MIR195 (microRNA 195)

Gene

• Entrez ID: 406971
• Gene name: MicroRNA 195
• Gene symbol: MIR195
• Synonyms: MIRN195, miRNA195, mir-195
• Chromosome: 17
• Chromosome location: 17p13.1
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002931	Process	Response to ischemia	IEP	30497184
GO:0003245	Process	Cardiac muscle tissue growth involved in heart morphogenesis	ISS
GO:0003300	Process	Cardiac muscle hypertrophy	ISS
GO:0003730	Function	MRNA 3'-UTR binding	IDA	26440600
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	24294368
GO:0010666	Process	Positive regulation of cardiac muscle cell apoptotic process	ISS
GO:0010972	Process	Negative regulation of G2/M transition of mitotic cell cycle	ISS
GO:0032691	Process	Negative regulation of interleukin-1 beta production	ISS	30497184
GO:0032715	Process	Negative regulation of interleukin-6 production	ISS	30497184
GO:0032720	Process	Negative regulation of tumor necrosis factor production	ISS	30497184
GO:0035195	Process	Gene silencing by miRNA	HDA	18320040
GO:0035195	Process	Gene silencing by miRNA	IDA	23487264, 24294368, 26440600, 26823724, 29665645, 30497184
GO:0035195	Process	Gene silencing by miRNA	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IDA	24294368
GO:0043124	Process	Negative regulation of I-kappaB kinase/NF-kappaB signaling	IDA	23487264
GO:0045930	Process	Negative regulation of mitotic cell cycle	ISS
GO:0061049	Process	Cell growth involved in cardiac muscle cell development	ISS
GO:0090272	Process	Negative regulation of fibroblast growth factor production	IMP	26823724
GO:0150079	Process	Negative regulation of neuroinflammatory response	ISS	30497184
GO:1903202	Process	Negative regulation of oxidative stress-induced cell death	ISS	30497184
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	IDA	24294368, 26823724, 29665645, 30497184
GO:1904046	Process	Negative regulation of vascular endothelial growth factor production	HMP	18320040
GO:1904046	Process	Negative regulation of vascular endothelial growth factor production	IMP	26823724
GO:1904684	Process	Negative regulation of metalloendopeptidase activity	ISS
GO:1905205	Process	Positive regulation of connective tissue replacement	ISS

Other IDs

• MIM: 610718
• HGNC: 31566
• e!Ensembl: ENSG00000284112

Pathways

KEGG:

MicroRNAs in cancer

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	24478399
Hirschsprung disease	Hirschsprung Disease	rs104893891, rs76262710, rs75075748, rs75996173, rs79014735, rs77316810, rs75076352, rs76087194, rs76534745, rs76764689, rs76449634, rs78098482, rs79661516, rs104894389, rs769735757, rs267606780, rs1568823467, rs377767412, rs193922699, rs75030001, rs606231342, rs1553540620, rs759944122, rs1057519322, rs1057519323, rs1057519052, rs1588873476, rs1588866040, rs1838178869	25007945

Unknown
Disease name	Disease term	dbSNP ID	References
Colonic aganglionosis	Aganglionosis, Colonic, Aganglionosis, Rectosigmoid Colon		25007945
Congenital intestinal aganglionosis	Congenital Intestinal Aganglionosis		25007945