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RHOC (ras homolog family member C)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
389
Gene nameGene Name - the full gene name approved by the HGNC.
Ras homolog family member C
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
RHOC
SynonymsGene synonyms aliases
ARH9, ARHC, H9, RHOH9
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskel
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000495 hsa-miR-138-5p qRT-PCR, Luciferase reporter assay, Western blot 20232393
MIRT005932 hsa-miR-372-3p Immunocytochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21490602
MIRT005932 hsa-miR-372-3p Immunocytochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21490602
MIRT005933 hsa-miR-302b-3p Immunocytochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21490602
MIRT005933 hsa-miR-302b-3p Immunocytochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21490602
Transcription factors
Transcription factor Regulation Reference
ETS1 Activation 21732343
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000281 Process Mitotic cytokinesis IDA 16236794
GO:0003924 Function GTPase activity IBA 21873635
GO:0005515 Function Protein binding IPI 20974804, 25416956, 27807006, 32296183
GO:0005525 Function GTP binding IBA 21873635
GO:0005829 Component Cytosol TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P08134
Protein name Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Protein function Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell
PDB 1Z2C , 2GCN , 2GCO , 2GCP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras
7 180
Ras family
Domain
Sequence
Sequence length 193
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases Activate Formins
Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Myocardial ischemia Myocardial Ischemia 16214533

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