GPR153 (G protein-coupled receptor 153)

Gene

• Entrez ID: 387509
• Gene name: G protein-coupled receptor 153
• Gene symbol: GPR153
• Synonyms: PGR1
• Chromosome: 1
• Chromosome location: 1p36.31
• Summary: This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associ

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs776061422	G>A,T	Likely-pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018324	hsa-miR-335-5p	Microarray	18185580
MIRT487782	hsa-miR-132-5p	PAR-CLIP	23592263
MIRT487781	hsa-miR-1254	PAR-CLIP	23592263
MIRT487780	hsa-miR-3116	PAR-CLIP	23592263
MIRT487779	hsa-miR-661	PAR-CLIP	23592263
MIRT487782	hsa-miR-132-5p	PAR-CLIP	23592263
MIRT487781	hsa-miR-1254	PAR-CLIP	23592263
MIRT487780	hsa-miR-3116	PAR-CLIP	23592263
MIRT487779	hsa-miR-661	PAR-CLIP	23592263
MIRT1030582	hsa-miR-103a	CLIP-seq
MIRT1030583	hsa-miR-107	CLIP-seq
MIRT1030584	hsa-miR-124	CLIP-seq
MIRT1030585	hsa-miR-1273f	CLIP-seq
MIRT1030586	hsa-miR-1286	CLIP-seq
MIRT1030587	hsa-miR-1287	CLIP-seq
MIRT1030588	hsa-miR-1293	CLIP-seq
MIRT1030589	hsa-miR-143	CLIP-seq
MIRT1030590	hsa-miR-1471	CLIP-seq
MIRT1030591	hsa-miR-15a	CLIP-seq
MIRT1030592	hsa-miR-15b	CLIP-seq
MIRT1030593	hsa-miR-16	CLIP-seq
MIRT1030594	hsa-miR-1827	CLIP-seq
MIRT1030595	hsa-miR-1910	CLIP-seq
MIRT1030596	hsa-miR-195	CLIP-seq
MIRT1030597	hsa-miR-2110	CLIP-seq
MIRT1030598	hsa-miR-223	CLIP-seq
MIRT1030599	hsa-miR-3150a-3p	CLIP-seq
MIRT1030600	hsa-miR-3150b-3p	CLIP-seq
MIRT1030601	hsa-miR-3175	CLIP-seq
MIRT1030602	hsa-miR-3187-3p	CLIP-seq
MIRT1030603	hsa-miR-331-3p	CLIP-seq
MIRT1030604	hsa-miR-3614-3p	CLIP-seq
MIRT1030605	hsa-miR-3652	CLIP-seq
MIRT1030606	hsa-miR-3978	CLIP-seq
MIRT1030607	hsa-miR-424	CLIP-seq
MIRT1030608	hsa-miR-4271	CLIP-seq
MIRT1030609	hsa-miR-4292	CLIP-seq
MIRT1030610	hsa-miR-4300	CLIP-seq
MIRT1030611	hsa-miR-4302	CLIP-seq
MIRT1030612	hsa-miR-4310	CLIP-seq
MIRT1030613	hsa-miR-4419a	CLIP-seq
MIRT1030614	hsa-miR-4430	CLIP-seq
MIRT1030615	hsa-miR-4435	CLIP-seq
MIRT1030616	hsa-miR-4436a	CLIP-seq
MIRT1030617	hsa-miR-4446-3p	CLIP-seq
MIRT1030618	hsa-miR-4483	CLIP-seq
MIRT1030619	hsa-miR-4492	CLIP-seq
MIRT1030620	hsa-miR-4493	CLIP-seq
MIRT1030621	hsa-miR-4498	CLIP-seq
MIRT1030622	hsa-miR-4510	CLIP-seq
MIRT1030623	hsa-miR-455-3p	CLIP-seq
MIRT1030624	hsa-miR-4635	CLIP-seq
MIRT1030625	hsa-miR-4649-3p	CLIP-seq
MIRT1030626	hsa-miR-4667-5p	CLIP-seq
MIRT1030627	hsa-miR-4685-5p	CLIP-seq
MIRT1030628	hsa-miR-4697-3p	CLIP-seq
MIRT1030629	hsa-miR-4700-5p	CLIP-seq
MIRT1030630	hsa-miR-4701-5p	CLIP-seq
MIRT1030631	hsa-miR-4725-3p	CLIP-seq
MIRT1030632	hsa-miR-4738-3p	CLIP-seq
MIRT1030633	hsa-miR-4749-3p	CLIP-seq
MIRT1030634	hsa-miR-4756-3p	CLIP-seq
MIRT1030635	hsa-miR-4770	CLIP-seq
MIRT1030636	hsa-miR-4784	CLIP-seq
MIRT1030637	hsa-miR-4802-5p	CLIP-seq
MIRT1030638	hsa-miR-497	CLIP-seq
MIRT1030639	hsa-miR-506	CLIP-seq
MIRT1030640	hsa-miR-516b	CLIP-seq
MIRT1030641	hsa-miR-541	CLIP-seq
MIRT1030642	hsa-miR-548s	CLIP-seq
MIRT1030643	hsa-miR-584	CLIP-seq
MIRT1030644	hsa-miR-588	CLIP-seq
MIRT1030645	hsa-miR-654-5p	CLIP-seq
MIRT1030646	hsa-miR-762	CLIP-seq
MIRT1030647	hsa-miR-765	CLIP-seq
MIRT1030648	hsa-miR-920	CLIP-seq
