ITPKA (inositol-trisphosphate 3-kinase A)

Gene

• Entrez ID: 3706
• Gene name: Inositol-trisphosphate 3-kinase A
• Gene symbol: ITPKA
• Synonyms: IP3-3KA, IP3KA
• Chromosome: 15
• Chromosome location: 15q15.1
• Summary: Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016467	hsa-miR-193b-3p	Microarray	20304954
MIRT1074802	hsa-miR-1289	CLIP-seq
MIRT1074803	hsa-miR-129-3p	CLIP-seq
MIRT1074804	hsa-miR-3121-5p	CLIP-seq
MIRT1074805	hsa-miR-3127-3p	CLIP-seq
MIRT1074806	hsa-miR-3185	CLIP-seq
MIRT1074807	hsa-miR-4313	CLIP-seq
MIRT1074808	hsa-miR-4433	CLIP-seq
MIRT1074809	hsa-miR-4706	CLIP-seq
MIRT1074810	hsa-miR-4749-5p	CLIP-seq
MIRT1074802	hsa-miR-1289	CLIP-seq
MIRT1074808	hsa-miR-4433	CLIP-seq
MIRT1074809	hsa-miR-4706	CLIP-seq
MIRT1074810	hsa-miR-4749-5p	CLIP-seq
MIRT2389518	hsa-miR-146b-3p	CLIP-seq
MIRT2389519	hsa-miR-3130-3p	CLIP-seq
MIRT2389520	hsa-miR-3173-5p	CLIP-seq
MIRT2389521	hsa-miR-874	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000828	Function	Inositol hexakisphosphate kinase activity	IBA	21873635
GO:0004683	Function	Calmodulin-dependent protein kinase activity	IEA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006020	Process	Inositol metabolic process	IEA
GO:0006468	Process	Protein phosphorylation	IEA
GO:0007165	Process	Signal transduction	TAS	1847047, 2176078
GO:0008440	Function	Inositol-1,4,5-trisphosphate 3-kinase activity	IEA
GO:0016301	Function	Kinase activity	IBA	21873635
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0032958	Process	Inositol phosphate biosynthetic process	IBA	21873635
GO:0043197	Component	Dendritic spine	IEA
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0046854	Process	Phosphatidylinositol phosphorylation	IBA	21873635
GO:0048167	Process	Regulation of synaptic plasticity	IEA
GO:0061003	Process	Positive regulation of dendritic spine morphogenesis	IEA
GO:0097062	Process	Dendritic spine maintenance	IEA

Other IDs

• MIM: 147521
• HGNC: 6178
• e!Ensembl: ENSG00000137825

Protein

• UniProt ID: P23677
• Protein name: Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A)
• Protein function: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:15350214, ECO
• PDB: 1W2C, 1W2D, 1W2F, 4UPU, 8PP8, 8PP9, 8PPA, 8PPB, 8PPC, 8PPD, 8PPE, 8PPF, 8PPG, 8PPH, 8PPI, 8PPJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03770	IPK	245 → 456	Inositol polyphosphate kinase	Family

• Sequence:

  MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAK
  RRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSPGPPERERDCLPAAGSSHLQQPRRL
  STSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVIS
  PFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVER
  DGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAP
  TEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFE
  EFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKT
  TPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER

• Sequence length: 461

Pathways

KEGG:

Inositol phosphate metabolism
Metabolic pathways
Calcium signaling pathway
Phosphatidylinositol signaling system

Reactome:

Synthesis of IP3 and IP4 in the cytosol

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma, Childhood asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	30929738

Unknown
Disease name	Disease term	dbSNP ID	References
Respiratory tract diseases	Respiratory Tract Diseases		30595370