ITGA9 (integrin subunit alpha 9)

Gene

• Entrez ID: 3680
• Gene name: Integrin subunit alpha 9
• Gene symbol: ITGA9
• Synonyms: ALPHA-RLC, ITGA4L, RLC
• Chromosome: 3
• Chromosome location: 3p22.2
• Summary: This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain,

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005895	hsa-miR-194-5p	Luciferase reporter assay, qRT-PCR, Western blot	20979124
MIRT041874	hsa-miR-484	CLASH	23622248
MIRT053450	hsa-miR-452-5p	Microarray	23807165
MIRT573157	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT573156	hsa-miR-4639-3p	PAR-CLIP	20371350
MIRT573155	hsa-miR-759	PAR-CLIP	20371350
MIRT573154	hsa-miR-519d-5p	PAR-CLIP	20371350
MIRT573153	hsa-miR-5695	PAR-CLIP	20371350
MIRT573152	hsa-miR-302b-5p	PAR-CLIP	20371350
MIRT573151	hsa-miR-302d-5p	PAR-CLIP	20371350
MIRT573150	hsa-miR-6794-3p	PAR-CLIP	20371350
MIRT573149	hsa-miR-452-3p	PAR-CLIP	20371350
MIRT573148	hsa-miR-515-5p	PAR-CLIP	20371350
MIRT573147	hsa-miR-519e-5p	PAR-CLIP	20371350
MIRT736034	hsa-miR-148a-3p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), qRT-PCR	31489579
MIRT573157	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT573156	hsa-miR-4639-3p	PAR-CLIP	20371350
MIRT573155	hsa-miR-759	PAR-CLIP	20371350
MIRT573154	hsa-miR-519d-5p	PAR-CLIP	20371350
MIRT573153	hsa-miR-5695	PAR-CLIP	20371350
MIRT573152	hsa-miR-302b-5p	PAR-CLIP	20371350
MIRT573151	hsa-miR-302d-5p	PAR-CLIP	20371350
MIRT573150	hsa-miR-6794-3p	PAR-CLIP	20371350
MIRT573149	hsa-miR-452-3p	PAR-CLIP	20371350
MIRT573148	hsa-miR-515-5p	PAR-CLIP	20371350
MIRT573147	hsa-miR-519e-5p	PAR-CLIP	20371350
MIRT1073725	hsa-miR-1202	CLIP-seq
MIRT1073726	hsa-miR-134	CLIP-seq
MIRT1073727	hsa-miR-194	CLIP-seq
MIRT1073728	hsa-miR-3118	CLIP-seq
MIRT1073729	hsa-miR-3163	CLIP-seq
MIRT1073730	hsa-miR-3164	CLIP-seq
MIRT1073731	hsa-miR-3165	CLIP-seq
MIRT1073732	hsa-miR-3194-5p	CLIP-seq
MIRT1073733	hsa-miR-331-5p	CLIP-seq
MIRT1073734	hsa-miR-340	CLIP-seq
MIRT1073735	hsa-miR-3607-5p	CLIP-seq
MIRT1073736	hsa-miR-369-5p	CLIP-seq
MIRT1073737	hsa-miR-3972	CLIP-seq
MIRT1073738	hsa-miR-4320	CLIP-seq
MIRT1073739	hsa-miR-4456	CLIP-seq
MIRT1073740	hsa-miR-4501	CLIP-seq
MIRT1073741	hsa-miR-548c-3p	CLIP-seq
MIRT1073742	hsa-miR-767-5p	CLIP-seq
MIRT2018206	hsa-miR-346	CLIP-seq
MIRT2018207	hsa-miR-4288	CLIP-seq
MIRT2018208	hsa-miR-632	CLIP-seq
MIRT2018209	hsa-miR-654-3p	CLIP-seq
MIRT2250087	hsa-miR-132	CLIP-seq
MIRT1073727	hsa-miR-194	CLIP-seq
MIRT2250088	hsa-miR-212	CLIP-seq
MIRT1073733	hsa-miR-331-5p	CLIP-seq
MIRT2250089	hsa-miR-4328	CLIP-seq
MIRT2250090	hsa-miR-4446-5p	CLIP-seq
MIRT2437973	hsa-miR-4659a-3p	CLIP-seq
MIRT2437974	hsa-miR-4659b-3p	CLIP-seq
MIRT2437975	hsa-miR-4666-5p	CLIP-seq
MIRT2437976	hsa-miR-664	CLIP-seq
MIRT1073726	hsa-miR-134	CLIP-seq
MIRT1073728	hsa-miR-3118	CLIP-seq
MIRT1073730	hsa-miR-3164	CLIP-seq
MIRT1073735	hsa-miR-3607-5p	CLIP-seq
MIRT2451994	hsa-miR-3650	CLIP-seq
MIRT2451995	hsa-miR-3688-5p	CLIP-seq
MIRT1073740	hsa-miR-4501	CLIP-seq
MIRT2451996	hsa-miR-4772-5p	CLIP-seq
MIRT2451997	hsa-miR-644	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MEIS1	Unknown	23139255
TBX5	Unknown	23139255

