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ITGA5 (integrin subunit alpha 5)

Gene

3678

Integrin subunit alpha 5

ITGA5

CD49e, FNRA, VLA-5, VLA5A

12q13.13

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is

Show/Hide all(280)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003031	hsa-miR-92a-3p	Luciferase reporter assay, Western blot, Microarray	19460962
MIRT004976	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	19524507
MIRT004976	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	19524507
MIRT007314	hsa-miR-148b-3p	Western blot	23238785
MIRT007314	hsa-miR-148b-3p	Western blot	23238785
MIRT007314	hsa-miR-148b-3p	Western blot	23238785
MIRT027753	hsa-miR-98-5p	Microarray	19088304
MIRT047079	hsa-miR-183-5p	CLASH	23622248
MIRT042174	hsa-miR-484	CLASH	23622248
MIRT036327	hsa-miR-1229-3p	CLASH	23622248
MIRT053040	hsa-miR-152-3p	Luciferase reporter assay, qRT-PCR, Western blot	23238588
MIRT053480	hsa-miR-148a-3p	Luciferase reporter assay, Microarray, qRT-PCR	21703006
MIRT054779	hsa-miR-205-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24434435
MIRT007314	hsa-miR-148b-3p	Luciferase reporter assay	23233531
MIRT007314	hsa-miR-148b-3p	Luciferase reporter assay	23233531
MIRT007314	hsa-miR-148b-3p	Luciferase reporter assay	23233531
MIRT702642	hsa-miR-1295b-5p	HITS-CLIP	23313552
MIRT702641	hsa-miR-1912	HITS-CLIP	23313552
MIRT702640	hsa-miR-3130-5p	HITS-CLIP	23313552
MIRT702639	hsa-miR-4482-5p	HITS-CLIP	23313552
MIRT702638	hsa-miR-3065-3p	HITS-CLIP	23313552
MIRT702637	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT702636	hsa-miR-6887-3p	HITS-CLIP	23313552
MIRT702635	hsa-miR-4667-3p	HITS-CLIP	23313552
MIRT702634	hsa-miR-5585-5p	HITS-CLIP	23313552
MIRT702633	hsa-miR-6846-3p	HITS-CLIP	23313552
MIRT702632	hsa-miR-222-5p	HITS-CLIP	23313552
MIRT702631	hsa-miR-30a-3p	HITS-CLIP	23313552
MIRT702630	hsa-miR-30d-3p	HITS-CLIP	23313552
MIRT702629	hsa-miR-30e-3p	HITS-CLIP	23313552
MIRT731168	hsa-miR-26a-5p	Western blot, Luciferase reporter assay	25537511
MIRT731168	hsa-miR-26a-5p	Western blot, Luciferase reporter assay	25537511
MIRT004976	hsa-miR-31-5p	Luciferase reporter assay	27050274
MIRT004976	hsa-miR-31-5p	Luciferase reporter assay	27050274
MIRT731715	hsa-miR-17-3p	Luciferase reporter assay, qRT-PCR, Western blot	27499367
