IRF4 (interferon regulatory factor 4)

Gene

• Entrez ID: 3662
• Gene name: Interferon regulatory factor 4
• Gene symbol: IRF4
• Synonyms: IMD131, LSIRF, MUM1, NF-EM5, SHEP8
• Chromosome: 6
• Chromosome location: 6p25.3
• Summary: The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs12203592	C>T	Affects	Intron variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004534	hsa-miR-125b-5p	qRT-PCR, Luciferase reporter assay	20497960
MIRT504380	hsa-miR-574-3p	HITS-CLIP	21572407
MIRT504379	hsa-miR-3943	HITS-CLIP	21572407
MIRT504378	hsa-miR-1324	HITS-CLIP	21572407
MIRT504377	hsa-miR-1199-5p	HITS-CLIP	21572407
MIRT504376	hsa-miR-6751-3p	HITS-CLIP	21572407
MIRT504375	hsa-miR-1225-3p	HITS-CLIP	21572407
MIRT504374	hsa-miR-1233-3p	HITS-CLIP	21572407
MIRT218940	hsa-miR-6847-3p	HITS-CLIP	21572407
MIRT504380	hsa-miR-574-3p	PAR-CLIP	20371350
MIRT504379	hsa-miR-3943	PAR-CLIP	20371350
MIRT504378	hsa-miR-1324	PAR-CLIP	20371350
MIRT169069	hsa-miR-125a-5p	PAR-CLIP	20371350
MIRT004534	hsa-miR-125b-5p	PAR-CLIP	20371350
MIRT169110	hsa-miR-4319	PAR-CLIP	20371350
MIRT504377	hsa-miR-1199-5p	PAR-CLIP	20371350
MIRT504376	hsa-miR-6751-3p	PAR-CLIP	20371350
MIRT504375	hsa-miR-1225-3p	PAR-CLIP	20371350
MIRT504374	hsa-miR-1233-3p	PAR-CLIP	20371350
MIRT504373	hsa-miR-4313	PAR-CLIP	20371350
MIRT504380	hsa-miR-574-3p	PAR-CLIP	21572407
MIRT504379	hsa-miR-3943	PAR-CLIP	21572407
MIRT504378	hsa-miR-1324	PAR-CLIP	21572407
MIRT169069	hsa-miR-125a-5p	PAR-CLIP	21572407
MIRT004534	hsa-miR-125b-5p	PAR-CLIP	21572407
MIRT169110	hsa-miR-4319	PAR-CLIP	21572407
MIRT504377	hsa-miR-1199-5p	PAR-CLIP	21572407
MIRT504376	hsa-miR-6751-3p	PAR-CLIP	21572407
MIRT504375	hsa-miR-1225-3p	PAR-CLIP	21572407
MIRT504374	hsa-miR-1233-3p	PAR-CLIP	21572407
MIRT218940	hsa-miR-6847-3p	PAR-CLIP	21572407
MIRT504380	hsa-miR-574-3p	PAR-CLIP	23446348
MIRT504379	hsa-miR-3943	PAR-CLIP	23446348
MIRT504378	hsa-miR-1324	PAR-CLIP	23446348
MIRT169069	hsa-miR-125a-5p	PAR-CLIP	23446348
MIRT004534	hsa-miR-125b-5p	PAR-CLIP	23446348
MIRT169110	hsa-miR-4319	PAR-CLIP	23446348
MIRT504377	hsa-miR-1199-5p	PAR-CLIP	23446348
MIRT504376	hsa-miR-6751-3p	PAR-CLIP	23446348
MIRT504375	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT504374	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT504373	hsa-miR-4313	PAR-CLIP	23446348
MIRT218940	hsa-miR-6847-3p	PAR-CLIP	23446348
MIRT504380	hsa-miR-574-3p	PAR-CLIP	23446348
MIRT504379	hsa-miR-3943	PAR-CLIP	23446348
MIRT504378	hsa-miR-1324	PAR-CLIP	23446348
MIRT169069	hsa-miR-125a-5p	PAR-CLIP	23446348
MIRT004534	hsa-miR-125b-5p	PAR-CLIP	23446348
MIRT169110	hsa-miR-4319	PAR-CLIP	23446348
MIRT504377	hsa-miR-1199-5p	PAR-CLIP	23446348
MIRT504376	hsa-miR-6751-3p	PAR-CLIP	23446348
MIRT504375	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT504374	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT504373	hsa-miR-4313	PAR-CLIP	23446348
MIRT218940	hsa-miR-6847-3p	PAR-CLIP	23446348
MIRT497330	hsa-miR-497-3p	PAR-CLIP	22291592
MIRT497329	hsa-miR-4678	PAR-CLIP	22291592
