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LOX (lysyl oxidase)

Gene

4015

Lysyl oxidase

LOX

AAT10

5q23.1

This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the m

Show/Hide all(3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs886040966	C>T	Likely-pathogenic, pathogenic	Coding sequence variant, upstream transcript variant, genic upstream transcript variant, stop gained
rs1372924173	G>-	Likely-pathogenic	Coding sequence variant, genic upstream transcript variant, frameshift variant, upstream transcript variant
rs1473260982	C>A,T	Pathogenic	Missense variant, stop gained, coding sequence variant, genic upstream transcript variant, upstream transcript variant

Show/Hide all(426)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003516	hsa-miR-124-3p	Review	20144549
MIRT018405	hsa-miR-335-5p	Microarray	18185580
MIRT437550	hsa-miR-29a-3p	Luciferase reporter assay	22745231
MIRT437556	hsa-miR-29b-3p	Luciferase reporter assay	22745231
MIRT437561	hsa-miR-29c-3p	Luciferase reporter assay	22745231
MIRT437571	hsa-miR-767-5p	Luciferase reporter assay	22745231
MIRT437556	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR	23354167
MIRT438051	hsa-miR-200b-3p	Luciferase reporter assay, qRT-PCR, Western blot	23975428
MIRT437556	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR	23354167
MIRT438051	hsa-miR-200b-3p	Luciferase reporter assay, qRT-PCR, Western blot	23975428
MIRT442626	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442625	hsa-miR-4280	PAR-CLIP	22100165
MIRT442624	hsa-miR-3120-5p	PAR-CLIP	22100165
MIRT442623	hsa-miR-6830-3p	PAR-CLIP	22100165
MIRT442622	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT442621	hsa-miR-6888-3p	PAR-CLIP	22100165
MIRT442620	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT442619	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT442618	hsa-miR-4743-3p	PAR-CLIP	22100165
MIRT442626	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442625	hsa-miR-4280	PAR-CLIP	22100165
MIRT442624	hsa-miR-3120-5p	PAR-CLIP	22100165
MIRT442623	hsa-miR-6830-3p	PAR-CLIP	22100165
MIRT442622	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT442621	hsa-miR-6888-3p	PAR-CLIP	22100165
MIRT442620	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT442619	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT442618	hsa-miR-4743-3p	PAR-CLIP	22100165
MIRT731147	hsa-miR-30a-5p	Western blot, Luciferase reporter assay, Immunohistochemistry	25488748
MIRT731147	hsa-miR-30a-5p	Western blot, Luciferase reporter assay, Immunohistochemistry	25488748
MIRT437556	hsa-miR-29b-3p	qRT-PCR	25744716
MIRT437556	hsa-miR-29b-3p	qRT-PCR	25744716
MIRT442626	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442625	hsa-miR-4280	PAR-CLIP	22100165
MIRT442624	hsa-miR-3120-5p	PAR-CLIP	22100165
MIRT442623	hsa-miR-6830-3p	PAR-CLIP	22100165
MIRT442622	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT442621	hsa-miR-6888-3p	PAR-CLIP	22100165
MIRT442620	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT442619	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT442618	hsa-miR-4743-3p	PAR-CLIP	22100165
MIRT442626	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442625	hsa-miR-4280	PAR-CLIP	22100165
MIRT442624	hsa-miR-3120-5p	PAR-CLIP	22100165
MIRT442623	hsa-miR-6830-3p	PAR-CLIP	22100165
MIRT442622	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT442621	hsa-miR-6888-3p	PAR-CLIP	22100165
MIRT442620	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT442619	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT442618	hsa-miR-4743-3p	PAR-CLIP	22100165
MIRT1115331	hsa-miR-124	CLIP-seq
MIRT1115332	hsa-miR-1273g	CLIP-seq
MIRT1115333	hsa-miR-3065-5p	CLIP-seq
MIRT1115334	hsa-miR-3714	CLIP-seq
MIRT1115335	hsa-miR-3910	CLIP-seq
MIRT1115336	hsa-miR-4477b	CLIP-seq
MIRT1115337	hsa-miR-506	CLIP-seq
MIRT1115338	hsa-miR-583	CLIP-seq
MIRT1115339	hsa-miR-935	CLIP-seq
MIRT1115340	hsa-miR-1260	CLIP-seq
MIRT1115341	hsa-miR-1260b	CLIP-seq
MIRT1115342	hsa-miR-188-3p	CLIP-seq
MIRT1115343	hsa-miR-3145-3p	CLIP-seq
MIRT1115344	hsa-miR-3156-3p	CLIP-seq
MIRT1115345	hsa-miR-3653	CLIP-seq
MIRT1115346	hsa-miR-3658	CLIP-seq
MIRT1115347	hsa-miR-3689a-5p	CLIP-seq
MIRT1115348	hsa-miR-3689b	CLIP-seq
