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KPNA3 (karyopherin subunit alpha 3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3839
Gene nameGene Name - the full gene name approved by the HGNC.
Karyopherin subunit alpha 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
KPNA3
SynonymsGene synonyms aliases
IPOA4, SPG88, SRP1, SRP1gamma, SRP4, hSRP1
ChromosomeChromosome number
13
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q14.2
SummarySummary of gene provided in NCBI Entrez Gene.
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusio
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001447 hsa-miR-16-5p pSILAC 18668040
MIRT001447 hsa-miR-16-5p Proteomics;Other 18668040
MIRT049397 hsa-miR-92a-3p CLASH 23622248
MIRT068854 hsa-miR-219a-1-3p HITS-CLIP 21572407
MIRT522810 hsa-miR-455-5p HITS-CLIP 21572407
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 10523667, 15057270, 16189514, 17500595, 19412186, 19447967, 21516116, 21988832, 23816991, 25416956, 25910212, 26382858, 26496610, 28611246, 29370303, 30833792, 32296183, 32814053, 33060197
GO:0005634 Component Nucleus IBA 21873635
GO:0005643 Component Nuclear pore TAS 9154134
GO:0005654 Component Nucleoplasm IBA 21873635
GO:0005654 Component Nucleoplasm TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O00505
Protein name Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma)
Protein function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01749 IBB
11 93
Importin beta binding domain
Family
PF00514 Arm
103 144
Armadillo/beta-catenin-like repeat
Repeat
PF00514 Arm
146 186
Armadillo/beta-catenin-like repeat
Repeat
PF00514 Arm
188 229
Armadillo/beta-catenin-like repeat
Repeat
PF00514 Arm
232 271
Armadillo/beta-catenin-like repeat
Repeat
PF00514 Arm
273 313
Armadillo/beta-catenin-like repeat
Repeat
PF00514 Arm
315 355
Armadillo/beta-catenin-like repeat
Repeat
PF00514 Arm
357 397
Armadillo/beta-catenin-like repeat
Repeat
PF00514 Arm
400 440
Armadillo/beta-catenin-like repeat
Repeat
PF16186 Arm_3
447 499
Atypical Arm repeat
Family
Sequence
Sequence length 521
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Nucleocytoplasmic transport
Salmonella infection
Chemical carcinogenesis - receptor activation
  ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 22960338, 16644122, 15882913
Unknown
Disease name Disease term dbSNP ID References
Mental depression Unipolar Depression, Major Depressive Disorder rs587778876, rs587778877 22960338

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