LNPEP (leucyl and cystinyl aminopeptidase)

Gene

• Entrez ID: 4012
• Gene name: Leucyl and cystinyl aminopeptidase
• Gene symbol: LNPEP
• Synonyms: CAP, IRAP, P-LAP, PLAP
• Chromosome: 5
• Chromosome location: 5q15
• Summary: This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023791	hsa-miR-1-3p	Proteomics	18668040
MIRT044123	hsa-miR-30e-3p	CLASH	23622248
MIRT044081	hsa-miR-361-5p	CLASH	23622248
MIRT040837	hsa-miR-18a-3p	CLASH	23622248
MIRT037514	hsa-miR-744-5p	CLASH	23622248
MIRT037306	hsa-miR-877-5p	CLASH	23622248
MIRT608154	hsa-miR-8485	HITS-CLIP	22927820
MIRT608151	hsa-miR-603	HITS-CLIP	23313552
MIRT702245	hsa-miR-8080	HITS-CLIP	23313552
MIRT702244	hsa-miR-1197	HITS-CLIP	23313552
MIRT702243	hsa-miR-128-3p	HITS-CLIP	23313552
MIRT702242	hsa-miR-216a-3p	HITS-CLIP	23313552
MIRT702241	hsa-miR-3681-3p	HITS-CLIP	23313552
MIRT493293	hsa-miR-4302	HITS-CLIP	23313552
MIRT702240	hsa-miR-1253	HITS-CLIP	23313552
MIRT702239	hsa-miR-6770-5p	HITS-CLIP	23313552
MIRT608154	hsa-miR-8485	HITS-CLIP	23824327
MIRT656708	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT656707	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT656706	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT656705	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT656704	hsa-miR-4469	HITS-CLIP	23824327
MIRT656703	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT656702	hsa-miR-5705	HITS-CLIP	23824327
MIRT656701	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT656700	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT656699	hsa-miR-6844	HITS-CLIP	23824327
MIRT608154	hsa-miR-8485	HITS-CLIP	23824327
MIRT608154	hsa-miR-8485	HITS-CLIP	24906430
MIRT608153	hsa-miR-329-3p	HITS-CLIP	24906430
MIRT608152	hsa-miR-362-3p	HITS-CLIP	24906430
MIRT608151	hsa-miR-603	HITS-CLIP	24906430
MIRT608150	hsa-miR-3941	HITS-CLIP	24906430
MIRT608154	hsa-miR-8485	HITS-CLIP	24906430
MIRT608153	hsa-miR-329-3p	HITS-CLIP	24906430
MIRT608152	hsa-miR-362-3p	HITS-CLIP	24906430
MIRT608151	hsa-miR-603	HITS-CLIP	24906430
MIRT608150	hsa-miR-3941	HITS-CLIP	24906430
MIRT511221	hsa-miR-138-5p	PAR-CLIP	20371350
MIRT511220	hsa-miR-148a-3p	PAR-CLIP	20371350
MIRT511219	hsa-miR-152-3p	PAR-CLIP	20371350
MIRT511218	hsa-miR-148b-3p	PAR-CLIP	20371350
MIRT511217	hsa-miR-512-3p	PAR-CLIP	20371350
MIRT511215	hsa-miR-4704-3p	PAR-CLIP	20371350
MIRT511216	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT511214	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT511213	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT511212	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT511211	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT511210	hsa-miR-133a-5p	PAR-CLIP	20371350
MIRT511209	hsa-miR-6131	PAR-CLIP	20371350
MIRT511208	hsa-miR-4697-3p	PAR-CLIP	20371350