MIRT1115349	hsa-miR-3689e	CLIP-seq
MIRT1115350	hsa-miR-3689f	CLIP-seq
MIRT1115351	hsa-miR-3713	CLIP-seq
MIRT1115352	hsa-miR-3924	CLIP-seq
MIRT1115353	hsa-miR-4279	CLIP-seq
MIRT1115354	hsa-miR-4301	CLIP-seq
MIRT1115355	hsa-miR-4446-5p	CLIP-seq
MIRT1115356	hsa-miR-4474-5p	CLIP-seq
MIRT1115357	hsa-miR-4477a	CLIP-seq
MIRT1115358	hsa-miR-4670-3p	CLIP-seq
MIRT1115359	hsa-miR-4711-3p	CLIP-seq
MIRT1115360	hsa-miR-4724-5p	CLIP-seq
MIRT1115361	hsa-miR-4790-3p	CLIP-seq
MIRT1115362	hsa-miR-942	CLIP-seq
MIRT1550797	hsa-miR-1200	CLIP-seq
MIRT1550798	hsa-miR-1273d	CLIP-seq
MIRT1550799	hsa-miR-134	CLIP-seq
MIRT1550800	hsa-miR-200b	CLIP-seq
MIRT1550801	hsa-miR-200c	CLIP-seq
MIRT1550802	hsa-miR-24	CLIP-seq
MIRT1550803	hsa-miR-3118	CLIP-seq
MIRT1550804	hsa-miR-3136-5p	CLIP-seq
MIRT1550805	hsa-miR-3140-5p	CLIP-seq
MIRT1550806	hsa-miR-3148	CLIP-seq
MIRT1550807	hsa-miR-3164	CLIP-seq
MIRT1550808	hsa-miR-3675-3p	CLIP-seq
MIRT1550809	hsa-miR-374c	CLIP-seq
MIRT1550810	hsa-miR-4284	CLIP-seq
MIRT1550811	hsa-miR-429	CLIP-seq
MIRT1550812	hsa-miR-4427	CLIP-seq
MIRT1550813	hsa-miR-4439	CLIP-seq
MIRT1550814	hsa-miR-4496	CLIP-seq
MIRT1550815	hsa-miR-4513	CLIP-seq
MIRT1550816	hsa-miR-4659a-5p	CLIP-seq
MIRT1550817	hsa-miR-4659b-5p	CLIP-seq
MIRT1550818	hsa-miR-4720-3p	CLIP-seq
MIRT1550819	hsa-miR-4768-5p	CLIP-seq
MIRT1550820	hsa-miR-4776-3p	CLIP-seq
MIRT1550821	hsa-miR-4777-5p	CLIP-seq
MIRT1550822	hsa-miR-4795-3p	CLIP-seq
MIRT1550823	hsa-miR-488	CLIP-seq
MIRT1550824	hsa-miR-518d-5p	CLIP-seq
MIRT1550825	hsa-miR-519b-5p	CLIP-seq
MIRT1550826	hsa-miR-519c-5p	CLIP-seq
MIRT1550827	hsa-miR-520c-5p	CLIP-seq
MIRT1550828	hsa-miR-526a	CLIP-seq
MIRT1550829	hsa-miR-655	CLIP-seq
MIRT1550830	hsa-miR-889	CLIP-seq
MIRT1550797	hsa-miR-1200	CLIP-seq
MIRT1550798	hsa-miR-1273d	CLIP-seq
MIRT1550799	hsa-miR-134	CLIP-seq
MIRT1550800	hsa-miR-200b	CLIP-seq
MIRT1550801	hsa-miR-200c	CLIP-seq
MIRT1550803	hsa-miR-3118	CLIP-seq
MIRT1550804	hsa-miR-3136-5p	CLIP-seq
MIRT1550805	hsa-miR-3140-5p	CLIP-seq
MIRT1550807	hsa-miR-3164	CLIP-seq
MIRT1550811	hsa-miR-429	CLIP-seq
MIRT1550812	hsa-miR-4427	CLIP-seq
MIRT1550813	hsa-miR-4439	CLIP-seq
MIRT1550815	hsa-miR-4513	CLIP-seq
MIRT1550831	hsa-miR-514	CLIP-seq
MIRT1550832	hsa-miR-514b-3p	CLIP-seq
MIRT1550833	hsa-miR-526b	CLIP-seq
MIRT1550834	hsa-miR-578	CLIP-seq
MIRT2032453	hsa-miR-145	CLIP-seq
MIRT2262949	hsa-miR-2054	CLIP-seq
MIRT2262950	hsa-miR-3646	CLIP-seq
MIRT1550809	hsa-miR-374c	CLIP-seq
MIRT2262951	hsa-miR-380	CLIP-seq
MIRT2262952	hsa-miR-425	CLIP-seq
MIRT2262953	hsa-miR-4495	CLIP-seq
MIRT2262954	hsa-miR-4698	CLIP-seq
MIRT2262955	hsa-miR-590-3p	CLIP-seq
MIRT1550829	hsa-miR-655	CLIP-seq
MIRT1550800	hsa-miR-200b	CLIP-seq
MIRT1550801	hsa-miR-200c	CLIP-seq
MIRT2262950	hsa-miR-3646	CLIP-seq
MIRT1550811	hsa-miR-429	CLIP-seq
MIRT1550822	hsa-miR-4795-3p	CLIP-seq
MIRT1550800	hsa-miR-200b	CLIP-seq
MIRT1550801	hsa-miR-200c	CLIP-seq
MIRT1550802	hsa-miR-24	CLIP-seq
MIRT2262950	hsa-miR-3646	CLIP-seq
MIRT1550810	hsa-miR-4284	CLIP-seq
MIRT1550811	hsa-miR-429	CLIP-seq
MIRT2262953	hsa-miR-4495	CLIP-seq
MIRT2430796	hsa-miR-4775	CLIP-seq
MIRT1550822	hsa-miR-4795-3p	CLIP-seq
MIRT1550823	hsa-miR-488	CLIP-seq
MIRT2430797	hsa-miR-591	CLIP-seq
MIRT1115335	hsa-miR-3910	CLIP-seq
MIRT2262950	hsa-miR-3646	CLIP-seq
MIRT1550822	hsa-miR-4795-3p	CLIP-seq
MIRT1550823	hsa-miR-488	CLIP-seq
MIRT2562218	hsa-miR-105	CLIP-seq
MIRT1550797	hsa-miR-1200	CLIP-seq
MIRT2562219	hsa-miR-1244	CLIP-seq
MIRT2562220	hsa-miR-1257	CLIP-seq
MIRT1550798	hsa-miR-1273d	CLIP-seq
MIRT2562221	hsa-miR-128	CLIP-seq
MIRT2562222	hsa-miR-129-5p	CLIP-seq
MIRT2562223	hsa-miR-1910	CLIP-seq
MIRT2562224	hsa-miR-1914	CLIP-seq
MIRT2562225	hsa-miR-199a-3p	CLIP-seq
MIRT2562226	hsa-miR-199b-3p	CLIP-seq
MIRT1550800	hsa-miR-200b	CLIP-seq
MIRT1550801	hsa-miR-200c	CLIP-seq
MIRT2562227	hsa-miR-219-5p	CLIP-seq
MIRT2562228	hsa-miR-27a	CLIP-seq
MIRT2562229	hsa-miR-27b	CLIP-seq
MIRT2562230	hsa-miR-28-5p	CLIP-seq
MIRT2562231	hsa-miR-298	CLIP-seq
MIRT2562232	hsa-miR-29a	CLIP-seq
MIRT2562233	hsa-miR-29b	CLIP-seq
MIRT2562234	hsa-miR-29c	CLIP-seq
MIRT2562235	hsa-miR-3065-3p	CLIP-seq
MIRT2562236	hsa-miR-3129-5p	CLIP-seq
MIRT2562237	hsa-miR-3139	CLIP-seq
MIRT1550805	hsa-miR-3140-5p	CLIP-seq
