Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
3673 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Integrin subunit alpha 2 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
ITGA2 |
SynonymsGene synonyms aliases
|
BR, CD49B, FMAIT3, GPIa, HPA-5, VLA-2, VLAA2 |
ChromosomeChromosome number
|
5 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
5q11.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss o |
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0001540 |
Function |
Amyloid-beta binding |
ISS |
|
GO:0001618 |
Function |
Virus receptor activity |
IEA |
|
GO:0001666 |
Process |
Response to hypoxia |
IEA |
|
GO:0002687 |
Process |
Positive regulation of leukocyte migration |
IEA |
|
GO:0005178 |
Function |
Integrin binding |
IEA |
|
GO:0005515 |
Function |
Protein binding |
IPI |
7639691, 10397731, 14681217, 16754661, 16754960, 18587047, 21596751, 21947080, 26779610 |
GO:0005518 |
Function |
Collagen binding |
IMP |
11518510 |
GO:0005634 |
Component |
Nucleus |
IEA |
|
GO:0005886 |
Component |
Plasma membrane |
IDA |
21310825 |
GO:0005886 |
Component |
Plasma membrane |
TAS |
|
GO:0005925 |
Component |
Focal adhesion |
HDA |
21423176 |
GO:0005925 |
Component |
Focal adhesion |
IDA |
11518510 |
GO:0006929 |
Process |
Substrate-dependent cell migration |
IMP |
11518510 |
GO:0006971 |
Process |
Hypotonic response |
IEA |
|
GO:0007155 |
Process |
Cell adhesion |
TAS |
10201960, 10942362 |
GO:0007160 |
Process |
Cell-matrix adhesion |
IMP |
11518510, 24823363 |
GO:0007229 |
Process |
Integrin-mediated signaling pathway |
IMP |
24823363 |
GO:0007565 |
Process |
Female pregnancy |
IEA |
|
GO:0007596 |
Process |
Blood coagulation |
TAS |
2933589 |
GO:0008283 |
Process |
Cell population proliferation |
IEA |
|
GO:0008305 |
Component |
Integrin complex |
TAS |
2545729 |
GO:0009887 |
Process |
Animal organ morphogenesis |
TAS |
9391074 |
GO:0009897 |
Component |
External side of plasma membrane |
IEA |
|
GO:0009986 |
Component |
Cell surface |
HDA |
19581412, 23382103, 23658023 |
GO:0009986 |
Component |
Cell surface |
IDA |
19933311, 20563599, 21310825 |
GO:0010634 |
Process |
Positive regulation of epithelial cell migration |
IEA |
|
GO:0010694 |
Process |
Positive regulation of alkaline phosphatase activity |
IEA |
|
GO:0014075 |
Process |
Response to amine |
IEA |
|
GO:0014850 |
Process |
Response to muscle activity |
IEA |
|
GO:0014911 |
Process |
Positive regulation of smooth muscle cell migration |
IEA |
|
GO:0030198 |
Process |
Extracellular matrix organization |
TAS |
|
GO:0030879 |
Process |
Mammary gland development |
IEA |
|
GO:0031346 |
Process |
Positive regulation of cell projection organization |
IEA |
|
GO:0031589 |
Process |
Cell-substrate adhesion |
IMP |
19933311 |
GO:0032967 |
Process |
Positive regulation of collagen biosynthetic process |
IEA |
|
GO:0033343 |
Process |
Positive regulation of collagen binding |
IEA |
|
GO:0033591 |
Process |
Response to L-ascorbic acid |
IEA |
|
GO:0033627 |
Process |
Cell adhesion mediated by integrin |
IMP |
11518510 |
GO:0034666 |
Component |
Integrin alpha2-beta1 complex |
IDA |
24823363 |
GO:0038064 |
Function |
Collagen receptor activity |
IMP |
11518510 |
GO:0038065 |
Process |
Collagen-activated signaling pathway |
IMP |
11518510 |
GO:0042493 |
Process |
Response to drug |
IEA |
|
GO:0043236 |
Function |
Laminin binding |
IEA |
|
GO:0043388 |
Process |
Positive regulation of DNA binding |
IEA |
|
GO:0043395 |
Function |
Heparan sulfate proteoglycan binding |
TAS |
21126803 |
GO:0043589 |
Process |
Skin morphogenesis |
IEA |
|
GO:0043679 |
Component |
Axon terminus |
IEA |
|
GO:0044877 |
Function |
Protein-containing complex binding |