MIRT731715	hsa-miR-17-3p	Luciferase reporter assay, qRT-PCR, Western blot	27499367
MIRT731715	hsa-miR-17-3p	Luciferase reporter assay, qRT-PCR, Western blot	27499367
MIRT731715	hsa-miR-17-3p	Luciferase reporter assay, qRT-PCR, Western blot	27499367
MIRT004976	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	26729197
MIRT004976	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	26729197
MIRT004976	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	26729197
MIRT004976	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	26729197
MIRT004976	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	26729197
MIRT004976	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	26729197
MIRT733156	hsa-miR-210-3p	qRT-PCR	34135940
MIRT733158	hsa-miR-216a-5p	qRT-PCR	34101338
MIRT733163	hsa-miR-3677-3p	qRT-PCR	34101338
MIRT003031	hsa-miR-92a-3p	qRT-PCR, Western blotting	33742265
MIRT735591	hsa-miR-760	Western blotting, Immunohistochemistry (IHC), qRT-PCR	32089706
MIRT702642	hsa-miR-1295b-5p	HITS-CLIP	23313552
MIRT702641	hsa-miR-1912	HITS-CLIP	23313552
MIRT702640	hsa-miR-3130-5p	HITS-CLIP	23313552
MIRT702639	hsa-miR-4482-5p	HITS-CLIP	23313552
MIRT702638	hsa-miR-3065-3p	HITS-CLIP	23313552
MIRT702637	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT702636	hsa-miR-6887-3p	HITS-CLIP	23313552
MIRT702635	hsa-miR-4667-3p	HITS-CLIP	23313552
MIRT702634	hsa-miR-5585-5p	HITS-CLIP	23313552
MIRT702633	hsa-miR-6846-3p	HITS-CLIP	23313552
MIRT702632	hsa-miR-222-5p	HITS-CLIP	23313552
MIRT702631	hsa-miR-30a-3p	HITS-CLIP	23313552
MIRT702630	hsa-miR-30d-3p	HITS-CLIP	23313552
MIRT702629	hsa-miR-30e-3p	HITS-CLIP	23313552
MIRT054779	hsa-miR-205-5p	Microarray, qRT-PCR	35816043
MIRT1073592	hsa-miR-103a	CLIP-seq
MIRT1073593	hsa-miR-107	CLIP-seq
MIRT1073594	hsa-miR-1207-3p	CLIP-seq
MIRT1073595	hsa-miR-1207-5p	CLIP-seq
MIRT1073596	hsa-miR-1231	CLIP-seq
MIRT1073597	hsa-miR-1267	CLIP-seq
MIRT1073598	hsa-miR-128	CLIP-seq
MIRT1073599	hsa-miR-1301	CLIP-seq
MIRT1073600	hsa-miR-1343	CLIP-seq
MIRT1073601	hsa-miR-148a	CLIP-seq
MIRT1073602	hsa-miR-148b	CLIP-seq
MIRT1073603	hsa-miR-152	CLIP-seq
MIRT1073604	hsa-miR-199a-3p	CLIP-seq
MIRT1073605	hsa-miR-199b-3p	CLIP-seq
MIRT1073606	hsa-miR-205	CLIP-seq
MIRT1073607	hsa-miR-2681	CLIP-seq
MIRT1073608	hsa-miR-27a	CLIP-seq
MIRT1073609	hsa-miR-27b	CLIP-seq
MIRT1073610	hsa-miR-3127-3p	CLIP-seq
