ITGAL (integrin subunit alpha L)

Gene

• Entrez ID: 3683
• Gene name: Integrin subunit alpha L
• Gene symbol: ITGAL
• Synonyms: CD11A, LFA-1, LFA1A
• Chromosome: 16
• Chromosome location: 16p11.2
• Summary: ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte fu

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT631592	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT631591	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631590	hsa-miR-764	HITS-CLIP	23824327
MIRT631589	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631588	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT631587	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT631586	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT631585	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631584	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT631583	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT631582	hsa-miR-4764-3p	HITS-CLIP	23824327
MIRT631581	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631580	hsa-miR-640	HITS-CLIP	23824327
MIRT631579	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT631592	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT631591	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631590	hsa-miR-764	HITS-CLIP	23824327
MIRT631589	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631588	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT631587	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT631586	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT631585	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631584	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT631583	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT631582	hsa-miR-4764-3p	HITS-CLIP	23824327
MIRT631581	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631580	hsa-miR-640	HITS-CLIP	23824327
MIRT631579	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT631592	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT631591	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631590	hsa-miR-764	HITS-CLIP	23824327
MIRT631589	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631588	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT631587	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT631586	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT631585	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631584	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT631583	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT631582	hsa-miR-4764-3p	HITS-CLIP	23824327
MIRT631581	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631580	hsa-miR-640	HITS-CLIP	23824327
MIRT631579	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT631592	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT631591	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631590	hsa-miR-764	HITS-CLIP	23824327
MIRT631589	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631588	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT631587	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT631586	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT631585	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631584	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT631583	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT631582	hsa-miR-4764-3p	HITS-CLIP	23824327
MIRT631581	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631580	hsa-miR-640	HITS-CLIP	23824327
MIRT631579	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT1073773	hsa-miR-1227	CLIP-seq
MIRT1073774	hsa-miR-1252	CLIP-seq
MIRT1073775	hsa-miR-1254	CLIP-seq
MIRT1073776	hsa-miR-1290	CLIP-seq
MIRT1073777	hsa-miR-1304	CLIP-seq
MIRT1073778	hsa-miR-130a	CLIP-seq
MIRT1073779	hsa-miR-130b	CLIP-seq
MIRT1073780	hsa-miR-139-3p	CLIP-seq
MIRT1073781	hsa-miR-218	CLIP-seq
MIRT1073782	hsa-miR-301a	CLIP-seq
MIRT1073783	hsa-miR-301b	CLIP-seq
MIRT1073784	hsa-miR-3116	CLIP-seq
MIRT1073785	hsa-miR-3126-5p	CLIP-seq
MIRT1073786	hsa-miR-3149	CLIP-seq
MIRT1073787	hsa-miR-3167	CLIP-seq
MIRT1073788	hsa-miR-3650	CLIP-seq
