PCR, Western blot 24675462
Transcription factors
Transcription factor Regulation Reference
SMAD3 Unknown 21345218
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 10723141, 12837246
GO:0000785 Component Chromatin IDA 12837246
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 10723141
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q05195
Protein name Max dimerization protein 1 (Max dimerizer 1) (Protein MAD)
Protein function Component of a transcriptional repressor complex together with MAX (PubMed:8425218). In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218). Antagonizes MYC transcriptional activity by competing with MYC for MAX bind
PDB 1E91 , 1G1E , 1NLW , 1PD7 , 1S5Q
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00010 HLH
57 109
Helix-loop-helix DNA-binding domain
Domain
Sequence
MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNNSSSRST
HNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLE
DCDRKAVHQID
QLQREQRHLKRQLEKLGIERIRMDSIGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSS
SSVSDSDERGSMQSLGSDEGYSSTSIKRIKLQDSHKACLGL
Sequence length 221
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Dermatitis Dermatitis, Allergic Contact rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 17374397

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