MIR29C (microRNA 29c)

Gene

• Entrez ID: 407026
• Gene name: MicroRNA 29c
• Gene symbol: MIR29C
• Synonyms: MIRN29C, miRNA29C, mir-29c
• Chromosome: 1
• Chromosome location: 1q32.2
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001953	Process	Negative regulation of cell-matrix adhesion	IDA	23936390
GO:0003730	Function	MRNA 3'-UTR binding	IDA	21565331, 25973041, 26766915
GO:0005615	Component	Extracellular space	HDA	26646931
GO:0005739	Component	Mitochondrion	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	20086245, 23936390, 24091622, 24130168
GO:0010629	Process	Negative regulation of gene expression	IDA	20570858, 26175848
GO:0016525	Process	Negative regulation of angiogenesis	IDA	26175848
GO:0030336	Process	Negative regulation of cell migration	IDA	23936390, 24091622, 24130168, 25428377
GO:0035195	Process	Gene silencing by miRNA	IDA	18390668, 20041405, 20086245, 20570858, 22745231, 23857059, 23936390, 24091622, 24130168, 24578160, 25428377, 25973041, 26045889, 26175848, 26687115, 26766915
GO:0035195	Process	Gene silencing by miRNA	IEA
GO:0035278	Process	MiRNA mediated inhibition of translation	IDA	21565331
GO:0043065	Process	Positive regulation of apoptotic process	IDA	20041405, 24130168
GO:0043569	Process	Negative regulation of insulin-like growth factor receptor signaling pathway	IDA	26045889, 26175848
GO:0044030	Process	Regulation of DNA methylation	IDA	23857059
GO:0051898	Process	Negative regulation of protein kinase B signaling	IDA	25428377
GO:0061754	Process	Negative regulation of circulating fibrinogen levels	IDA	20570858
GO:0070062	Component	Extracellular exosome	IDA	28159509
GO:0090051	Process	Negative regulation of cell migration involved in sprouting angiogenesis	IDA	26045889, 26175848
GO:1902110	Process	Positive regulation of mitochondrial membrane permeability involved in apoptotic process	IDA	20041405
GO:1902430	Process	Negative regulation of amyloid-beta formation	IC	21565331
GO:1902430	Process	Negative regulation of amyloid-beta formation	IDA	25973041
GO:1902807	Process	Negative regulation of cell cycle G1/S phase transition	IDA	26045889
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	IDA	18390668, 20041405, 20086245, 20570858, 21565331, 22745231, 23857059, 23936390, 24091622, 24130168, 24578160, 25428377, 25973041, 26045889, 26175848, 26687115, 26766915
GO:1903561	Component	Extracellular vesicle	HDA	28798470
GO:1903588	Process	Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA	26045889
GO:1904684	Process	Negative regulation of metalloendopeptidase activity	IDA	23936390
GO:1905563	Process	Negative regulation of vascular endothelial cell proliferation	IDA	26175848
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	IDA	24130168

Other IDs

• MIM: 610784
• HGNC: 31621
• e!Ensembl: ENSG00000284214

Pathways

KEGG:

MicroRNAs in cancer
Chemical carcinogenesis - receptor activation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Pulmonary fibrosis	Pulmonary Fibrosis	rs121918666, rs199422300, rs121917737, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs863223336, rs786205702, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899, rs938938578	25926378

Unknown
Disease name	Disease term	dbSNP ID	References
Pancreatitis	Pancreatitis	rs61734659	27840954
Alveolitis	Alveolitis, Fibrosing		25926378
Urinary bladder cancer	Malignant neoplasm of urinary bladder		30026881
Bladder neoplasm	Bladder Neoplasm		30026881
Liver cirrhosis	Liver Cirrhosis		22363424
Liver fibrosis	Fibrosis, Liver		22363424