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RND3 (Rho family GTPase 3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
390
Gene nameGene Name - the full gene name approved by the HGNC.
Rho family GTPase 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
RND3
SynonymsGene synonyms aliases
ARHE, Rho8, RhoE, memB
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q23.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Mult
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
Transcription factors
Transcription factor Regulation Reference
AES Activation 23546594
FOXD3 Unknown 21478267
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0003924 Function GTPase activity IBA 21873635
GO:0005515 Function Protein binding IPI 14732713, 23622247, 29040270, 32296183
GO:0005525 Function GTP binding IBA 21873635
GO:0005856 Component Cytoskeleton IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P61587
Protein name Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3)
Protein function Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
PDB 1M7B , 2V55 , 4BG6 , 7OBC , 7OBD , 8B2K , 8BFC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras
25 199
Ras family
Domain
Sequence
Sequence length 244
Interactions View interactions
Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Liver carcinoma Liver carcinoma 28284560

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