ITGAM (integrin subunit alpha M)

Gene

• Entrez ID: 3684
• Gene name: Integrin subunit alpha M
• Gene symbol: ITGAM
• Synonyms: CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6
• Chromosome: 16
• Chromosome location: 16p11.2
• Summary: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific i

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1073816	hsa-miR-203	CLIP-seq
MIRT1073817	hsa-miR-224	CLIP-seq
MIRT1073818	hsa-miR-23a	CLIP-seq
MIRT1073819	hsa-miR-23b	CLIP-seq
MIRT1073820	hsa-miR-23c	CLIP-seq
MIRT1073821	hsa-miR-338-3p	CLIP-seq
MIRT1073822	hsa-miR-4488	CLIP-seq
MIRT1073823	hsa-miR-4489	CLIP-seq
MIRT1073824	hsa-miR-4530	CLIP-seq
MIRT1073825	hsa-miR-4643	CLIP-seq
MIRT1073826	hsa-miR-4697-5p	CLIP-seq
MIRT1073827	hsa-miR-517b	CLIP-seq
MIRT1073828	hsa-miR-603	CLIP-seq
MIRT1073829	hsa-miR-637	CLIP-seq
MIRT1073830	hsa-miR-661	CLIP-seq
MIRT1073825	hsa-miR-4643	CLIP-seq
MIRT1073828	hsa-miR-603	CLIP-seq
MIRT2250108	hsa-miR-342-3p	CLIP-seq
MIRT2250109	hsa-miR-3650	CLIP-seq
MIRT2250110	hsa-miR-377	CLIP-seq
MIRT1073825	hsa-miR-4643	CLIP-seq
MIRT2250111	hsa-miR-4717-3p	CLIP-seq
MIRT2250112	hsa-miR-4802-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SPI1	Activation	15163413;8095266;9295016

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IC
GO:0001774	Process	Microglial cell activation	ISS
GO:0001851	Function	Complement component C3b binding	ISS
GO:0005178	Function	Integrin binding	NAS	20199584
GO:0005515	Function	Protein binding	IPI	12208882, 15004192, 15194813, 16246332, 21193407, 28939773, 32296183
GO:0005615	Component	Extracellular space	IDA	25645918
GO:0005886	Component	Plasma membrane	IDA	28807980
GO:0005886	Component	Plasma membrane	TAS
GO:0006898	Process	Receptor-mediated endocytosis	ISS
GO:0006911	Process	Phagocytosis, engulfment	ISS
GO:0007155	Process	Cell adhesion	TAS	2563162
GO:0007229	Process	Integrin-mediated signaling pathway	IEA
GO:0008305	Component	Integrin complex	TAS	2563162
GO:0009897	Component	External side of plasma membrane	NAS	20199584
GO:0009986	Component	Cell surface	HDA	23981064
GO:0009986	Component	Cell surface	IDA	19234460
GO:0010668	Process	Ectodermal cell differentiation	IEP	23154389
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0030900	Process	Forebrain development	ISS
GO:0031072	Function	Heat shock protein binding	IPI	12496435
GO:0032930	Process	Positive regulation of superoxide anion generation	IGI	21193407
GO:0032930	Process	Positive regulation of superoxide anion generation	ISS
GO:0034142	Process	Toll-like receptor 4 signaling pathway	TAS
GO:0034688	Component	Integrin alphaM-beta2 complex	ISS
GO:0035579	Component	Specific granule membrane	TAS
GO:0038024	Function	Cargo receptor activity	ISS
GO:0038024	Function	Cargo receptor activity	ISS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043315	Process	Positive regulation of neutrophil degranulation	IGI	21193407
GO:0044853	Component	Plasma membrane raft	IDA	21193407
GO:0045087	Process	Innate immune response	IEA
GO:0045963	Process	Negative regulation of dopamine metabolic process	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0050900	Process	Leukocyte migration	TAS
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070821	Component	Tertiary granule membrane	TAS
GO:0090314	Process	Positive regulation of protein targeting to membrane	ISS
GO:0097190	Process	Apoptotic signaling pathway	ISS
GO:0097242	Process	Amyloid-beta clearance	ISS
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	NAS	20199584
GO:0110090	Process	Positive regulation of hippocampal neuron apoptotic process	ISS
GO:0150062	Process	Complement-mediated synapse pruning	ISS
GO:0150064	Process	Vertebrate eye-specific patterning	ISS
GO:1901216	Process	Positive regulation of neuron death	ISS
GO:1904151	Process	Positive regulation of microglial cell mediated cytotoxicity	ISS
GO:1905114	Process	Cell surface receptor signaling pathway involved in cell-cell signaling	ISS
GO:2000363	Process	Positive regulation of prostaglandin-E synthase activity	ISS

