MIR98 (microRNA 98)

Gene

• Entrez ID: 407054
• Gene name: MicroRNA 98
• Gene symbol: MIR98
• Synonyms: MIRLET7L, MIRN98, hsa-mir-98, miR-98
• Chromosome: X
• Chromosome location: Xp11.22
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003730	Function	MRNA 3'-UTR binding	IDA	31886314
GO:0005615	Component	Extracellular space	HDA	26646931
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	31886314
GO:0010629	Process	Negative regulation of gene expression	IDA	31886314
GO:0010716	Process	Negative regulation of extracellular matrix disassembly	IDA	26587789
GO:0032691	Process	Negative regulation of interleukin-1 beta production	IDA	31886314
GO:0032691	Process	Negative regulation of interleukin-1 beta production	IGI	31886314
GO:0032693	Process	Negative regulation of interleukin-10 production	IDA	29702181, 31886314
GO:0032715	Process	Negative regulation of interleukin-6 production	IDA	31886314
GO:0032717	Process	Negative regulation of interleukin-8 production	IDA	31886314
GO:0032717	Process	Negative regulation of interleukin-8 production	IGI	31886314
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IDA	31886314
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IGI	31886314
GO:0035195	Process	Gene silencing by miRNA	IDA	26098770, 26587789, 29702181, 31886314
GO:0035195	Process	Gene silencing by miRNA	IEA
GO:0035195	Process	Gene silencing by miRNA	IGI	31886314
GO:0035278	Process	MiRNA mediated inhibition of translation	IDA	27541017
GO:0042532	Process	Negative regulation of tyrosine phosphorylation of STAT protein	IGI	31886314
GO:0043525	Process	Positive regulation of neuron apoptotic process	IMP	27541017
GO:0070102	Process	Interleukin-6-mediated signaling pathway	IGI	31886314
GO:0070104	Process	Negative regulation of interleukin-6-mediated signaling pathway	IDA	26587789
GO:1900015	Process	Regulation of cytokine production involved in inflammatory response	IDA	29702181
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	IDA	31886314
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	IDA	26098770, 26587789, 27541017, 29702181, 31886314
GO:1904646	Process	Cellular response to amyloid-beta	IMP	27541017
GO:1905563	Process	Negative regulation of vascular endothelial cell proliferation	IDA	26098770

Other IDs

• MIM: 300810
• HGNC: 31649
• e!Ensembl: ENSG00000271886

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Colonic neoplasms	Malignant tumor of colon, Colonic Neoplasms	rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483	27270317
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	28545106
Esophagus neoplasm	Esophageal Neoplasms, Malignant neoplasm of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	27270317
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	27270317

Unknown
Disease name	Disease term	dbSNP ID	References
Lung neoplasms	Lung Neoplasms		27270317
Ovarian epithelial carcinoma	Carcinoma, Ovarian Epithelial		30365097