JUNB (JunB proto-oncogene, AP-1 transcription factor subunit)

Gene

• Entrez ID: 3726
• Gene name: JunB proto-oncogene, AP-1 transcription factor subunit
• Gene symbol: JUNB
• Synonyms: AP-1
• Chromosome: 19
• Chromosome location: 19p13.13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004391	hsa-miR-199a-5p	Microarray, Northern blot	16331254
MIRT000783	hsa-miR-199a-3p	Microarray, Northern blot	16331254
MIRT005353	hsa-miR-663a	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	20622002
MIRT005353	hsa-miR-663a	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	20622002
MIRT005353	hsa-miR-663a	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	20622002
MIRT005353	hsa-miR-663a	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	20622002
MIRT020720	hsa-miR-155-5p	Proteomics	18668040
MIRT036441	hsa-miR-1226-3p	CLASH	23622248
MIRT005353	hsa-miR-663a	Luciferase reporter assay, qRT-PCR, Western blot	24014830
MIRT004391	hsa-miR-199a-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	25938468
MIRT004391	hsa-miR-199a-5p	PAR-CLIP	26701625
MIRT004391	hsa-miR-199a-5p	PAR-CLIP	26701625
MIRT004391	hsa-miR-199a-5p	PAR-CLIP	26701625
MIRT004391	hsa-miR-199a-5p	PAR-CLIP	26701625
MIRT004391	hsa-miR-199a-5p	PAR-CLIP	26701625
MIRT1078170	hsa-miR-101	CLIP-seq
MIRT1078171	hsa-miR-1236	CLIP-seq
MIRT1078172	hsa-miR-1273g	CLIP-seq
MIRT1078173	hsa-miR-1303	CLIP-seq
MIRT1078174	hsa-miR-1908	CLIP-seq
MIRT1078175	hsa-miR-1911	CLIP-seq
MIRT1078176	hsa-miR-1915	CLIP-seq
MIRT1078177	hsa-miR-2467-3p	CLIP-seq
MIRT1078178	hsa-miR-302a	CLIP-seq
MIRT1078179	hsa-miR-302b	CLIP-seq
MIRT1078180	hsa-miR-302c	CLIP-seq
MIRT1078181	hsa-miR-302d	CLIP-seq
MIRT1078182	hsa-miR-302e	CLIP-seq
MIRT1078183	hsa-miR-30a	CLIP-seq
MIRT1078184	hsa-miR-30b	CLIP-seq
MIRT1078185	hsa-miR-30c	CLIP-seq
MIRT1078186	hsa-miR-30d	CLIP-seq
MIRT1078187	hsa-miR-30e	CLIP-seq
MIRT1078188	hsa-miR-3127-3p	CLIP-seq
MIRT1078189	hsa-miR-3179	CLIP-seq
MIRT1078190	hsa-miR-3190	CLIP-seq
MIRT1078191	hsa-miR-339-5p	CLIP-seq
MIRT1078192	hsa-miR-3616-3p	CLIP-seq
MIRT1078193	hsa-miR-3676	CLIP-seq
MIRT1078194	hsa-miR-3678-3p	CLIP-seq
MIRT1078195	hsa-miR-3692	CLIP-seq
MIRT1078196	hsa-miR-372	CLIP-seq
MIRT1078197	hsa-miR-373	CLIP-seq
MIRT1078198	hsa-miR-3937	CLIP-seq
MIRT1078199	hsa-miR-4267	CLIP-seq
MIRT1078200	hsa-miR-4313	CLIP-seq
MIRT1078201	hsa-miR-4467	CLIP-seq
MIRT1078202	hsa-miR-4640-5p	CLIP-seq
MIRT1078203	hsa-miR-4726-3p	CLIP-seq
MIRT1078204	hsa-miR-4726-5p	CLIP-seq
MIRT1078205	hsa-miR-4728-5p	CLIP-seq
MIRT1078206	hsa-miR-4743	CLIP-seq
MIRT1078207	hsa-miR-4787-5p	CLIP-seq
MIRT1078208	hsa-miR-519a	CLIP-seq
MIRT1078209	hsa-miR-519b-3p	CLIP-seq
MIRT1078210	hsa-miR-519c-3p	CLIP-seq
MIRT1078211	hsa-miR-520a-3p	CLIP-seq
MIRT1078212	hsa-miR-520b	CLIP-seq
MIRT1078213	hsa-miR-520c-3p	CLIP-seq
MIRT1078214	hsa-miR-520d-3p	CLIP-seq
MIRT1078215	hsa-miR-520e	CLIP-seq
MIRT1078216	hsa-miR-615-5p	CLIP-seq
MIRT1078217	hsa-miR-663	CLIP-seq
MIRT1078218	hsa-miR-744	CLIP-seq
MIRT1078170	hsa-miR-101	CLIP-seq
MIRT1078177	hsa-miR-2467-3p	CLIP-seq
MIRT1078178	hsa-miR-302a	CLIP-seq
MIRT1078179	hsa-miR-302b	CLIP-seq
MIRT1078180	hsa-miR-302c	CLIP-seq
MIRT1078181	hsa-miR-302d	CLIP-seq
MIRT1078182	hsa-miR-302e	CLIP-seq
MIRT1078193	hsa-miR-3676	CLIP-seq
MIRT1078194	hsa-miR-3678-3p	CLIP-seq
MIRT1078195	hsa-miR-3692	CLIP-seq
MIRT1078196	hsa-miR-372	CLIP-seq
MIRT1078197	hsa-miR-373	CLIP-seq
MIRT1078208	hsa-miR-519a	CLIP-seq
MIRT1078209	hsa-miR-519b-3p	CLIP-seq
MIRT1078210	hsa-miR-519c-3p	CLIP-seq
MIRT1078211	hsa-miR-520a-3p	CLIP-seq
MIRT1078212	hsa-miR-520b	CLIP-seq
MIRT1078213	hsa-miR-520c-3p	CLIP-seq
MIRT1078214	hsa-miR-520d-3p	CLIP-seq
MIRT1078215	hsa-miR-520e	CLIP-seq
MIRT1078170	hsa-miR-101	CLIP-seq
