ITGAE (integrin subunit alpha E)

Gene

• Entrez ID: 3682
• Gene name: Integrin subunit alpha E
• Gene symbol: ITGAE
• Synonyms: CD103, HUMINAE
• Chromosome: 17
• Chromosome location: 17p13.2
• Summary: Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked h

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1073749	hsa-miR-129-5p	CLIP-seq
MIRT1073750	hsa-miR-1302	CLIP-seq
MIRT1073751	hsa-miR-1915	CLIP-seq
MIRT1073752	hsa-miR-193a-5p	CLIP-seq
MIRT1073753	hsa-miR-3122	CLIP-seq
MIRT1073754	hsa-miR-3691-3p	CLIP-seq
MIRT1073755	hsa-miR-3913-5p	CLIP-seq
MIRT1073756	hsa-miR-4298	CLIP-seq
MIRT1073757	hsa-miR-450b-5p	CLIP-seq
MIRT1073758	hsa-miR-4726-3p	CLIP-seq
MIRT1073759	hsa-miR-4731-5p	CLIP-seq
MIRT1073760	hsa-miR-507	CLIP-seq
MIRT1073761	hsa-miR-515-5p	CLIP-seq
MIRT1073762	hsa-miR-518a-5p	CLIP-seq
MIRT1073763	hsa-miR-527	CLIP-seq
MIRT1073764	hsa-miR-548ac	CLIP-seq
MIRT1073765	hsa-miR-548ae	CLIP-seq
MIRT1073766	hsa-miR-548aj	CLIP-seq
MIRT1073767	hsa-miR-548am	CLIP-seq
MIRT1073768	hsa-miR-548d-3p	CLIP-seq
MIRT1073769	hsa-miR-548x	CLIP-seq
MIRT1073770	hsa-miR-548z	CLIP-seq
MIRT1073771	hsa-miR-557	CLIP-seq
MIRT1073772	hsa-miR-584	CLIP-seq
MIRT1073749	hsa-miR-129-5p	CLIP-seq
MIRT1073757	hsa-miR-450b-5p	CLIP-seq
MIRT1073760	hsa-miR-507	CLIP-seq
MIRT1073771	hsa-miR-557	CLIP-seq
MIRT2553642	hsa-miR-1252	CLIP-seq
MIRT1073750	hsa-miR-1302	CLIP-seq
MIRT1073751	hsa-miR-1915	CLIP-seq
MIRT1073752	hsa-miR-193a-5p	CLIP-seq
MIRT2553643	hsa-miR-3064-5p	CLIP-seq
MIRT1073753	hsa-miR-3122	CLIP-seq
MIRT2553644	hsa-miR-3129-3p	CLIP-seq
MIRT2553645	hsa-miR-3140-5p	CLIP-seq
MIRT2553646	hsa-miR-3148	CLIP-seq
MIRT2553647	hsa-miR-3169	CLIP-seq
MIRT1073754	hsa-miR-3691-3p	CLIP-seq
MIRT1073755	hsa-miR-3913-5p	CLIP-seq
MIRT1073756	hsa-miR-4298	CLIP-seq
MIRT2553648	hsa-miR-4515	CLIP-seq
MIRT1073758	hsa-miR-4726-3p	CLIP-seq
MIRT1073759	hsa-miR-4731-5p	CLIP-seq
MIRT2553649	hsa-miR-4777-5p	CLIP-seq
MIRT2553650	hsa-miR-4793-5p	CLIP-seq
MIRT1073761	hsa-miR-515-5p	CLIP-seq
MIRT1073762	hsa-miR-518a-5p	CLIP-seq
MIRT1073763	hsa-miR-527	CLIP-seq
MIRT2553651	hsa-miR-548a-5p	CLIP-seq
MIRT2553652	hsa-miR-548ab	CLIP-seq
MIRT1073764	hsa-miR-548ac	CLIP-seq
MIRT1073765	hsa-miR-548ae	CLIP-seq
MIRT1073766	hsa-miR-548aj	CLIP-seq
MIRT2553653	hsa-miR-548ak	CLIP-seq
MIRT1073767	hsa-miR-548am	CLIP-seq
