CENPP (centromere protein P)

Gene

• Entrez ID: 401541
• Gene name: Centromere protein P
• Gene symbol: CENPP
• Synonyms: CENP-P
• Chromosome: 9
• Chromosome location: 9q22.31
• Summary: CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[sup

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051416	hsa-let-7e-5p	CLASH	23622248
MIRT571038	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT571036	hsa-miR-6769a-3p	PAR-CLIP	20371350
MIRT571037	hsa-miR-125a-5p	PAR-CLIP	20371350
MIRT571035	hsa-miR-125b-5p	PAR-CLIP	20371350
MIRT571033	hsa-miR-4319	PAR-CLIP	20371350
MIRT571034	hsa-miR-4324	PAR-CLIP	20371350
MIRT571032	hsa-miR-143-3p	PAR-CLIP	20371350
MIRT571031	hsa-miR-4770	PAR-CLIP	20371350
MIRT571030	hsa-miR-6088	PAR-CLIP	20371350
MIRT571029	hsa-miR-4708-5p	PAR-CLIP	20371350
MIRT571028	hsa-miR-1273f	PAR-CLIP	20371350
MIRT571026	hsa-miR-3194-5p	PAR-CLIP	20371350
MIRT571027	hsa-miR-210-5p	PAR-CLIP	20371350
MIRT571038	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT571036	hsa-miR-6769a-3p	PAR-CLIP	20371350
MIRT571037	hsa-miR-125a-5p	PAR-CLIP	20371350
MIRT571035	hsa-miR-125b-5p	PAR-CLIP	20371350
MIRT571033	hsa-miR-4319	PAR-CLIP	20371350
MIRT571034	hsa-miR-4324	PAR-CLIP	20371350
MIRT571032	hsa-miR-143-3p	PAR-CLIP	20371350
MIRT571031	hsa-miR-4770	PAR-CLIP	20371350
MIRT571030	hsa-miR-6088	PAR-CLIP	20371350
MIRT571029	hsa-miR-4708-5p	PAR-CLIP	20371350
MIRT571028	hsa-miR-1273f	PAR-CLIP	20371350
MIRT571026	hsa-miR-3194-5p	PAR-CLIP	20371350
MIRT571027	hsa-miR-210-5p	PAR-CLIP	20371350
MIRT885307	hsa-let-7a	CLIP-seq
MIRT885308	hsa-let-7b	CLIP-seq
MIRT885309	hsa-let-7c	CLIP-seq
MIRT885310	hsa-let-7d	CLIP-seq
MIRT885311	hsa-let-7e	CLIP-seq
MIRT885312	hsa-let-7f	CLIP-seq
MIRT885313	hsa-let-7g	CLIP-seq
MIRT885314	hsa-let-7i	CLIP-seq
MIRT885315	hsa-miR-1197	CLIP-seq
MIRT885316	hsa-miR-1224-5p	CLIP-seq
MIRT885317	hsa-miR-1294	CLIP-seq
MIRT885318	hsa-miR-1297	CLIP-seq
MIRT885319	hsa-miR-1343	CLIP-seq
MIRT885320	hsa-miR-143	CLIP-seq
MIRT885321	hsa-miR-196a	CLIP-seq
MIRT885322	hsa-miR-196b	CLIP-seq
MIRT885323	hsa-miR-19a	CLIP-seq
MIRT885324	hsa-miR-19b	CLIP-seq
MIRT885325	hsa-miR-23a	CLIP-seq
MIRT885326	hsa-miR-23b	CLIP-seq
MIRT885327	hsa-miR-23c	CLIP-seq
MIRT885328	hsa-miR-26a	CLIP-seq
MIRT885329	hsa-miR-26b	CLIP-seq
MIRT885330	hsa-miR-3126-5p	CLIP-seq
MIRT885331	hsa-miR-3160-3p	CLIP-seq