MIRT1030649	hsa-miR-939	CLIP-seq
MIRT1030650	hsa-miR-940	CLIP-seq
MIRT1030582	hsa-miR-103a	CLIP-seq
MIRT1030583	hsa-miR-107	CLIP-seq
MIRT2005772	hsa-miR-1178	CLIP-seq
MIRT2005773	hsa-miR-1207-5p	CLIP-seq
MIRT1030585	hsa-miR-1273f	CLIP-seq
MIRT2005774	hsa-miR-1285	CLIP-seq
MIRT1030587	hsa-miR-1287	CLIP-seq
MIRT1030590	hsa-miR-1471	CLIP-seq
MIRT1030591	hsa-miR-15a	CLIP-seq
MIRT1030592	hsa-miR-15b	CLIP-seq
MIRT1030593	hsa-miR-16	CLIP-seq
MIRT2005775	hsa-miR-1909	CLIP-seq
MIRT1030596	hsa-miR-195	CLIP-seq
MIRT2005776	hsa-miR-2355-5p	CLIP-seq
MIRT2005777	hsa-miR-3117-5p	CLIP-seq
MIRT2005778	hsa-miR-3144-5p	CLIP-seq
MIRT1030600	hsa-miR-3150b-3p	CLIP-seq
MIRT2005779	hsa-miR-3155	CLIP-seq
MIRT2005780	hsa-miR-3155b	CLIP-seq
MIRT2005781	hsa-miR-3184	CLIP-seq
MIRT1030602	hsa-miR-3187-3p	CLIP-seq
MIRT2005782	hsa-miR-3187-5p	CLIP-seq
MIRT2005783	hsa-miR-3191	CLIP-seq
MIRT2005784	hsa-miR-3199	CLIP-seq
MIRT1030605	hsa-miR-3652	CLIP-seq
MIRT2005785	hsa-miR-423-5p	CLIP-seq
MIRT1030607	hsa-miR-424	CLIP-seq
MIRT1030610	hsa-miR-4300	CLIP-seq
MIRT1030612	hsa-miR-4310	CLIP-seq
MIRT1030613	hsa-miR-4419a	CLIP-seq
MIRT1030614	hsa-miR-4430	CLIP-seq
MIRT1030615	hsa-miR-4435	CLIP-seq
MIRT1030617	hsa-miR-4446-3p	CLIP-seq
MIRT1030619	hsa-miR-4492	CLIP-seq
MIRT1030621	hsa-miR-4498	CLIP-seq
MIRT1030622	hsa-miR-4510	CLIP-seq
MIRT2005786	hsa-miR-4514	CLIP-seq
MIRT2005787	hsa-miR-4515	CLIP-seq
MIRT2005788	hsa-miR-4652-5p	CLIP-seq
MIRT1030627	hsa-miR-4685-5p	CLIP-seq
MIRT2005789	hsa-miR-4692	CLIP-seq
MIRT1030630	hsa-miR-4701-5p	CLIP-seq
MIRT1030633	hsa-miR-4749-3p	CLIP-seq
MIRT1030634	hsa-miR-4756-3p	CLIP-seq
MIRT2005790	hsa-miR-4757-5p	CLIP-seq
MIRT2005791	hsa-miR-4761-5p	CLIP-seq
MIRT2005792	hsa-miR-4763-3p	CLIP-seq
MIRT1030636	hsa-miR-4784	CLIP-seq
MIRT1030637	hsa-miR-4802-5p	CLIP-seq
MIRT2005793	hsa-miR-484	CLIP-seq
MIRT2005794	hsa-miR-486-3p	CLIP-seq
MIRT2005795	hsa-miR-491-5p	CLIP-seq
MIRT1030638	hsa-miR-497	CLIP-seq
MIRT1030642	hsa-miR-548s	CLIP-seq
MIRT1030644	hsa-miR-588	CLIP-seq
MIRT2005796	hsa-miR-612	CLIP-seq
MIRT1030646	hsa-miR-762	CLIP-seq
MIRT1030647	hsa-miR-765	CLIP-seq
MIRT1030648	hsa-miR-920	CLIP-seq
MIRT1030650	hsa-miR-940	CLIP-seq
MIRT1030585	hsa-miR-1273f	CLIP-seq
MIRT2238378	hsa-miR-1324	CLIP-seq
MIRT2238379	hsa-miR-1343	CLIP-seq
MIRT1030615	hsa-miR-4435	CLIP-seq
MIRT2238380	hsa-miR-4438	CLIP-seq
MIRT2238381	hsa-miR-4646-5p	CLIP-seq
MIRT1030627	hsa-miR-4685-5p	CLIP-seq
MIRT2005790	hsa-miR-4757-5p	CLIP-seq
MIRT2681999	hsa-miR-1224-3p	CLIP-seq
MIRT2682000	hsa-miR-1228	CLIP-seq
MIRT2682001	hsa-miR-1260	CLIP-seq
MIRT2682002	hsa-miR-1260b	CLIP-seq
MIRT2682003	hsa-miR-1280	CLIP-seq
MIRT2682004	hsa-miR-2682	CLIP-seq
MIRT2682005	hsa-miR-4423-3p	CLIP-seq
MIRT2238380	hsa-miR-4438	CLIP-seq
MIRT2682006	hsa-miR-449c	CLIP-seq
MIRT2682007	hsa-miR-4512	CLIP-seq
MIRT2682008	hsa-miR-4530	CLIP-seq
MIRT2682009	hsa-miR-4640-5p	CLIP-seq
MIRT2682010	hsa-miR-4726-5p	CLIP-seq
MIRT2682011	hsa-miR-532-3p	CLIP-seq
MIRT2682012	hsa-miR-646	CLIP-seq
MIRT1030650	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016021	Component	Integral component of membrane	IEA

