MIA3 (MIA SH3 domain ER export factor 3)

Gene

• Entrez ID: 375056
• Gene name: MIA SH3 domain ER export factor 3
• Gene symbol: MIA3
• Synonyms: ARNT, D320, ODCD2, TANGO, TANGO1, UNQ6077
• Chromosome: 1
• Chromosome location: 1q41

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029370	hsa-miR-26b-5p	Microarray	19088304
MIRT535948	hsa-miR-384	PAR-CLIP	22012620
MIRT535949	hsa-miR-3685	PAR-CLIP	22012620
MIRT535950	hsa-miR-7975	PAR-CLIP	22012620
MIRT535951	hsa-miR-5571-3p	PAR-CLIP	22012620
MIRT535952	hsa-miR-155-3p	PAR-CLIP	22012620
MIRT535953	hsa-miR-4724-3p	PAR-CLIP	22012620
MIRT535954	hsa-miR-3124-3p	PAR-CLIP	22012620
MIRT535955	hsa-miR-3667-3p	PAR-CLIP	22012620
MIRT623246	hsa-miR-4795-3p	HITS-CLIP	23824327
MIRT623247	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT623248	hsa-miR-4528	HITS-CLIP	23824327
MIRT717950	hsa-miR-2681-5p	HITS-CLIP	19536157
MIRT717951	hsa-miR-6885-3p	HITS-CLIP	19536157
MIRT717952	hsa-miR-6772-3p	HITS-CLIP	19536157
MIRT717953	hsa-miR-127-5p	HITS-CLIP	19536157
MIRT717954	hsa-miR-7843-3p	HITS-CLIP	19536157
MIRT717955	hsa-miR-3140-3p	HITS-CLIP	19536157
MIRT717956	hsa-miR-4448	HITS-CLIP	19536157
MIRT717957	hsa-miR-4268	HITS-CLIP	19536157
MIRT717958	hsa-miR-6806-3p	HITS-CLIP	19536157
MIRT717959	hsa-miR-3928-5p	HITS-CLIP	19536157
MIRT717960	hsa-miR-208b-5p	HITS-CLIP	19536157
MIRT717961	hsa-miR-208a-5p	HITS-CLIP	19536157
MIRT727199	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT727200	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT727201	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT727202	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT727203	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT727204	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT727205	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT727206	hsa-miR-30b-5p	HITS-CLIP	22473208

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0002042	Process	Cell migration involved in sprouting angiogenesis	IMP	28341552
GO:0002687	Process	Positive regulation of leukocyte migration	IDA	17726152
GO:0005515	Function	Protein binding	IPI	17726152, 19269366, 21525241, 25202031, 27138255, 27170179, 27551091, 28442536, 32296183
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005789	Component	Endoplasmic reticulum membrane	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	19269366
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006887	Process	Exocytosis	IMP	19269366
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA	21873635
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	27138255
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	TAS
GO:0006897	Process	Endocytosis	IEA
GO:0007029	Process	Endoplasmic reticulum organization	IMP	28442536
GO:0007162	Process	Negative regulation of cell adhesion	IDA	17726152
GO:0009306	Process	Protein secretion	IBA	21873635
GO:0015031	Process	Protein transport	IMP	19269366
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IDA	19269366
GO:0030336	Process	Negative regulation of cell migration	IDA	17044017
GO:0035459	Process	Vesicle cargo loading	IBA	21873635
GO:0038024	Function	Cargo receptor activity	IMP	27138255
GO:0042060	Process	Wound healing	IDA	17044017
GO:0042953	Process	Lipoprotein transport	IMP	27138255
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043687	Process	Post-translational protein modification	TAS
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0070971	Component	Endoplasmic reticulum exit site	IBA	21873635
GO:0070971	Component	Endoplasmic reticulum exit site	IDA	21525241, 25202031, 28442536
GO:0070973	Process	Protein localization to endoplasmic reticulum exit site	IMP	28442536
GO:0090110	Process	COPII-coated vesicle cargo loading	IMP	27138255
GO:0140052	Process	Cellular response to oxidised low-density lipoprotein particle stimulus	IMP	28341552
GO:1903038	Process	Negative regulation of leukocyte cell-cell adhesion	IMP	28341552
GO:2000402	Process	Negative regulation of lymphocyte migration	IMP	28341552