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005518	Function	Collagen binding	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	IGI	21060781
GO:0007229	Process	Integrin-mediated signaling pathway	IEA
GO:0008305	Component	Integrin complex	TAS	8245132
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0034679	Component	Integrin alpha9-beta1 complex	IEA
GO:0042060	Process	Wound healing	IEA
GO:0043236	Function	Laminin binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 603963
• HGNC: 6145
• e!Ensembl: ENSG00000144668

Protein

• UniProt ID: Q13797
• Protein name: Integrin alpha-9 (Integrin alpha-RLC)
• Protein function: Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similar
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01839	FG-GAP	304 → 340	FG-GAP repeat	Repeat
  PF01839	FG-GAP	364 → 399	FG-GAP repeat	Repeat
  PF08441	Integrin_alpha2	459 → 909	Integrin alpha	Family

• Sequence:

  MGGPAAPRGAGRLRALLLALVVAGIPAGAYNLDPQRPVHFQGPADSFFGYAVLEHFHDNT
  RWVLVGAPKADSKYSPSVKSPGAVFKCRVHTNPDRRCTELDMARGKNRGTSCGKTCREDR
  DDEWMGVSLARQPKADGRVLACAHRWKNIYYEADHILPHGFCYIIPSNLQAKGRTLIPCY
  EEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWAGTIKVLNLTDNTYLKLNDEVIM
  NRRYTYLGYAVTAGHFSHPSTIDVVGGAPQDKGIGKVYIFRADRRSGTLIKIFQASGKKM
  GSYFGSSLCAVDLNGDGLSDLLVGAPMFSEIRDEGQVTVYINRGNGALEEQLALTGDGAY
  NAHFGESIASLDDLDNDGFPDVAIGAPKEDDFAGAVYIYHGDAGGIVPQYSMKLSGQKIN
  PVLRMFGQSISGGIDMDGNGYPDVTVGAFMSDSVVLLRARPVITVDVSIFLPGSINITAP
  QCHDGQQPVNCLNVTTCFSFHGKHVPGEIGLNYVLMADVAKKEKGQMPRVYFVLLGETMG
  QVTEKLQLTYMEETCRHYVAHVKRRVQDVISPIVFEAAYSLSEHVTGEEERELPPLTPVL
  RWKKGQKIAQKNQTVFERNCRSEDCAADLQLQGKLLLSSMDEKTLYLALGAVKNISLNIS
  ISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYE
  FSVIFDTSHLSGEEEVLSFIVTAQSGNTERSESLHDNTLVLMVPLMHEVDTSITGIMSPT
  SFVYGESVDAANFIQLDDLECHFQPINITLQVYNTGPSTLPGSSVSISFPNRLSSGGAEM
  FHVQEMVVGQEKGNCSFQKNPTPCIIPQEQENIFHTIFAFFTKSGRKVLDCEKPGISCLT
  AHCNFSALAKEESRTIDIYMLLNTEILKKDSSSVIQFMSRAKVKVDPALRVVEIAHGNPE
  EVTVVFEALHNLEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKN
  RKENEDSWDWVQKNQ

