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KLK2 (kallikrein related peptidase 2)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3817
Gene nameGene Name - the full gene name approved by the HGNC.
Kallikrein related peptidase 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
KLK2
SynonymsGene synonyms aliases
KLK2A2, hGK-1, hK2
ChromosomeChromosome number
19
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.33
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT722828 hsa-miR-21-5p HITS-CLIP 19536157
MIRT722827 hsa-miR-590-5p HITS-CLIP 19536157
MIRT722826 hsa-miR-1245a HITS-CLIP 19536157
MIRT722825 hsa-miR-8079 HITS-CLIP 19536157
MIRT722824 hsa-miR-5190 HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
AR Unknown 11532861;16751804;20688158;9241247
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003073 Process Regulation of systemic arterial blood pressure IBA 21873635
GO:0004252 Function Serine-type endopeptidase activity IDA 9042371
GO:0005576 Component Extracellular region TAS
GO:0022617 Process Extracellular matrix disassembly TAS
GO:0030141 Component Secretory granule IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P20151
Protein name Kallikrein-2 (EC 3.4.21.35) (Glandular kallikrein-1) (hGK-1) (Tissue kallikrein-2)
Protein function Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
PDB 4NFE , 4NFF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00089 Trypsin
25 253
Trypsin
Domain
Sequence
Sequence length 261
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Renin-angiotensin system
Endocrine and other factor-regulated calcium reabsorption
  Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17085659, 15643194
Unknown
Disease name Disease term dbSNP ID References
Prostatic neoplasms Prostatic Neoplasms 17085659, 15643194

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