Other IDs

• MIM: 614269
• HGNC: 23618
• e!Ensembl: ENSG00000158292

Protein

• UniProt ID: Q6NV75
• Protein name: Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1)
• Protein function: Orphan receptor.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	24 → 297	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MSDERRLPGSAVGWLVCGGLSLLANAWGILSVGAKQKKWKPLEFLLCTLAATHMLNVAVP
  IATYSVVQLRRQRPDFEWNEGLCKVFVSTFYTLTLATCFSVTSLSYHRMWMVCWPVNYRL
  SNAKKQAVHTVMGIWMVSFILSALPAVGWHDTSERFYTHGCRFIVAEIGLGFGVCFLLLV
  GGSVAMGVICTAIALFQTLAVQVGRQADRRAFTVPTIVVEDAQGKRRSSIDGSEPAKTSL
  QTTGLVTTIVFIYDCLMGFPVLVVSFSSLRADASAPWMALCVLWCSVAQALLLPVFLWAC
  DRYRADLKAVREKCMALMANDEESDDETSLEGGISPDLVLERSLDYGYGGDFVALDRMAK
  YEISALEGGLPQLYPLRPLQEDKMQYLQVPPTRRFSHDDADVWAAVPLPAFLPRWGSGED
  LAALAHLVLPAGPERRRASLLAFAEDAPPSRARRRSAESLLSLRPSALDSGPRGARDSPP
  GSPRRRPGPGPRSASASLLPDAFALTAFECEPQALRRPPGPFPAAPAAPDGADPGEAPTP
  PSSAQRSPGPRPSAHSHAGSLRPGLSASWGEPGGLRAAGGGGSTSSFLSSPSESSGYATL
  HSDSLGSAS

• Sequence length: 609

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia, Schizophrenia, Childhood	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	21822266, 26508570