MIRT885332	hsa-miR-3175	CLIP-seq
MIRT885333	hsa-miR-3184	CLIP-seq
MIRT885334	hsa-miR-3192	CLIP-seq
MIRT885335	hsa-miR-3200-5p	CLIP-seq
MIRT885336	hsa-miR-326	CLIP-seq
MIRT885337	hsa-miR-330-5p	CLIP-seq
MIRT885338	hsa-miR-3605-5p	CLIP-seq
MIRT885339	hsa-miR-3607-5p	CLIP-seq
MIRT885340	hsa-miR-3677-5p	CLIP-seq
MIRT885341	hsa-miR-3689d	CLIP-seq
MIRT885342	hsa-miR-3911	CLIP-seq
MIRT885343	hsa-miR-423-5p	CLIP-seq
MIRT885344	hsa-miR-4257	CLIP-seq
MIRT885345	hsa-miR-4286	CLIP-seq
MIRT885346	hsa-miR-4314	CLIP-seq
MIRT885347	hsa-miR-4316	CLIP-seq
MIRT885348	hsa-miR-4330	CLIP-seq
MIRT885349	hsa-miR-4419a	CLIP-seq
MIRT885350	hsa-miR-4458	CLIP-seq
MIRT885351	hsa-miR-4465	CLIP-seq
MIRT885352	hsa-miR-4487	CLIP-seq
MIRT885353	hsa-miR-4500	CLIP-seq
MIRT885354	hsa-miR-4510	CLIP-seq
MIRT885355	hsa-miR-4646-5p	CLIP-seq
MIRT885356	hsa-miR-4649-3p	CLIP-seq
MIRT885357	hsa-miR-4716-3p	CLIP-seq
MIRT885358	hsa-miR-4717-3p	CLIP-seq
MIRT885359	hsa-miR-4723-5p	CLIP-seq
MIRT885360	hsa-miR-4731-5p	CLIP-seq
MIRT885361	hsa-miR-4735-5p	CLIP-seq
MIRT885362	hsa-miR-4747-5p	CLIP-seq
MIRT885363	hsa-miR-4751	CLIP-seq
MIRT885364	hsa-miR-519a	CLIP-seq
MIRT885365	hsa-miR-519b-3p	CLIP-seq
MIRT885366	hsa-miR-519c-3p	CLIP-seq
MIRT885367	hsa-miR-556-5p	CLIP-seq
MIRT885368	hsa-miR-558	CLIP-seq
MIRT885369	hsa-miR-576-5p	CLIP-seq
MIRT885370	hsa-miR-765	CLIP-seq
MIRT885371	hsa-miR-98	CLIP-seq
MIRT885323	hsa-miR-19a	CLIP-seq
MIRT885324	hsa-miR-19b	CLIP-seq
MIRT885344	hsa-miR-4257	CLIP-seq
MIRT885348	hsa-miR-4330	CLIP-seq
MIRT885361	hsa-miR-4735-5p	CLIP-seq
MIRT885369	hsa-miR-576-5p	CLIP-seq
MIRT885315	hsa-miR-1197	CLIP-seq
MIRT885316	hsa-miR-1224-5p	CLIP-seq
MIRT1962599	hsa-miR-1231	CLIP-seq
MIRT1962600	hsa-miR-139-3p	CLIP-seq
MIRT1962601	hsa-miR-296-5p	CLIP-seq
MIRT1962602	hsa-miR-302f	CLIP-seq
MIRT1962603	hsa-miR-329	CLIP-seq
MIRT1962604	hsa-miR-3614-5p	CLIP-seq
MIRT1962605	hsa-miR-362-3p	CLIP-seq
MIRT885341	hsa-miR-3689d	CLIP-seq
MIRT1962606	hsa-miR-3941	CLIP-seq
MIRT1962607	hsa-miR-4443	CLIP-seq
MIRT1962608	hsa-miR-4633-3p	CLIP-seq
MIRT1962609	hsa-miR-4691-5p	CLIP-seq
MIRT1962610	hsa-miR-4718	CLIP-seq
MIRT885363	hsa-miR-4751	CLIP-seq
MIRT1962611	hsa-miR-485-3p	CLIP-seq
MIRT1962612	hsa-miR-532-3p	CLIP-seq
MIRT1962613	hsa-miR-602	CLIP-seq
MIRT1962614	hsa-miR-603	CLIP-seq
MIRT2198902	hsa-miR-1279	CLIP-seq
MIRT885323	hsa-miR-19a	CLIP-seq