• Sequence length: 1035

Pathways

KEGG:

PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules
Regulation of actin cytoskeleton
Cytoskeleton in muscle cells
Human papillomavirus infection
Hypertrophic cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy
Dilated cardiomyopathy

Reactome:

Integrin cell surface interactions
ECM proteoglycans
Signal transduction by L1

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Amyotrophic lateral sclerosis	AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder), AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE	rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733, rs80356731, rs80356726, rs267606928, rs267606929, rs1885090126, rs121434591, rs121912431, rs121912432, rs121912433, rs121912434, rs121912435, rs121912440, rs121912436, rs121912437, rs121912438, rs121912439, rs74315452, rs121912442, rs121912443, rs121912444, rs121912446, rs121912447, rs1197141604, rs121912448, rs121912449, rs121912450, rs121912451, rs121912452, rs121912453, rs121912454, rs369600566, rs121912455, rs121912456, rs121912457, rs121912458, rs1555836889, rs121909667, rs121909668, rs121909669, rs121909671, rs121909535, rs121909537, rs121909538, rs121909539, rs121909540, rs121909542, rs121909544, rs80356734, rs367543041, rs80356740, rs80356719, rs80356721, rs80356723, rs80356725, rs387906627, rs387906628, rs387906709, rs387906710, rs387906711, rs387906829, rs387907264, rs387907265, rs387907266, rs312262739, rs312262709, rs312262749, rs200793464, rs147713329, rs312262788, rs397514262, rs63751180, rs587777132, rs730880025, rs730880026, rs730880027, rs368743618, rs730880029, rs730882255, rs730882256, rs786205611, rs121912441, rs199947197, rs780136067, rs772731615, rs879253926, rs879254294, rs764717219, rs886041390, rs750159428, rs753207473, rs267607087, rs767350733, rs778305085, rs1554707680, rs1554707622, rs1393363759, rs750959420, rs1555509569, rs1554716504, rs11556620, rs1247392012, rs142083484, rs140385286, rs749428135, rs371575563, rs1402429085, rs1218712729, rs1555179091, rs1555179087, rs746971952, rs1555836950, rs368276916, rs140376902, rs747220413, rs76731700, rs770684782, rs1200906022, rs1804449, rs1482760341, rs769898852, rs140599944, rs757972700, rs1555451521, rs1592362719, rs1555836803, rs763455928, rs1378590183, rs1583695322, rs1362178149, rs1197928094, rs368751524, rs1555509609, rs1574787779, rs1601157750, rs1301635320, rs1341055534, rs1402092579, rs1568809172, rs1555836170, rs1315541036, rs1339283341, rs1643659556, rs1644506661, rs1435710212, rs1553122918, rs1689580631, rs374047961, rs775935265, rs2076486420, rs1820836522, rs757260058, rs1844420892, rs1833371664, rs1833438306, rs1833451208, rs2083790483, rs1303294230, rs1226110412, rs2053207945, rs2053208751, rs2053501632, rs2053539304, rs1567479067, rs544088874, rs1228194239, rs1568807400, rs1169198442, rs2049594204, rs2049594311, rs1568810641, rs1568811372, rs2049618449, rs1476760624, rs2079347087	24529757
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Lateral sclerosis	AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic	rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048	24529757
Nasopharyngeal carcinoma	Nasopharyngeal carcinoma	rs200046052	20512145, 19478819

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		23280964
Major affective disorder	MAJOR AFFECTIVE DISORDER 2	rs1601436804	23280964
Nasopharyngeal neoplasms	Nasopharyngeal Neoplasms		19478819