MIRT2553654	hsa-miR-548b-5p	CLIP-seq
MIRT2553655	hsa-miR-548c-5p	CLIP-seq
MIRT1073768	hsa-miR-548d-3p	CLIP-seq
MIRT2553656	hsa-miR-548d-5p	CLIP-seq
MIRT2553657	hsa-miR-548h	CLIP-seq
MIRT2553658	hsa-miR-548i	CLIP-seq
MIRT2553659	hsa-miR-548j	CLIP-seq
MIRT2553660	hsa-miR-548n	CLIP-seq
MIRT2553661	hsa-miR-548w	CLIP-seq
MIRT1073769	hsa-miR-548x	CLIP-seq
MIRT2553662	hsa-miR-548y	CLIP-seq
MIRT1073770	hsa-miR-548z	CLIP-seq
MIRT2553663	hsa-miR-559	CLIP-seq
MIRT1073772	hsa-miR-584	CLIP-seq
MIRT2553664	hsa-miR-892b	CLIP-seq
MIRT2553642	hsa-miR-1252	CLIP-seq
MIRT1073750	hsa-miR-1302	CLIP-seq
MIRT1073751	hsa-miR-1915	CLIP-seq
MIRT1073752	hsa-miR-193a-5p	CLIP-seq
MIRT2553643	hsa-miR-3064-5p	CLIP-seq
MIRT1073753	hsa-miR-3122	CLIP-seq
MIRT2553644	hsa-miR-3129-3p	CLIP-seq
MIRT2553645	hsa-miR-3140-5p	CLIP-seq
MIRT2553646	hsa-miR-3148	CLIP-seq
MIRT2553647	hsa-miR-3169	CLIP-seq
MIRT1073754	hsa-miR-3691-3p	CLIP-seq
MIRT1073755	hsa-miR-3913-5p	CLIP-seq
MIRT1073756	hsa-miR-4298	CLIP-seq
MIRT2553648	hsa-miR-4515	CLIP-seq
MIRT1073758	hsa-miR-4726-3p	CLIP-seq
MIRT1073759	hsa-miR-4731-5p	CLIP-seq
MIRT2553649	hsa-miR-4777-5p	CLIP-seq
MIRT2553650	hsa-miR-4793-5p	CLIP-seq
MIRT1073761	hsa-miR-515-5p	CLIP-seq
MIRT1073762	hsa-miR-518a-5p	CLIP-seq
MIRT1073763	hsa-miR-527	CLIP-seq
MIRT2553651	hsa-miR-548a-5p	CLIP-seq
MIRT2553652	hsa-miR-548ab	CLIP-seq
MIRT1073764	hsa-miR-548ac	CLIP-seq
MIRT1073765	hsa-miR-548ae	CLIP-seq
MIRT1073766	hsa-miR-548aj	CLIP-seq
MIRT2553653	hsa-miR-548ak	CLIP-seq
MIRT1073767	hsa-miR-548am	CLIP-seq
MIRT2553654	hsa-miR-548b-5p	CLIP-seq
MIRT2553655	hsa-miR-548c-5p	CLIP-seq
MIRT1073768	hsa-miR-548d-3p	CLIP-seq
MIRT2553656	hsa-miR-548d-5p	CLIP-seq
MIRT2553657	hsa-miR-548h	CLIP-seq
MIRT2553658	hsa-miR-548i	CLIP-seq
MIRT2553659	hsa-miR-548j	CLIP-seq
MIRT2553660	hsa-miR-548n	CLIP-seq
MIRT2553661	hsa-miR-548w	CLIP-seq
MIRT1073769	hsa-miR-548x	CLIP-seq
MIRT2553662	hsa-miR-548y	CLIP-seq
MIRT1073770	hsa-miR-548z	CLIP-seq
MIRT2553663	hsa-miR-559	CLIP-seq
MIRT1073772	hsa-miR-584	CLIP-seq
MIRT2553664	hsa-miR-892b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007229	Process	Integrin-mediated signaling pathway	IEA
GO:0008305	Component	Integrin complex	IEA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 604682
• HGNC: 6147
• e!Ensembl: ENSG00000083457