MIRT1073789	hsa-miR-3666	CLIP-seq
MIRT1073790	hsa-miR-3672	CLIP-seq
MIRT1073791	hsa-miR-4294	CLIP-seq
MIRT1073792	hsa-miR-4295	CLIP-seq
MIRT1073793	hsa-miR-4419a	CLIP-seq
MIRT1073794	hsa-miR-4423-5p	CLIP-seq
MIRT1073795	hsa-miR-4428	CLIP-seq
MIRT1073796	hsa-miR-4438	CLIP-seq
MIRT1073797	hsa-miR-4476	CLIP-seq
MIRT1073798	hsa-miR-4496	CLIP-seq
MIRT1073799	hsa-miR-4510	CLIP-seq
MIRT1073800	hsa-miR-4514	CLIP-seq
MIRT1073801	hsa-miR-4533	CLIP-seq
MIRT1073802	hsa-miR-454	CLIP-seq
MIRT1073803	hsa-miR-4671-3p	CLIP-seq
MIRT1073804	hsa-miR-4690-3p	CLIP-seq
MIRT1073805	hsa-miR-4692	CLIP-seq
MIRT1073806	hsa-miR-4715-3p	CLIP-seq
MIRT1073807	hsa-miR-5095	CLIP-seq
MIRT1073808	hsa-miR-518a-5p	CLIP-seq
MIRT1073809	hsa-miR-527	CLIP-seq
MIRT1073810	hsa-miR-636	CLIP-seq
MIRT1073811	hsa-miR-720	CLIP-seq
MIRT1073812	hsa-miR-876-5p	CLIP-seq
MIRT1073813	hsa-miR-940	CLIP-seq
MIRT1073814	hsa-miR-4733-5p	CLIP-seq
MIRT1073815	hsa-miR-4761-5p	CLIP-seq
MIRT2018210	hsa-miR-4279	CLIP-seq
MIRT2018211	hsa-miR-106a	CLIP-seq
MIRT2018212	hsa-miR-106b	CLIP-seq
MIRT2018213	hsa-miR-17	CLIP-seq
MIRT2018214	hsa-miR-20a	CLIP-seq
MIRT2018215	hsa-miR-20b	CLIP-seq
MIRT2018216	hsa-miR-302a	CLIP-seq
MIRT2018217	hsa-miR-302b	CLIP-seq
MIRT2018218	hsa-miR-302c	CLIP-seq
MIRT2018219	hsa-miR-302d	CLIP-seq
MIRT2018220	hsa-miR-302e	CLIP-seq
MIRT2018221	hsa-miR-372	CLIP-seq
MIRT2018222	hsa-miR-373	CLIP-seq
MIRT2018223	hsa-miR-512-3p	CLIP-seq
MIRT2018224	hsa-miR-519d	CLIP-seq
MIRT2018225	hsa-miR-520a-3p	CLIP-seq
MIRT2018226	hsa-miR-520b	CLIP-seq
MIRT2018227	hsa-miR-520c-3p	CLIP-seq
MIRT2018228	hsa-miR-520d-3p	CLIP-seq
MIRT2018229	hsa-miR-520e	CLIP-seq
MIRT2018230	hsa-miR-520g	CLIP-seq
MIRT2018231	hsa-miR-520h	CLIP-seq
MIRT2018232	hsa-miR-93	CLIP-seq
MIRT2250096	hsa-miR-1236	CLIP-seq
MIRT1073774	hsa-miR-1252	CLIP-seq
MIRT2250097	hsa-miR-1324	CLIP-seq
MIRT2250098	hsa-miR-1827	CLIP-seq
MIRT2250099	hsa-miR-1915	CLIP-seq
MIRT2250100	hsa-miR-24	CLIP-seq
MIRT2250101	hsa-miR-2467-3p	CLIP-seq
MIRT2250102	hsa-miR-3677-5p	CLIP-seq
MIRT2250103	hsa-miR-4284	CLIP-seq
MIRT1073797	hsa-miR-4476	CLIP-seq
MIRT1073798	hsa-miR-4496	CLIP-seq
MIRT1073801	hsa-miR-4533	CLIP-seq
MIRT2250104	hsa-miR-4726-3p	CLIP-seq
MIRT2250105	hsa-miR-4753-3p	CLIP-seq
MIRT2250106	hsa-miR-4772-3p	CLIP-seq
MIRT2250107	hsa-miR-759	CLIP-seq
MIRT1073778	hsa-miR-130a	CLIP-seq
MIRT1073779	hsa-miR-130b	CLIP-seq
MIRT1073782	hsa-miR-301a	CLIP-seq
MIRT1073783	hsa-miR-301b	CLIP-seq
MIRT1073789	hsa-miR-3666	CLIP-seq
MIRT1073792	hsa-miR-4295	CLIP-seq
MIRT1073802	hsa-miR-454	CLIP-seq
MIRT2389517	hsa-miR-652	CLIP-seq
MIRT2451998	hsa-miR-122	CLIP-seq
MIRT1073780	hsa-miR-139-3p	CLIP-seq
MIRT2451999	hsa-miR-3135b	CLIP-seq
MIRT2452000	hsa-miR-3652	CLIP-seq
MIRT2452001	hsa-miR-4276	CLIP-seq
MIRT1073791	hsa-miR-4294	CLIP-seq
MIRT1073794	hsa-miR-4423-5p	CLIP-seq
MIRT2452002	hsa-miR-4430	CLIP-seq
MIRT1073811	hsa-miR-720	CLIP-seq
MIRT2452001	hsa-miR-4276	CLIP-seq
MIRT2451998	hsa-miR-122	CLIP-seq
MIRT1073778	hsa-miR-130a	CLIP-seq
MIRT1073779	hsa-miR-130b	CLIP-seq
MIRT2250100	hsa-miR-24	CLIP-seq
MIRT1073782	hsa-miR-301a	CLIP-seq
MIRT1073783	hsa-miR-301b	CLIP-seq
MIRT2451999	hsa-miR-3135b	CLIP-seq
MIRT2452000	hsa-miR-3652	CLIP-seq
MIRT1073789	hsa-miR-3666	CLIP-seq
MIRT2250103	hsa-miR-4284	CLIP-seq
MIRT1073792	hsa-miR-4295	CLIP-seq
MIRT1073794	hsa-miR-4423-5p	CLIP-seq
MIRT2452002	hsa-miR-4430	CLIP-seq
MIRT1073802	hsa-miR-454	CLIP-seq
MIRT2250106	hsa-miR-4772-3p	CLIP-seq
MIRT2389517	hsa-miR-652	CLIP-seq
MIRT2451998	hsa-miR-122	CLIP-seq
MIRT1073778	hsa-miR-130a	CLIP-seq
MIRT1073779	hsa-miR-130b	CLIP-seq
MIRT2250100	hsa-miR-24	CLIP-seq
MIRT1073782	hsa-miR-301a	CLIP-seq
MIRT1073783	hsa-miR-301b	CLIP-seq
MIRT2451999	hsa-miR-3135b	CLIP-seq
MIRT2452000	hsa-miR-3652	CLIP-seq
MIRT1073789	hsa-miR-3666	CLIP-seq
MIRT2250103	hsa-miR-4284	CLIP-seq
MIRT1073792	hsa-miR-4295	CLIP-seq
MIRT1073794	hsa-miR-4423-5p	CLIP-seq
MIRT2452002	hsa-miR-4430	CLIP-seq
MIRT1073802	hsa-miR-454	CLIP-seq
MIRT2250106	hsa-miR-4772-3p	CLIP-seq
MIRT2389517	hsa-miR-652	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
RFX1	Unknown	21192791

