MUC21 (mucin 21, cell surface associated)

Gene

• Entrez ID: 394263
• Gene name: Mucin 21, cell surface associated
• Gene symbol: MUC21
• Synonyms: C6orf205, KMQK697, MUC-21
• Chromosome: 6
• Chromosome location: 6p21.33
• Summary: This gene encodes a large membrane-bound glycoprotein which is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in in

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050861	hsa-miR-17-5p	CLASH	23622248
MIRT725361	hsa-miR-25-3p	HITS-CLIP	19536157
MIRT725360	hsa-miR-32-5p	HITS-CLIP	19536157
MIRT725359	hsa-miR-363-3p	HITS-CLIP	19536157
MIRT725358	hsa-miR-367-3p	HITS-CLIP	19536157
MIRT725357	hsa-miR-92a-3p	HITS-CLIP	19536157
MIRT725355	hsa-miR-92b-3p	HITS-CLIP	19536157
MIRT725356	hsa-miR-1323	HITS-CLIP	19536157
MIRT725354	hsa-miR-548o-3p	HITS-CLIP	19536157
MIRT725353	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT725352	hsa-miR-548aj-5p	HITS-CLIP	19536157
MIRT725351	hsa-miR-548f-5p	HITS-CLIP	19536157
MIRT725350	hsa-miR-548g-5p	HITS-CLIP	19536157
MIRT725349	hsa-miR-548x-5p	HITS-CLIP	19536157
MIRT725348	hsa-miR-1468-3p	HITS-CLIP	19536157
MIRT725347	hsa-miR-767-5p	HITS-CLIP	19536157
MIRT725346	hsa-miR-548aw	HITS-CLIP	19536157
MIRT725344	hsa-miR-500a-3p	HITS-CLIP	19536157
MIRT725361	hsa-miR-25-3p	HITS-CLIP	19536157
MIRT725360	hsa-miR-32-5p	HITS-CLIP	19536157
MIRT725359	hsa-miR-363-3p	HITS-CLIP	19536157
MIRT725358	hsa-miR-367-3p	HITS-CLIP	19536157
MIRT725357	hsa-miR-92a-3p	HITS-CLIP	19536157
MIRT725355	hsa-miR-92b-3p	HITS-CLIP	19536157
MIRT725356	hsa-miR-1323	HITS-CLIP	19536157
MIRT725354	hsa-miR-548o-3p	HITS-CLIP	19536157
MIRT725353	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT725352	hsa-miR-548aj-5p	HITS-CLIP	19536157
MIRT725351	hsa-miR-548f-5p	HITS-CLIP	19536157
MIRT725350	hsa-miR-548g-5p	HITS-CLIP	19536157
MIRT725349	hsa-miR-548x-5p	HITS-CLIP	19536157
MIRT725348	hsa-miR-1468-3p	HITS-CLIP	19536157
MIRT725347	hsa-miR-767-5p	HITS-CLIP	19536157
MIRT725346	hsa-miR-548aw	HITS-CLIP	19536157
MIRT725344	hsa-miR-500a-3p	HITS-CLIP	19536157
MIRT1166295	hsa-miR-1183	CLIP-seq
MIRT1166296	hsa-miR-1225-3p	CLIP-seq
MIRT1166297	hsa-miR-1233	CLIP-seq
MIRT1166298	hsa-miR-1236	CLIP-seq
MIRT1166299	hsa-miR-1254	CLIP-seq
MIRT1166300	hsa-miR-1266	CLIP-seq
MIRT1166301	hsa-miR-1289	CLIP-seq
MIRT1166302	hsa-miR-143	CLIP-seq
MIRT1166303	hsa-miR-1827	CLIP-seq
MIRT1166304	hsa-miR-2114	CLIP-seq
MIRT1166305	hsa-miR-3116	CLIP-seq
MIRT1166306	hsa-miR-3198	CLIP-seq
MIRT1166307	hsa-miR-3200-3p	CLIP-seq
MIRT1166308	hsa-miR-3649	CLIP-seq
MIRT1166309	hsa-miR-3664-3p	CLIP-seq
MIRT1166310	hsa-miR-3690	CLIP-seq
MIRT1166311	hsa-miR-378	CLIP-seq
MIRT1166312	hsa-miR-378b	CLIP-seq
MIRT1166313	hsa-miR-378c	CLIP-seq
MIRT1166314	hsa-miR-378d	CLIP-seq
MIRT1166315	hsa-miR-378e	CLIP-seq
MIRT1166316	hsa-miR-378f	CLIP-seq
MIRT1166317	hsa-miR-378h	CLIP-seq
