MIR143 (microRNA 143)

Gene

• Entrez ID: 406935
• Gene name: MicroRNA 143
• Gene symbol: MIR143
• Synonyms: MIRN143, mir-143
• Chromosome: 5
• Chromosome location: 5q32
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019094	hsa-miR-335-5p	Microarray	18185580

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003730	Function	MRNA 3'-UTR binding	IDA	23128394
GO:0005615	Component	Extracellular space	HDA	26646931
GO:0006940	Process	Regulation of smooth muscle contraction	ISS
GO:0016525	Process	Negative regulation of angiogenesis	IDA	25801897
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0032148	Process	Activation of protein kinase B activity	ISS
GO:0035195	Process	Gene silencing by miRNA	IDA	23128394, 25801897
GO:0035195	Process	Gene silencing by miRNA	IEA
GO:0038166	Process	Angiotensin-activated signaling pathway	ISS
GO:0043536	Process	Positive regulation of blood vessel endothelial cell migration	IDA	26311719
GO:0044663	Process	Establishment or maintenance of cell type involved in phenotypic switching	ISS
GO:0045766	Process	Positive regulation of angiogenesis	IDA	26311719
GO:0046325	Process	Negative regulation of glucose import	ISS
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	ISS
GO:0051897	Process	Positive regulation of protein kinase B signaling	ISS
GO:0060414	Process	Aorta smooth muscle tissue morphogenesis	ISS
GO:0070062	Component	Extracellular exosome	IDA	26311719
GO:1900239	Process	Regulation of phenotypic switching	ISS
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	IDA	23128394, 25801897
GO:1904754	Process	Positive regulation of vascular associated smooth muscle cell migration	IDA	26311719
GO:1905111	Process	Positive regulation of pulmonary blood vessel remodeling	ISS

Other IDs

• MIM: 612117
• HGNC: 31530
• e!Ensembl: ENSG00000284182

Pathways

KEGG:

MicroRNAs in cancer

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Cholestasis	Cholestasis	rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039	30125006
Lymphoma	Lymphoma	rs11540652, rs1592119138, rs1592123162, rs1599367044	28736328

Unknown
Disease name	Disease term	dbSNP ID	References
B-cell lymphoma	B-Cell Lymphomas		17892514
Kidney failure	Kidney Failure, Acute		30682439
Lymphocytic leukemia	Chronic Lymphocytic Leukemia		17892514
Acute kidney insufficiency	Acute Kidney Insufficiency		30682439