IPI |
25336636 |
GO:0045178 |
Component |
Basal part of cell |
IEA |
|
GO:0045184 |
Process |
Establishment of protein localization |
IEA |
|
GO:0045727 |
Process |
Positive regulation of translation |
IEA |
|
GO:0045785 |
Process |
Positive regulation of cell adhesion |
IEA |
|
GO:0045987 |
Process |
Positive regulation of smooth muscle contraction |
IEA |
|
GO:0046718 |
Process |
Viral entry into host cell |
IEA |
|
GO:0046872 |
Function |
Metal ion binding |
IEA |
|
GO:0048041 |
Process |
Focal adhesion assembly |
IEA |
|
GO:0048333 |
Process |
Mesodermal cell differentiation |
IEP |
23154389 |
GO:0048471 |
Component |
Perinuclear region of cytoplasm |
IEA |
|
GO:0048661 |
Process |
Positive regulation of smooth muscle cell proliferation |
IEA |
|
GO:0050729 |
Process |
Positive regulation of inflammatory response |
IEA |
|
GO:0050927 |
Process |
Positive regulation of positive chemotaxis |
IEA |
|
GO:0050966 |
Process |
Detection of mechanical stimulus involved in sensory perception of pain |
IEA |
|
GO:0051971 |
Process |
Positive regulation of transmission of nerve impulse |
IEA |
|
GO:0060100 |
Process |
Positive regulation of phagocytosis, engulfment |
IEA |
|
GO:0070365 |
Process |
Hepatocyte differentiation |
IEA |
|
GO:0071107 |
Process |
Response to parathyroid hormone |
IEA |
|
GO:0071260 |
Process |
Cellular response to mechanical stimulus |
IEA |
|
GO:0071392 |
Process |
Cellular response to estradiol stimulus |
IEA |
|
GO:0098639 |
Function |
Collagen binding involved in cell-matrix adhesion |
IMP |
24823363 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
P17301 |
Protein name |
Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) |
Protein function |
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells |
PDB |
1AOX
,
1DZI
,
1V7P
,
4BJ3
,
5HJ2
,
5THP
,
6ND8
,
6ND9
,
6NDA
,
6NDB
,
6NDC
,
6NDD
,
6NDE
,
6NDF
,
6NDG
,
6NDH
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00092 |
VWA |
174 → 355 |
von Willebrand factor type A domain |
Domain |
PF01839 |
FG-GAP |
554 → 589 |
FG-GAP repeat |
Repeat |
PF08441 |
Integrin_alpha2 |
649 → 1068 |
Integrin alpha |
Family |
|
Sequence |
|
Sequence length |
1181 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Alloimmune thrombocytopenia |
Fetal and neonatal alloimmune thrombocytopenia, Neonatal Alloimmune Thrombocytopenia |
rs1555572829 |
|
Cerebral palsy |
Cerebral Palsy |
rs121918149, rs75184679, rs730880264, rs587777428, rs797045067, rs767399782, rs564185858, rs886039513 |
|
Developmental delay |
Global developmental delay |
rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291, rs886041382, rs1057518991, rs1057518699, rs753254213, rs748294403, rs762552974, rs1135401795, rs1553121073, rs1553122926, rs1364690005, rs1554086554, rs1554210415, rs1554168326, rs1554776342, rs1553873247, rs1567860112, rs779009256, rs1557447255, rs1564568350, rs780011005, rs1597464953, rs1200336864, rs1569513017, rs1587459606, rs1570332505, rs748888652, rs1575155995, rs2087029320, rs1589669105, rs1601769604, rs1184981709, rs749201074 |
|
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Endometrioma |
Endometrioma |
|
20864642 |
Endometriosis |
Endometriosis |
rs1800629, rs1143634 |
20864642 |
Fetal and neonatal alloimmune thrombocytopenia |
FNAITP |
|
|
Glycoprotein ia deficiency |
Glycoprotein IA Deficiency |
|
10590055 |
Hematomas |
Spontaneous hematomas |
|
|
Retinal vein occlusion |
Retinal Vein Occlusion |
|
12928694 |
Sensorineural hearing loss |
Sensorineural hearing loss, bilateral |
|
|
Subarachnoid hemorrhage |
Subarachnoid Hemorrhage |
|
|
Thrombosis of retinal vein |
Thrombosis of retinal vein |
|
12928694 |
|