MIRT169035	hsa-miR-6792-5p	PAR-CLIP	22291592
MIRT218949	hsa-miR-331-5p	PAR-CLIP	22291592
MIRT401842	hsa-miR-4503	PAR-CLIP	22291592
MIRT169058	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT169067	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT169059	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT169070	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT168937	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT168938	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT004534	hsa-miR-125b-5p	qRT-PCR	27903272
MIRT735049	hsa-miR-155-5p	Microarray	32990751
MIRT504380	hsa-miR-574-3p	HITS-CLIP	21572407
MIRT504379	hsa-miR-3943	HITS-CLIP	21572407
MIRT504378	hsa-miR-1324	HITS-CLIP	21572407
MIRT504377	hsa-miR-1199-5p	HITS-CLIP	21572407
MIRT504376	hsa-miR-6751-3p	HITS-CLIP	21572407
MIRT504375	hsa-miR-1225-3p	HITS-CLIP	21572407
MIRT504374	hsa-miR-1233-3p	HITS-CLIP	21572407
MIRT218940	hsa-miR-6847-3p	HITS-CLIP	21572407
MIRT504380	hsa-miR-574-3p	PAR-CLIP	20371350
MIRT504379	hsa-miR-3943	PAR-CLIP	20371350
MIRT504378	hsa-miR-1324	PAR-CLIP	20371350
MIRT169069	hsa-miR-125a-5p	PAR-CLIP	20371350
MIRT004534	hsa-miR-125b-5p	PAR-CLIP	20371350
MIRT169110	hsa-miR-4319	PAR-CLIP	20371350
MIRT504377	hsa-miR-1199-5p	PAR-CLIP	20371350
MIRT504376	hsa-miR-6751-3p	PAR-CLIP	20371350
MIRT504375	hsa-miR-1225-3p	PAR-CLIP	20371350
MIRT504374	hsa-miR-1233-3p	PAR-CLIP	20371350
MIRT504373	hsa-miR-4313	PAR-CLIP	20371350
MIRT504380	hsa-miR-574-3p	PAR-CLIP	21572407
MIRT504379	hsa-miR-3943	PAR-CLIP	21572407
MIRT504378	hsa-miR-1324	PAR-CLIP	21572407
MIRT169069	hsa-miR-125a-5p	PAR-CLIP	21572407
MIRT004534	hsa-miR-125b-5p	PAR-CLIP	21572407
MIRT169110	hsa-miR-4319	PAR-CLIP	21572407
MIRT504377	hsa-miR-1199-5p	PAR-CLIP	21572407
MIRT504376	hsa-miR-6751-3p	PAR-CLIP	21572407
MIRT504375	hsa-miR-1225-3p	PAR-CLIP	21572407
MIRT504374	hsa-miR-1233-3p	PAR-CLIP	21572407
MIRT218940	hsa-miR-6847-3p	PAR-CLIP	21572407
MIRT504380	hsa-miR-574-3p	PAR-CLIP	23446348
MIRT504379	hsa-miR-3943	PAR-CLIP	23446348
MIRT504378	hsa-miR-1324	PAR-CLIP	23446348
MIRT169069	hsa-miR-125a-5p	PAR-CLIP	23446348
MIRT004534	hsa-miR-125b-5p	PAR-CLIP	23446348
MIRT169110	hsa-miR-4319	PAR-CLIP	23446348
MIRT504377	hsa-miR-1199-5p	PAR-CLIP	23446348
MIRT504376	hsa-miR-6751-3p	PAR-CLIP	23446348
MIRT504375	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT504374	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT504373	hsa-miR-4313	PAR-CLIP	23446348
MIRT218940	hsa-miR-6847-3p	PAR-CLIP	23446348
MIRT504380	hsa-miR-574-3p	PAR-CLIP	23446348
MIRT504379	hsa-miR-3943	PAR-CLIP	23446348
MIRT504378	hsa-miR-1324	PAR-CLIP	23446348
MIRT169069	hsa-miR-125a-5p	PAR-CLIP	23446348
MIRT004534	hsa-miR-125b-5p	PAR-CLIP	23446348
MIRT169110	hsa-miR-4319	PAR-CLIP	23446348
MIRT504377	hsa-miR-1199-5p	PAR-CLIP	23446348
MIRT504376	hsa-miR-6751-3p	PAR-CLIP	23446348
MIRT504375	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT504374	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT504373	hsa-miR-4313	PAR-CLIP	23446348