MIRT511207	hsa-miR-5007-3p	PAR-CLIP	20371350
MIRT511206	hsa-miR-548aw	PAR-CLIP	20371350
MIRT556446	hsa-miR-5692a	PAR-CLIP	21572407
MIRT556445	hsa-miR-4804-3p	PAR-CLIP	21572407
MIRT556444	hsa-miR-4720-3p	PAR-CLIP	21572407
MIRT556443	hsa-miR-636	PAR-CLIP	21572407
MIRT556442	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT522748	hsa-miR-485-3p	PAR-CLIP	23446348
MIRT522747	hsa-miR-539-3p	PAR-CLIP	23446348
MIRT522746	hsa-miR-4797-5p	PAR-CLIP	23446348
MIRT522745	hsa-miR-6888-5p	PAR-CLIP	23446348
MIRT522744	hsa-miR-6783-5p	PAR-CLIP	23446348
MIRT511221	hsa-miR-138-5p	PAR-CLIP	23446348
MIRT511220	hsa-miR-148a-3p	PAR-CLIP	23446348
MIRT511219	hsa-miR-152-3p	PAR-CLIP	23446348
MIRT511218	hsa-miR-148b-3p	PAR-CLIP	23446348
MIRT511217	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT511215	hsa-miR-4704-3p	PAR-CLIP	23446348
MIRT511216	hsa-miR-548aj-5p	PAR-CLIP	23446348
MIRT511214	hsa-miR-548f-5p	PAR-CLIP	23446348
MIRT511213	hsa-miR-548g-5p	PAR-CLIP	23446348
MIRT511212	hsa-miR-548x-5p	PAR-CLIP	23446348
MIRT511211	hsa-miR-1468-3p	PAR-CLIP	23446348
MIRT511210	hsa-miR-133a-5p	PAR-CLIP	23446348
MIRT511209	hsa-miR-6131	PAR-CLIP	23446348
MIRT511208	hsa-miR-4697-3p	PAR-CLIP	23446348
MIRT511207	hsa-miR-5007-3p	PAR-CLIP	23446348
MIRT511206	hsa-miR-548aw	PAR-CLIP	23446348
MIRT493293	hsa-miR-4302	PAR-CLIP	23592263
MIRT493292	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT493291	hsa-miR-4650-3p	PAR-CLIP	23592263
MIRT493290	hsa-miR-3529-5p	PAR-CLIP	23592263
MIRT493289	hsa-miR-379-5p	PAR-CLIP	23592263
MIRT493288	hsa-miR-4451	PAR-CLIP	23592263
MIRT493287	hsa-miR-3689a-5p	PAR-CLIP	23592263
MIRT493286	hsa-miR-3689b-5p	PAR-CLIP	23592263
MIRT493285	hsa-miR-3689e	PAR-CLIP	23592263
MIRT493284	hsa-miR-3689f	PAR-CLIP	23592263
MIRT493282	hsa-miR-4689	PAR-CLIP	23592263
MIRT493283	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT493290	hsa-miR-3529-5p	PAR-CLIP	26701625
MIRT493287	hsa-miR-3689a-5p	PAR-CLIP	26701625
MIRT493286	hsa-miR-3689b-5p	PAR-CLIP	26701625
MIRT493285	hsa-miR-3689e	PAR-CLIP	26701625
MIRT493284	hsa-miR-3689f	PAR-CLIP	26701625
MIRT493289	hsa-miR-379-5p	PAR-CLIP	26701625
MIRT493293	hsa-miR-4302	PAR-CLIP	26701625
MIRT493288	hsa-miR-4451	PAR-CLIP	26701625
MIRT493292	hsa-miR-4524a-3p	PAR-CLIP	26701625
MIRT493291	hsa-miR-4650-3p	PAR-CLIP	26701625
MIRT493282	hsa-miR-4689	PAR-CLIP	26701625
MIRT493283	hsa-miR-6858-5p	PAR-CLIP	26701625
MIRT576372	hsa-miR-8485	PAR-CLIP	27292025
MIRT608151	hsa-miR-603	HITS-CLIP	27418678
MIRT576372	hsa-miR-8485	HITS-CLIP	27418678
MIRT576372	hsa-miR-8485	HITS-CLIP	27418678
MIRT576372	hsa-miR-8485	HITS-CLIP	27418678
MIRT576372	hsa-miR-8485	HITS-CLIP	22927820
MIRT608151	hsa-miR-603	HITS-CLIP	23313552
MIRT702245	hsa-miR-8080	HITS-CLIP	23313552