MIRT2019480	hsa-miR-1207-5p	CLIP-seq
MIRT1078171	hsa-miR-1236	CLIP-seq
MIRT1078174	hsa-miR-1908	CLIP-seq
MIRT2019481	hsa-miR-1909	CLIP-seq
MIRT1078175	hsa-miR-1911	CLIP-seq
MIRT1078177	hsa-miR-2467-3p	CLIP-seq
MIRT1078183	hsa-miR-30a	CLIP-seq
MIRT1078184	hsa-miR-30b	CLIP-seq
MIRT1078185	hsa-miR-30c	CLIP-seq
MIRT1078186	hsa-miR-30d	CLIP-seq
MIRT1078187	hsa-miR-30e	CLIP-seq
MIRT1078188	hsa-miR-3127-3p	CLIP-seq
MIRT2019482	hsa-miR-3180	CLIP-seq
MIRT2019483	hsa-miR-3180-3p	CLIP-seq
MIRT1078190	hsa-miR-3190	CLIP-seq
MIRT2019484	hsa-miR-3196	CLIP-seq
MIRT1078191	hsa-miR-339-5p	CLIP-seq
MIRT1078192	hsa-miR-3616-3p	CLIP-seq
MIRT1078193	hsa-miR-3676	CLIP-seq
MIRT1078194	hsa-miR-3678-3p	CLIP-seq
MIRT1078195	hsa-miR-3692	CLIP-seq
MIRT1078198	hsa-miR-3937	CLIP-seq
MIRT1078199	hsa-miR-4267	CLIP-seq
MIRT1078200	hsa-miR-4313	CLIP-seq
MIRT2019485	hsa-miR-4436b-3p	CLIP-seq
MIRT1078201	hsa-miR-4467	CLIP-seq
MIRT2019486	hsa-miR-4488	CLIP-seq
MIRT1078202	hsa-miR-4640-5p	CLIP-seq
MIRT2019487	hsa-miR-4669	CLIP-seq
MIRT2019488	hsa-miR-4697-5p	CLIP-seq
MIRT2019489	hsa-miR-4719	CLIP-seq
MIRT1078204	hsa-miR-4726-5p	CLIP-seq
MIRT1078205	hsa-miR-4728-5p	CLIP-seq
MIRT2019490	hsa-miR-4731-3p	CLIP-seq
MIRT1078206	hsa-miR-4743	CLIP-seq
MIRT2019491	hsa-miR-4763-3p	CLIP-seq
MIRT1078207	hsa-miR-4787-5p	CLIP-seq
MIRT2019492	hsa-miR-4801	CLIP-seq
MIRT1078216	hsa-miR-615-5p	CLIP-seq
MIRT2019493	hsa-miR-656	CLIP-seq
MIRT1078217	hsa-miR-663	CLIP-seq
MIRT1078218	hsa-miR-744	CLIP-seq
MIRT1078170	hsa-miR-101	CLIP-seq
MIRT1078171	hsa-miR-1236	CLIP-seq
MIRT2251315	hsa-miR-1280	CLIP-seq
MIRT1078174	hsa-miR-1908	CLIP-seq
MIRT1078175	hsa-miR-1911	CLIP-seq
MIRT1078176	hsa-miR-1915	CLIP-seq
MIRT1078178	hsa-miR-302a	CLIP-seq
MIRT1078179	hsa-miR-302b	CLIP-seq
MIRT1078180	hsa-miR-302c	CLIP-seq
MIRT1078181	hsa-miR-302d	CLIP-seq
MIRT1078182	hsa-miR-302e	CLIP-seq
MIRT1078183	hsa-miR-30a	CLIP-seq
MIRT1078184	hsa-miR-30b	CLIP-seq
MIRT1078185	hsa-miR-30c	CLIP-seq
MIRT1078186	hsa-miR-30d	CLIP-seq
MIRT1078187	hsa-miR-30e	CLIP-seq
MIRT1078189	hsa-miR-3179	CLIP-seq
MIRT2251316	hsa-miR-3180-5p	CLIP-seq
MIRT1078190	hsa-miR-3190	CLIP-seq
MIRT2251317	hsa-miR-338-3p	CLIP-seq
MIRT1078191	hsa-miR-339-5p	CLIP-seq
MIRT2251318	hsa-miR-3613-3p	CLIP-seq
MIRT1078193	hsa-miR-3676	CLIP-seq
MIRT2251319	hsa-miR-3689a-3p	CLIP-seq
MIRT2251320	hsa-miR-3689c	CLIP-seq
MIRT2251321	hsa-miR-3690	CLIP-seq
MIRT1078195	hsa-miR-3692	CLIP-seq
MIRT1078196	hsa-miR-372	CLIP-seq
MIRT1078197	hsa-miR-373	CLIP-seq
MIRT1078198	hsa-miR-3937	CLIP-seq
MIRT1078199	hsa-miR-4267	CLIP-seq
MIRT2251322	hsa-miR-4272	CLIP-seq
MIRT2251323	hsa-miR-4292	CLIP-seq
MIRT2251324	hsa-miR-4308	CLIP-seq
MIRT1078200	hsa-miR-4313	CLIP-seq
MIRT1078201	hsa-miR-4467	CLIP-seq
MIRT2251325	hsa-miR-4517	CLIP-seq
MIRT2251326	hsa-miR-4530	CLIP-seq
MIRT1078202	hsa-miR-4640-5p	CLIP-seq
MIRT1078203	hsa-miR-4726-3p	CLIP-seq
MIRT1078204	hsa-miR-4726-5p	CLIP-seq
MIRT1078205	hsa-miR-4728-5p	CLIP-seq
MIRT2251327	hsa-miR-4796-3p	CLIP-seq
MIRT1078208	hsa-miR-519a	CLIP-seq
MIRT1078209	hsa-miR-519b-3p	CLIP-seq
MIRT1078210	hsa-miR-519c-3p	CLIP-seq
MIRT1078211	hsa-miR-520a-3p	CLIP-seq
MIRT1078212	hsa-miR-520b	CLIP-seq
MIRT1078213	hsa-miR-520c-3p	CLIP-seq
MIRT1078214	hsa-miR-520d-3p	CLIP-seq
MIRT1078215	hsa-miR-520e	CLIP-seq
MIRT2251328	hsa-miR-548t	CLIP-seq
MIRT2019493	hsa-miR-656	CLIP-seq
MIRT1078217	hsa-miR-663	CLIP-seq
MIRT2251329	hsa-miR-711	CLIP-seq
MIRT1078218	hsa-miR-744	CLIP-seq
MIRT2251330	hsa-miR-922	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ESR1	Activation	11477071
MYC	Repression	18838534
NFKB1	Activation	17018379
RBMX	Repression	16707624
RELA	Activation	17018379
STAT3	Activation	17204573
WT1	Unknown	17430890

