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KCNK1 (potassium two pore domain channel subfamily K member 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3775
Gene nameGene Name - the full gene name approved by the HGNC.
Potassium two pore domain channel subfamily K member 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
KCNK1
SynonymsGene synonyms aliases
DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q42.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins fo
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019653 hsa-miR-340-5p Sequencing 20371350
MIRT022480 hsa-miR-124-3p Microarray 18668037
MIRT028202 hsa-miR-33a-5p Sequencing 20371350
MIRT710232 hsa-miR-939-3p HITS-CLIP 19536157
MIRT710231 hsa-miR-6852-5p HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005242 Function Inward rectifier potassium channel activity TAS 8605869
GO:0005249 Function Voltage-gated potassium channel activity IDA 21653227
GO:0005267 Function Potassium channel activity IDA 22282804
GO:0005272 Function Sodium channel activity IDA 21653227
GO:0005515 Function Protein binding IPI 20498050, 32296183
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O00180
Protein name Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel K2P1) (Potassium channel KCNO1)
Protein function Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric chan
PDB 3UKM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07885 Ion_trans_2
82 158
Ion channel
Family
PF07885 Ion_trans_2
190 271
Ion channel
Family
Sequence
MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLK
RRFLEEHECLSEQQLEQFLGRVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGY
GHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITV
HVTRRPVLYFHIRWGFSKQVVA
IVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQK
FRELYKIGITCYLLLGLIAMLVVLETFCELH
ELKKFRKMFYVKKDKDEDQVHIIEHDQLS
FSSITDQAAGMKEDQKQNEPFVATQSSACVDGPANH
Sequence length 336
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
Phase 4 - resting membrane potential
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928 26503814
Unknown
Disease name Disease term dbSNP ID References
Ischemic stroke Ischemic stroke rs6025, rs1799963, rs1799983 26718567

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