MIRT702244	hsa-miR-1197	HITS-CLIP	23313552
MIRT702243	hsa-miR-128-3p	HITS-CLIP	23313552
MIRT702242	hsa-miR-216a-3p	HITS-CLIP	23313552
MIRT702241	hsa-miR-3681-3p	HITS-CLIP	23313552
MIRT493293	hsa-miR-4302	HITS-CLIP	23313552
MIRT702240	hsa-miR-1253	HITS-CLIP	23313552
MIRT702239	hsa-miR-6770-5p	HITS-CLIP	23313552
MIRT576372	hsa-miR-8485	HITS-CLIP	23824327
MIRT656708	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT656707	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT656706	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT656705	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT656704	hsa-miR-4469	HITS-CLIP	23824327
MIRT656703	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT656702	hsa-miR-5705	HITS-CLIP	23824327
MIRT656701	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT656700	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT656699	hsa-miR-6844	HITS-CLIP	23824327
MIRT576372	hsa-miR-8485	HITS-CLIP	23824327
MIRT511221	hsa-miR-138-5p	PAR-CLIP	20371350
MIRT511220	hsa-miR-148a-3p	PAR-CLIP	20371350
MIRT511219	hsa-miR-152-3p	PAR-CLIP	20371350
MIRT511218	hsa-miR-148b-3p	PAR-CLIP	20371350
MIRT511217	hsa-miR-512-3p	PAR-CLIP	20371350
MIRT511215	hsa-miR-4704-3p	PAR-CLIP	20371350
MIRT511216	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT511214	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT511213	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT511212	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT511211	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT511210	hsa-miR-133a-5p	PAR-CLIP	20371350
MIRT511209	hsa-miR-6131	PAR-CLIP	20371350
MIRT511208	hsa-miR-4697-3p	PAR-CLIP	20371350
MIRT511207	hsa-miR-5007-3p	PAR-CLIP	20371350
MIRT511206	hsa-miR-548aw	PAR-CLIP	20371350
MIRT556446	hsa-miR-5692a	PAR-CLIP	21572407
MIRT556445	hsa-miR-4804-3p	PAR-CLIP	21572407
MIRT556444	hsa-miR-4720-3p	PAR-CLIP	21572407
MIRT556443	hsa-miR-636	PAR-CLIP	21572407
MIRT556442	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT522748	hsa-miR-485-3p	PAR-CLIP	23446348
MIRT522747	hsa-miR-539-3p	PAR-CLIP	23446348
MIRT522746	hsa-miR-4797-5p	PAR-CLIP	23446348
MIRT522745	hsa-miR-6888-5p	PAR-CLIP	23446348
MIRT522744	hsa-miR-6783-5p	PAR-CLIP	23446348
MIRT511221	hsa-miR-138-5p	PAR-CLIP	23446348
MIRT511220	hsa-miR-148a-3p	PAR-CLIP	23446348
MIRT511219	hsa-miR-152-3p	PAR-CLIP	23446348
MIRT511218	hsa-miR-148b-3p	PAR-CLIP	23446348
MIRT511217	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT511215	hsa-miR-4704-3p	PAR-CLIP	23446348
MIRT511216	hsa-miR-548aj-5p	PAR-CLIP	23446348
MIRT511214	hsa-miR-548f-5p	PAR-CLIP	23446348
MIRT511213	hsa-miR-548g-5p	PAR-CLIP	23446348
MIRT511212	hsa-miR-548x-5p	PAR-CLIP	23446348
MIRT511211	hsa-miR-1468-3p	PAR-CLIP	23446348