MIRT1166318	hsa-miR-378i	CLIP-seq
MIRT1166319	hsa-miR-3919	CLIP-seq
MIRT1166320	hsa-miR-3929	CLIP-seq
MIRT1166321	hsa-miR-422a	CLIP-seq
MIRT1166322	hsa-miR-4270	CLIP-seq
MIRT1166323	hsa-miR-4292	CLIP-seq
MIRT1166324	hsa-miR-4294	CLIP-seq
MIRT1166325	hsa-miR-4308	CLIP-seq
MIRT1166326	hsa-miR-4309	CLIP-seq
MIRT1166327	hsa-miR-4419b	CLIP-seq
MIRT1166328	hsa-miR-4433	CLIP-seq
MIRT1166329	hsa-miR-4441	CLIP-seq
MIRT1166330	hsa-miR-4459	CLIP-seq
MIRT1166331	hsa-miR-4478	CLIP-seq
MIRT1166332	hsa-miR-4518	CLIP-seq
MIRT1166333	hsa-miR-4649-3p	CLIP-seq
MIRT1166334	hsa-miR-4695-5p	CLIP-seq
MIRT1166335	hsa-miR-4722-5p	CLIP-seq
MIRT1166336	hsa-miR-4738-3p	CLIP-seq
MIRT1166337	hsa-miR-4768-3p	CLIP-seq
MIRT1166338	hsa-miR-4770	CLIP-seq
MIRT1166339	hsa-miR-485-5p	CLIP-seq
MIRT1166340	hsa-miR-486-3p	CLIP-seq
MIRT1166341	hsa-miR-488	CLIP-seq
MIRT1166342	hsa-miR-510	CLIP-seq
MIRT1166343	hsa-miR-512-5p	CLIP-seq
MIRT1166344	hsa-miR-539	CLIP-seq
MIRT1166345	hsa-miR-548g	CLIP-seq
MIRT1166346	hsa-miR-661	CLIP-seq
MIRT1166347	hsa-miR-670	CLIP-seq
MIRT1166348	hsa-miR-924	CLIP-seq
MIRT1166349	hsa-miR-940	CLIP-seq
MIRT1166295	hsa-miR-1183	CLIP-seq
MIRT2048034	hsa-miR-1228	CLIP-seq
MIRT1166303	hsa-miR-1827	CLIP-seq
MIRT1166304	hsa-miR-2114	CLIP-seq
MIRT2048035	hsa-miR-216a	CLIP-seq
MIRT2048036	hsa-miR-216b	CLIP-seq
MIRT2048037	hsa-miR-24	CLIP-seq
MIRT2048038	hsa-miR-3122	CLIP-seq
MIRT2048039	hsa-miR-342-3p	CLIP-seq
MIRT1166309	hsa-miR-3664-3p	CLIP-seq
MIRT2048040	hsa-miR-3689a-3p	CLIP-seq
MIRT2048041	hsa-miR-3689c	CLIP-seq
MIRT2048042	hsa-miR-3714	CLIP-seq
MIRT2048043	hsa-miR-3913-5p	CLIP-seq
MIRT2048044	hsa-miR-4254	CLIP-seq
MIRT2048045	hsa-miR-4284	CLIP-seq
MIRT2048046	hsa-miR-4310	CLIP-seq
MIRT1166328	hsa-miR-4433	CLIP-seq
MIRT1166330	hsa-miR-4459	CLIP-seq
MIRT1166335	hsa-miR-4722-5p	CLIP-seq
MIRT2048047	hsa-miR-4728-5p	CLIP-seq
MIRT1166336	hsa-miR-4738-3p	CLIP-seq
MIRT1166337	hsa-miR-4768-3p	CLIP-seq
MIRT1166342	hsa-miR-510	CLIP-seq
MIRT1166343	hsa-miR-512-5p	CLIP-seq
MIRT1166345	hsa-miR-548g	CLIP-seq
MIRT2048048	hsa-miR-582-3p	CLIP-seq
MIRT2048049	hsa-miR-765	CLIP-seq
MIRT1166349	hsa-miR-940	CLIP-seq
MIRT1166295	hsa-miR-1183	CLIP-seq
MIRT2048034	hsa-miR-1228	CLIP-seq
MIRT1166303	hsa-miR-1827	CLIP-seq
MIRT1166304	hsa-miR-2114	CLIP-seq
MIRT2048035	hsa-miR-216a	CLIP-seq
MIRT2048036	hsa-miR-216b	CLIP-seq
MIRT2048038	hsa-miR-3122	CLIP-seq
MIRT1166309	hsa-miR-3664-3p	CLIP-seq
MIRT2048040	hsa-miR-3689a-3p	CLIP-seq
MIRT2048041	hsa-miR-3689c	CLIP-seq
MIRT2048042	hsa-miR-3714	CLIP-seq
MIRT2048043	hsa-miR-3913-5p	CLIP-seq
MIRT1166320	hsa-miR-3929	CLIP-seq
MIRT2048046	hsa-miR-4310	CLIP-seq
MIRT1166327	hsa-miR-4419b	CLIP-seq
MIRT1166328	hsa-miR-4433	CLIP-seq
MIRT1166330	hsa-miR-4459	CLIP-seq
MIRT1166331	hsa-miR-4478	CLIP-seq
MIRT1166333	hsa-miR-4649-3p	CLIP-seq
MIRT1166334	hsa-miR-4695-5p	CLIP-seq
