MIR17 (microRNA 17)

Gene

• Entrez ID: 406952
• Gene name: MicroRNA 17
• Gene symbol: MIR17
• Synonyms: MIR17-5p, MIR91, MIRN17, MIRN91, hsa-mir-17, miR-17, miR17-3p, miRNA17, miRNA91
• Chromosome: 13
• Chromosome location: 13q31.3
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003085	Process	Negative regulation of systemic arterial blood pressure	ISS
GO:0003151	Process	Outflow tract morphogenesis	ISS
GO:0003730	Function	MRNA 3'-UTR binding	IDA	21982160
GO:0005615	Component	Extracellular space	HDA	26646931
GO:0005739	Component	Mitochondrion	IEA
GO:0010629	Process	Negative regulation of gene expression	IDA	22161164
GO:0010666	Process	Positive regulation of cardiac muscle cell apoptotic process	ISS
GO:0010989	Process	Negative regulation of low-density lipoprotein particle clearance	IDA	23285084
GO:0034122	Process	Negative regulation of toll-like receptor signaling pathway	IMP	26041742
GO:0035195	Process	Gene silencing by miRNA	HDA	18320040
GO:0035195	Process	Gene silencing by miRNA	IDA	20190813, 20299512, 20940405, 21067317, 21508257, 21982160, 22473208, 23285084, 23969726, 25200830, 26041742, 27640178
GO:0035195	Process	Gene silencing by miRNA	IEA
GO:0035195	Process	Gene silencing by miRNA	IGI	21145484
GO:0035278	Process	MiRNA mediated inhibition of translation	IDA	23562609
GO:0035278	Process	MiRNA mediated inhibition of translation	IMP	19390056
GO:0042985	Process	Negative regulation of amyloid precursor protein biosynthetic process	IDA	21982160
GO:0043154	Process	Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISS
GO:0045777	Process	Positive regulation of blood pressure	ISS
GO:0048146	Process	Positive regulation of fibroblast proliferation	ISS
GO:0050766	Process	Positive regulation of phagocytosis	ISS
GO:0070062	Component	Extracellular exosome	IDA	31926946
GO:0071222	Process	Cellular response to lipopolysaccharide	ISS
GO:0071456	Process	Cellular response to hypoxia	IMP	27640178
GO:1900017	Process	Positive regulation of cytokine production involved in inflammatory response	ISS
GO:1901300	Process	Positive regulation of hydrogen peroxide-mediated programmed cell death	ISS
GO:1902109	Process	Negative regulation of mitochondrial membrane permeability involved in apoptotic process	ISS
GO:1903206	Process	Negative regulation of hydrogen peroxide-induced cell death	ISS
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	HDA	18320040
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	IDA	20190813, 20299512, 20940405, 21067317, 21982160, 22473208, 23285084, 23562609, 23969726, 25200830, 26041742, 27640178
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	IGI	21145484
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	IMP	19390056
GO:1903244	Process	Positive regulation of cardiac muscle hypertrophy in response to stress	ISS
GO:1903561	Component	Extracellular vesicle	HDA	28798470
GO:1903671	Process	Negative regulation of sprouting angiogenesis	IDA	20299512
GO:1904046	Process	Negative regulation of vascular endothelial growth factor production	HMP	18320040
GO:1904598	Process	Positive regulation of connective tissue replacement involved in inflammatory response wound healing	ISS
GO:1904685	Process	Positive regulation of metalloendopeptidase activity	ISS
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	IDA	22161164
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	IMP	27640178
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	ISS
GO:1905101	Process	Negative regulation of apoptosome assembly	ISS
GO:1905111	Process	Positive regulation of pulmonary blood vessel remodeling	ISS
GO:1905149	Process	Positive regulation of smooth muscle hypertrophy	ISS
GO:1905460	Process	Negative regulation of vascular associated smooth muscle cell apoptotic process	IMP	27640178
GO:1905601	Process	Negative regulation of receptor-mediated endocytosis involved in cholesterol transport	IDA	23285084
GO:2000773	Process	Negative regulation of cellular senescence	ISS
GO:2001243	Process	Negative regulation of intrinsic apoptotic signaling pathway	ISS

Other IDs

• MIM: 609416
• HGNC: 31547
• e!Ensembl: ENSG00000284536

Pathways

KEGG:

MicroRNAs in cancer

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	22094284

Unknown
Disease name	Disease term	dbSNP ID	References
Alcoholic liver cirrhosis	Liver Cirrhosis, Alcoholic		28545106
Fatty liver	Fatty Liver, Steatohepatitis		22363424
Ovarian epithelial carcinoma	Carcinoma, Ovarian Epithelial		30365097