ITGAX (integrin subunit alpha X)

Gene

• Entrez ID: 3687
• Gene name: Integrin subunit alpha X
• Gene symbol: ITGAX
• Synonyms: CD11C, SLEB6
• Chromosome: 16
• Chromosome location: 16p11.2
• Summary: This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030204	hsa-miR-26b-5p	Microarray	19088304
MIRT1073963	hsa-miR-1262	CLIP-seq
MIRT1073964	hsa-miR-2114	CLIP-seq
MIRT1073965	hsa-miR-25	CLIP-seq
MIRT1073966	hsa-miR-32	CLIP-seq
MIRT1073967	hsa-miR-338-3p	CLIP-seq
MIRT1073968	hsa-miR-363	CLIP-seq
MIRT1073969	hsa-miR-3664-3p	CLIP-seq
MIRT1073970	hsa-miR-367	CLIP-seq
MIRT1073971	hsa-miR-4325	CLIP-seq
MIRT1073972	hsa-miR-4433	CLIP-seq
MIRT1073973	hsa-miR-4701-3p	CLIP-seq
MIRT1073974	hsa-miR-4768-3p	CLIP-seq
MIRT1073975	hsa-miR-508-5p	CLIP-seq
MIRT1073976	hsa-miR-510	CLIP-seq
MIRT1073977	hsa-miR-512-5p	CLIP-seq
MIRT1073978	hsa-miR-542-3p	CLIP-seq
MIRT1073979	hsa-miR-550a	CLIP-seq
MIRT1073980	hsa-miR-661	CLIP-seq
MIRT1073981	hsa-miR-766	CLIP-seq
MIRT1073982	hsa-miR-92a	CLIP-seq
MIRT1073983	hsa-miR-92b	CLIP-seq
MIRT1073963	hsa-miR-1262	CLIP-seq
MIRT1073965	hsa-miR-25	CLIP-seq
MIRT2018286	hsa-miR-3181	CLIP-seq
MIRT1073966	hsa-miR-32	CLIP-seq
MIRT1073968	hsa-miR-363	CLIP-seq
MIRT1073970	hsa-miR-367	CLIP-seq
MIRT1073971	hsa-miR-4325	CLIP-seq
MIRT2018287	hsa-miR-4649-5p	CLIP-seq
MIRT1073973	hsa-miR-4701-3p	CLIP-seq
MIRT1073975	hsa-miR-508-5p	CLIP-seq
MIRT1073981	hsa-miR-766	CLIP-seq
MIRT1073982	hsa-miR-92a	CLIP-seq
MIRT1073983	hsa-miR-92b	CLIP-seq
MIRT1073963	hsa-miR-1262	CLIP-seq
MIRT1073965	hsa-miR-25	CLIP-seq
MIRT2250143	hsa-miR-298	CLIP-seq
MIRT1073966	hsa-miR-32	CLIP-seq
MIRT1073968	hsa-miR-363	CLIP-seq
MIRT1073970	hsa-miR-367	CLIP-seq
MIRT2250144	hsa-miR-3944-5p	CLIP-seq
MIRT1073971	hsa-miR-4325	CLIP-seq
MIRT1073973	hsa-miR-4701-3p	CLIP-seq
MIRT1073975	hsa-miR-508-5p	CLIP-seq
MIRT1073978	hsa-miR-542-3p	CLIP-seq
MIRT1073980	hsa-miR-661	CLIP-seq
MIRT1073981	hsa-miR-766	CLIP-seq
MIRT2250145	hsa-miR-922	CLIP-seq
MIRT1073982	hsa-miR-92a	CLIP-seq
MIRT1073983	hsa-miR-92b	CLIP-seq
MIRT2018286	hsa-miR-3181	CLIP-seq
MIRT2018287	hsa-miR-4649-5p	CLIP-seq
MIRT2250143	hsa-miR-298	CLIP-seq
MIRT2250144	hsa-miR-3944-5p	CLIP-seq
MIRT1073963	hsa-miR-1262	CLIP-seq
MIRT1073965	hsa-miR-25	CLIP-seq
MIRT1073966	hsa-miR-32	CLIP-seq
MIRT2553697	hsa-miR-3613-3p	CLIP-seq
MIRT1073968	hsa-miR-363	CLIP-seq
MIRT1073970	hsa-miR-367	CLIP-seq
MIRT2553698	hsa-miR-371-5p	CLIP-seq
MIRT2553699	hsa-miR-371b-5p	CLIP-seq
MIRT1073971	hsa-miR-4325	CLIP-seq
MIRT1073973	hsa-miR-4701-3p	CLIP-seq
MIRT1073975	hsa-miR-508-5p	CLIP-seq
MIRT1073978	hsa-miR-542-3p	CLIP-seq
MIRT1073980	hsa-miR-661	CLIP-seq
MIRT1073981	hsa-miR-766	CLIP-seq
MIRT1073982	hsa-miR-92a	CLIP-seq
MIRT1073983	hsa-miR-92b	CLIP-seq
MIRT1073963	hsa-miR-1262	CLIP-seq
MIRT1073965	hsa-miR-25	CLIP-seq
MIRT1073966	hsa-miR-32	CLIP-seq
MIRT2553697	hsa-miR-3613-3p	CLIP-seq
MIRT1073968	hsa-miR-363	CLIP-seq
MIRT1073970	hsa-miR-367	CLIP-seq
MIRT2553698	hsa-miR-371-5p	CLIP-seq
MIRT2553699	hsa-miR-371b-5p	CLIP-seq
MIRT1073971	hsa-miR-4325	CLIP-seq
MIRT1073973	hsa-miR-4701-3p	CLIP-seq
MIRT1073975	hsa-miR-508-5p	CLIP-seq
MIRT1073980	hsa-miR-661	CLIP-seq
MIRT1073981	hsa-miR-766	CLIP-seq
MIRT1073982	hsa-miR-92a	CLIP-seq
MIRT1073983	hsa-miR-92b	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CEBPA	Activation	9360988
JUN	Unknown	8649405;8649434
NFKB1	Unknown	7678251
RELA	Unknown	7678251
SP1	Unknown	7678251;8649405
SPI1	Repression	9295016
SPI1	Unknown	7678251
WT1	Activation	9484784

