Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
3836 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Karyopherin subunit alpha 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
KPNA1 |
SynonymsGene synonyms aliases
|
IPOA5, NPI-1, RCH2, SRP1 |
ChromosomeChromosome number
|
3 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
3q21.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusio |
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
Transcription factor |
Regulation |
Reference |
SRF |
Unknown |
21131446 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000018 |
Process |
Regulation of DNA recombination |
TAS |
8052633 |
GO:0005515 |
Function |
Protein binding |
IPI |
10523667, 12011095, 15942031, 16713569, 17310249, 17596301, 18985028, 19084525, 19412186, 21385873, 21988832, 21994455, 22500989, 25416956, 25599645, 26420826, 26496610, 26966684, 29370303, 31515488, 32296183, 33060197 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005634 |
Component |
Nucleus |
ISS |
|
GO:0005643 |
Component |
Nuclear pore |
TAS |
8052633 |
GO:0005654 |
Component |
Nucleoplasm |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
TAS |
7754385 |
GO:0005829 |
Component |
Cytosol |
IDA |
|
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0006309 |
Process |
Apoptotic DNA fragmentation |
TAS |
|
GO:0006607 |
Process |
NLS-bearing protein import into nucleus |
IBA |
21873635 |
GO:0008139 |
Function |
Nuclear localization sequence binding |
IBA |
21873635 |
GO:0014069 |
Component |
Postsynaptic density |
IEA |
|
GO:0014841 |
Process |
Skeletal muscle satellite cell proliferation |
IEA |
|
GO:0014901 |
Process |
Satellite cell activation involved in skeletal muscle regeneration |
IEA |
|
GO:0019054 |
Process |
Modulation by virus of host cellular process |
TAS |
|
GO:0030425 |
Component |
Dendrite |
ISS |
|
GO:0042981 |
Process |
Regulation of apoptotic process |
IEA |
|
GO:0043657 |
Component |
Host cell |
IEA |
|
GO:0060828 |
Process |
Regulation of canonical Wnt signaling pathway |
IEA |
|
GO:0061608 |
Function |
Nuclear import signal receptor activity |
IBA |
21873635 |
GO:0075733 |
Process |
Intracellular transport of virus |
TAS |
|
GO:0098978 |
Component |
Glutamatergic synapse |
IEA |
|
GO:0099527 |
Process |
Postsynapse to nucleus signaling pathway |
IBA |
21873635 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P52294 |
Protein name |
Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] |
Protein function |
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:27713473, PubMed:7892216, PubMed:8692858). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:27713 |
PDB |
2JDQ
,
3TJ3
,
4B18
,
6WX9
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01749 |
IBB |
10 → 104 |
Importin beta binding domain |
Family |
PF00514 |
Arm |
114 → 156 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514 |
Arm |
158 → 198 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514 |
Arm |
200 → 241 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514 |
Arm |
243 → 283 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514 |
Arm |
285 → 325 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514 |
Arm |
327 → 367 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514 |
Arm |
369 → 409 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514 |
Arm |
412 → 452 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF16186 |
Arm_3 |
466 → 517 |
Atypical Arm repeat |
Family |
|
Sequence |
|
Sequence length |
538 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
|
|
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Leukemia |
Leukemia, Myelocytic, Acute |
rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601 |
27903959 |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
21743468 |
|