MIRT511210	hsa-miR-133a-5p	PAR-CLIP	23446348
MIRT511209	hsa-miR-6131	PAR-CLIP	23446348
MIRT511208	hsa-miR-4697-3p	PAR-CLIP	23446348
MIRT511207	hsa-miR-5007-3p	PAR-CLIP	23446348
MIRT511206	hsa-miR-548aw	PAR-CLIP	23446348
MIRT493293	hsa-miR-4302	PAR-CLIP	23592263
MIRT493292	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT493291	hsa-miR-4650-3p	PAR-CLIP	23592263
MIRT493290	hsa-miR-3529-5p	PAR-CLIP	23592263
MIRT493289	hsa-miR-379-5p	PAR-CLIP	23592263
MIRT493288	hsa-miR-4451	PAR-CLIP	23592263
MIRT493287	hsa-miR-3689a-5p	PAR-CLIP	23592263
MIRT493286	hsa-miR-3689b-5p	PAR-CLIP	23592263
MIRT493285	hsa-miR-3689e	PAR-CLIP	23592263
MIRT493284	hsa-miR-3689f	PAR-CLIP	23592263
MIRT493282	hsa-miR-4689	PAR-CLIP	23592263
MIRT493283	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT1112419	hsa-miR-1228	CLIP-seq
MIRT1112420	hsa-miR-130a	CLIP-seq
MIRT1112421	hsa-miR-130b	CLIP-seq
MIRT1112422	hsa-miR-140-3p	CLIP-seq
MIRT1112423	hsa-miR-19a	CLIP-seq
MIRT1112424	hsa-miR-19b	CLIP-seq
MIRT1112425	hsa-miR-2116	CLIP-seq
MIRT1112426	hsa-miR-223	CLIP-seq
MIRT1112427	hsa-miR-301a	CLIP-seq
MIRT1112428	hsa-miR-301b	CLIP-seq
MIRT1112429	hsa-miR-3130-3p	CLIP-seq
MIRT1112430	hsa-miR-3145-5p	CLIP-seq
MIRT1112431	hsa-miR-3622a-3p	CLIP-seq
MIRT1112432	hsa-miR-3622b-3p	CLIP-seq
MIRT1112433	hsa-miR-3666	CLIP-seq
MIRT1112434	hsa-miR-4277	CLIP-seq
MIRT1112435	hsa-miR-4295	CLIP-seq
MIRT1112436	hsa-miR-454	CLIP-seq
MIRT1112437	hsa-miR-4793-3p	CLIP-seq
MIRT1112438	hsa-miR-544b	CLIP-seq
MIRT1112439	hsa-miR-582-5p	CLIP-seq
MIRT1112440	hsa-miR-600	CLIP-seq
MIRT1112419	hsa-miR-1228	CLIP-seq
MIRT1112441	hsa-miR-148a	CLIP-seq
MIRT1112442	hsa-miR-148b	CLIP-seq
MIRT1112443	hsa-miR-152	CLIP-seq
MIRT1112425	hsa-miR-2116	CLIP-seq
MIRT1112426	hsa-miR-223	CLIP-seq
MIRT1112444	hsa-miR-29a	CLIP-seq
MIRT1112445	hsa-miR-29b	CLIP-seq
MIRT1112446	hsa-miR-29c	CLIP-seq
MIRT1112429	hsa-miR-3130-3p	CLIP-seq
MIRT1112447	hsa-miR-3137	CLIP-seq
MIRT1112448	hsa-miR-3148	CLIP-seq
MIRT1112431	hsa-miR-3622a-3p	CLIP-seq
MIRT1112432	hsa-miR-3622b-3p	CLIP-seq
MIRT1112449	hsa-miR-3973	CLIP-seq
MIRT1112434	hsa-miR-4277	CLIP-seq
MIRT1112437	hsa-miR-4793-3p	CLIP-seq
MIRT1112450	hsa-miR-4794	CLIP-seq
MIRT1112438	hsa-miR-544b	CLIP-seq
MIRT1112451	hsa-miR-548c-3p	CLIP-seq
MIRT1112439	hsa-miR-582-5p	CLIP-seq
MIRT1112440	hsa-miR-600	CLIP-seq
MIRT2031410	hsa-miR-125a-5p	CLIP-seq
MIRT2031411	hsa-miR-125b	CLIP-seq
MIRT2031412	hsa-miR-1291	CLIP-seq
MIRT1112420	hsa-miR-130a	CLIP-seq
MIRT1112421	hsa-miR-130b	CLIP-seq
MIRT2031413	hsa-miR-1972	CLIP-seq
MIRT1112423	hsa-miR-19a	CLIP-seq
MIRT1112424	hsa-miR-19b	CLIP-seq
MIRT1112427	hsa-miR-301a	CLIP-seq
MIRT1112428	hsa-miR-301b	CLIP-seq
MIRT1112430	hsa-miR-3145-5p	CLIP-seq
MIRT1112433	hsa-miR-3666	CLIP-seq
MIRT1112449	hsa-miR-3973	CLIP-seq
