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KLC1 (kinesin light chain 1)

Gene

3831

Kinesin light chain 1

KLC1

KLC, KNS2, KNS2A

14q32.33

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various c

Show/Hide all(228)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004189	hsa-miR-197-3p	Microarray	16822819
MIRT025439	hsa-miR-34a-5p	Proteomics	21566225
MIRT1095542	hsa-miR-105	CLIP-seq
MIRT1095543	hsa-miR-1289	CLIP-seq
MIRT1095544	hsa-miR-1321	CLIP-seq
MIRT1095545	hsa-miR-147	CLIP-seq
MIRT1095546	hsa-miR-15a	CLIP-seq
MIRT1095547	hsa-miR-15b	CLIP-seq
MIRT1095548	hsa-miR-16	CLIP-seq
MIRT1095549	hsa-miR-1915	CLIP-seq
MIRT1095550	hsa-miR-195	CLIP-seq
MIRT1095551	hsa-miR-221	CLIP-seq
MIRT1095552	hsa-miR-222	CLIP-seq
MIRT1095553	hsa-miR-296-5p	CLIP-seq
MIRT1095554	hsa-miR-3065-3p	CLIP-seq
MIRT1095555	hsa-miR-3120-3p	CLIP-seq
MIRT1095556	hsa-miR-3123	CLIP-seq
MIRT1095557	hsa-miR-3126-3p	CLIP-seq
MIRT1095558	hsa-miR-3128	CLIP-seq
MIRT1095559	hsa-miR-3162-5p	CLIP-seq
MIRT1095560	hsa-miR-34b	CLIP-seq
MIRT1095561	hsa-miR-361-3p	CLIP-seq
MIRT1095562	hsa-miR-365	CLIP-seq
MIRT1095563	hsa-miR-3663-3p	CLIP-seq
MIRT1095564	hsa-miR-374c	CLIP-seq
MIRT1095565	hsa-miR-377	CLIP-seq
MIRT1095566	hsa-miR-3914	CLIP-seq
MIRT1095567	hsa-miR-3925-5p	CLIP-seq
MIRT1095568	hsa-miR-3945	CLIP-seq
MIRT1095569	hsa-miR-411	CLIP-seq
MIRT1095570	hsa-miR-421	CLIP-seq
MIRT1095571	hsa-miR-424	CLIP-seq
MIRT1095572	hsa-miR-4420	CLIP-seq
MIRT1095573	hsa-miR-4470	CLIP-seq
MIRT1095574	hsa-miR-4666-5p	CLIP-seq
MIRT1095575	hsa-miR-4670-3p	CLIP-seq
MIRT1095576	hsa-miR-4672	CLIP-seq
MIRT1095577	hsa-miR-4685-5p	CLIP-seq
MIRT1095578	hsa-miR-4709-5p	CLIP-seq
MIRT1095579	hsa-miR-4718	CLIP-seq
MIRT1095580	hsa-miR-4719	CLIP-seq
MIRT1095581	hsa-miR-4720-5p	CLIP-seq
MIRT1095582	hsa-miR-4731-3p	CLIP-seq
MIRT1095583	hsa-miR-4739	CLIP-seq
MIRT1095584	hsa-miR-4756-5p	CLIP-seq
MIRT1095585	hsa-miR-4781-5p	CLIP-seq
MIRT1095586	hsa-miR-4799-3p	CLIP-seq
MIRT1095587	hsa-miR-4801	CLIP-seq
MIRT1095588	hsa-miR-486-3p	CLIP-seq
MIRT1095589	hsa-miR-497	CLIP-seq
MIRT1095590	hsa-miR-505	CLIP-seq
MIRT1095591	hsa-miR-513a-3p	CLIP-seq
MIRT1095592	hsa-miR-545	CLIP-seq
MIRT1095593	hsa-miR-581	CLIP-seq
MIRT1095594	hsa-miR-582-5p	CLIP-seq
MIRT1095595	hsa-miR-598	CLIP-seq
MIRT1095596	hsa-miR-615-3p	CLIP-seq
MIRT1095597	hsa-miR-655	CLIP-seq
MIRT1095598	hsa-miR-656	CLIP-seq
MIRT1095599	hsa-miR-744	CLIP-seq
MIRT1095600	hsa-miR-873	CLIP-seq
MIRT1095542	hsa-miR-105	CLIP-seq
MIRT2025678	hsa-miR-1246	CLIP-seq
MIRT2025679	hsa-miR-1290	CLIP-seq
MIRT1095545	hsa-miR-147	CLIP-seq
MIRT1095546	hsa-miR-15a	CLIP-seq
MIRT1095547	hsa-miR-15b	CLIP-seq
