NPSR1 (neuropeptide S receptor 1)

Gene

• Entrez ID: 387129
• Gene name: Neuropeptide S receptor 1
• Gene symbol: NPSR1
• Synonyms: ASRT2, GPR154, GPRA, NPSR, PGR14, VRR1
• Chromosome: 7
• Chromosome location: 7p14.3
• Summary: This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1191311	hsa-miR-1343	CLIP-seq
MIRT1191312	hsa-miR-2110	CLIP-seq
MIRT1191313	hsa-miR-3064-5p	CLIP-seq
MIRT1191314	hsa-miR-3173-3p	CLIP-seq
MIRT1191315	hsa-miR-3652	CLIP-seq
MIRT1191316	hsa-miR-3667-3p	CLIP-seq
MIRT1191317	hsa-miR-4271	CLIP-seq
MIRT1191318	hsa-miR-4430	CLIP-seq
MIRT1191319	hsa-miR-4446-3p	CLIP-seq
MIRT1191320	hsa-miR-4476	CLIP-seq
MIRT1191321	hsa-miR-4492	CLIP-seq
MIRT1191322	hsa-miR-4498	CLIP-seq
MIRT1191323	hsa-miR-4505	CLIP-seq
MIRT1191324	hsa-miR-4533	CLIP-seq
MIRT1191325	hsa-miR-4646-5p	CLIP-seq
MIRT1191326	hsa-miR-4721	CLIP-seq
MIRT1191327	hsa-miR-4725-3p	CLIP-seq
MIRT1191328	hsa-miR-4779	CLIP-seq
MIRT1191329	hsa-miR-4790-3p	CLIP-seq
MIRT1191330	hsa-miR-491-5p	CLIP-seq
MIRT1191331	hsa-miR-541	CLIP-seq
MIRT1191332	hsa-miR-654-5p	CLIP-seq
MIRT1191333	hsa-miR-762	CLIP-seq
MIRT1191334	hsa-miR-1253	CLIP-seq
MIRT1191335	hsa-miR-3918	CLIP-seq
MIRT1191336	hsa-miR-4269	CLIP-seq
MIRT1191337	hsa-miR-4645-5p	CLIP-seq
MIRT1191338	hsa-miR-4673	CLIP-seq
MIRT1191339	hsa-miR-4733-3p	CLIP-seq
MIRT1191340	hsa-miR-4795-5p	CLIP-seq
MIRT2284398	hsa-miR-4504	CLIP-seq
MIRT1191314	hsa-miR-3173-3p	CLIP-seq
MIRT2582352	hsa-miR-4435	CLIP-seq
MIRT1191319	hsa-miR-4446-3p	CLIP-seq
MIRT1191321	hsa-miR-4492	CLIP-seq
MIRT1191322	hsa-miR-4498	CLIP-seq
MIRT1191323	hsa-miR-4505	CLIP-seq
MIRT1191324	hsa-miR-4533	CLIP-seq
MIRT1191325	hsa-miR-4646-5p	CLIP-seq
MIRT1191326	hsa-miR-4721	CLIP-seq
MIRT2582353	hsa-miR-4747-5p	CLIP-seq
MIRT1191328	hsa-miR-4779	CLIP-seq
MIRT1191333	hsa-miR-762	CLIP-seq
MIRT1191314	hsa-miR-3173-3p	CLIP-seq
MIRT2582352	hsa-miR-4435	CLIP-seq
MIRT1191319	hsa-miR-4446-3p	CLIP-seq
MIRT1191321	hsa-miR-4492	CLIP-seq
MIRT1191322	hsa-miR-4498	CLIP-seq
MIRT1191323	hsa-miR-4505	CLIP-seq
MIRT1191324	hsa-miR-4533	CLIP-seq
MIRT1191325	hsa-miR-4646-5p	CLIP-seq
MIRT1191326	hsa-miR-4721	CLIP-seq
MIRT2582353	hsa-miR-4747-5p	CLIP-seq
MIRT1191328	hsa-miR-4779	CLIP-seq
MIRT1191333	hsa-miR-762	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
RORA	Repression	23565190

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005000	Function	Vasopressin receptor activity	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IDA	16790440
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007218	Process	Neuropeptide signaling pathway	IEA
GO:0008188	Function	Neuropeptide receptor activity	IDA	16790440
GO:0051281	Process	Positive regulation of release of sequestered calcium ion into cytosol	IDA	16790440

Other IDs

• MIM: 608595
• HGNC: 23631
• e!Ensembl: ENSG00000187258

Protein

• UniProt ID: Q6W5P4
• Protein name: Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility)
• Protein function: G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	66 → 330	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLF
  VFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLV
  CRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIP
  TLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIK
  SKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFN
  LLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERH
  EMQILSKPEFI

• Sequence length: 371

Pathways

KEGG:

Neuroactive ligand-receptor interaction

Reactome:

Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	15710598, 16926187, 15764725
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	17669576, 22078257

Unknown
Disease name	Disease term	dbSNP ID	References
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	20171785