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ZKSCAN4 (zinc finger with KRAB and SCAN domains 4)

Gene

387032

Zinc finger with KRAB and SCAN domains 4

ZKSCAN4

P1P373C6, ZNF307, ZNF427, ZSCAN36

6p22.1

Show/Hide all(221)

miRTarBase ID	miRNA	Experiments	Reference
MIRT692276	hsa-miR-595	HITS-CLIP	23313552
MIRT641773	hsa-miR-8485	HITS-CLIP	23313552
MIRT651261	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT651260	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT651259	hsa-miR-603	HITS-CLIP	23313552
MIRT651258	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT651257	hsa-miR-3941	HITS-CLIP	23313552
MIRT651256	hsa-miR-4789-5p	HITS-CLIP	23313552
MIRT641772	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT632195	hsa-miR-3188	HITS-CLIP	23824327
MIRT632194	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT632193	hsa-miR-623	HITS-CLIP	23824327
MIRT632192	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT632191	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT641771	hsa-miR-1287-3p	HITS-CLIP	23824327
MIRT632190	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT632189	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT632188	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT632187	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT632186	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT632185	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT632198	hsa-miR-3121-3p	HITS-CLIP	23824327
MIRT641773	hsa-miR-8485	HITS-CLIP	23824327
MIRT651261	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT651260	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT651259	hsa-miR-603	HITS-CLIP	23824327
MIRT632197	hsa-miR-4719	HITS-CLIP	23824327
MIRT651257	hsa-miR-3941	HITS-CLIP	23824327
MIRT632194	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT651256	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT651265	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT651264	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT651263	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT651262	hsa-miR-498	HITS-CLIP	23824327
MIRT632198	hsa-miR-3121-3p	HITS-CLIP	23824327
MIRT641773	hsa-miR-8485	HITS-CLIP	23824327
MIRT651261	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT651260	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT651259	hsa-miR-603	HITS-CLIP	23824327
MIRT632197	hsa-miR-4719	HITS-CLIP	23824327
MIRT651258	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT651257	hsa-miR-3941	HITS-CLIP	23824327
MIRT632194	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT651256	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT632198	hsa-miR-3121-3p	HITS-CLIP	23824327
MIRT641773	hsa-miR-8485	HITS-CLIP	23824327
MIRT632197	hsa-miR-4719	HITS-CLIP	23824327
MIRT632196	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT641772	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT632195	hsa-miR-3188	HITS-CLIP	23824327
MIRT632194	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT632193	hsa-miR-623	HITS-CLIP	23824327
MIRT632192	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT632191	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT641771	hsa-miR-1287-3p	HITS-CLIP	23824327
MIRT632190	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT632189	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT632188	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT632187	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT632186	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT632185	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT632198	hsa-miR-3121-3p	HITS-CLIP	23824327
MIRT632197	hsa-miR-4719	HITS-CLIP	23824327
MIRT632196	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT632195	hsa-miR-3188	HITS-CLIP	23824327
MIRT632194	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT632193	hsa-miR-623	HITS-CLIP	23824327
MIRT632192	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT632191	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT632190	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT632189	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT632188	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT632187	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT632186	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT632185	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT519828	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT519827	hsa-miR-1273f	PAR-CLIP	23446348
MIRT519826	hsa-miR-4755-3p	PAR-CLIP	23446348
MIRT519825	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT519824	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT519823	hsa-miR-4732-5p	PAR-CLIP	23446348
MIRT519822	hsa-miR-548s	PAR-CLIP	23446348
MIRT519821	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT519820	hsa-miR-588	PAR-CLIP	23446348
MIRT519819	hsa-miR-4435	PAR-CLIP	23446348
MIRT519818	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT519817	hsa-miR-3170	PAR-CLIP	23446348
MIRT519816	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT519815	hsa-miR-5096	PAR-CLIP	23446348
MIRT692276	hsa-miR-595	HITS-CLIP	23313552
MIRT641773	hsa-miR-8485	HITS-CLIP	23313552
MIRT651261	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT651260	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT651259	hsa-miR-603	HITS-CLIP	23313552
MIRT651258	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT651257	hsa-miR-3941	HITS-CLIP	23313552
MIRT651256	hsa-miR-4789-5p	HITS-CLIP	23313552
MIRT641772	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT632195	hsa-miR-3188	HITS-CLIP	23824327
MIRT632194	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT632193	hsa-miR-623	HITS-CLIP	23824327