MIRT1166335	hsa-miR-4722-5p	CLIP-seq
MIRT2048047	hsa-miR-4728-5p	CLIP-seq
MIRT1166337	hsa-miR-4768-3p	CLIP-seq
MIRT1166339	hsa-miR-485-5p	CLIP-seq
MIRT1166342	hsa-miR-510	CLIP-seq
MIRT1166343	hsa-miR-512-5p	CLIP-seq
MIRT2048049	hsa-miR-765	CLIP-seq
MIRT1166349	hsa-miR-940	CLIP-seq
MIRT1166296	hsa-miR-1225-3p	CLIP-seq
MIRT1166297	hsa-miR-1233	CLIP-seq
MIRT1166303	hsa-miR-1827	CLIP-seq
MIRT1166309	hsa-miR-3664-3p	CLIP-seq
MIRT1166320	hsa-miR-3929	CLIP-seq
MIRT1166327	hsa-miR-4419b	CLIP-seq
MIRT1166328	hsa-miR-4433	CLIP-seq
MIRT1166330	hsa-miR-4459	CLIP-seq
MIRT1166331	hsa-miR-4478	CLIP-seq
MIRT1166333	hsa-miR-4649-3p	CLIP-seq
MIRT1166334	hsa-miR-4695-5p	CLIP-seq
MIRT1166335	hsa-miR-4722-5p	CLIP-seq
MIRT1166337	hsa-miR-4768-3p	CLIP-seq
MIRT1166339	hsa-miR-485-5p	CLIP-seq
MIRT1166342	hsa-miR-510	CLIP-seq
MIRT1166343	hsa-miR-512-5p	CLIP-seq
MIRT1166349	hsa-miR-940	CLIP-seq
MIRT2048034	hsa-miR-1228	CLIP-seq
MIRT2048035	hsa-miR-216a	CLIP-seq
MIRT2048036	hsa-miR-216b	CLIP-seq
MIRT2048038	hsa-miR-3122	CLIP-seq
MIRT2048040	hsa-miR-3689a-3p	CLIP-seq
MIRT2048041	hsa-miR-3689c	CLIP-seq
MIRT2048043	hsa-miR-3913-5p	CLIP-seq
MIRT2048046	hsa-miR-4310	CLIP-seq
MIRT2048047	hsa-miR-4728-5p	CLIP-seq
MIRT2048034	hsa-miR-1228	CLIP-seq
MIRT2048035	hsa-miR-216a	CLIP-seq
MIRT2048036	hsa-miR-216b	CLIP-seq
MIRT2575562	hsa-miR-2909	CLIP-seq
MIRT2048038	hsa-miR-3122	CLIP-seq
MIRT2575563	hsa-miR-34c-3p	CLIP-seq
MIRT2048040	hsa-miR-3689a-3p	CLIP-seq
MIRT2048041	hsa-miR-3689c	CLIP-seq
MIRT2048042	hsa-miR-3714	CLIP-seq
MIRT2048043	hsa-miR-3913-5p	CLIP-seq
MIRT2575564	hsa-miR-4278	CLIP-seq
MIRT2048046	hsa-miR-4310	CLIP-seq
MIRT2575565	hsa-miR-4438	CLIP-seq
MIRT2575566	hsa-miR-4639-3p	CLIP-seq
MIRT2575567	hsa-miR-4687-3p	CLIP-seq
MIRT1166335	hsa-miR-4722-5p	CLIP-seq
MIRT2048047	hsa-miR-4728-5p	CLIP-seq
MIRT2575568	hsa-miR-4777-5p	CLIP-seq
MIRT2575569	hsa-miR-518d-5p	CLIP-seq
MIRT2575570	hsa-miR-519b-5p	CLIP-seq
MIRT2575571	hsa-miR-519c-5p	CLIP-seq
MIRT2575572	hsa-miR-520c-5p	CLIP-seq
MIRT2575573	hsa-miR-526a	CLIP-seq
MIRT1166349	hsa-miR-940	CLIP-seq
MIRT2048034	hsa-miR-1228	CLIP-seq
MIRT2048035	hsa-miR-216a	CLIP-seq
MIRT2048036	hsa-miR-216b	CLIP-seq
MIRT2048038	hsa-miR-3122	CLIP-seq
MIRT2575563	hsa-miR-34c-3p	CLIP-seq
MIRT2048040	hsa-miR-3689a-3p	CLIP-seq
MIRT2048041	hsa-miR-3689c	CLIP-seq
MIRT2048042	hsa-miR-3714	CLIP-seq
MIRT2048043	hsa-miR-3913-5p	CLIP-seq
MIRT2048046	hsa-miR-4310	CLIP-seq
MIRT2575565	hsa-miR-4438	CLIP-seq
MIRT2575566	hsa-miR-4639-3p	CLIP-seq
MIRT1166335	hsa-miR-4722-5p	CLIP-seq
MIRT2048047	hsa-miR-4728-5p	CLIP-seq
MIRT1166349	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0016021	Component	Integral component of membrane	IEA
GO:0016266	Process	O-glycan processing	TAS
GO:0022408	Process	Negative regulation of cell-cell adhesion	IBA	21873635

