Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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392 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Rho GTPase activating protein 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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ARHGAP1 |
SynonymsGene synonyms aliases
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CDC42GAP, RHOGAP, RHOGAP1, p50rhoGAP |
ChromosomeChromosome number
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11 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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11p11.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided b |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
Q07960 |
Protein name |
Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP) |
Protein function |
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate. |
PDB |
1AM4
,
1GRN
,
1OW3
,
1RGP
,
1TX4
,
2NGR
,
5M6X
,
5M70
,
6R3V
,
7QSC
,
7QTM
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF13716 |
CRAL_TRIO_2 |
82 → 216 |
Divergent CRAL/TRIO domain |
Domain |
PF00620 |
RhoGAP |
260 → 408 |
RhoGAP domain |
Domain |
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Sequence |
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Sequence length |
439 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
22530067 |
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