MIR34A (microRNA 34a)

Gene

• Entrez ID: 407040
• Gene name: MicroRNA 34a
• Gene symbol: MIR34A
• Synonyms: MIRN34A, miRNA34A, mir-34, mir-34a
• Chromosome: 1
• Chromosome location: 1p36.22|1p36.22
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003730	Function	MRNA 3'-UTR binding	IDA	24637697, 26330104
GO:0006974	Process	Cellular response to DNA damage stimulus	IDA	30111844
GO:0010628	Process	Positive regulation of gene expression	IDA	27302634
GO:0010629	Process	Negative regulation of gene expression	IMP	26330104
GO:0010666	Process	Positive regulation of cardiac muscle cell apoptotic process	IDA	23426265
GO:0010884	Process	Positive regulation of lipid storage	IMP	26330104
GO:0010942	Process	Positive regulation of cell death	IMP	22651868
GO:0016525	Process	Negative regulation of angiogenesis	IDA	20424141, 24048733
GO:0030336	Process	Negative regulation of cell migration	IMP	22651868
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IDA	26949937
GO:0035195	Process	Gene silencing by miRNA	HDA	18320040
GO:0035195	Process	Gene silencing by miRNA	IDA	20424141, 22651868, 23426265, 23462268, 24637697, 24792364, 26330104, 26949937, 27302634, 27780189, 30111844
GO:0035195	Process	Gene silencing by miRNA	IEA
GO:0035195	Process	Gene silencing by miRNA	IGI	23047694
GO:0035359	Process	Negative regulation of peroxisome proliferator activated receptor signaling pathway	IMP	26330104
GO:0042632	Process	Cholesterol homeostasis	ISS
GO:0048678	Process	Response to axon injury	ISS	27780189
GO:0050859	Process	Negative regulation of B cell receptor signaling pathway	IDA	30111844
GO:0051152	Process	Positive regulation of smooth muscle cell differentiation	IDA	25526086
GO:0051898	Process	Negative regulation of protein kinase B signaling	ISS
GO:0061044	Process	Negative regulation of vascular wound healing	IDA	26493107
GO:0070062	Component	Extracellular exosome	IDA	31926946
GO:0070328	Process	Triglyceride homeostasis	ISS
GO:0071158	Process	Positive regulation of cell cycle arrest	ISS
GO:0071456	Process	Cellular response to hypoxia	IDA	27302634
GO:0071672	Process	Negative regulation of smooth muscle cell chemotaxis	IDA	26493107
GO:0071901	Process	Negative regulation of protein serine/threonine kinase activity	IMP	26330104
GO:0090281	Process	Negative regulation of calcium ion import	IDA	27302634
GO:0110058	Process	Positive regulation of blood vessel endothelial cell differentiation	IDA	24792364
GO:0110114	Process	Negative regulation of lipid transporter activity	ISS
GO:1900222	Process	Negative regulation of amyloid-beta clearance	ISS
GO:1901985	Process	Positive regulation of protein acetylation	IDA	20424141
GO:1902532	Process	Negative regulation of intracellular signal transduction	IMP	26330104
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	HDA	18320040
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	IDA	23426265, 23462268, 24637697, 24792364, 26330104, 26949937, 27302634, 30111844
GO:1903561	Component	Extracellular vesicle	HDA	28798470
GO:1903671	Process	Negative regulation of sprouting angiogenesis	IDA	23426265
GO:1903671	Process	Negative regulation of sprouting angiogenesis	ISS
GO:1904046	Process	Negative regulation of vascular endothelial growth factor production	HMP	18320040
GO:1904706	Process	Negative regulation of vascular associated smooth muscle cell proliferation	IDA	24792364, 26493107, 27302634
GO:1904753	Process	Negative regulation of vascular associated smooth muscle cell migration	IDA	26493107, 27302634
GO:1905205	Process	Positive regulation of connective tissue replacement	ISS
GO:1905206	Process	Positive regulation of hydrogen peroxide-induced cell death	IMP	22651868
GO:1905563	Process	Negative regulation of vascular endothelial cell proliferation	IDA	28276476
GO:2000774	Process	Positive regulation of cellular senescence	IDA	20424141

Other IDs

• MIM: 611172
• HGNC: 31635
• e!Ensembl: ENSG00000284357

Pathways

KEGG:

MicroRNAs in cancer

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	23834033

Unknown
Disease name	Disease term	dbSNP ID	References
Anxiety disorder	Anxiety Disorders, Anxiety States, Neurotic		27424985
Fatty liver	Fatty Liver, Steatohepatitis		23834033
Heart diseases	Heart Diseases		25448438