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001570	Process	Vasculogenesis	IEA
GO:0001649	Process	Osteoblast differentiation	IEA
GO:0001829	Process	Trophectodermal cell differentiation	IEA
GO:0003677	Function	DNA binding	TAS	10764760
GO:0005515	Function	Protein binding	IPI	16189514, 16511568, 18692475, 19064921, 19321746, 20102225, 20195357, 21988832, 24029232, 25416956, 25609649, 26496610, 28514442, 29997244, 30833792, 31467278, 32296183, 32814053
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IBA	21873635
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0008134	Function	Transcription factor binding	IBA	21873635
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0030316	Process	Osteoclast differentiation	IEA
GO:0033687	Process	Osteoblast proliferation	IEA
GO:0035976	Component	Transcription factor AP-1 complex	IDA	10508860
GO:0042127	Process	Regulation of cell population proliferation	IBA	21873635
GO:0045597	Process	Positive regulation of cell differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	10508860
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	TAS
GO:0046697	Process	Decidualization	IEA
GO:0051726	Process	Regulation of cell cycle	IBA	21873635
GO:0060136	Process	Embryonic process involved in female pregnancy	IEA
GO:0060716	Process	Labyrinthine layer blood vessel development	IEA
GO:0071277	Process	Cellular response to calcium ion	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 165161
• HGNC: 6205
• e!Ensembl: ENSG00000171223

