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LCN2 (lipocalin 2)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3934
Gene nameGene Name - the full gene name approved by the HGNC.
Lipocalin 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
LCN2
SynonymsGene synonyms aliases
24p3, MSFI, NGAL, p25
ChromosomeChromosome number
9
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q34.11
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT438755 hsa-miR-138-5p Luciferase reporter assay, qRT-PCR, Western blot 23300839
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
NFKB1 Activation 15536164
NFKB1 Unknown 19707556;20220144;24391115
NR3C2 Unknown 22469622
RELA Activation 15536164
RELA Unknown 19707556;20220144;24391115
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0005506 Function Iron ion binding IDA 27780864
GO:0005506 Function Iron ion binding ISS
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region HDA 27068509
GO:0005576 Component Extracellular region ISS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P80188
Protein name Neutrophil gelatinase-associated lipocalin (NGAL) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3) (Siderocalin) (p25)
Protein function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:27780864, PubMed:20581821). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:27780864). Can also bind siderophores from M.tuberculosis (PubMed:15642259, PubMed:21978368).
PDB 1DFV , 1L6M , 1NGL , 1QQS , 1X71 , 1X89 , 1X8U , 3BY0 , 3CBC , 3CMP , 3DSZ , 3DTQ , 3FW4 , 3FW5 , 3HWD , 3HWE , 3HWF , 3HWG , 3I0A , 3K3L , 3PEC , 3PED , 3T1D , 3TF6 , 3TZS , 3U0D , 4GH7 , 4IAW , 4IAX , 4K19 , 4MVI , 4MVK , 4MVL , 4QAE , 4ZFX , 4ZHC , 4ZHD , 4ZHF , 4ZHG , 4ZHH , 5JR8 , 5KHP , 5KIC , 5KID , 5MHH , 5N47 , 5N48 , 5NKN , 6GQZ , 6GR0 , 6O5D
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin
48 → 193
Lipocalin / cytosolic fatty-acid binding protein family
 Domain
Sequence
Sequence length 198
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  IL-17 signaling pathway   Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Metal sequestration by antimicrobial proteins
Iron uptake and transport
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs-1, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 23272119
Rheumatoid arthritis Rheumatoid Arthritis rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963 7554268
Tumoral calcinosis Tumoral calcinosis rs104894343, rs104894344, rs745655924, rs137853086, rs375879489, rs761396172, rs137853087, rs137853091, rs137853088, rs137853089, rs137853090, rs766750282, rs760830864, rs786205250, rs267606841, rs1555096583, rs1220533001, rs762936774, rs775341386 21335463
Kidney disease Kidney Diseases, Chronic Kidney Diseases rs74315342, rs749740335, rs757649673, rs112417755, rs35138315 20181666, 27026710, 20438795, 19349640, 24714768
Unknown
Disease name Disease term dbSNP ID References
Celiac disease Celiac Disease rs2305764, rs35218876 30097691
Benign neoplasm Benign Neoplasm 17114340
Cardiac valvular disease Heart valve disease 21335463
Cooley`s anemia Cooley`s anemia 16755567

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