MIRT2562238	hsa-miR-3143	CLIP-seq
MIRT1550806	hsa-miR-3148	CLIP-seq
MIRT2562239	hsa-miR-3163	CLIP-seq
MIRT2562240	hsa-miR-3189-3p	CLIP-seq
MIRT2562241	hsa-miR-337-3p	CLIP-seq
MIRT2562242	hsa-miR-3591-3p	CLIP-seq
MIRT2562243	hsa-miR-3611	CLIP-seq
MIRT2562244	hsa-miR-3613-3p	CLIP-seq
MIRT2262950	hsa-miR-3646	CLIP-seq
MIRT1115345	hsa-miR-3653	CLIP-seq
MIRT2562245	hsa-miR-3657	CLIP-seq
MIRT1115346	hsa-miR-3658	CLIP-seq
MIRT2562246	hsa-miR-3662	CLIP-seq
MIRT2562247	hsa-miR-3671	CLIP-seq
MIRT2562248	hsa-miR-3672	CLIP-seq
MIRT1550808	hsa-miR-3675-3p	CLIP-seq
MIRT2562249	hsa-miR-3678-3p	CLIP-seq
MIRT2562250	hsa-miR-3680	CLIP-seq
MIRT1550809	hsa-miR-374c	CLIP-seq
MIRT1115352	hsa-miR-3924	CLIP-seq
MIRT2562251	hsa-miR-4263	CLIP-seq
MIRT2562252	hsa-miR-4282	CLIP-seq
MIRT1550811	hsa-miR-429	CLIP-seq
MIRT2562253	hsa-miR-4325	CLIP-seq
MIRT2562254	hsa-miR-4326	CLIP-seq
MIRT2562255	hsa-miR-4328	CLIP-seq
MIRT2562256	hsa-miR-4420	CLIP-seq
MIRT1550812	hsa-miR-4427	CLIP-seq
MIRT2562257	hsa-miR-4445	CLIP-seq
MIRT1550814	hsa-miR-4496	CLIP-seq
MIRT2562258	hsa-miR-4503	CLIP-seq
MIRT2562259	hsa-miR-450b-5p	CLIP-seq
MIRT2562260	hsa-miR-451b	CLIP-seq
MIRT2562261	hsa-miR-4540	CLIP-seq
MIRT2562262	hsa-miR-4637	CLIP-seq
MIRT2562263	hsa-miR-4645-3p	CLIP-seq
MIRT2562264	hsa-miR-4652-3p	CLIP-seq
MIRT2562265	hsa-miR-4668-3p	CLIP-seq
MIRT2562266	hsa-miR-4669	CLIP-seq
MIRT1115358	hsa-miR-4670-3p	CLIP-seq
MIRT2262954	hsa-miR-4698	CLIP-seq
MIRT2562267	hsa-miR-4714-5p	CLIP-seq
MIRT2562268	hsa-miR-4717-3p	CLIP-seq
MIRT1550818	hsa-miR-4720-3p	CLIP-seq
MIRT2562269	hsa-miR-4735-5p	CLIP-seq
MIRT2562270	hsa-miR-4764-3p	CLIP-seq
MIRT2562271	hsa-miR-4766-5p	CLIP-seq
MIRT1550821	hsa-miR-4777-5p	CLIP-seq
MIRT2562272	hsa-miR-4781-3p	CLIP-seq
MIRT2562273	hsa-miR-4782-3p	CLIP-seq
MIRT2562274	hsa-miR-4799-5p	CLIP-seq
MIRT2562275	hsa-miR-4804-3p	CLIP-seq
MIRT1550823	hsa-miR-488	CLIP-seq
MIRT2562276	hsa-miR-507	CLIP-seq
MIRT2562277	hsa-miR-508-3p	CLIP-seq
MIRT2562278	hsa-miR-511	CLIP-seq
MIRT2562279	hsa-miR-513a-5p	CLIP-seq
MIRT1550824	hsa-miR-518d-5p	CLIP-seq
MIRT1550825	hsa-miR-519b-5p	CLIP-seq
MIRT1550826	hsa-miR-519c-5p	CLIP-seq
MIRT1550827	hsa-miR-520c-5p	CLIP-seq
MIRT1550828	hsa-miR-526a	CLIP-seq
MIRT2562280	hsa-miR-543	CLIP-seq
MIRT2562281	hsa-miR-548l	CLIP-seq
MIRT2562282	hsa-miR-550b	CLIP-seq
MIRT2562283	hsa-miR-557	CLIP-seq
MIRT2562284	hsa-miR-576-3p	CLIP-seq
MIRT2562285	hsa-miR-576-5p	CLIP-seq
MIRT2562286	hsa-miR-577	CLIP-seq
MIRT2562287	hsa-miR-607	CLIP-seq
MIRT2562288	hsa-miR-626	CLIP-seq
MIRT1550829	hsa-miR-655	CLIP-seq
MIRT2562289	hsa-miR-656	CLIP-seq
MIRT2562290	hsa-miR-708	CLIP-seq
MIRT2562291	hsa-miR-875-3p	CLIP-seq
MIRT1550830	hsa-miR-889	CLIP-seq
MIRT2562218	hsa-miR-105	CLIP-seq
MIRT1550797	hsa-miR-1200	CLIP-seq
MIRT1115331	hsa-miR-124	CLIP-seq
MIRT2562219	hsa-miR-1244	CLIP-seq
MIRT2562220	hsa-miR-1257	CLIP-seq
MIRT1550798	hsa-miR-1273d	CLIP-seq
MIRT2562221	hsa-miR-128	CLIP-seq
MIRT2684008	hsa-miR-1283	CLIP-seq
MIRT2562222	hsa-miR-129-5p	CLIP-seq
MIRT2684009	hsa-miR-1297	CLIP-seq
MIRT2684010	hsa-miR-140-3p	CLIP-seq
MIRT2684011	hsa-miR-155	CLIP-seq
MIRT2562223	hsa-miR-1910	CLIP-seq
MIRT2684012	hsa-miR-1913	CLIP-seq
MIRT2562224	hsa-miR-1914	CLIP-seq
MIRT2684013	hsa-miR-197	CLIP-seq
MIRT2684014	hsa-miR-1976	CLIP-seq
MIRT2562225	hsa-miR-199a-3p	CLIP-seq
MIRT2562226	hsa-miR-199b-3p	CLIP-seq
MIRT1550800	hsa-miR-200b	CLIP-seq
MIRT1550801	hsa-miR-200c	CLIP-seq
MIRT2262949	hsa-miR-2054	CLIP-seq
MIRT2684015	hsa-miR-218	CLIP-seq
MIRT2562227	hsa-miR-219-5p	CLIP-seq
MIRT2684016	hsa-miR-223	CLIP-seq
MIRT2684017	hsa-miR-26a	CLIP-seq
MIRT2684018	hsa-miR-26b	CLIP-seq
MIRT2562228	hsa-miR-27a	CLIP-seq
MIRT2562229	hsa-miR-27b	CLIP-seq
MIRT2562230	hsa-miR-28-5p	CLIP-seq
MIRT2562231	hsa-miR-298	CLIP-seq
MIRT2562232	hsa-miR-29a	CLIP-seq
MIRT2562233	hsa-miR-29b	CLIP-seq
MIRT2562234	hsa-miR-29c	CLIP-seq
MIRT2562235	hsa-miR-3065-3p	CLIP-seq
MIRT2684019	hsa-miR-30a	CLIP-seq
MIRT2684020	hsa-miR-30b	CLIP-seq
MIRT2684021	hsa-miR-30c	CLIP-seq
MIRT2684022	hsa-miR-30d	CLIP-seq
MIRT2684023	hsa-miR-30e	CLIP-seq
MIRT2684024	hsa-miR-3121-5p	CLIP-seq
MIRT2562236	hsa-miR-3129-5p	CLIP-seq
MIRT2562237	hsa-miR-3139	CLIP-seq
MIRT1550805	hsa-miR-3140-5p	CLIP-seq
MIRT2562238	hsa-miR-3143	CLIP-seq