MIRT1073611	hsa-miR-3127-5p	CLIP-seq
MIRT1073612	hsa-miR-3129-5p	CLIP-seq
MIRT1073613	hsa-miR-3153	CLIP-seq
MIRT1073614	hsa-miR-3176	CLIP-seq
MIRT1073615	hsa-miR-3180-5p	CLIP-seq
MIRT1073616	hsa-miR-3184	CLIP-seq
MIRT1073617	hsa-miR-3665	CLIP-seq
MIRT1073618	hsa-miR-3922-3p	CLIP-seq
MIRT1073619	hsa-miR-3929	CLIP-seq
MIRT1073620	hsa-miR-3944-5p	CLIP-seq
MIRT1073621	hsa-miR-423-5p	CLIP-seq
MIRT1073622	hsa-miR-4419b	CLIP-seq
MIRT1073623	hsa-miR-4423-5p	CLIP-seq
MIRT1073624	hsa-miR-4435	CLIP-seq
MIRT1073625	hsa-miR-4447	CLIP-seq
MIRT1073626	hsa-miR-4472	CLIP-seq
MIRT1073627	hsa-miR-4478	CLIP-seq
MIRT1073628	hsa-miR-4487	CLIP-seq
MIRT1073629	hsa-miR-4514	CLIP-seq
MIRT1073630	hsa-miR-4520a-3p	CLIP-seq
MIRT1073631	hsa-miR-4633-3p	CLIP-seq
MIRT1073632	hsa-miR-4638-3p	CLIP-seq
MIRT1073633	hsa-miR-4646-5p	CLIP-seq
MIRT1073634	hsa-miR-4659a-5p	CLIP-seq
MIRT1073635	hsa-miR-4659b-5p	CLIP-seq
MIRT1073636	hsa-miR-4660	CLIP-seq
MIRT1073637	hsa-miR-4668-5p	CLIP-seq
MIRT1073638	hsa-miR-4688	CLIP-seq
MIRT1073639	hsa-miR-4692	CLIP-seq
MIRT1073640	hsa-miR-4711-5p	CLIP-seq
MIRT1073641	hsa-miR-4736	CLIP-seq
MIRT1073642	hsa-miR-4755-3p	CLIP-seq
MIRT1073643	hsa-miR-4763-3p	CLIP-seq
MIRT1073644	hsa-miR-4776-3p	CLIP-seq
MIRT1073645	hsa-miR-486-3p	CLIP-seq
MIRT1073646	hsa-miR-5047	CLIP-seq
MIRT1073647	hsa-miR-513a-5p	CLIP-seq
MIRT1073648	hsa-miR-520a-5p	CLIP-seq
MIRT1073649	hsa-miR-525-5p	CLIP-seq
MIRT1073650	hsa-miR-544	CLIP-seq
MIRT1073651	hsa-miR-657	CLIP-seq
MIRT1073652	hsa-miR-936	CLIP-seq
MIRT1073601	hsa-miR-148a	CLIP-seq
MIRT1073602	hsa-miR-148b	CLIP-seq
MIRT1073603	hsa-miR-152	CLIP-seq
MIRT1073617	hsa-miR-3665	CLIP-seq
MIRT1073628	hsa-miR-4487	CLIP-seq
MIRT1073630	hsa-miR-4520a-3p	CLIP-seq
MIRT1073631	hsa-miR-4633-3p	CLIP-seq
MIRT1073632	hsa-miR-4638-3p	CLIP-seq
MIRT1556581	hsa-miR-654-3p	CLIP-seq
MIRT1073651	hsa-miR-657	CLIP-seq
MIRT1073594	hsa-miR-1207-3p	CLIP-seq
MIRT1073595	hsa-miR-1207-5p	CLIP-seq
MIRT2018188	hsa-miR-1285	CLIP-seq
MIRT2018189	hsa-miR-1291	CLIP-seq
MIRT1073599	hsa-miR-1301	CLIP-seq
MIRT2018190	hsa-miR-28-5p	CLIP-seq
MIRT1073610	hsa-miR-3127-3p	CLIP-seq
MIRT1073611	hsa-miR-3127-5p	CLIP-seq
MIRT2018191	hsa-miR-3139	CLIP-seq
MIRT2018192	hsa-miR-3187-5p	CLIP-seq
MIRT736869	hsa-miR-326	CLIP-seq
MIRT2018193	hsa-miR-378g	CLIP-seq
MIRT2018194	hsa-miR-3920	CLIP-seq
