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KPNA1 (karyopherin subunit alpha 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3836
Gene nameGene Name - the full gene name approved by the HGNC.
Karyopherin subunit alpha 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
KPNA1
SynonymsGene synonyms aliases
IPOA5, NPI-1, RCH2, SRP1
ChromosomeChromosome number
3
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q21.1
SummarySummary of gene provided in NCBI Entrez Gene.
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusio
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025234 hsa-miR-34a-5p Proteomics 21566225
MIRT025234 hsa-miR-34a-5p Proteomics 21566225
MIRT027097 hsa-miR-103a-3p Sequencing 20371350
MIRT028495 hsa-miR-30a-5p Proteomics 18668040
MIRT031732 hsa-miR-16-5p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
SRF Unknown 21131446
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000018 Process Regulation of DNA recombination TAS 8052633
GO:0005515 Function Protein binding IPI 10523667, 12011095, 15942031, 16713569, 17310249, 17596301, 18985028, 19084525, 19412186, 21385873, 21988832, 21994455, 22500989, 25416956, 25599645, 26420826, 26496610, 26966684, 29370303, 31515488, 32296183, 33060197
GO:0005634 Component Nucleus IBA 21873635
GO:0005634 Component Nucleus ISS
GO:0005643 Component Nuclear pore TAS 8052633
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P52294
Protein name Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]
Protein function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:27713473, PubMed:7892216, PubMed:8692858). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:27713
PDB 2JDQ , 3TJ3 , 4B18 , 6WX9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01749 IBB
10 104
Importin beta binding domain
Family
PF00514 Arm
114 156
Armadillo/beta-catenin-like repeat
Repeat
PF00514 Arm
158 198
Armadillo/beta-catenin-like repeat
Repeat
PF00514 Arm
200 241
Armadillo/beta-catenin-like repeat
Repeat
PF00514 Arm
243 283
Armadillo/beta-catenin-like repeat
Repeat
PF00514 Arm
285 325
Armadillo/beta-catenin-like repeat
Repeat
PF00514 Arm
327 367
Armadillo/beta-catenin-like repeat
Repeat
PF00514 Arm
369 409
Armadillo/beta-catenin-like repeat
Repeat
PF00514 Arm
412 452
Armadillo/beta-catenin-like repeat
Repeat
PF16186 Arm_3
466 517
Atypical Arm repeat
Family
Sequence
Sequence length 538
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Nucleocytoplasmic transport
Salmonella infection
Influenza A
Chemical carcinogenesis - receptor activation
  ISG15 antiviral mechanism
Apoptosis induced DNA fragmentation
Integration of provirus
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Vpr-mediated nuclear import of PICs
Inhibition of nitric oxide production
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601 27903959
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 21743468

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