MIRT885324	hsa-miR-19b	CLIP-seq
MIRT885344	hsa-miR-4257	CLIP-seq
MIRT885348	hsa-miR-4330	CLIP-seq
MIRT2198903	hsa-miR-4693-3p	CLIP-seq
MIRT2198904	hsa-miR-4712-3p	CLIP-seq
MIRT885361	hsa-miR-4735-5p	CLIP-seq
MIRT2198905	hsa-miR-4778-5p	CLIP-seq
MIRT2198906	hsa-miR-520g	CLIP-seq
MIRT2198907	hsa-miR-520h	CLIP-seq
MIRT885369	hsa-miR-576-5p	CLIP-seq
MIRT2198908	hsa-miR-595	CLIP-seq
MIRT2198909	hsa-miR-648	CLIP-seq
MIRT885369	hsa-miR-576-5p	CLIP-seq
MIRT2446865	hsa-miR-1236	CLIP-seq
MIRT2446866	hsa-miR-1291	CLIP-seq
MIRT2446867	hsa-miR-1299	CLIP-seq
MIRT2446868	hsa-miR-2117	CLIP-seq
MIRT2446869	hsa-miR-3064-3p	CLIP-seq
MIRT2446870	hsa-miR-3173-5p	CLIP-seq
MIRT2446871	hsa-miR-3202	CLIP-seq
MIRT2446872	hsa-miR-4533	CLIP-seq
MIRT1962609	hsa-miR-4691-5p	CLIP-seq
MIRT2446873	hsa-miR-4768-5p	CLIP-seq
MIRT2446874	hsa-miR-4782-5p	CLIP-seq
MIRT2446875	hsa-miR-516b	CLIP-seq
MIRT2446876	hsa-miR-875-3p	CLIP-seq
MIRT2501675	hsa-miR-1204	CLIP-seq
MIRT885316	hsa-miR-1224-5p	CLIP-seq
MIRT1962599	hsa-miR-1231	CLIP-seq
MIRT2446865	hsa-miR-1236	CLIP-seq
MIRT2501676	hsa-miR-1258	CLIP-seq
MIRT2501677	hsa-miR-1273g	CLIP-seq
MIRT2446866	hsa-miR-1291	CLIP-seq
MIRT2501678	hsa-miR-1293	CLIP-seq
MIRT2446867	hsa-miR-1299	CLIP-seq
MIRT2501679	hsa-miR-1306	CLIP-seq
MIRT1962600	hsa-miR-139-3p	CLIP-seq
MIRT2501680	hsa-miR-1825	CLIP-seq
MIRT2501681	hsa-miR-199a-5p	CLIP-seq
MIRT2501682	hsa-miR-199b-5p	CLIP-seq
MIRT2446868	hsa-miR-2117	CLIP-seq
MIRT1962601	hsa-miR-296-5p	CLIP-seq
MIRT2446869	hsa-miR-3064-3p	CLIP-seq
MIRT2501683	hsa-miR-3064-5p	CLIP-seq
MIRT2501684	hsa-miR-3117-5p	CLIP-seq
MIRT2501685	hsa-miR-3127-5p	CLIP-seq
MIRT2501686	hsa-miR-3150b-3p	CLIP-seq
MIRT2501687	hsa-miR-3152-5p	CLIP-seq
MIRT2501688	hsa-miR-3170	CLIP-seq
MIRT2446870	hsa-miR-3173-5p	CLIP-seq
MIRT2446871	hsa-miR-3202	CLIP-seq
MIRT2501689	hsa-miR-339-5p	CLIP-seq
MIRT2501690	hsa-miR-342-5p	CLIP-seq
MIRT2501691	hsa-miR-3672	CLIP-seq
MIRT2501692	hsa-miR-3915	CLIP-seq
MIRT2501693	hsa-miR-3925-3p	CLIP-seq
MIRT2501694	hsa-miR-3929	CLIP-seq
MIRT2501695	hsa-miR-4263	CLIP-seq
MIRT2501696	hsa-miR-4287	CLIP-seq
MIRT2501697	hsa-miR-4312	CLIP-seq
MIRT2501698	hsa-miR-4326	CLIP-seq
MIRT2501699	hsa-miR-4419b	CLIP-seq
MIRT2501700	hsa-miR-4425	CLIP-seq
MIRT2501701	hsa-miR-4455	CLIP-seq
MIRT2501702	hsa-miR-4469	CLIP-seq
MIRT2501703	hsa-miR-4478	CLIP-seq
