KRT19 (keratin 19)

Gene

• Entrez ID: 3880
• Gene name: Keratin 19
• Gene symbol: KRT19
• Synonyms: CK19, K19, K1CS
• Chromosome: 17
• Chromosome location: 17q21.2
• Summary: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratin

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016304	hsa-miR-193b-3p	Proteomics	21512034
MIRT016860	hsa-miR-335-5p	Microarray	18185580
MIRT1101175	hsa-miR-1207-5p	CLIP-seq
MIRT1101176	hsa-miR-1253	CLIP-seq
MIRT1101177	hsa-miR-1912	CLIP-seq
MIRT1101178	hsa-miR-298	CLIP-seq
MIRT1101179	hsa-miR-3130-5p	CLIP-seq
MIRT1101180	hsa-miR-3619-3p	CLIP-seq
MIRT1101181	hsa-miR-3667-3p	CLIP-seq
MIRT1101182	hsa-miR-4323	CLIP-seq
MIRT1101183	hsa-miR-4433	CLIP-seq
MIRT1101184	hsa-miR-4434	CLIP-seq
MIRT1101185	hsa-miR-4459	CLIP-seq
MIRT1101186	hsa-miR-4482	CLIP-seq
MIRT1101187	hsa-miR-4516	CLIP-seq
MIRT1101188	hsa-miR-4535	CLIP-seq
MIRT1101189	hsa-miR-4736	CLIP-seq
MIRT1101190	hsa-miR-4763-3p	CLIP-seq
MIRT1101191	hsa-miR-4768-3p	CLIP-seq
MIRT1101192	hsa-miR-4776-5p	CLIP-seq
MIRT1101193	hsa-miR-4780	CLIP-seq
MIRT1101194	hsa-miR-4787-5p	CLIP-seq
MIRT1101195	hsa-miR-513a-3p	CLIP-seq
MIRT1101196	hsa-miR-555	CLIP-seq
MIRT1101197	hsa-miR-623	CLIP-seq
MIRT1101198	hsa-miR-642a	CLIP-seq
MIRT1101199	hsa-miR-922	CLIP-seq
MIRT1101175	hsa-miR-1207-5p	CLIP-seq
MIRT1101176	hsa-miR-1253	CLIP-seq
MIRT1101177	hsa-miR-1912	CLIP-seq
MIRT1101178	hsa-miR-298	CLIP-seq
MIRT1101179	hsa-miR-3130-5p	CLIP-seq
MIRT1101181	hsa-miR-3667-3p	CLIP-seq
MIRT1101182	hsa-miR-4323	CLIP-seq
MIRT1101183	hsa-miR-4433	CLIP-seq
MIRT1101184	hsa-miR-4434	CLIP-seq
MIRT1101185	hsa-miR-4459	CLIP-seq
MIRT1101186	hsa-miR-4482	CLIP-seq
MIRT1101187	hsa-miR-4516	CLIP-seq
MIRT1101189	hsa-miR-4736	CLIP-seq
MIRT1101190	hsa-miR-4763-3p	CLIP-seq
MIRT1101191	hsa-miR-4768-3p	CLIP-seq
MIRT1101194	hsa-miR-4787-5p	CLIP-seq
MIRT1101196	hsa-miR-555	CLIP-seq
MIRT1101198	hsa-miR-642a	CLIP-seq
MIRT1101199	hsa-miR-922	CLIP-seq
MIRT1101175	hsa-miR-1207-5p	CLIP-seq
MIRT1101176	hsa-miR-1253	CLIP-seq
MIRT1101177	hsa-miR-1912	CLIP-seq
MIRT1101178	hsa-miR-298	CLIP-seq
MIRT1101179	hsa-miR-3130-5p	CLIP-seq
MIRT1101181	hsa-miR-3667-3p	CLIP-seq
MIRT1101182	hsa-miR-4323	CLIP-seq
MIRT1101183	hsa-miR-4433	CLIP-seq
MIRT1101184	hsa-miR-4434	CLIP-seq
MIRT1101185	hsa-miR-4459	CLIP-seq
MIRT1101186	hsa-miR-4482	CLIP-seq
MIRT1101187	hsa-miR-4516	CLIP-seq
MIRT1101189	hsa-miR-4736	CLIP-seq
MIRT1101190	hsa-miR-4763-3p	CLIP-seq
MIRT1101191	hsa-miR-4768-3p	CLIP-seq
MIRT1101194	hsa-miR-4787-5p	CLIP-seq
MIRT1101195	hsa-miR-513a-3p	CLIP-seq
MIRT1101196	hsa-miR-555	CLIP-seq
MIRT1101198	hsa-miR-642a	CLIP-seq
MIRT1101199	hsa-miR-922	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ESR1	Activation	11026574
KLF4	Activation	10859317
SP1	Activation	10859317