Other IDs

• MIM: 613455
• HGNC: 24008
• e!Ensembl: ENSG00000154305

Protein

• UniProt ID: Q5JRA6
• Protein name: Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3)
• Protein function: Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536).
• PDB: 5KYN, 5KYU, 5KYW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07653	SH3_2	49 → 105	Variant SH3 domain	Domain

• Sequence:

  MAAAPGLLVWLLVLRLPWRVPGQLDPSTGRRFSEHKLCADDECSMLMYRGEALEDFTGPD
  CRFVNFKKGDPVYVYYKLARGWPEVWAGSVGRTFGYFPKDLIQVVHEYTKEELQVPTDET
  DFVCFDGGRDDFHNYNVEELLGFLELYNSAATDSEKAVEKTLQDMEKNPELSKEREPEPE
  PVEANSEESDSVFSENTEDLQEQFTTQKHHSHANSQANHAQGEQASFESFEEMLQDKLKV
  PESENNKTSNSSQVSNEQDKIDAYKLLKKEMTLDLKTKFGSTADALVSDDETTRLVTSLE
  DDFDEELDTEYYAVGKEDEENQEDFDELPLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNE
  EDKVQLTVPPGIKNDDKNILTTWGDTIFSIVTGGEETRDTMDLESSSSEEEKEDDDDALV
  PDSKQGKPQSATDYSDPDNVDDGLFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQ
  DKTELEDENQEGMTVHSSVHSNNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGML
  HEEKPGEQILEGGSESESAQKAAGNQMNDRKIQQESLGSAPLMGDDHPNASRDSVEGDAL
  VNGAKLHTLSVEHQREELKEELVLKTQNQPRFSSPDEIDLPRELEDEVPILGRNLPWQQE
  RDVAATASKQMSEKIRLSEGEAKEDSLDEEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKV
  EEDDYPSEELLEDENAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQ
  ETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPE
  LGEVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPE
  DDSFHWTPHTSVEPGHSDKREDLLIISSFFKEQQSLQRFQKYFNVHELEALLQEMSSKLK
  SAQQESLPYNMEKVLDKVFRASESQILSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDD
  IQDLIYFVRYKHSTAEETATLVMAPPLEEGLGGAMEEMQPLHEDNFSREKTAELNVQVPE
  EPTHLDQRVIGDTHASEVSQKPNTEKDLDPGPVTTEDTPMDAIDANKQPETAAEEPASVT
  PLENAILLIYSFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRT
  VLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSD
  EAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISM
  NASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQ
  IKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVG
  GDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRN
  SLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAV
  SAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAA
  NLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQNPPRRGPLSQNGSFGPSPVSGGECSPP
  LTVEPPVRPLSATLNRRDMPRSEFGSVDGPLPHPRWSAEASGKPSPSDPGSGTATMMNSS
  SRGSSPTRVLDEGKVNMAPKGPPPFPGVPLMSTPMGGPVPPPIRYGPPPQLCGPFGPRPL
  PPPFGPGMRPPLGLREFAPGVPPGRRDLPLHPRGFLPGHAPFRPLGSLGPREYFIPGTRL
  PPPTHGPQEYPPPPAVRDLLPSGSRDEPPPASQSTSQDCSQALKQSP

• Sequence length: 1907

Pathways

Reactome:

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Cargo concentration in the ER
Post-translational protein phosphorylation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	21378990, 28714975, 29212778, 30104761, 26343387
Coronary heart disease	Coronary heart disease	rs-1	17634449, 22319020, 21347282, 21378990, 21966275
Myocardial infarction	Myocardial Infarction	rs12316150, rs41303970, rs909253, rs7291467, rs2234693	19198609, 26343387

Unknown
Disease name	Disease term	dbSNP ID	References
Coronary arteriosclerosis	Coronary Arteriosclerosis		21378990