MIRT2018195	hsa-miR-4486	CLIP-seq
MIRT1073628	hsa-miR-4487	CLIP-seq
MIRT1073629	hsa-miR-4514	CLIP-seq
MIRT1073631	hsa-miR-4633-3p	CLIP-seq
MIRT1073636	hsa-miR-4660	CLIP-seq
MIRT1073639	hsa-miR-4692	CLIP-seq
MIRT1073641	hsa-miR-4736	CLIP-seq
MIRT2018196	hsa-miR-4762-3p	CLIP-seq
MIRT1073643	hsa-miR-4763-3p	CLIP-seq
MIRT1073646	hsa-miR-5047	CLIP-seq
MIRT2018197	hsa-miR-612	CLIP-seq
MIRT2018198	hsa-miR-708	CLIP-seq
MIRT2018189	hsa-miR-1291	CLIP-seq
MIRT1073600	hsa-miR-1343	CLIP-seq
MIRT1073610	hsa-miR-3127-3p	CLIP-seq
MIRT1073611	hsa-miR-3127-5p	CLIP-seq
MIRT1073600	hsa-miR-1343	CLIP-seq
MIRT1073628	hsa-miR-4487	CLIP-seq
MIRT1073631	hsa-miR-4633-3p	CLIP-seq
MIRT2389487	hsa-miR-4761-5p	CLIP-seq
MIRT1073604	hsa-miR-199a-3p	CLIP-seq
MIRT1073605	hsa-miR-199b-3p	CLIP-seq
MIRT2018190	hsa-miR-28-5p	CLIP-seq
MIRT1073612	hsa-miR-3129-5p	CLIP-seq
MIRT2018191	hsa-miR-3139	CLIP-seq
MIRT2430133	hsa-miR-4287	CLIP-seq
MIRT2430134	hsa-miR-4292	CLIP-seq
MIRT2430135	hsa-miR-4308	CLIP-seq
MIRT2430136	hsa-miR-4469	CLIP-seq
MIRT2430137	hsa-miR-4482	CLIP-seq
MIRT2430138	hsa-miR-4685-3p	CLIP-seq
MIRT2430139	hsa-miR-4713-5p	CLIP-seq
MIRT2018198	hsa-miR-708	CLIP-seq
MIRT1073652	hsa-miR-936	CLIP-seq
MIRT1073598	hsa-miR-128	CLIP-seq
MIRT2018188	hsa-miR-1285	CLIP-seq
MIRT2018189	hsa-miR-1291	CLIP-seq
MIRT2437926	hsa-miR-1297	CLIP-seq
MIRT2437927	hsa-miR-1321	CLIP-seq
MIRT1073600	hsa-miR-1343	CLIP-seq
MIRT1073601	hsa-miR-148a	CLIP-seq
MIRT1073602	hsa-miR-148b	CLIP-seq
MIRT2437928	hsa-miR-149	CLIP-seq
MIRT1073603	hsa-miR-152	CLIP-seq
MIRT2437929	hsa-miR-1587	CLIP-seq
MIRT1073604	hsa-miR-199a-3p	CLIP-seq
MIRT1073605	hsa-miR-199b-3p	CLIP-seq
MIRT1073606	hsa-miR-205	CLIP-seq
MIRT2437930	hsa-miR-2110	CLIP-seq
MIRT2437931	hsa-miR-2355-5p	CLIP-seq
MIRT2437932	hsa-miR-26a	CLIP-seq
MIRT2437933	hsa-miR-26b	CLIP-seq
MIRT1073608	hsa-miR-27a	CLIP-seq
MIRT1073609	hsa-miR-27b	CLIP-seq
MIRT2018190	hsa-miR-28-5p	CLIP-seq
MIRT2437934	hsa-miR-2861	CLIP-seq
MIRT1073612	hsa-miR-3129-5p	CLIP-seq
MIRT2018191	hsa-miR-3139	CLIP-seq
MIRT2437935	hsa-miR-3150a-3p	CLIP-seq
MIRT2437936	hsa-miR-3175	CLIP-seq
MIRT1073614	hsa-miR-3176	CLIP-seq
MIRT2018192	hsa-miR-3187-5p	CLIP-seq
MIRT2437937	hsa-miR-3199	CLIP-seq
MIRT736869	hsa-miR-326	CLIP-seq
MIRT2437938	hsa-miR-328	CLIP-seq
MIRT2437939	hsa-miR-331-3p	CLIP-seq