MIRT1095548	hsa-miR-16	CLIP-seq
MIRT1095550	hsa-miR-195	CLIP-seq
MIRT1095551	hsa-miR-221	CLIP-seq
MIRT1095552	hsa-miR-222	CLIP-seq
MIRT1095554	hsa-miR-3065-3p	CLIP-seq
MIRT2025680	hsa-miR-3117-5p	CLIP-seq
MIRT1095555	hsa-miR-3120-3p	CLIP-seq
MIRT1095557	hsa-miR-3126-3p	CLIP-seq
MIRT2025681	hsa-miR-3167	CLIP-seq
MIRT2025682	hsa-miR-3174	CLIP-seq
MIRT1095560	hsa-miR-34b	CLIP-seq
MIRT1095562	hsa-miR-365	CLIP-seq
MIRT1095563	hsa-miR-3663-3p	CLIP-seq
MIRT1095564	hsa-miR-374c	CLIP-seq
MIRT1095565	hsa-miR-377	CLIP-seq
MIRT1095566	hsa-miR-3914	CLIP-seq
MIRT1095568	hsa-miR-3945	CLIP-seq
MIRT1095569	hsa-miR-411	CLIP-seq
MIRT1095570	hsa-miR-421	CLIP-seq
MIRT1095571	hsa-miR-424	CLIP-seq
MIRT1095572	hsa-miR-4420	CLIP-seq
MIRT2025683	hsa-miR-4477a	CLIP-seq
MIRT2025684	hsa-miR-4504	CLIP-seq
MIRT2025685	hsa-miR-4636	CLIP-seq
MIRT1095574	hsa-miR-4666-5p	CLIP-seq
MIRT1095576	hsa-miR-4672	CLIP-seq
MIRT2025686	hsa-miR-4694-3p	CLIP-seq
MIRT1095578	hsa-miR-4709-5p	CLIP-seq
MIRT1095580	hsa-miR-4719	CLIP-seq
MIRT1095582	hsa-miR-4731-3p	CLIP-seq
MIRT2025687	hsa-miR-4775	CLIP-seq
MIRT1095587	hsa-miR-4801	CLIP-seq
MIRT1095588	hsa-miR-486-3p	CLIP-seq
MIRT1095589	hsa-miR-497	CLIP-seq
MIRT1095590	hsa-miR-505	CLIP-seq
MIRT1095591	hsa-miR-513a-3p	CLIP-seq
MIRT2025688	hsa-miR-522	CLIP-seq
MIRT2025689	hsa-miR-542-3p	CLIP-seq
MIRT1095592	hsa-miR-545	CLIP-seq
MIRT1095593	hsa-miR-581	CLIP-seq
MIRT1095594	hsa-miR-582-5p	CLIP-seq
MIRT2025690	hsa-miR-590-3p	CLIP-seq
MIRT1095595	hsa-miR-598	CLIP-seq
MIRT1095597	hsa-miR-655	CLIP-seq
MIRT1095600	hsa-miR-873	CLIP-seq
MIRT2025691	hsa-miR-876-5p	CLIP-seq
MIRT1095542	hsa-miR-105	CLIP-seq
MIRT2256866	hsa-miR-1286	CLIP-seq
MIRT1095545	hsa-miR-147	CLIP-seq
MIRT1095546	hsa-miR-15a	CLIP-seq
MIRT1095547	hsa-miR-15b	CLIP-seq
MIRT1095548	hsa-miR-16	CLIP-seq
MIRT2256867	hsa-miR-185	CLIP-seq
MIRT1095550	hsa-miR-195	CLIP-seq
MIRT1095551	hsa-miR-221	CLIP-seq
MIRT1095552	hsa-miR-222	CLIP-seq
MIRT1095554	hsa-miR-3065-3p	CLIP-seq
MIRT2025680	hsa-miR-3117-5p	CLIP-seq
MIRT1095555	hsa-miR-3120-3p	CLIP-seq
MIRT1095557	hsa-miR-3126-3p	CLIP-seq
MIRT1095558	hsa-miR-3128	CLIP-seq
MIRT2256868	hsa-miR-3154	CLIP-seq
MIRT2256869	hsa-miR-3197	CLIP-seq
MIRT1095560	hsa-miR-34b	CLIP-seq
MIRT2256870	hsa-miR-3609	CLIP-seq
MIRT1095562	hsa-miR-365	CLIP-seq
MIRT1095563	hsa-miR-3663-3p	CLIP-seq
MIRT1095565	hsa-miR-377	CLIP-seq
MIRT1095566	hsa-miR-3914	CLIP-seq
MIRT1095568	hsa-miR-3945	CLIP-seq
MIRT1095569	hsa-miR-411	CLIP-seq
MIRT1095570	hsa-miR-421	CLIP-seq
MIRT1095571	hsa-miR-424	CLIP-seq
MIRT2256871	hsa-miR-4302	CLIP-seq
MIRT2256872	hsa-miR-4305	CLIP-seq
MIRT2256873	hsa-miR-4306	CLIP-seq
MIRT2256874	hsa-miR-4312	CLIP-seq
