Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
3839 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Karyopherin subunit alpha 3 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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KPNA3 |
SynonymsGene synonyms aliases
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IPOA4, SPG88, SRP1, SRP1gamma, SRP4, hSRP1 |
ChromosomeChromosome number
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13 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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13q14.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusio |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0005515 |
Function |
Protein binding |
IPI |
10523667, 15057270, 16189514, 17500595, 19412186, 19447967, 21516116, 21988832, 23816991, 25416956, 25910212, 26382858, 26496610, 28611246, 29370303, 30833792, 32296183, 32814053, 33060197 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005643 |
Component |
Nuclear pore |
TAS |
9154134 |
GO:0005654 |
Component |
Nucleoplasm |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
TAS |
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GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0006607 |
Process |
NLS-bearing protein import into nucleus |
IBA |
21873635 |
GO:0008022 |
Function |
Protein C-terminus binding |
IEA |
|
GO:0008139 |
Function |
Nuclear localization sequence binding |
IBA |
21873635 |
GO:0019054 |
Process |
Modulation by virus of host cellular process |
TAS |
|
GO:0043657 |
Component |
Host cell |
IEA |
|
GO:0046718 |
Process |
Viral entry into host cell |
IEA |
|
GO:0061608 |
Function |
Nuclear import signal receptor activity |
IBA |
21873635 |
GO:0065003 |
Process |
Protein-containing complex assembly |
TAS |
9435235 |
GO:0075732 |
Process |
Viral penetration into host nucleus |
IEA |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
O00505 |
Protein name |
Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma) |
Protein function |
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01749 |
IBB |
11 → 93 |
Importin beta binding domain |
Family |
PF00514 |
Arm |
103 → 144 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514 |
Arm |
146 → 186 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514 |
Arm |
188 → 229 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514 |
Arm |
232 → 271 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514 |
Arm |
273 → 313 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514 |
Arm |
315 → 355 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514 |
Arm |
357 → 397 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514 |
Arm |
400 → 440 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF16186 |
Arm_3 |
447 → 499 |
Atypical Arm repeat |
Family |
|
Sequence |
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Sequence length |
521 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
22960338, 16644122, 15882913 |
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Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Mental depression |
Unipolar Depression, Major Depressive Disorder |
rs587778876, rs587778877 |
22960338 |
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