MIRT2018193	hsa-miR-378g	CLIP-seq
MIRT1073618	hsa-miR-3922-3p	CLIP-seq
MIRT1073619	hsa-miR-3929	CLIP-seq
MIRT2437940	hsa-miR-4267	CLIP-seq
MIRT2437941	hsa-miR-4268	CLIP-seq
MIRT2437942	hsa-miR-4270	CLIP-seq
MIRT2437943	hsa-miR-4271	CLIP-seq
MIRT2430133	hsa-miR-4287	CLIP-seq
MIRT2430134	hsa-miR-4292	CLIP-seq
MIRT2437944	hsa-miR-4294	CLIP-seq
MIRT2430135	hsa-miR-4308	CLIP-seq
MIRT1073622	hsa-miR-4419b	CLIP-seq
MIRT2437945	hsa-miR-4441	CLIP-seq
MIRT1073625	hsa-miR-4447	CLIP-seq
MIRT2437946	hsa-miR-4465	CLIP-seq
MIRT2430136	hsa-miR-4469	CLIP-seq
MIRT1073626	hsa-miR-4472	CLIP-seq
MIRT1073627	hsa-miR-4478	CLIP-seq
MIRT2430137	hsa-miR-4482	CLIP-seq
MIRT2018195	hsa-miR-4486	CLIP-seq
MIRT2437947	hsa-miR-4492	CLIP-seq
MIRT2437948	hsa-miR-4498	CLIP-seq
MIRT2437949	hsa-miR-4505	CLIP-seq
MIRT2437950	hsa-miR-4512	CLIP-seq
MIRT2437951	hsa-miR-4515	CLIP-seq
MIRT2437952	hsa-miR-4652-5p	CLIP-seq
MIRT2437953	hsa-miR-4656	CLIP-seq
MIRT2437954	hsa-miR-4667-5p	CLIP-seq
MIRT2437955	hsa-miR-4675	CLIP-seq
MIRT2430138	hsa-miR-4685-3p	CLIP-seq
MIRT2437956	hsa-miR-4700-5p	CLIP-seq
MIRT2437957	hsa-miR-4711-3p	CLIP-seq
MIRT2437958	hsa-miR-4713-3p	CLIP-seq
MIRT2430139	hsa-miR-4713-5p	CLIP-seq
MIRT2437959	hsa-miR-4723-5p	CLIP-seq
MIRT2437960	hsa-miR-4725-3p	CLIP-seq
MIRT2437961	hsa-miR-4728-5p	CLIP-seq
MIRT2437962	hsa-miR-4731-5p	CLIP-seq
MIRT2437963	hsa-miR-4739	CLIP-seq
MIRT2437964	hsa-miR-4741	CLIP-seq
MIRT2437965	hsa-miR-4756-5p	CLIP-seq
MIRT2437966	hsa-miR-4766-5p	CLIP-seq
MIRT2437967	hsa-miR-4768-5p	CLIP-seq
MIRT1073647	hsa-miR-513a-5p	CLIP-seq
MIRT2437968	hsa-miR-593	CLIP-seq
MIRT2018197	hsa-miR-612	CLIP-seq
MIRT2437969	hsa-miR-637	CLIP-seq
MIRT1556581	hsa-miR-654-3p	CLIP-seq
MIRT2018198	hsa-miR-708	CLIP-seq
MIRT2437970	hsa-miR-762	CLIP-seq
MIRT2437971	hsa-miR-873	CLIP-seq
MIRT1073652	hsa-miR-936	CLIP-seq
MIRT2437972	hsa-miR-939	CLIP-seq
MIRT736869	hsa-miR-326	CLIP-seq
MIRT1073597	hsa-miR-1267	CLIP-seq
MIRT2437928	hsa-miR-149	CLIP-seq
MIRT2437931	hsa-miR-2355-5p	CLIP-seq
MIRT1073607	hsa-miR-2681	CLIP-seq
MIRT1073610	hsa-miR-3127-3p	CLIP-seq
MIRT2437939	hsa-miR-331-3p	CLIP-seq
MIRT2437940	hsa-miR-4267	CLIP-seq
MIRT2437941	hsa-miR-4268	CLIP-seq
MIRT1073623	hsa-miR-4423-5p	CLIP-seq
MIRT1073634	hsa-miR-4659a-5p	CLIP-seq
MIRT1073635	hsa-miR-4659b-5p	CLIP-seq
MIRT1073644	hsa-miR-4776-3p	CLIP-seq