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002291	Process	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IMP	2477710
GO:0005515	Function	Protein binding	IPI	11544294, 11812992, 12208882, 12526797, 15946252, 16595626, 18985028, 29100055
GO:0005886	Component	Plasma membrane	TAS
GO:0006909	Process	Phagocytosis	IEA
GO:0006954	Process	Inflammatory response	NAS	8103515
GO:0007155	Process	Cell adhesion	NAS	8103515
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP	2477710
GO:0007159	Process	Leukocyte cell-cell adhesion	IMP	2477710, 11812992
GO:0007160	Process	Cell-matrix adhesion	IMP	19029120
GO:0007165	Process	Signal transduction	NAS	8103515
GO:0007229	Process	Integrin-mediated signaling pathway	IEA
GO:0008305	Component	Integrin complex	NAS	8103515
GO:0009986	Component	Cell surface	HDA	23981064
GO:0009986	Component	Cell surface	IDA	19029120, 19234460
GO:0016020	Component	Membrane	HDA	19946888
GO:0016032	Process	Viral process	IEA
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0030369	Function	ICAM-3 receptor activity	IMP	19029120
GO:0034687	Component	Integrin alphaL-beta2 complex	IDA	19029120
GO:0035579	Component	Specific granule membrane	TAS
GO:0035683	Process	Memory T cell extravasation	IDA	11812992
GO:0043113	Process	Receptor clustering	IMP	19029120
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050776	Process	Regulation of immune response	TAS
GO:0050839	Function	Cell adhesion molecule binding	IMP	19029120
GO:0050839	Function	Cell adhesion molecule binding	IPI	1448173
GO:0050900	Process	Leukocyte migration	TAS
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0098609	Process	Cell-cell adhesion	ISS	12652296

Other IDs

• MIM: 153370
• HGNC: 6148
• e!Ensembl: ENSG00000005844

Protein

• UniProt ID: P20701
• Protein name: Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a)
• Protein function: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the i
• PDB: 1CQP, 1DGQ, 1LFA, 1MJN, 1MQ8, 1MQ9, 1MQA, 1RD4, 1T0P, 1XDD, 1XDG, 1XUO, 1ZON, 1ZOO, 1ZOP, 2ICA, 2K8O, 2M3E, 2O7N, 3BN3, 3BQM, 3BQN, 3E2M, 3EOA, 3EOB, 3F74, 3F78, 3HI6, 3M6F, 3TCX, 4IXD, 5E6R, 5E6S, 5E6U, 6BXB, 6BXF, 6BXJ, 6CKB, 7KC3, 7KC5, 7KC6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00092	VWA	156 → 326	von Willebrand factor type A domain	Domain
  PF01839	FG-GAP	521 → 554	FG-GAP repeat	Repeat
  PF08441	Integrin_alpha2	612 → 1002	Integrin alpha	Family
  PF00357	Integrin_alpha	1113 → 1127	Integrin alpha cytoplasmic region	Family

• Sequence:

  MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGA
  PGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCD
  QNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMK
  DVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYV
  ATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLH
  KFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSR
  GHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLL
  ASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLI
  GAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVA
  VGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVA
  VGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLI
  PQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQD
  LISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEAN
  LRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQ
  IPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTC
  NNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPS
  IHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFR
  CPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMK
  VDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDS
  EQLASGQEAGDPGCLKPLHEKDSESGGGKD

• Sequence length: 1170

Pathways

KEGG:

Rap1 signaling pathway
Cell adhesion molecules
Neutrophil extracellular trap formation
Natural killer cell mediated cytotoxicity
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Malaria
Staphylococcus aureus infection
Human T-cell leukemia virus 1 infection
Epstein-Barr virus infection
Rheumatoid arthritis
Viral myocarditis

Reactome:

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Neutrophil degranulation
RUNX3 Regulates Immune Response and Cell Migration

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Behcet syndrome	Behcet Syndrome	rs886040969, rs886039866, rs746055479, rs752615209, rs774164456, rs751454741	8712863
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	28067908
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26974007

Unknown
Disease name	Disease term	dbSNP ID	References
Ankylosing spondylitis	Ankylosing spondylitis		26974007
Cholangitis	Cholangitis, Sclerosing		26974007
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	26974007
Dental caries	Dental caries of smooth surface		24556642
Mental depression	clinical depression	rs587778876, rs587778877	20516718
Promyelocytic leukemia	Acute Promyelocytic Leukemia		16764927
Ulcerative colitis	Ulcerative Colitis		26974007