Protein

• UniProt ID: P38570
• Protein name: Integrin alpha-E (HML-1 antigen) (Integrin alpha-IEL) (Mucosal lymphocyte 1 antigen) (CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]
• Protein function: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.
• PDB: 8ZJF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00092	VWA	202 → 381	von Willebrand factor type A domain	Domain
  PF01839	FG-GAP	514 → 551	FG-GAP repeat	Repeat
  PF01839	FG-GAP	577 → 618	FG-GAP repeat	Repeat
  PF08441	Integrin_alpha2	676 → 965	Integrin alpha	Family
  PF00357	Integrin_alpha	1148 → 1162	Integrin alpha cytoplasmic region	Family

• Sequence:

  MWLFHTLLCIASLALLAAFNVDVARPWLTPKGGAPFVLSSLLHQDPSTNQTWLLVTSPRT
  KRTPGPLHRCSLVQDEILCHPVEHVPIPKGRHRGVTVVRSHHGVLICIQVLVRRPHSLSS
  ELTGTCSLLGPDLRPQAQANFFDLENLLDPDARVDTGDCYSNKEGGGEDDVNTARQRRAL
  EKEEEEDKEEEEDEEEEEAGTEIAIILDGSGSIDPPDFQRAKDFISNMMRNFYEKCFECN
  FALVQYGGVIQTEFDLRDSQDVMASLARVQNITQVGSVTKTASAMQHVLDSIFTSSHGSR
  RKASKVMVVLTDGGIFEDPLNLTTVINSPKMQGVERFAIGVGEEFKSARTARELNLIASD
  PDETHAFKVTNYMALDGLLSKLRYNIISMEGTVGDALHYQLAQIGFSAQILDERQVLLGA
  VGAFDWSGGALLYDTRSRRGRFLNQTAAAAADAEAAQYSYLGYAVAVLHKTCSLSYIAGA
  PRYKHHGAVFELQKEGREASFLPVLEGEQMGSYFGSELCPVDIDMDGSTDFLLVAAPFYH
  VHGEEGRVYVYRLSEQDGSFSLARILSGHPGFTNARFGFAMAAMGDLSQDKLTDVAIGAP
  LEGFGADDGASFGSVYIYNGHWDGLSASPSQRIRASTVAPGLQYFGMSMAGGFDISGDGL
  ADITVGTLGQAVVFRSRPVVRLKVSMAFTPSALPIGFNGVVNVRLCFEISSVTTASESGL
  REALLNFTLDVDVGKQRRRLQCSDVRSCLGCLREWSSGSQLCEDLLLMPTEGELCEEDCF
  SNASVKVSYQLQTPEGQTDHPQPILDRYTEPFAIFQLPYEKACKNKLFCVAELQLATTVS
  QQELVVGLTKELTLNINLTNSGEDSYMTSMALNYPRNLQLKRMQKPPSPNIQCDDPQPVA
  SVLIMNCRIGHPVLKRSSAHVSVVWQLEENAFPNRTADITVTVTNSNERRSLANETHTLQ
  FRHGFVAVLSKPSIMYVNTGQGLSHHKEFLFHVHGENLFGAEYQLQICVPTKLRGLQVVA
  VKKLTRTQASTVCTWSQERACAYSSVQHVEEWHSVSCVIASDKENVTVAAEISWDHSEEL
  LKDVTELQILGEISFNKSLYEGLNAENHRTKITVVFLKDEKYHSLPIIIKGSVGGLLVLI
  VILVILFKCGFFKRKYQQLNLESIRKAQLKSENLLEEEN

• Sequence length: 1179

Pathways

KEGG:

Regulation of actin cytoskeleton

Reactome:

Integrin cell surface interactions

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Attention deficit hyperactivity disorder	Attention deficit hyperactivity disorder	rs120074176, rs786205019	18839057