Other IDs

• MIM: 120980
• HGNC: 6149
• e!Ensembl: ENSG00000169896

Protein

• UniProt ID: P11215
• Protein name: Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)
• Protein function: Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:20008295, PubMed:9558116). It is identical wit
• PDB: 1BHO, 1BHQ, 1IDN, 1IDO, 1JLM, 1M1U, 1MF7, 1N9Z, 1NA5, 2LKE, 2LKJ, 3Q3G, 3QA3, 4M76, 4XW2, 6RHW, 7AKK, 7P2D, 7USL, 7USM, 8CE6, 8CE9, 8VOH, 8VOI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00092	VWA	150 → 327	von Willebrand factor type A domain	Domain
  PF01839	FG-GAP	520 → 555	FG-GAP repeat	Repeat
  PF08441	Integrin_alpha2	614 → 1005	Integrin alpha	Family
  PF00357	Integrin_alpha	1129 → 1143	Integrin alpha cytoplasmic region	Family

• Sequence:

  MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQR
  GSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVK
  GLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQL
  KKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFN
  ITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQEL
  NTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAIT
  SNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLV
  LGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAP
  HYYEQTRGGQVSVCPLPRGRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAI
  GAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVD
  LTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKS
  TRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPN
  CIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDL
  SITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQ
  RSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKAN
  VTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNL
  GQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVV
  NCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFT
  LLPGQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDM
  MSEGGPPGAEPQ

• Sequence length: 1152

Pathways

KEGG:

Rap1 signaling pathway
Phagosome
Cell adhesion molecules
Complement and coagulation cascades
Neutrophil extracellular trap formation
Hematopoietic cell lineage
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Pertussis
Legionellosis
Leishmaniasis
Amoebiasis
Staphylococcus aureus infection
Tuberculosis
Transcriptional misregulation in cancer
Acute myeloid leukemia

Reactome:

Toll Like Receptor 4 (TLR4) Cascade
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Dermatitis, Allergic Contact	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	16033404
Hyperinsulinism	Hyperinsulinism	rs387906407, rs151344623, rs121913156, rs137853245, rs80356655, rs104894010, rs104894012, rs104894014, rs104894015, rs137852676, rs587783169, rs72559716, rs541269678, rs151344624, rs797045209, rs761749884, rs797045624, rs863225280, rs139964066, rs1057516281, rs1057516317, rs576684889, rs201682634, rs1350717554, rs768951263, rs1260178539, rs200670692, rs72559734, rs1400535021, rs372307320, rs1554923999, rs751279984, rs1008906426, rs367850779, rs1382448285, rs1564977373, rs750586210, rs1599937180	29035695
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	22190364
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	29035695
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	23566496
Systemic lupus erythematosus	Systemic lupus erythematosus	rs77571059, rs10954213, rs2070197, rs72556554, rs3219018, rs121912990, rs1575496354, rs7574865, rs1307379746, rs758750492, rs1575497576

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		19488045
Compensatory hyperinsulinemia	Compensatory Hyperinsulinemia		29035695
Endogenous hyperinsulinism	Endogenous Hyperinsulinism		29035695
Exogenous hyperinsulinism	Exogenous Hyperinsulinism		29035695
Hyperglycemia	Hyperglycemia		29035695
Ileitis	Ileitis		10647630
Lupus erythematosus	Lupus Erythematosus, Systemic		23943494, 18204446, 24871463, 19838195, 18204448, 23740937, 27399966, 26606652, 21408207, 19286673, 26502338, 23917156, 28714469
Lupus meningoencephalitis	Lupus Meningoencephalitis		26773105
Central nervous system lupus	Lupus Vasculitis, Central Nervous System		26773105
Neuropsychiatric systemic lupus erythematosus	Neuropsychiatric Systemic Lupus Erythematosus		26773105
Nonbacterial verrucal endocardiosis	Libman-Sacks Disease		18204448, 18204446
Promyelocytic leukemia	Acute Promyelocytic Leukemia		16764927
Scleroderma	Systemic Scleroderma		23740937