Transcription factors

Show/Hide all(5)

Transcription factor	Regulation	Reference
HOXD3	Unknown	14610084
NFIC	Repression	18775869
PAX6	Unknown	10954416
SP1	Activation	18775869
ZEB2	Activation	22227038

Show/Hide all(49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	TAS	19267251
GO:0001618	Function	Virus receptor activity	IEA
GO:0001726	Component	Ruffle	TAS	11919189
GO:0005154	Function	Epidermal growth factor receptor binding	IEA
GO:0005161	Function	Platelet-derived growth factor receptor binding	TAS	19267251
GO:0005178	Function	Integrin binding	IEA
GO:0005515	Function	Protein binding	IPI	12695522, 12724312, 12807887, 14970227, 16051604, 16099422, 17158881, 19141530, 19175293, 21947080, 22178926, 22940691, 24011356, 30021884, 31331973, 33102950
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IDA	19141530
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	IDA	14970227
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005925	Component	Focal adhesion	IDA	17158881, 29162887
GO:0005925	Component	Focal adhesion	IDA	14970227
GO:0007044	Process	Cell-substrate junction assembly	IEA
GO:0007155	Process	Cell adhesion	IDA	19703720
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IEA
GO:0007159	Process	Leukocyte cell-cell adhesion	IEA
GO:0007229	Process	Integrin-mediated signaling pathway	IDA	31331973
GO:0007565	Process	Female pregnancy	IEA
GO:0007613	Process	Memory	IEA
GO:0008305	Component	Integrin complex	TAS	2454952
GO:0009897	Component	External side of plasma membrane	IEA
GO:0009986	Component	Cell surface	HDA	19581412, 23658023
GO:0009986	Component	Cell surface	IDA	17158881, 20563599, 23154389
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IEA
GO:0023035	Process	CD40 signaling pathway	IDA	31331973
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0030335	Process	Positive regulation of cell migration	IEA
GO:0030949	Process	Positive regulation of vascular endothelial growth factor receptor signaling pathway	TAS	19267251
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031589	Process	Cell-substrate adhesion	IMP	19933311
GO:0032587	Component	Ruffle membrane	IDA	14970227
GO:0033627	Process	Cell adhesion mediated by integrin	IDA	12807887, 17158881
GO:0033631	Process	Cell-cell adhesion mediated by integrin	IEA
GO:0034113	Process	Heterotypic cell-cell adhesion	IMP	20563599
GO:0034674	Component	Integrin alpha5-beta1 complex	IDA	31331973, 33102950
GO:0035313	Process	Wound healing, spreading of epidermal cells	IEP	14970227
GO:0035987	Process	Endodermal cell differentiation	IMP	23154389
GO:0043184	Function	Vascular endothelial growth factor receptor 2 binding	TAS	19267251
GO:0045202	Component	Synapse	IEA
GO:0046718	Process	Viral entry into host cell	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050731	Process	Positive regulation of peptidyl-tyrosine phosphorylation	IMP	10022831
GO:0050900	Process	Leukocyte migration	TAS
GO:0071062	Component	Alphav-beta3 integrin-vitronectin complex	TAS	19267251
GO:1903672	Process	Positive regulation of sprouting angiogenesis	IMP	19460962
GO:2000811	Process	Negative regulation of anoikis	IMP	15006356

MIM	HGNC	e!Ensembl
135620	6141	ENSG00000161638

Protein

UniProt ID

P08648

Protein name

Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]

Protein function

Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site

PDB

3VI3 , 3VI4 , 4WJK , 4WK0 , 4WK2 , 4WK4 , 7NWL , 7NXD , 9B9J , 9B9K , 9CKV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01839	FG-GAP	326 → 368	FG-GAP repeat	Repeat
PF01839	FG-GAP	392 → 428	FG-GAP repeat	Repeat
PF08441	Integrin_alpha2	489 → 921	Integrin alpha	Family

Sequence

MGSRTPESPLHAVQLRWGPRRRPPLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFF
GFSVEFYRPGTDGVSVLVGAPKANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRL
LESSLSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLST
DNFTRILEYAPCRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQ
IAESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTY
GYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQ
EVGRVYVYLQHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGET
QQGVVFVFPGGPGGLGSKPSQVLQPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFG
VDKAVVYRGRPIVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSI
GFTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDK
LSPIHIALNFSLDPQAPVDSHGLRPALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVF
GEQNHVYLGDKNALNLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDY
FAVNQSRLLVCDLGNPMKAGASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVV
SFRLSVEAQAQVTLNGVSKPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSI
SQGVLELSCPQALEGQQLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQQKREAPSRS
SASSGPQILKCPEAECFRLRCELGPLHQQESQSLQLHFRVWAKTFLQREHQPFSLQCEAV
YKALKMPYRILPRQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFGLLLLGLLIYIL
YKLGFFKRSLPYGTAMEKAQLKPPATSDA

Sequence length

1049

Interactions

View interactions

	KEGG		Reactome
	Virion - Herpesvirus Phagosome PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Hematopoietic cell lineage Regulation of actin cytoskeleton Cytoskeleton in muscle cells Bacterial invasion of epithelial cells Shigellosis Pertussis Yersinia infection Human papillomavirus infection Herpes simplex virus 1 infection Proteoglycans in cancer MicroRNAs in cancer Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy		Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma	Squamous cell carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	21401805
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	17786296

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		17786296

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