SUMO4 (small ubiquitin like modifier 4)

Gene

• Entrez ID: 387082
• Gene name: Small ubiquitin like modifier 4
• Gene symbol: SUMO4
• Synonyms: IDDM5, SMT3H4, SUMO-4, dJ281H8.4
• Chromosome: 6
• Chromosome location: 6q25.1
• Summary: This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins` subcellular localization, stability, or activity. The protein described in this rec

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1403355	hsa-miR-1261	CLIP-seq
MIRT1403356	hsa-miR-186	CLIP-seq
MIRT1403357	hsa-miR-2053	CLIP-seq
MIRT1403358	hsa-miR-27a	CLIP-seq
MIRT1403359	hsa-miR-27b	CLIP-seq
MIRT1403360	hsa-miR-28-3p	CLIP-seq
MIRT1403361	hsa-miR-3123	CLIP-seq
MIRT1403362	hsa-miR-3925-5p	CLIP-seq
MIRT1403363	hsa-miR-3976	CLIP-seq
MIRT1403364	hsa-miR-4252	CLIP-seq
MIRT1403365	hsa-miR-5096	CLIP-seq
MIRT1403366	hsa-miR-513a-5p	CLIP-seq
MIRT1403367	hsa-miR-548p	CLIP-seq
MIRT1403355	hsa-miR-1261	CLIP-seq
MIRT1403358	hsa-miR-27a	CLIP-seq
MIRT1403359	hsa-miR-27b	CLIP-seq
MIRT1403364	hsa-miR-4252	CLIP-seq
MIRT2120869	hsa-miR-4793-5p	CLIP-seq
MIRT1403365	hsa-miR-5096	CLIP-seq
MIRT1403366	hsa-miR-513a-5p	CLIP-seq
MIRT1403355	hsa-miR-1261	CLIP-seq
MIRT2342879	hsa-miR-1299	CLIP-seq
MIRT2342880	hsa-miR-1323	CLIP-seq
MIRT1403356	hsa-miR-186	CLIP-seq
MIRT1403358	hsa-miR-27a	CLIP-seq
MIRT1403359	hsa-miR-27b	CLIP-seq
MIRT2342881	hsa-miR-2964a-5p	CLIP-seq
MIRT2342882	hsa-miR-3133	CLIP-seq
MIRT1403364	hsa-miR-4252	CLIP-seq
MIRT2342883	hsa-miR-4263	CLIP-seq
MIRT2342884	hsa-miR-4328	CLIP-seq
MIRT2342885	hsa-miR-4436b-5p	CLIP-seq
MIRT2342886	hsa-miR-4446-5p	CLIP-seq
MIRT2342887	hsa-miR-4461	CLIP-seq
MIRT2342888	hsa-miR-4705	CLIP-seq
MIRT2342889	hsa-miR-4735-5p	CLIP-seq
MIRT2342890	hsa-miR-4773	CLIP-seq
MIRT2342891	hsa-miR-4782-5p	CLIP-seq
MIRT2120869	hsa-miR-4793-5p	CLIP-seq
MIRT1403365	hsa-miR-5096	CLIP-seq
MIRT1403366	hsa-miR-513a-5p	CLIP-seq
MIRT2342892	hsa-miR-516b	CLIP-seq
MIRT2342893	hsa-miR-548o	CLIP-seq
MIRT2342894	hsa-miR-576-5p	CLIP-seq
MIRT1403355	hsa-miR-1261	CLIP-seq
MIRT1403358	hsa-miR-27a	CLIP-seq
MIRT1403359	hsa-miR-27b	CLIP-seq
MIRT1403364	hsa-miR-4252	CLIP-seq
MIRT1403365	hsa-miR-5096	CLIP-seq
MIRT1403366	hsa-miR-513a-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005634	Component	Nucleus	IBA	21873635
GO:0016925	Process	Protein sumoylation	IBA	21873635
GO:0016925	Process	Protein sumoylation	IDA	15247916, 16236267, 18708028
GO:0031386	Function	Protein tag	IBA	21873635
GO:0034599	Process	Cellular response to oxidative stress	IDA	16236267, 18708028
GO:0043122	Process	Regulation of I-kappaB kinase/NF-kappaB signaling	IDA	15247916, 18708028
GO:0043388	Process	Positive regulation of DNA binding	IDA	16236267
GO:0043392	Process	Negative regulation of DNA binding	IDA	16236267
GO:0044389	Function	Ubiquitin-like protein ligase binding	IBA	21873635
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IDA	15247916, 16236267
GO:0106068	Component	SUMO ligase complex	IDA	16236267
GO:1900180	Process	Regulation of protein localization to nucleus	IDA	16236267

Other IDs

• MIM: 608829
• HGNC: 21181
• e!Ensembl: ENSG00000177688

Protein

• UniProt ID: Q6EEV6
• Protein name: Small ubiquitin-related modifier 4 (SUMO-4) (Small ubiquitin-like protein 4)
• Protein function: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugat
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11976	Rad60-SLD	18 → 88	Ubiquitin-2 like Rad60 SUMO-like	Family

• Sequence:

  MANEKPTEEVKTENNNHINLKVAGQDGSVVQFKIKRQTPLSKLMKAYCEPRGLSMKQIRF
  RFGGQPISGTDKPAQLEMEDEDTIDVFQQPTGGVY

• Sequence length: 95

Pathways

KEGG:

Nucleocytoplasmic transport
Fluid shear stress and atherosclerosis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	DIABETES MELLITUS, INSULIN-DEPENDENT, 5	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261