MIRT632192	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT632191	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT641771	hsa-miR-1287-3p	HITS-CLIP	23824327
MIRT632190	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT632189	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT632188	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT632187	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT632186	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT632185	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT632198	hsa-miR-3121-3p	HITS-CLIP	23824327
MIRT641773	hsa-miR-8485	HITS-CLIP	23824327
MIRT651261	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT651260	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT651259	hsa-miR-603	HITS-CLIP	23824327
MIRT632197	hsa-miR-4719	HITS-CLIP	23824327
MIRT651257	hsa-miR-3941	HITS-CLIP	23824327
MIRT632194	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT651256	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT651265	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT651264	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT651263	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT651262	hsa-miR-498	HITS-CLIP	23824327
MIRT632198	hsa-miR-3121-3p	HITS-CLIP	23824327
MIRT641773	hsa-miR-8485	HITS-CLIP	23824327
MIRT651261	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT651260	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT651259	hsa-miR-603	HITS-CLIP	23824327
MIRT632197	hsa-miR-4719	HITS-CLIP	23824327
MIRT651258	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT651257	hsa-miR-3941	HITS-CLIP	23824327
MIRT632194	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT651256	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT632198	hsa-miR-3121-3p	HITS-CLIP	23824327
MIRT641773	hsa-miR-8485	HITS-CLIP	23824327
MIRT632197	hsa-miR-4719	HITS-CLIP	23824327
MIRT632196	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT641772	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT632195	hsa-miR-3188	HITS-CLIP	23824327
MIRT632194	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT632193	hsa-miR-623	HITS-CLIP	23824327
MIRT632192	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT632191	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT641771	hsa-miR-1287-3p	HITS-CLIP	23824327
MIRT632190	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT632189	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT632188	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT632187	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT632186	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT632185	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT632198	hsa-miR-3121-3p	HITS-CLIP	23824327
MIRT632197	hsa-miR-4719	HITS-CLIP	23824327
MIRT632196	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT632195	hsa-miR-3188	HITS-CLIP	23824327
MIRT632194	hsa-miR-6866-5p	HITS-CLIP	23824327
MIRT632193	hsa-miR-623	HITS-CLIP	23824327
MIRT632192	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT632191	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT632190	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT632189	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT632188	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT632187	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT632186	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT632185	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT519828	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT519827	hsa-miR-1273f	PAR-CLIP	23446348
MIRT519826	hsa-miR-4755-3p	PAR-CLIP	23446348
MIRT519825	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT519824	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT519823	hsa-miR-4732-5p	PAR-CLIP	23446348
MIRT519822	hsa-miR-548s	PAR-CLIP	23446348
MIRT519821	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT519820	hsa-miR-588	PAR-CLIP	23446348
MIRT519819	hsa-miR-4435	PAR-CLIP	23446348
MIRT519818	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT519817	hsa-miR-3170	PAR-CLIP	23446348
MIRT519816	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT519815	hsa-miR-5096	PAR-CLIP	23446348
MIRT1514022	hsa-miR-15a	CLIP-seq
MIRT1514023	hsa-miR-15b	CLIP-seq
MIRT1514024	hsa-miR-16	CLIP-seq
MIRT1514025	hsa-miR-195	CLIP-seq
MIRT1514026	hsa-miR-2278	CLIP-seq
MIRT1514027	hsa-miR-3943	CLIP-seq
MIRT1514028	hsa-miR-424	CLIP-seq
MIRT1514029	hsa-miR-497	CLIP-seq
MIRT2155052	hsa-miR-140-5p	CLIP-seq
MIRT2155053	hsa-miR-3171	CLIP-seq
MIRT2155054	hsa-miR-3545-5p	CLIP-seq
MIRT2155055	hsa-miR-4263	CLIP-seq
MIRT2155056	hsa-miR-4460	CLIP-seq
MIRT2155057	hsa-miR-576-5p	CLIP-seq
MIRT2374964	hsa-miR-106a	CLIP-seq
MIRT2374965	hsa-miR-106b	CLIP-seq
MIRT2374966	hsa-miR-17	CLIP-seq
MIRT2374967	hsa-miR-20a	CLIP-seq
MIRT2374968	hsa-miR-20b	CLIP-seq
MIRT2374969	hsa-miR-2964a-5p	CLIP-seq
MIRT2374970	hsa-miR-302a	CLIP-seq
MIRT2374971	hsa-miR-302b	CLIP-seq
MIRT2374972	hsa-miR-302c	CLIP-seq
MIRT2374973	hsa-miR-302d	CLIP-seq
MIRT2374974	hsa-miR-302e	CLIP-seq
MIRT2374975	hsa-miR-3064-5p	CLIP-seq
MIRT2374976	hsa-miR-3609	CLIP-seq
MIRT2374977	hsa-miR-372	CLIP-seq
MIRT2374978	hsa-miR-373	CLIP-seq
MIRT2374979	hsa-miR-4796-3p	CLIP-seq
MIRT2374980	hsa-miR-512-3p	CLIP-seq
MIRT2374981	hsa-miR-519d	CLIP-seq
MIRT2374982	hsa-miR-520a-3p	CLIP-seq
MIRT2374983	hsa-miR-520b	CLIP-seq
MIRT2374984	hsa-miR-520c-3p	CLIP-seq
MIRT2374985	hsa-miR-520d-3p	CLIP-seq
MIRT2374986	hsa-miR-520e	CLIP-seq
MIRT2374987	hsa-miR-548ah	CLIP-seq
MIRT2374988	hsa-miR-676	CLIP-seq
MIRT2374989	hsa-miR-93	CLIP-seq
MIRT2397417	hsa-miR-4276	CLIP-seq
MIRT2397418	hsa-miR-4277	CLIP-seq
MIRT2397419	hsa-miR-4504	CLIP-seq