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005200	Function	Structural constituent of cytoskeleton	TAS	2448790
GO:0005515	Function	Protein binding	IPI	15846844, 16000376, 16189514, 20080707, 25416956, 25910212, 26871637, 29892012, 31515488, 32296183, 32814053
GO:0005829	Component	Cytosol	TAS
GO:0005882	Component	Intermediate filament	IEA
GO:0005886	Component	Plasma membrane	IDA	23377137
GO:0007219	Process	Notch signaling pathway	IEA
GO:0008307	Function	Structural constituent of muscle	IDA	16000376
GO:0016010	Component	Dystrophin-associated glycoprotein complex	IEA
GO:0016032	Process	Viral process	IEA
GO:0016327	Component	Apicolateral plasma membrane	IEA
GO:0030018	Component	Z disc	IEA
GO:0031424	Process	Keratinization	TAS
GO:0042383	Component	Sarcolemma	IEA
GO:0043034	Component	Costamere	IDA	16000376
GO:0043627	Process	Response to estrogen	IEP	10037815
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045214	Process	Sarcomere organization	IDA	16000376
GO:0060706	Process	Cell differentiation involved in embryonic placenta development	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0070268	Process	Cornification	TAS
GO:0071944	Component	Cell periphery	IDA	19185580
GO:1990357	Component	Terminal web	IEA

Other IDs

• MIM: 148020
• HGNC: 6436
• e!Ensembl: ENSG00000171345

Protein

• UniProt ID: P08727
• Protein name: Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)
• Protein function: Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
• PDB: 8XTN, 8XTO, 8Y3S, 8ZUG
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00038	Filament	79 → 390	Intermediate filament protein	Coiled-coil

• Sequence:

  MTSYSYRQSSATSSFGGLGGGSVRFGPGVAFRAPSIHGGSGGRGVSVSSARFVSSSSSGA
  YGGGYGGVLTASDGLLAGNEKLTMQNLNDRLASYLDKVRALEAANGELEVKIRDWYQKQG
  PGPSRDYSHYYTTIQDLRDKILGATIENSRIVLQIDNARLAADDFRTKFETEQALRMSVE
  ADINGLRRVLDELTLARTDLEMQIEGLKEELAYLKKNHEEEISTLRGQVGGQVSVEVDSA
  PGTDLAKILSDMRSQYEVMAEQNRKDAEAWFTSRTEELNREVAGHTEQLQMSRSEVTDLR
  RTLQGLEIELQSQLSMKAALEDTLAETEARFGAQLAHIQALISGIEAQLGDVRADSERQN
  QEYQRLMDIKSRLEQEIATYRSLLEGQEDHYNNLSASKVL

• Sequence length: 400

Pathways

KEGG:

Estrogen signaling pathway
Staphylococcus aureus infection

Reactome:

Keratinization
Formation of the cornified envelope

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	15478392
Autoimmune diseases	Autoimmune Diseases	rs41285370, rs869025224	25055964
Esophagus neoplasm	Squamous cell carcinoma of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	21517111

Unknown
Disease name	Disease term	dbSNP ID	References
Cholangitis	Cholangitis		25055964
Copper-overload cirrhosis	Copper-Overload Cirrhosis		22879914