MIRT1095572	hsa-miR-4420	CLIP-seq
MIRT2256875	hsa-miR-4435	CLIP-seq
MIRT1095573	hsa-miR-4470	CLIP-seq
MIRT2025684	hsa-miR-4504	CLIP-seq
MIRT2256876	hsa-miR-4644	CLIP-seq
MIRT1095574	hsa-miR-4666-5p	CLIP-seq
MIRT1095576	hsa-miR-4672	CLIP-seq
MIRT1095578	hsa-miR-4709-5p	CLIP-seq
MIRT1095579	hsa-miR-4718	CLIP-seq
MIRT1095580	hsa-miR-4719	CLIP-seq
MIRT1095581	hsa-miR-4720-5p	CLIP-seq
MIRT2256877	hsa-miR-4722-5p	CLIP-seq
MIRT2256878	hsa-miR-4734	CLIP-seq
MIRT2256879	hsa-miR-4768-3p	CLIP-seq
MIRT1095586	hsa-miR-4799-3p	CLIP-seq
MIRT2256880	hsa-miR-485-5p	CLIP-seq
MIRT1095588	hsa-miR-486-3p	CLIP-seq
MIRT1095589	hsa-miR-497	CLIP-seq
MIRT1095590	hsa-miR-505	CLIP-seq
MIRT1095591	hsa-miR-513a-3p	CLIP-seq
MIRT2256881	hsa-miR-520g	CLIP-seq
MIRT2256882	hsa-miR-520h	CLIP-seq
MIRT2256883	hsa-miR-532-5p	CLIP-seq
MIRT2025689	hsa-miR-542-3p	CLIP-seq
MIRT1095592	hsa-miR-545	CLIP-seq
MIRT2256884	hsa-miR-548ah	CLIP-seq
MIRT1095593	hsa-miR-581	CLIP-seq
MIRT1095595	hsa-miR-598	CLIP-seq
MIRT2256885	hsa-miR-606	CLIP-seq
MIRT1095600	hsa-miR-873	CLIP-seq
MIRT2025678	hsa-miR-1246	CLIP-seq
MIRT2025679	hsa-miR-1290	CLIP-seq
MIRT1095551	hsa-miR-221	CLIP-seq
MIRT1095552	hsa-miR-222	CLIP-seq
MIRT2025680	hsa-miR-3117-5p	CLIP-seq
MIRT1095557	hsa-miR-3126-3p	CLIP-seq
MIRT1095558	hsa-miR-3128	CLIP-seq
MIRT2025681	hsa-miR-3167	CLIP-seq
MIRT2256870	hsa-miR-3609	CLIP-seq
MIRT1095564	hsa-miR-374c	CLIP-seq
MIRT2558292	hsa-miR-3941	CLIP-seq
MIRT1095573	hsa-miR-4470	CLIP-seq
MIRT2025683	hsa-miR-4477a	CLIP-seq
MIRT2025685	hsa-miR-4636	CLIP-seq
MIRT2558293	hsa-miR-466	CLIP-seq
MIRT1095574	hsa-miR-4666-5p	CLIP-seq
MIRT1095576	hsa-miR-4672	CLIP-seq
MIRT2025686	hsa-miR-4694-3p	CLIP-seq
MIRT1095581	hsa-miR-4720-5p	CLIP-seq
MIRT2025687	hsa-miR-4775	CLIP-seq
MIRT1095586	hsa-miR-4799-3p	CLIP-seq
MIRT2256881	hsa-miR-520g	CLIP-seq
MIRT2256882	hsa-miR-520h	CLIP-seq
MIRT2025688	hsa-miR-522	CLIP-seq
MIRT2256884	hsa-miR-548ah	CLIP-seq
MIRT1095594	hsa-miR-582-5p	CLIP-seq
MIRT2025690	hsa-miR-590-3p	CLIP-seq
MIRT2256885	hsa-miR-606	CLIP-seq
MIRT1095597	hsa-miR-655	CLIP-seq
MIRT1095598	hsa-miR-656	CLIP-seq
MIRT2025691	hsa-miR-876-5p	CLIP-seq
MIRT2025678	hsa-miR-1246	CLIP-seq
MIRT2025679	hsa-miR-1290	CLIP-seq
MIRT2025680	hsa-miR-3117-5p	CLIP-seq
MIRT2025681	hsa-miR-3167	CLIP-seq
MIRT2256870	hsa-miR-3609	CLIP-seq
MIRT1095564	hsa-miR-374c	CLIP-seq
MIRT2558292	hsa-miR-3941	CLIP-seq
MIRT2025683	hsa-miR-4477a	CLIP-seq
MIRT2025685	hsa-miR-4636	CLIP-seq
MIRT2558293	hsa-miR-466	CLIP-seq
MIRT1095576	hsa-miR-4672	CLIP-seq
MIRT2025686	hsa-miR-4694-3p	CLIP-seq
MIRT2025687	hsa-miR-4775	CLIP-seq
MIRT2256881	hsa-miR-520g	CLIP-seq
MIRT2256882	hsa-miR-520h	CLIP-seq