Show/Hide all(7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0005515	Function	Protein binding	IPI	25416956, 26871637, 28514442, 31515488, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0042802	Function	Identical protein binding	IPI	25416956, 26871637
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
611643	13854	ENSG00000187626

Protein

UniProt ID

Q969J2

Protein name

Zinc finger protein with KRAB and SCAN domains 4 (P373c6.1) (Zinc finger protein 307) (Zinc finger protein 427)

Protein function

May be involved in the transcriptional activation of MDM2 and EP300 genes.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02023	SCAN	49 → 138	SCAN domain	Domain
PF01352	KRAB	220 → 260	KRAB box	Family
PF00096	zf-C2H2	320 → 342	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	348 → 370	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	376 → 398	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	404 → 426	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	432 → 454	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	487 → 509	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	515 → 537	Zinc finger, C2H2 type	Domain

Sequence

MAREPRKNAALDAQSAEDQTGLLTVKVEKEEASALTAEVRAPCSPARGPERSRQRFRGFR
YPEAAGPREALSRLRELCGQWLQPEMHSKEQILELLVLEQFLTILPGNLQSWVREQHPES
GEEVVVLLEYLERQLDEPAPQVPVGDQGQELLCCKMALLTQTQGSQSSQCQPMKALFKHE
SLGSQPLHDRVLQVPGLAQGGCCREDAMVASRLTPGSQGLLKMEDVALTLTPGWTQLDSS
QVNLYRDEKQENHSSLVSLGGEIQTKSRDLPPVKKLPEKEHGKICHLREDIAQIPTHAEA
GEQEGRLQRKQKNAIGSRRHYCHECGKSFAQSSGLTKHRRIHTGEKPYECEDCGKTFIGS
SALVIHQRVHTGEKPYECEECGKVFSHSSNLIKHQRTHTGEKPYECDDCGKTFSQSCSLL
EHHKIHTGEKPYQCNMCGKAFRRNSHLLRHQRIHGDKNVQNPEHGESWESQGRTESQWEN
TEAPVSYKCNECERSFTRNRSLIEHQKIHTGEKPYQCDTCGKGFTRTSYLVQHQRSHVGK
KTLSQ

Sequence length

545

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	19503088
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	22037552, 30285260

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Lupus erythematosus	Lupus Erythematosus, Systemic		24871463

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