MIRT1112435	hsa-miR-4295	CLIP-seq
MIRT2031414	hsa-miR-4319	CLIP-seq
MIRT1112436	hsa-miR-454	CLIP-seq
MIRT2031415	hsa-miR-4650-5p	CLIP-seq
MIRT2031416	hsa-miR-520g	CLIP-seq
MIRT2031417	hsa-miR-520h	CLIP-seq
MIRT2031418	hsa-miR-610	CLIP-seq
MIRT2031419	hsa-miR-885-3p	CLIP-seq
MIRT2262326	hsa-miR-1255a	CLIP-seq
MIRT2262327	hsa-miR-1255b	CLIP-seq
MIRT2031410	hsa-miR-125a-5p	CLIP-seq
MIRT2031411	hsa-miR-125b	CLIP-seq
MIRT2031412	hsa-miR-1291	CLIP-seq
MIRT1112422	hsa-miR-140-3p	CLIP-seq
MIRT2031413	hsa-miR-1972	CLIP-seq
MIRT2262328	hsa-miR-3134	CLIP-seq
MIRT2031414	hsa-miR-4319	CLIP-seq
MIRT2262329	hsa-miR-4426	CLIP-seq
MIRT2262330	hsa-miR-4647	CLIP-seq
MIRT2031415	hsa-miR-4650-5p	CLIP-seq
MIRT2262331	hsa-miR-4662b	CLIP-seq
MIRT2262332	hsa-miR-511	CLIP-seq
MIRT2031418	hsa-miR-610	CLIP-seq
MIRT2430787	hsa-miR-3119	CLIP-seq
MIRT2561898	hsa-miR-1234	CLIP-seq
MIRT1112426	hsa-miR-223	CLIP-seq
MIRT2561899	hsa-miR-2355-3p	CLIP-seq
MIRT2561900	hsa-miR-3132	CLIP-seq
MIRT2561901	hsa-miR-3163	CLIP-seq
MIRT2561902	hsa-miR-320a	CLIP-seq
MIRT2561903	hsa-miR-320b	CLIP-seq
MIRT2561904	hsa-miR-320c	CLIP-seq
MIRT2561905	hsa-miR-320d	CLIP-seq
MIRT2561906	hsa-miR-3616-5p	CLIP-seq
MIRT2561907	hsa-miR-3647-5p	CLIP-seq
MIRT2561908	hsa-miR-3674	CLIP-seq
MIRT2561909	hsa-miR-374a	CLIP-seq
MIRT2561910	hsa-miR-374b	CLIP-seq
MIRT2561911	hsa-miR-3935	CLIP-seq
MIRT2561912	hsa-miR-4289	CLIP-seq
MIRT2561913	hsa-miR-4318	CLIP-seq
MIRT2561914	hsa-miR-4429	CLIP-seq
MIRT2561915	hsa-miR-4467	CLIP-seq
MIRT2561916	hsa-miR-4646-3p	CLIP-seq
MIRT2561917	hsa-miR-4693-5p	CLIP-seq
MIRT2561918	hsa-miR-4795-5p	CLIP-seq
MIRT2561919	hsa-miR-502-5p	CLIP-seq
MIRT2561920	hsa-miR-573	CLIP-seq
MIRT2561921	hsa-miR-592	CLIP-seq
MIRT2561922	hsa-miR-597	CLIP-seq
MIRT2561923	hsa-miR-892a	CLIP-seq
MIRT2561924	hsa-miR-944	CLIP-seq
MIRT2561898	hsa-miR-1234	CLIP-seq
MIRT2561900	hsa-miR-3132	CLIP-seq
MIRT2561901	hsa-miR-3163	CLIP-seq
MIRT2561902	hsa-miR-320a	CLIP-seq
MIRT2561903	hsa-miR-320b	CLIP-seq
MIRT2561904	hsa-miR-320c	CLIP-seq
MIRT2561905	hsa-miR-320d	CLIP-seq
MIRT2683953	hsa-miR-337-3p	CLIP-seq
MIRT2561906	hsa-miR-3616-5p	CLIP-seq
MIRT2561907	hsa-miR-3647-5p	CLIP-seq
MIRT2561908	hsa-miR-3674	CLIP-seq
MIRT2683954	hsa-miR-3685	CLIP-seq
MIRT2561909	hsa-miR-374a	CLIP-seq
MIRT2561910	hsa-miR-374b	CLIP-seq
MIRT2683955	hsa-miR-384	CLIP-seq
MIRT2561911	hsa-miR-3935	CLIP-seq
MIRT2561912	hsa-miR-4289	CLIP-seq
MIRT2683956	hsa-miR-4328	CLIP-seq
MIRT2561914	hsa-miR-4429	CLIP-seq
MIRT2561915	hsa-miR-4467	CLIP-seq
MIRT2683957	hsa-miR-4729	CLIP-seq
MIRT2561918	hsa-miR-4795-5p	CLIP-seq
MIRT2561919	hsa-miR-502-5p	CLIP-seq
MIRT2561920	hsa-miR-573	CLIP-seq
MIRT2561924	hsa-miR-944	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
TFAP2A	Activation	15894523