MIRT2501704	hsa-miR-4483	CLIP-seq
MIRT2446872	hsa-miR-4533	CLIP-seq
MIRT2501705	hsa-miR-4651	CLIP-seq
MIRT2501706	hsa-miR-4655-3p	CLIP-seq
MIRT2501707	hsa-miR-4664-5p	CLIP-seq
MIRT2501708	hsa-miR-4667-5p	CLIP-seq
MIRT2501709	hsa-miR-4685-3p	CLIP-seq
MIRT2501710	hsa-miR-4689	CLIP-seq
MIRT1962609	hsa-miR-4691-5p	CLIP-seq
MIRT2501711	hsa-miR-4700-5p	CLIP-seq
MIRT2501712	hsa-miR-4757-5p	CLIP-seq
MIRT2446873	hsa-miR-4768-5p	CLIP-seq
MIRT2501713	hsa-miR-4774-3p	CLIP-seq
MIRT2446874	hsa-miR-4782-5p	CLIP-seq
MIRT2501714	hsa-miR-4784	CLIP-seq
MIRT2501715	hsa-miR-508-5p	CLIP-seq
MIRT2446875	hsa-miR-516b	CLIP-seq
MIRT2198906	hsa-miR-520g	CLIP-seq
MIRT2198907	hsa-miR-520h	CLIP-seq
MIRT2501716	hsa-miR-563	CLIP-seq
MIRT885369	hsa-miR-576-5p	CLIP-seq
MIRT2198908	hsa-miR-595	CLIP-seq
MIRT2501717	hsa-miR-604	CLIP-seq
MIRT2501718	hsa-miR-608	CLIP-seq
MIRT2501719	hsa-miR-615-5p	CLIP-seq
MIRT2501720	hsa-miR-637	CLIP-seq
MIRT2501721	hsa-miR-647	CLIP-seq
MIRT2198909	hsa-miR-648	CLIP-seq
MIRT2446876	hsa-miR-875-3p	CLIP-seq
MIRT2501722	hsa-miR-876-3p	CLIP-seq
MIRT2501675	hsa-miR-1204	CLIP-seq
MIRT885316	hsa-miR-1224-5p	CLIP-seq
MIRT1962599	hsa-miR-1231	CLIP-seq
MIRT2446865	hsa-miR-1236	CLIP-seq
MIRT2501676	hsa-miR-1258	CLIP-seq
MIRT2501677	hsa-miR-1273g	CLIP-seq
MIRT2446866	hsa-miR-1291	CLIP-seq
MIRT2501678	hsa-miR-1293	CLIP-seq
MIRT2446867	hsa-miR-1299	CLIP-seq
MIRT2501679	hsa-miR-1306	CLIP-seq
MIRT1962600	hsa-miR-139-3p	CLIP-seq
MIRT2501680	hsa-miR-1825	CLIP-seq
MIRT2501681	hsa-miR-199a-5p	CLIP-seq
MIRT2501682	hsa-miR-199b-5p	CLIP-seq
MIRT2446868	hsa-miR-2117	CLIP-seq
MIRT1962601	hsa-miR-296-5p	CLIP-seq
MIRT2446869	hsa-miR-3064-3p	CLIP-seq
MIRT2501683	hsa-miR-3064-5p	CLIP-seq
MIRT2501684	hsa-miR-3117-5p	CLIP-seq
MIRT2501685	hsa-miR-3127-5p	CLIP-seq
MIRT2501686	hsa-miR-3150b-3p	CLIP-seq
MIRT2501687	hsa-miR-3152-5p	CLIP-seq
MIRT2501688	hsa-miR-3170	CLIP-seq
MIRT2446870	hsa-miR-3173-5p	CLIP-seq
MIRT2446871	hsa-miR-3202	CLIP-seq
MIRT2501689	hsa-miR-339-5p	CLIP-seq
MIRT2501690	hsa-miR-342-5p	CLIP-seq
MIRT2501691	hsa-miR-3672	CLIP-seq
MIRT2501692	hsa-miR-3915	CLIP-seq
MIRT2501693	hsa-miR-3925-3p	CLIP-seq
MIRT2501694	hsa-miR-3929	CLIP-seq
MIRT2501695	hsa-miR-4263	CLIP-seq
MIRT2678018	hsa-miR-4282	CLIP-seq
MIRT2501696	hsa-miR-4287	CLIP-seq
MIRT2501697	hsa-miR-4312	CLIP-seq
MIRT2501698	hsa-miR-4326	CLIP-seq