MIRT2025688	hsa-miR-522	CLIP-seq
MIRT2256884	hsa-miR-548ah	CLIP-seq
MIRT1095594	hsa-miR-582-5p	CLIP-seq
MIRT2025690	hsa-miR-590-3p	CLIP-seq
MIRT2256885	hsa-miR-606	CLIP-seq
MIRT1095597	hsa-miR-655	CLIP-seq
MIRT1095598	hsa-miR-656	CLIP-seq
MIRT2025691	hsa-miR-876-5p	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003774	Function	Motor activity	TAS	8786116
GO:0005515	Function	Protein binding	IPI	14970196, 16938850, 17332754, 19861499, 25416956, 25898167
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005871	Component	Kinesin complex	ISS
GO:0005874	Component	Microtubule	IEA
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	TAS
GO:0007018	Process	Microtubule-based movement	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016032	Process	Viral process	IEA
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
GO:0030426	Component	Growth cone	ISS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0035617	Process	Stress granule disassembly	ISS

MIM	HGNC	e!Ensembl
600025	6387	ENSG00000126214

Protein

UniProt ID

Q07866

Protein name

Kinesin light chain 1 (KLC 1)

Protein function

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:21385839). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By simil

PDB

3NF1 , 5OJ8 , 7AI4 , 7AIE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13424	TPR_12	211 → 287		Repeat
PF00515	TPR_1	297 → 329	Tetratricopeptide repeat	Repeat
PF13374	TPR_10	463 → 502		Repeat

Sequence

MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDD
ESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWL
RDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQAL
EDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATL
NNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEY
YYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVD
DENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKF
EAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGE
EVSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR

Sequence length

573

Interactions

View interactions

	KEGG		Reactome
	Motor proteins Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Salmonella infection		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	31268507, 30285260, 31374203, 25056061, 28540026, 26198764

Show/Hide Unknown Diseases (3)

Unknown
Disease name	Disease term	dbSNP ID	References
Cytochrome-c oxidase deficiency	Cytochrome-c Oxidase Deficiency	rs28461189, rs267606883
Development disorder	Child Development Disorders, Pervasive		28540026
Mental depression	Major Depressive Disorder	rs587778876, rs587778877	29662059

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