MIRT2684025	hsa-miR-3146	CLIP-seq
MIRT1550806	hsa-miR-3148	CLIP-seq
MIRT2684026	hsa-miR-3153	CLIP-seq
MIRT2562239	hsa-miR-3163	CLIP-seq
MIRT2562240	hsa-miR-3189-3p	CLIP-seq
MIRT2684027	hsa-miR-324-3p	CLIP-seq
MIRT2684028	hsa-miR-331-5p	CLIP-seq
MIRT2562241	hsa-miR-337-3p	CLIP-seq
MIRT2562242	hsa-miR-3591-3p	CLIP-seq
MIRT2562243	hsa-miR-3611	CLIP-seq
MIRT2562244	hsa-miR-3613-3p	CLIP-seq
MIRT2684029	hsa-miR-361-5p	CLIP-seq
MIRT2262950	hsa-miR-3646	CLIP-seq
MIRT1115345	hsa-miR-3653	CLIP-seq
MIRT2562245	hsa-miR-3657	CLIP-seq
MIRT1115346	hsa-miR-3658	CLIP-seq
MIRT2562246	hsa-miR-3662	CLIP-seq
MIRT2562247	hsa-miR-3671	CLIP-seq
MIRT2562248	hsa-miR-3672	CLIP-seq
MIRT1550808	hsa-miR-3675-3p	CLIP-seq
MIRT2562249	hsa-miR-3678-3p	CLIP-seq
MIRT2562250	hsa-miR-3680	CLIP-seq
MIRT1115334	hsa-miR-3714	CLIP-seq
MIRT1550809	hsa-miR-374c	CLIP-seq
MIRT2684030	hsa-miR-375	CLIP-seq
MIRT2262951	hsa-miR-380	CLIP-seq
MIRT1115335	hsa-miR-3910	CLIP-seq
MIRT1115352	hsa-miR-3924	CLIP-seq
MIRT2684031	hsa-miR-410	CLIP-seq
MIRT2262952	hsa-miR-425	CLIP-seq
MIRT2562251	hsa-miR-4263	CLIP-seq
MIRT2562252	hsa-miR-4282	CLIP-seq
MIRT1550811	hsa-miR-429	CLIP-seq
MIRT2684032	hsa-miR-4307	CLIP-seq
MIRT2562253	hsa-miR-4325	CLIP-seq
MIRT2562254	hsa-miR-4326	CLIP-seq
MIRT2562255	hsa-miR-4328	CLIP-seq
MIRT2562256	hsa-miR-4420	CLIP-seq
MIRT2684033	hsa-miR-4421	CLIP-seq
MIRT1550812	hsa-miR-4427	CLIP-seq
MIRT2562257	hsa-miR-4445	CLIP-seq
MIRT2684034	hsa-miR-4452	CLIP-seq
MIRT2684035	hsa-miR-4465	CLIP-seq
MIRT1115336	hsa-miR-4477b	CLIP-seq
MIRT2262953	hsa-miR-4495	CLIP-seq
MIRT1550814	hsa-miR-4496	CLIP-seq
MIRT2562258	hsa-miR-4503	CLIP-seq
MIRT2562259	hsa-miR-450b-5p	CLIP-seq
MIRT2562260	hsa-miR-451b	CLIP-seq
MIRT2562261	hsa-miR-4540	CLIP-seq
MIRT2684036	hsa-miR-455-5p	CLIP-seq
MIRT2684037	hsa-miR-4635	CLIP-seq
MIRT2562262	hsa-miR-4637	CLIP-seq
MIRT2684038	hsa-miR-4639-5p	CLIP-seq
MIRT2684039	hsa-miR-4641	CLIP-seq
MIRT2562263	hsa-miR-4645-3p	CLIP-seq
MIRT2562264	hsa-miR-4652-3p	CLIP-seq
MIRT2562265	hsa-miR-4668-3p	CLIP-seq
MIRT2684040	hsa-miR-4668-5p	CLIP-seq
MIRT2562266	hsa-miR-4669	CLIP-seq
MIRT1115358	hsa-miR-4670-3p	CLIP-seq
MIRT2684041	hsa-miR-4697-3p	CLIP-seq
MIRT2262954	hsa-miR-4698	CLIP-seq
MIRT2684042	hsa-miR-4700-3p	CLIP-seq
MIRT2562267	hsa-miR-4714-5p	CLIP-seq
MIRT2562268	hsa-miR-4717-3p	CLIP-seq
MIRT1550818	hsa-miR-4720-3p	CLIP-seq
MIRT2562269	hsa-miR-4735-5p	CLIP-seq
MIRT2684043	hsa-miR-4760-3p	CLIP-seq
MIRT2562270	hsa-miR-4764-3p	CLIP-seq
MIRT2562271	hsa-miR-4766-5p	CLIP-seq
MIRT2430796	hsa-miR-4775	CLIP-seq
MIRT1550821	hsa-miR-4777-5p	CLIP-seq
MIRT2562272	hsa-miR-4781-3p	CLIP-seq
MIRT2562273	hsa-miR-4782-3p	CLIP-seq
MIRT1550822	hsa-miR-4795-3p	CLIP-seq
MIRT2562274	hsa-miR-4799-5p	CLIP-seq
MIRT2562275	hsa-miR-4804-3p	CLIP-seq
MIRT1550823	hsa-miR-488	CLIP-seq
MIRT2684044	hsa-miR-499-3p	CLIP-seq
MIRT2684045	hsa-miR-499a-3p	CLIP-seq
MIRT1115337	hsa-miR-506	CLIP-seq
MIRT2562276	hsa-miR-507	CLIP-seq
MIRT2562277	hsa-miR-508-3p	CLIP-seq
MIRT2562278	hsa-miR-511	CLIP-seq
MIRT2562279	hsa-miR-513a-5p	CLIP-seq
MIRT1550824	hsa-miR-518d-5p	CLIP-seq
MIRT1550825	hsa-miR-519b-5p	CLIP-seq
MIRT1550826	hsa-miR-519c-5p	CLIP-seq
MIRT1550827	hsa-miR-520c-5p	CLIP-seq
MIRT1550828	hsa-miR-526a	CLIP-seq
MIRT1550833	hsa-miR-526b	CLIP-seq
MIRT2562280	hsa-miR-543	CLIP-seq
MIRT2562281	hsa-miR-548l	CLIP-seq
MIRT2684046	hsa-miR-548n	CLIP-seq
MIRT2684047	hsa-miR-548p	CLIP-seq
MIRT2684048	hsa-miR-548t	CLIP-seq
MIRT2562282	hsa-miR-550b	CLIP-seq
MIRT2562283	hsa-miR-557	CLIP-seq
MIRT2562284	hsa-miR-576-3p	CLIP-seq
MIRT2562285	hsa-miR-576-5p	CLIP-seq
MIRT2562286	hsa-miR-577	CLIP-seq
MIRT1550834	hsa-miR-578	CLIP-seq
MIRT2684049	hsa-miR-579	CLIP-seq
MIRT1115338	hsa-miR-583	CLIP-seq
MIRT2262955	hsa-miR-590-3p	CLIP-seq
MIRT2562287	hsa-miR-607	CLIP-seq
MIRT2562288	hsa-miR-626	CLIP-seq
MIRT2684050	hsa-miR-636	CLIP-seq
MIRT1550829	hsa-miR-655	CLIP-seq
MIRT2562289	hsa-miR-656	CLIP-seq
MIRT2684051	hsa-miR-660	CLIP-seq
MIRT2562290	hsa-miR-708	CLIP-seq
MIRT2562291	hsa-miR-875-3p	CLIP-seq
MIRT2684052	hsa-miR-888	CLIP-seq
MIRT1550830	hsa-miR-889	CLIP-seq
MIRT1115339	hsa-miR-935	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
GATA3	Repression	21892208
HIF1A	Unknown	17685448