Protein

• UniProt ID: P17275
• Protein name: Transcription factor JunB (Transcription factor AP-1 subunit JunB)
• Protein function: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby en
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03957	Jun	5 → 257	Jun-like transcription factor	Family
  PF00170	bZIP_1	266 → 329	bZIP transcription factor	Coiled-coil

• Sequence:

  MCTKMEQPFYHDDSYTATGYGRAPGGLSLHDYKLLKPSLAVNLADPYRSLKAPGARGPGP
  EGGGGGSYFSGQGSDTGASLKLASSELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGG
  AGGAGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGATGGPPAGPGGVYAGPEPPP
  VYTNLSSYSPASASSGGAGAAVGTGSSYPTTTISYLPHAPPFAGGHPAQLGLGRGASTFK
  EEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKV
  KTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSNGCQLLLGVKGHAF

• Sequence length: 347

Pathways

KEGG:

Osteoclast differentiation
TNF signaling pathway
Growth hormone synthesis, secretion and action

Reactome:

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Interleukin-4 and Interleukin-13 signaling
NGF-stimulated transcription

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	24366584
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	27935865, 16289808

Unknown
Disease name	Disease term	dbSNP ID	References
Cerebral infraction	Infarction, Middle Cerebral Artery		12374626
Cerebral thrombosis	Middle Cerebral Artery Thrombosis		12374626
Grand mal status epilepticus	Grand Mal Status Epilepticus		7984056
Lung neoplasms	Lung Neoplasms		16289808, 27935865
Myocardial ischemia	Myocardial Ischemia		16214533
Nonconvulsive status epilepticus	Non-Convulsive Status Epilepticus		7984056
Petit mal status	Petit mal status		7984056
Status epilepticus	Status Epilepticus, Complex Partial Status Epilepticus, Status Epilepticus, Subclinical		7984056