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	TAS
GO:0002480	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	TAS
GO:0004177	Function	Aminopeptidase activity	EXP	19498108, 19918052
GO:0004177	Function	Aminopeptidase activity	TAS	15691326
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005576	Component	Extracellular region	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	ISS
GO:0005887	Component	Integral component of plasma membrane	IDA	11108258
GO:0006508	Process	Proteolysis	IBA	21873635
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0007267	Process	Cell-cell signaling	TAS	8550619
GO:0007565	Process	Female pregnancy	TAS	8550619
GO:0008217	Process	Regulation of blood pressure	IBA	21873635
GO:0008237	Function	Metallopeptidase activity	TAS	9177475
GO:0008270	Function	Zinc ion binding	IBA	21873635
GO:0016020	Component	Membrane	HDA	19946888
GO:0031905	Component	Early endosome lumen	TAS
GO:0042277	Function	Peptide binding	IBA	21873635
GO:0043171	Process	Peptide catabolic process	IBA	21873635
GO:0070006	Function	Metalloaminopeptidase activity	IBA	21873635
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	25534853

Other IDs

• MIM: 151300
• HGNC: 6656
• e!Ensembl: ENSG00000113441

Protein

• UniProt ID: Q9UIQ6
• Protein name: Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC 3.4.11.3) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) [Cleaved into: Leucyl-cystinyl a
• Protein function: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be
• PDB: 4P8Q, 4PJ6, 4Z7I, 5C97, 5JHQ, 5MJ6, 7ZYF, 8CGP, 8CGW, 8P0I
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF17900	Peptidase_M1_N	173 → 358		Domain
  PF01433	Peptidase_M1	392 → 610	Peptidase family M1 domain	Domain
  PF11838	ERAP1_C	689 → 1009	ERAP1-like C-terminal domain	Domain

• Sequence:

  MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE
  HEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVV
  AVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELS
  LHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYH
  GQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAAR
  SAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA
  FIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLV
  AIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWW
  NDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQI
  EEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQT
  LDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVT
  EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP
  YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE
  KLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAM
  KLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASS
  EDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGS
  YTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKS
  LTWWL

• Sequence length: 1025

Pathways

KEGG:

Renin-angiotensin system

Reactome:

Endosomal/Vacuolar pathway
Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Arthritis	Systemic onset juvenile chronic arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	23603761
Rheumatoid arthritis	Rheumatoid Arthritis, Systemic Juvenile	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	23603761

Unknown
Disease name	Disease term	dbSNP ID	References
Birdshot chorioretinopathy	Birdshot chorioretinopathy		24957906
Memory disorders	Memory Disorders		11730987
Age-related memory disorders	Age-Related Memory Disorders		11730987
Oligoarticular arthritis	Oligoarticular Juvenile Idiopathic Arthritis		23603761
Pauciarticular chronic arthritis	Juvenile pauciarticular chronic arthritis		23603761
Seronegative polyarthritis	Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative		23603761
Still disease	Juvenile-Onset Still Disease		23603761