Show/Hide all(47)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	IEA
GO:0001932	Process	Regulation of protein phosphorylation	IEA
GO:0004720	Function	Protein-lysine 6-oxidase activity	IBA	21873635
GO:0004720	Function	Protein-lysine 6-oxidase activity	IDA	31152061
GO:0004720	Function	Protein-lysine 6-oxidase activity	ISS
GO:0005507	Function	Copper ion binding	IEA
GO:0005515	Function	Protein binding	IPI	19570982, 19855011, 21690299, 22919265, 25118846, 26601954, 27339457
GO:0005518	Function	Collagen binding	IDA	31152061
GO:0005576	Component	Extracellular region	ISS
GO:0005576	Component	Extracellular region	TAS
GO:0005581	Component	Collagen trimer	IEA
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	31152061
GO:0005634	Component	Nucleus	IEA
GO:0006464	Process	Cellular protein modification process	TAS	1685472
GO:0007507	Process	Heart development	IEA
GO:0010468	Process	Regulation of gene expression	IEA
GO:0016202	Process	Regulation of striated muscle tissue development	IEA
GO:0017015	Process	Regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0018057	Process	Peptidyl-lysine oxidation	IBA	21873635
GO:0018057	Process	Peptidyl-lysine oxidation	IDA	31152061
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0030199	Process	Collagen fibril organization	IBA	21873635
GO:0030282	Process	Bone mineralization	IEA
GO:0030324	Process	Lung development	IEA
GO:0031012	Component	Extracellular matrix	IEA
GO:0035791	Process	Platelet-derived growth factor receptor-beta signaling pathway	IEA
GO:0035905	Process	Ascending aorta development	IEA
GO:0035906	Process	Descending aorta development	IEA
GO:0042060	Process	Wound healing	IEA
GO:0042493	Process	Response to drug	IEA
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0043491	Process	Protein kinase B signaling	IEA
GO:0045652	Process	Regulation of megakaryocyte differentiation	IEA
GO:0046716	Process	Muscle cell cellular homeostasis	IEA
GO:0048251	Process	Elastic fiber assembly	IEA
GO:0048514	Process	Blood vessel morphogenesis	ISS
GO:0048545	Process	Response to steroid hormone	IEA
GO:0048747	Process	Muscle fiber development	IEA
GO:0060326	Process	Cell chemotaxis	IEA
GO:0061448	Process	Connective tissue development	IEA
GO:0071897	Process	DNA biosynthetic process	IEA
GO:1900120	Process	Regulation of receptor binding	IEA
GO:1903010	Process	Regulation of bone development	IEA
GO:1990869	Process	Cellular response to chemokine	IEA
GO:2000586	Process	Regulation of platelet-derived growth factor receptor-beta signaling pathway	IEA

