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ARHGAP1 (Rho GTPase activating protein 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
392
Gene nameGene Name - the full gene name approved by the HGNC.
Rho GTPase activating protein 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ARHGAP1
SynonymsGene synonyms aliases
CDC42GAP, RHOGAP, RHOGAP1, p50rhoGAP
ChromosomeChromosome number
11
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p11.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided b
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020316 hsa-miR-130b-3p Sequencing 20371350
MIRT025280 hsa-miR-34a-5p Proteomics 21566225
MIRT025280 hsa-miR-34a-5p Proteomics 21566225
MIRT025280 hsa-miR-34a-5p Sequencing 20371350
MIRT025280 hsa-miR-34a-5p Proteomics 21566225
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005096 Function GTPase activator activity IDA 8253717, 8288572
GO:0005515 Function Protein binding IPI 9262406, 9846874, 12901880, 16189514, 31467278, 32296183
GO:0005737 Component Cytoplasm IDA 25468996
GO:0005829 Component Cytosol TAS
GO:0007264 Process Small GTPase mediated signal transduction IDA 8253717, 8288572
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q07960
Protein name Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP)
Protein function GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.
PDB 1AM4 , 1GRN , 1OW3 , 1RGP , 1TX4 , 2NGR , 5M6X , 5M70 , 6R3V , 7QSC , 7QTM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13716 CRAL_TRIO_2
82 216
Divergent CRAL/TRIO domain
Domain
PF00620 RhoGAP
260 408
RhoGAP domain
Domain
Sequence
Sequence length 439
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Rho GTPase cycle
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 22530067

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