Other IDs

• MIM: 616991
• HGNC: 21661
• e!Ensembl: ENSG00000204544

Protein

• UniProt ID: Q5SSG8
• Protein name: Mucin-21 (MUC-21) (Epiglycanin)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05647	Epiglycanin_TR	18 → 83	Tandem-repeating region of mucin, epiglycanin-like	Repeat
  PF05647	Epiglycanin_TR	76 → 137	Tandem-repeating region of mucin, epiglycanin-like	Repeat
  PF05647	Epiglycanin_TR	123 → 182	Tandem-repeating region of mucin, epiglycanin-like	Repeat
  PF05647	Epiglycanin_TR	167 → 227	Tandem-repeating region of mucin, epiglycanin-like	Repeat
  PF05647	Epiglycanin_TR	181 → 239	Tandem-repeating region of mucin, epiglycanin-like	Repeat
  PF05647	Epiglycanin_TR	211 → 274	Tandem-repeating region of mucin, epiglycanin-like	Repeat
  PF05647	Epiglycanin_TR	271 → 334	Tandem-repeating region of mucin, epiglycanin-like	Repeat
  PF05647	Epiglycanin_TR	331 → 393	Tandem-repeating region of mucin, epiglycanin-like	Repeat
  PF05647	Epiglycanin_TR	391 → 458	Tandem-repeating region of mucin, epiglycanin-like	Repeat
  PF14654	Epiglycanin_C	463 → 564	Mucin, catalytic, TM and cytoplasmic tail region	Domain

• Sequence:

  MKMQKGNVLLMFGLLLHLEAATNSNETSTSANTGSSVISSGASTATNSGSSVTSSGVSTA
  TISGSSVTSNGVSIVTNSEFHTTSSGISTATNSEFSTVSSGISIATNSESSTTSSGASTA
  TNSESSTPSSGASTATNSDSSTTSSGASTATNSDSSTTSSEASTATNSESSTTSSGASTA
  TNSESSTVSSRASTATNSESSTTSSGASTATNSESRTTSNGAGTATNSESSTTSSGASTA
  TNSESSTPSSGAGTATNSESSTTSSGAGTATNSESSTVSSGISTVTNSESSTPSSGANTA
  TNSESSTTSSGANTATNSDSSTTSSGASTATNSESSTTSSGASTATNSESSTTSSGASTA
  TNSGSSTTSSGTSTATNSESSTVSSGASTATTSESSTTSSGASTATNSESSTVSSGASTA
  TNSESSTTSSGANTATNSGSSVTSAGSGTAALTGMHTTSHSASTAVSEAKPGGSLVPWEI
  FLITLVSVVAAVGLFAGLFFCVRNSLSLRNTFNTAVYHPHGLNHGLGPGPGGNHGAPHRP
  RWSPNWFWRRPVSSIAMEMSGRNSGP

• Sequence length: 566

Pathways

Reactome:

Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Dectin-2 family
O-linked glycosylation of mucins
Termination of O-glycan biosynthesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	17632545
Myasthenia gravis	Myasthenia Gravis	rs5030818, rs121912815, rs121912817, rs121912818, rs121912821, rs75466054, rs121912822, rs121912823, rs794727516, rs764497513, rs376808313, rs1279554995, rs1554802792, rs369251527, rs372760913, rs1554802808, rs769234940, rs201439531, rs1272947184, rs757303526, rs760936252, rs1590576560, rs1838635262	23055271

Unknown
Disease name	Disease term	dbSNP ID	References
Lupus erythematosus	Lupus Erythematosus, Systemic		24871463