MIM	HGNC	e!Ensembl
153455	6664	ENSG00000113083

Protein

UniProt ID

P28300

Protein name

Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase) [Cleaved into: Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form]

Protein function

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aort

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01186	Lysyl_oxidase	213 → 414	Lysyl oxidase	Family

Sequence

MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSL
GSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPT
ARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDD
NPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAA
EENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDE
FSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADID
CQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

Sequence length

417

Interactions

View interactions

	Reactome
			Elastic fibre formation Crosslinking of collagen fibrils

Associated diseases

Show/Hide Causal Diseases (8)

Causal
Disease name	Disease term	dbSNP ID	References
Aortic aneurysm	Aortic Aneurysm, Aortic Aneurysm, Abdominal, AORTIC ANEURYSM, FAMILIAL THORACIC 10	rs1555554098, rs267606902, rs121434526, rs121434527, rs121434528, rs387906592, rs387906781, rs387906782, rs397516685, rs397514037, rs112901682, rs397515325, rs397515330, rs794728025, rs112602953, rs794728021, rs8046180, rs797045725, rs876657852, rs878854466, rs886038978, rs746972765, rs886039303, rs886040965, rs886040966, rs886040967, rs886229659, rs1553781304, rs1060502531, rs1553795301, rs1553803235, rs1213452826, rs869025352, rs1553780501, rs1553785222, rs1382893400, rs1554841990, rs1430822242, rs1567692384, rs1576422965, rs1596712899, rs2059732940, rs2041090817, rs1439991530	27432961, 27432961, 26838787
Bicuspid aortic valve	Bicuspid aortic valve	rs1569484234, rs1569484208
Congenital aneurysm of ascending aorta	Congenital aneurysm of ascending aorta	rs387906853, rs1553508473
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	28714974
Hypertension	Hypertensive disease	rs13306026, rs13333226
Patent ductus arteriosus	Patent ductus arteriosus	rs80338911, rs879253870, rs879253871, rs879255278, rs879255279, rs879253872
Scoliosis	Scoliosis, unspecified	rs1057518828, rs147296805, rs758163506, rs1555613564, rs1596852902, rs1596853067, rs1596853085
Thoracic aortic aneurysm and aortic dissection	Familial thoracic aortic aneurysm and aortic dissection	rs121964962, rs121964964, rs5742905, rs121964969, rs28934891, rs375846341, rs121964972, rs121964973, rs587776600, rs121908172, rs121908173, rs121918714, rs104893809, rs104893815, rs104893810, rs104893811, rs104893816, rs104893817, rs104893819, rs111854391, rs113605875, rs111426349, rs267606902, rs121913552, rs267606796, rs137854458, rs137854461, rs137854463, rs137854464, rs137854466, rs112989722, rs137854476, rs137854477, rs137854478, rs137854479, rs137854480, rs137854485, rs786200923, rs113485686, rs397509370, rs121912927, rs121912923, rs121912926, rs121434526, rs121434527, rs121434528, rs387906592, rs387906606, rs387906623, rs387906697, rs387906781, rs387906782, rs387906850, rs587776881, rs387906853, rs193922183, rs193922185, rs193921256, rs112202622, rs193922198, rs193922204, rs113871094, rs147195031, rs193922236, rs397514558, rs397514590, rs397515757, rs113812345, rs25403, rs397515766, rs397515767, rs25404, rs397515774, rs397515784, rs397515788, rs397515793, rs397515805, rs397515808, rs397515811, rs397515812, rs111231312, rs113905529, rs113249837, rs397515821, rs397515823, rs397515829, rs111687884, rs113080385, rs397515848, rs397515854, rs397515867, rs397516685, rs112901682, rs397515330, rs587779450, rs587779461, rs587779471, rs587779476, rs587779478, rs587779479, rs587779482, rs587779490, rs587779504, rs397509372, rs587779518, rs587779534, rs587779536, rs587779540, rs587779550, rs587779535, rs587779563, rs587779583, rs587779584, rs587779596, rs587779604, rs587779609, rs587779500, rs587779620, rs587779625, rs587779626, rs587779541, rs587779650, rs587779671, rs112371422, rs587779685, rs587779687, rs587779691, rs587779692, rs587779695, rs587779533, rs587779706, rs587779712, rs587782948, rs587782977, rs587782979, rs587781259, rs767864243, rs146579504, rs864309481, rs370547023, rs727503476, rs727503472, rs727504292, rs727503054, rs140593, rs727503057, rs727505006, rs727504421, rs730880223, rs730880102, rs112645512, rs730880097, rs730880214, rs771298943, rs764160782, rs770095972, rs781444670, rs794727798, rs149119723, rs794728040, rs794728054, rs794728057, rs794728060, rs112602953, rs794728021, rs794728288, rs794728283, rs794728281, rs794728280, rs794728337, rs112118237, rs794728336, rs794728270, rs794728319, rs794728262, rs794728253, rs76702162, rs794728335, rs794728334, rs763091520, rs761857514, rs794728234, rs140627, rs140630, rs794728228, rs794728216, rs763449629, rs794728208, rs794728204, rs794728306, rs794728203, rs794728305, rs794728322, rs794728195, rs794728194, rs794728190, rs794728188, rs113422242, rs794728166, rs794728325, rs794728165, rs794728162, rs112660651, rs796051885, rs863223796, rs863223792, rs863223847, rs863223852, rs863223854, rs863223444, rs863223478, rs863223473, rs863223829, rs760079636, rs863223818, rs863223750, rs863223762, rs863223756, rs768713596, rs745672741, rs863223759, rs863223760, rs863223737, rs863223738, rs863223739, rs863223740, rs863223768, rs863223754, rs372010465, rs148865119, rs863224935, rs864622754, rs869025531, rs869025537, rs869025