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005178	Function	Integrin binding	TAS	8020569
GO:0005515	Function	Protein binding	IPI	17726152, 20033057, 20679211
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	TAS	2303426
GO:0007229	Process	Integrin-mediated signaling pathway	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	30873824
GO:0008305	Component	Integrin complex	TAS	2303426
GO:0009887	Process	Animal organ morphogenesis	TAS	3327687
GO:0009986	Component	Cell surface	HDA	23981064
GO:0009986	Component	Cell surface	IC	20563599
GO:0009986	Component	Cell surface	IDA	19234460
GO:0010628	Process	Positive regulation of gene expression	IMP	30873824
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0016020	Component	Membrane	HDA	19946888
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0030335	Process	Positive regulation of cell migration	IMP	30873824
GO:0030667	Component	Secretory granule membrane	TAS
GO:0030971	Function	Receptor tyrosine kinase binding	IPI	30873824
GO:0031643	Process	Positive regulation of myelination	ISS
GO:0034113	Process	Heterotypic cell-cell adhesion	IMP	20563599
GO:0034689	Component	Integrin alphaX-beta2 complex	TAS	8020569
GO:0038023	Function	Signaling receptor activity	TAS	2303426
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045766	Process	Positive regulation of angiogenesis	IMP	30873824
GO:0046872	Function	Metal ion binding	IEA
GO:0050900	Process	Leukocyte migration	TAS
GO:0070821	Component	Tertiary granule membrane	TAS
GO:0101003	Component	Ficolin-1-rich granule membrane	TAS
GO:1905956	Process	Positive regulation of endothelial tube morphogenesis	IMP	30873824

Other IDs

• MIM: 151510
• HGNC: 6152
• e!Ensembl: ENSG00000140678

Protein

• UniProt ID: P20702
• Protein name: Integrin alpha-X (CD11 antigen-like family member C) (Leu M5) (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (CD antigen CD11c)
• Protein function: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
• PDB: 1N3Y, 2LUV, 3K6S, 3K71, 3K72, 4NEH, 4NEN, 5ES4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00092	VWA	151 → 328	von Willebrand factor type A domain	Domain
  PF01839	FG-GAP	458 → 495	FG-GAP repeat	Repeat
  PF01839	FG-GAP	521 → 556	FG-GAP repeat	Repeat
  PF08441	Integrin_alpha2	615 → 1015	Integrin alpha	Family
  PF00357	Integrin_alpha	1129 → 1143	Integrin alpha cytoplasmic region	Family

• Sequence:

  MTRTRAALLLFTALATSLGFNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAA
  NQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNM
  YLTGLCFLLGPTQLTQRLPVSRQECPRQEQDIVFLIDGSGSISSRNFATMMNFVRAVISQ
  FQRPSTQFSLMQFSNKFQTHFTFEEFRRSSNPLSLLASVHQLQGFTYTATAIQNVVHRLF
  HASYGARRDAAKILIVITDGKKEGDSLDYKDVIPMADAAGIIRYAIGVGLAFQNRNSWKE
  LNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIFAIEGTETTSSSSFELEMAQEGFSAVF
  TPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSL
  VLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGA
  PHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVV
  IGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLV
  DLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDK
  RSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLP
  SCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDN
  LGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQ
  LRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANV
  SSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNL
  GQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVL
  DCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYS
  QLPGQEAFMRAQTTTVLEKYKVHNPTPLIVGSSIGGLLLLALITAVLYKVGFFKRQYKEM
  MEEANGQIAPENGTQTPSPPSEK

• Sequence length: 1163

Pathways

KEGG:

Complement and coagulation cascades
Regulation of actin cytoskeleton
Tuberculosis

Reactome:

Cell surface interactions at the vascular wall
Integrin cell surface interactions
ECM proteoglycans
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	23040885
Glomerulonephritis	IGA Glomerulonephritis	rs778043831	26028593, 25305756
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959

Unknown
Disease name	Disease term	dbSNP ID	References
Lupus erythematosus	Lupus Erythematosus, Systemic		18204098
Promyelocytic leukemia	Acute Promyelocytic Leukemia		16764927