EML6 (EMAP like 6)

Gene

• Entrez ID: 400954
• Gene name: EMAP like 6
• Gene symbol: EML6
• Synonyms: -
• Chromosome: 2
• Chromosome location: 2p16.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT446357	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT446356	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT446355	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT446354	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT446353	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT446352	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT446351	hsa-miR-543	PAR-CLIP	22100165
MIRT446350	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT446349	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT446348	hsa-miR-6759-3p	PAR-CLIP	22100165
MIRT446346	hsa-miR-3143	PAR-CLIP	22100165
MIRT446347	hsa-miR-192-5p	PAR-CLIP	22100165
MIRT446345	hsa-miR-215-5p	PAR-CLIP	22100165
MIRT446344	hsa-miR-302c-5p	PAR-CLIP	22100165
MIRT446357	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT446356	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT446355	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT446354	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT446353	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT446352	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT446351	hsa-miR-543	PAR-CLIP	22100165
MIRT446350	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT446349	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT446348	hsa-miR-6759-3p	PAR-CLIP	22100165
MIRT446346	hsa-miR-3143	PAR-CLIP	22100165
MIRT446347	hsa-miR-192-5p	PAR-CLIP	22100165
MIRT446345	hsa-miR-215-5p	PAR-CLIP	22100165
MIRT446344	hsa-miR-302c-5p	PAR-CLIP	22100165
MIRT962212	hsa-miR-135a	CLIP-seq
MIRT962213	hsa-miR-135b	CLIP-seq
MIRT962214	hsa-miR-15a	CLIP-seq
MIRT962215	hsa-miR-15b	CLIP-seq
MIRT962216	hsa-miR-16	CLIP-seq
MIRT962217	hsa-miR-195	CLIP-seq
MIRT962218	hsa-miR-219-5p	CLIP-seq
MIRT962219	hsa-miR-3184	CLIP-seq
MIRT962220	hsa-miR-3942-5p	CLIP-seq
MIRT962221	hsa-miR-423-5p	CLIP-seq
MIRT962222	hsa-miR-424	CLIP-seq
MIRT962223	hsa-miR-4436a	CLIP-seq
MIRT962224	hsa-miR-4490	CLIP-seq
MIRT962225	hsa-miR-4524	CLIP-seq
MIRT962226	hsa-miR-4639-5p	CLIP-seq
MIRT962227	hsa-miR-4686	CLIP-seq
MIRT962228	hsa-miR-4703-5p	CLIP-seq
MIRT962229	hsa-miR-4774-5p	CLIP-seq
MIRT962230	hsa-miR-4782-3p	CLIP-seq
MIRT962231	hsa-miR-4788	CLIP-seq
MIRT962232	hsa-miR-4803	CLIP-seq
MIRT962233	hsa-miR-497	CLIP-seq
MIRT962234	hsa-miR-503	CLIP-seq
MIRT962235	hsa-miR-603	CLIP-seq
MIRT962236	hsa-miR-642b	CLIP-seq
MIRT962237	hsa-miR-646	CLIP-seq
MIRT1985195	hsa-miR-103a	CLIP-seq
MIRT1985196	hsa-miR-107	CLIP-seq
MIRT1985197	hsa-miR-4274	CLIP-seq
MIRT1985198	hsa-miR-486-3p	CLIP-seq
MIRT962214	hsa-miR-15a	CLIP-seq
MIRT962215	hsa-miR-15b	CLIP-seq
MIRT962216	hsa-miR-16	CLIP-seq
MIRT962217	hsa-miR-195	CLIP-seq
MIRT2219884	hsa-miR-3182	CLIP-seq
MIRT2219885	hsa-miR-3652	CLIP-seq
MIRT2219886	hsa-miR-3663-3p	CLIP-seq
MIRT962220	hsa-miR-3942-5p	CLIP-seq
MIRT962222	hsa-miR-424	CLIP-seq
MIRT2219887	hsa-miR-4276	CLIP-seq
MIRT2219888	hsa-miR-4428	CLIP-seq
MIRT2219889	hsa-miR-4430	CLIP-seq
MIRT2219890	hsa-miR-4434	CLIP-seq
MIRT2219891	hsa-miR-4505	CLIP-seq
MIRT2219892	hsa-miR-4516	CLIP-seq
MIRT962225	hsa-miR-4524	CLIP-seq
MIRT2219893	hsa-miR-4531	CLIP-seq
MIRT2219894	hsa-miR-4536	CLIP-seq
MIRT962228	hsa-miR-4703-5p	CLIP-seq
MIRT2219895	hsa-miR-4802-5p	CLIP-seq
MIRT962233	hsa-miR-497	CLIP-seq
MIRT962234	hsa-miR-503	CLIP-seq
MIRT2219896	hsa-miR-539	CLIP-seq
MIRT962237	hsa-miR-646	CLIP-seq
MIRT962214	hsa-miR-15a	CLIP-seq
MIRT962215	hsa-miR-15b	CLIP-seq
MIRT962216	hsa-miR-16	CLIP-seq
MIRT962217	hsa-miR-195	CLIP-seq
MIRT962222	hsa-miR-424	CLIP-seq
MIRT962233	hsa-miR-497	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005874	Component	Microtubule	IEA
GO:0008017	Function	Microtubule binding	IBA	21873635

Other IDs

• MIM: 621084
• HGNC: 35412
• e!Ensembl: ENSG00000214595

Protein

• UniProt ID: Q6ZMW3
• Protein name: Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like)
• Protein function: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03451	HELP	1 → 49	HELP motif	Family
  PF00400	WD40	51 → 91	WD domain, G-beta repeat	Repeat
  PF00400	WD40	96 → 136	WD domain, G-beta repeat	Repeat
  PF00400	WD40	314 → 353	WD domain, G-beta repeat	Repeat
  PF12894	ANAPC4_WD40	372 → 462	Anaphase-promoting complex subunit 4 WD40 domain	Repeat
  PF00400	WD40	553 → 592	WD domain, G-beta repeat	Repeat
  PF03451	HELP	652 → 715	HELP motif	Family
  PF00400	WD40	715 → 757	WD domain, G-beta repeat	Repeat
  PF00400	WD40	988 → 1026	WD domain, G-beta repeat	Repeat
  PF00400	WD40	1229 → 1267	WD domain, G-beta repeat	Repeat
  PF03451	HELP	1330 → 1402	HELP motif	Family
  PF00400	WD40	1678 → 1715	WD domain, G-beta repeat	Repeat
  PF12894	ANAPC4_WD40	1734 → 1867	Anaphase-promoting complex subunit 4 WD40 domain	Repeat
  PF00400	WD40	1917 → 1956	WD domain, G-beta repeat	Repeat

• Sequence:

  MADRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGH
  NDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQR
  LASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLC
  GNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQGAHSAGI
  FSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGT
  QDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI
  ARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDG
  SYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERLFYRM
  PSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFG
  LVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEGVSN
  GMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSKEK
  NHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQ
  RLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDF
  SADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHI
  KFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVK
  AHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPS
  IRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDK
  TLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHH
  RKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLL
  QVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAAS
  LTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGAD
  TALMIWTREFVGTQESKLVDSEESDTDVEEDGGYDSDVAREKAIDYTTKIYAVSIREMEG
  TKPHQQLKEVSVEERPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNL
  HYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTT
  PSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVA
  SRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLS
  VAFGANNLTFTGAINGDVYVWKDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTK
  EGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNI
  LIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDG
  EMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLT
  QGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKIT
  WASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKH
  KRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL

• Sequence length: 1958

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Hypertension	Hypertensive disease	rs13306026, rs13333226	30487518
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	19553259