494, rs112642323, rs869025414, rs869025411, rs869025418, rs869312903, rs876657852, rs878854610, rs878854611, rs878853686, rs878853689, rs878853682, rs745409628, rs794728044, rs886038853, rs886038952, rs863223845, rs886039106, rs886038783, rs886038919, rs886038954, rs886038978, rs746972765, rs886038870, rs886038869, rs886038975, rs886038786, rs886038955, rs886038930, rs886039092, rs886039158, rs886038894, rs886038949, rs886038967, rs886038976, rs886039047, rs886038957, rs794728241, rs886038959, rs886038790, rs886039167, rs886038838, rs886038979, rs886039120, rs886038970, rs886038940, rs886039035, rs886039196, rs886038802, rs886038956, rs886038996, rs886038877, rs886039054, rs886039038, rs886038984, rs886038972, rs886039034, rs886039036, rs886039072, rs886039066, rs886038987, rs565513365, rs886039551, rs886039492, rs140583, rs886039550, rs886037823, rs886039820, rs886040966, rs886041046, rs886044547, rs755952006, rs1057518075, rs397514037, rs1057518653, rs1057521150, rs1057521106, rs1057524810, rs1057523796, rs1057523647, rs1057521101, rs1060501984, rs104893807, rs1060502045, rs1060502046, rs1060502827, rs1555399379, rs1060501035, rs1555412070, rs1555394151, rs1060501051, rs753486471, rs1060500770, rs1060500766, rs1060501092, rs1060501055, rs1060501021, rs1060501038, rs1060500773, rs1064796256, rs1064797017, rs1064794130, rs1064796636, rs1064794789, rs1555414236, rs757106110, rs1085307921, rs1085308004, rs1131691996, rs1131691766, rs363804, rs397515764, rs1555394195, rs113603747, rs528689432, rs587782947, rs1553303213, rs1553630171, rs1555360368, rs1555393875, rs1555395256, rs1555396427, rs1555397548, rs1006530719, rs587779704, rs587779578, rs104893812, rs1553630235, rs1553630289, rs1553630426, rs1553631693, rs1554122857, rs1057524497, rs1554700672, rs1555395486, rs1555396998, rs1555360229, rs1555412069, rs1555413579, rs1555397203, rs112375043, rs1555397720, rs140599, rs1555400373, rs1555405031, rs1555397008, rs1555405108, rs1015798796, rs1553631968, rs1555394904, rs1553303352, rs1553508338, rs1555398835, rs1555401011, rs1555395826, rs1555399481, rs1347651454, rs1553508039, rs1553507180, rs1553507867, rs1553808296, rs727503475, rs1554799402, rs1554701881, rs1554702262, rs1555393516, rs1555393856, rs1555394142, rs1555395209, rs1555395742, rs1555396638, rs1555398830, rs1555399166, rs1555399387, rs1555400378, rs1555401687, rs1555459260, rs1433428588, rs1401035675, rs1553292123, rs1553303357, rs1553303745, rs1393544920, rs1553507574, rs1553507991, rs587779433, rs587779458, rs1553508957, rs1553509869, rs1554122896, rs1554123064, rs1554787526, rs1554792869, rs1554805638, rs1554726251, rs1554698926, rs1554700603, rs869025352, rs1555360047, rs1555393539, rs1555393823, rs1555393837, rs1555393844, rs1555393871, rs1555393880, rs1555394146, rs1555394149, rs1555394196, rs1555394396, rs1555394400, rs1555394433, rs112550005, rs1555394566, rs112836174, rs1555394781, rs1555394927, rs1555395002, rs1555395206, rs794728247, rs1304643689, rs1555395461, rs1555395652, rs1555395658, rs1555395840, rs765387131, rs1555396429, rs1555396760, rs1555396835, rs1555397000, rs1555397014, rs1555397016, rs1555397148, rs1555397154, rs778710767, rs1555397557, rs1555397646, rs1555397704, rs1555398143, rs1555398272, rs1555398406, rs372404949, rs1555398680, rs1555398681, rs1555398828, rs1057523406, rs1555399143, rs1555399147, rs1555399205, rs1555399257, rs1555399361, rs1555399388, rs1555399764, rs1555399835, rs1555399839, rs1555400285, rs1555401686, rs1555401699, rs363852, rs1555404819, rs1555405039, rs1555405056, rs1555405534, rs1555407416, rs1555405092, rs730880215, rs1557179684, rs1555395980, rs1555396789, rs1555399816, rs1555393647, rs1555395645, rs1556337063, rs1553507614, rs1553509391, rs1553630438, rs1553630274, rs1555394238, rs1555396418, rs1206813753, rs1555399271, rs1555395663, rs1555397652, rs1555398283, rs1445085747, rs1554702463, rs363810, rs363806, rs1555395820, rs1555394189, rs1555394397, rs1555394399, rs1555394783, rs363815, rs1555395267, rs111239111, rs1555396993, rs1060501076, rs113693945, rs1555398404, rs1555398625, rs1555399162, rs1555399210, rs193922188, rs1060501017, rs1060501041, rs1555400049, rs1555400278, rs1555400279, rs1156747241, rs1555400372, rs1555400387, rs752010116, rs1555401679, rs1555404810, rs141502207, rs1553292145, rs375737772, rs1566891654, rs1566897374, rs1566905976, rs1566891655, rs1346043320, rs1566999621, rs1567002059, rs1567002115, rs1567003613, rs863223832, rs1566891808, rs1245476075, rs1566890005, rs1352478541, rs1566913670, rs1566894230, rs765692335, rs1566914030, rs1566999458, rs1569482431, rs886039176, rs1566891701, rs1566999423, rs1566999601, rs1566999610, rs1559472349, rs1566891668, rs1566891675, rs1566892872, rs1566898120, rs1566900492, rs1566903914, rs1566904526, rs1555397419, rs1566906506, rs1555398627, rs1566919637, rs869312034, rs1566900540, rs794728192, rs1566938153, rs1566892735, rs1603360542, rs1597516325, rs1597531796, rs755528878, rs1575165264, rs1597512600, rs1597516347, rs1555398144, rs1595942351, rs1595960447, rs1595965925, rs1595965945, rs1576468385, rs1595956832, rs1320208623, rs1575165272, rs1597562812, rs1575166666, rs1588477255, rs794728193, rs1688258933, rs1699392675, rs760797386, rs1699709401, rs1827902114, rs2035418540, rs2043116624, rs1555395745, rs2043594915, rs2043746138, rs2043846274, rs2044515247, rs1291288543, rs373782713, rs2042873946, rs1688274077	30675029, 12473682, 26838787, 27432961, 1975633, 12417550