MIRT2501699	hsa-miR-4419b	CLIP-seq
MIRT2501700	hsa-miR-4425	CLIP-seq
MIRT2501701	hsa-miR-4455	CLIP-seq
MIRT2501702	hsa-miR-4469	CLIP-seq
MIRT2501703	hsa-miR-4478	CLIP-seq
MIRT2501704	hsa-miR-4483	CLIP-seq
MIRT2446872	hsa-miR-4533	CLIP-seq
MIRT2501705	hsa-miR-4651	CLIP-seq
MIRT2501706	hsa-miR-4655-3p	CLIP-seq
MIRT2501707	hsa-miR-4664-5p	CLIP-seq
MIRT2501708	hsa-miR-4667-5p	CLIP-seq
MIRT2501709	hsa-miR-4685-3p	CLIP-seq
MIRT2501710	hsa-miR-4689	CLIP-seq
MIRT1962609	hsa-miR-4691-5p	CLIP-seq
MIRT2501711	hsa-miR-4700-5p	CLIP-seq
MIRT2501712	hsa-miR-4757-5p	CLIP-seq
MIRT2446873	hsa-miR-4768-5p	CLIP-seq
MIRT2501713	hsa-miR-4774-3p	CLIP-seq
MIRT2446874	hsa-miR-4782-5p	CLIP-seq
MIRT2501714	hsa-miR-4784	CLIP-seq
MIRT2501715	hsa-miR-508-5p	CLIP-seq
MIRT2446875	hsa-miR-516b	CLIP-seq
MIRT2198906	hsa-miR-520g	CLIP-seq
MIRT2198907	hsa-miR-520h	CLIP-seq
MIRT2501716	hsa-miR-563	CLIP-seq
MIRT885369	hsa-miR-576-5p	CLIP-seq
MIRT2198908	hsa-miR-595	CLIP-seq
MIRT2501717	hsa-miR-604	CLIP-seq
MIRT2501718	hsa-miR-608	CLIP-seq
MIRT2501719	hsa-miR-615-5p	CLIP-seq
MIRT2501720	hsa-miR-637	CLIP-seq
MIRT2501721	hsa-miR-647	CLIP-seq
MIRT2198909	hsa-miR-648	CLIP-seq
MIRT2446876	hsa-miR-875-3p	CLIP-seq
MIRT2501722	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 26496610, 28514442, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0005829	Component	Cytosol	TAS
GO:0034080	Process	CENP-A containing nucleosome assembly	TAS

Other IDs

• MIM: 611505
• HGNC: 32933
• e!Ensembl: ENSG00000188312

Protein

• UniProt ID: Q6IPU0
• Protein name: Centromere protein P (CENP-P)
• Protein function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesiz
• PDB: 7PB8, 7PKN, 7QOO, 7R5S, 7R5V, 7XHN, 7XHO, 7YWX, 7YYH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13096	CENP-P	103 → 279	CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P	Family

• Sequence:

  MDAELAEVRALQAEIAALRRACEDPPAPWEEKSRVQKSFQAIHQFNLEGWKSSKDLKNQL
  GHLESELSFLSTLTGINIRNHSKQTEDLTSTEMTEKSIRKVLQRHRLSGNCHMVTFQLEF
  QILEIQNKERLSSAVTDLNIIMEPTECSELSEFVSRAEERKDLFMFFRSLHFFVEWFEYR
  KRTFKHLKEKYPDAVYLSEGPSSCSMGIRSASRPGFELVIVWRIQIDEDGKVFPKLDLLT
  KVPQRALELDKNRAIETAPLSFRTLVGLLGIEAALESLIKSLCAEENN

• Sequence length: 288

Pathways

Reactome:

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung carcinoma	Squamous cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	29924316