Show/Hide Unknown Diseases (17)

Unknown
Disease name	Disease term	dbSNP ID	References
Aortic valve insufficiency	Aortic Valve Insufficiency		21216836
Arachnodactyly	Arachnodactyly
Biliary cirrhosis	Biliary cirrhosis, Biliary Cirrhosis, Primary, 1, Primary biliary cirrhosis		16023247
Coronary arteriosclerosis	Coronary Arteriosclerosis
Cutis marmorata	Cutis marmorata
Descending aortic dissection	Descending aortic dissection
Dyspnea, paroxysmal	Dyspnea, Paroxysmal
Hepatolenticular degeneration	Hepatolenticular Degeneration, Hepatic Form of Wilson Disease		16023247
Ischemic stroke	Ischemic stroke	rs6025, rs1799963, rs1799983
Liver cirrhosis	Liver Cirrhosis		26396155
Liver fibrosis	Fibrosis, Liver		26396155
Oral submucous fibrosis	Oral Submucous Fibrosis		16311067
Osteosarcoma	Osteosarcoma		23886186
Peripheral arterial stenosis	Peripheral arterial stenosis
Biliary cholangitis	Secondary Biliary Cholangitis		16023247
Subarachnoid hemorrhage	Subarachnoid Hemorrhage
Transient ischemic attack	Transient Ischemic Attack

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