MIRT218940	hsa-miR-6847-3p	PAR-CLIP	23446348
MIRT497330	hsa-miR-497-3p	PAR-CLIP	22291592
MIRT497329	hsa-miR-4678	PAR-CLIP	22291592
MIRT169035	hsa-miR-6792-5p	PAR-CLIP	22291592
MIRT218949	hsa-miR-331-5p	PAR-CLIP	22291592
MIRT401842	hsa-miR-4503	PAR-CLIP	22291592
MIRT1071207	hsa-miR-103a	CLIP-seq
MIRT1071208	hsa-miR-107	CLIP-seq
MIRT1071209	hsa-miR-1228	CLIP-seq
MIRT1071210	hsa-miR-1262	CLIP-seq
MIRT1071211	hsa-miR-127-5p	CLIP-seq
MIRT1071212	hsa-miR-1293	CLIP-seq
MIRT1071213	hsa-miR-1298	CLIP-seq
MIRT1071214	hsa-miR-15a	CLIP-seq
MIRT1071215	hsa-miR-15b	CLIP-seq
MIRT1071216	hsa-miR-16	CLIP-seq
MIRT1071217	hsa-miR-195	CLIP-seq
MIRT1071218	hsa-miR-24	CLIP-seq
MIRT1071219	hsa-miR-3122	CLIP-seq
MIRT1071220	hsa-miR-3130-5p	CLIP-seq
MIRT1071221	hsa-miR-3160-3p	CLIP-seq
MIRT1071222	hsa-miR-3171	CLIP-seq
MIRT1071223	hsa-miR-342-3p	CLIP-seq
MIRT1071224	hsa-miR-3682-5p	CLIP-seq
MIRT1071225	hsa-miR-3689d	CLIP-seq
MIRT1071226	hsa-miR-3913-5p	CLIP-seq
MIRT1071227	hsa-miR-424	CLIP-seq
MIRT1071228	hsa-miR-4264	CLIP-seq
MIRT1071229	hsa-miR-4284	CLIP-seq
MIRT1071230	hsa-miR-4320	CLIP-seq
MIRT1071231	hsa-miR-4328	CLIP-seq
MIRT1071232	hsa-miR-433	CLIP-seq
MIRT1071233	hsa-miR-4422	CLIP-seq
MIRT1071234	hsa-miR-4482	CLIP-seq
MIRT1071235	hsa-miR-4483	CLIP-seq
MIRT1071236	hsa-miR-4487	CLIP-seq
MIRT1071237	hsa-miR-450b-3p	CLIP-seq
MIRT1071238	hsa-miR-4520a-3p	CLIP-seq
MIRT1071239	hsa-miR-4638-3p	CLIP-seq
MIRT1071240	hsa-miR-4681	CLIP-seq
MIRT1071241	hsa-miR-4701-3p	CLIP-seq
MIRT1071242	hsa-miR-4760-3p	CLIP-seq
MIRT1071243	hsa-miR-4797-3p	CLIP-seq
MIRT1071244	hsa-miR-4803	CLIP-seq
MIRT1071245	hsa-miR-495	CLIP-seq
MIRT1071246	hsa-miR-497	CLIP-seq
MIRT1071247	hsa-miR-513a-3p	CLIP-seq
MIRT1071248	hsa-miR-548a-3p	CLIP-seq
MIRT1071249	hsa-miR-548ae	CLIP-seq
MIRT1071250	hsa-miR-548aj	CLIP-seq
MIRT1071251	hsa-miR-548am	CLIP-seq
MIRT1071252	hsa-miR-548c-3p	CLIP-seq
MIRT1071253	hsa-miR-548e	CLIP-seq
MIRT1071254	hsa-miR-548f	CLIP-seq
MIRT1071255	hsa-miR-548x	CLIP-seq
MIRT1071256	hsa-miR-558	CLIP-seq
MIRT1071257	hsa-miR-587	CLIP-seq
MIRT1071258	hsa-miR-592	CLIP-seq
MIRT1071259	hsa-miR-597	CLIP-seq
MIRT1071260	hsa-miR-599	CLIP-seq
MIRT1071261	hsa-miR-602	CLIP-seq
MIRT1071262	hsa-miR-668	CLIP-seq
MIRT1071263	hsa-miR-769-3p	CLIP-seq
MIRT1071264	hsa-miR-9	CLIP-seq
MIRT1071265	hsa-miR-1270	CLIP-seq
MIRT1071266	hsa-miR-1305	CLIP-seq
MIRT1071267	hsa-miR-2116	CLIP-seq
MIRT1071268	hsa-miR-300	CLIP-seq
MIRT1071219	hsa-miR-3122	CLIP-seq
MIRT1071269	hsa-miR-3124-3p	CLIP-seq
MIRT1071270	hsa-miR-3192	CLIP-seq
MIRT1071271	hsa-miR-3611	CLIP-seq
MIRT1071272	hsa-miR-3653	CLIP-seq
MIRT1071273	hsa-miR-3658	CLIP-seq
MIRT1071274	hsa-miR-3685	CLIP-seq
MIRT1071225	hsa-miR-3689d	CLIP-seq
MIRT1071275	hsa-miR-376c	CLIP-seq
MIRT1071276	hsa-miR-381	CLIP-seq
MIRT1071277	hsa-miR-384	CLIP-seq
MIRT1071226	hsa-miR-3913-5p	CLIP-seq
MIRT1071278	hsa-miR-4271	CLIP-seq
MIRT1071279	hsa-miR-4277	CLIP-seq
MIRT1071280	hsa-miR-432	CLIP-seq
MIRT1071230	hsa-miR-4320	CLIP-seq
MIRT1071281	hsa-miR-4434	CLIP-seq
MIRT1071282	hsa-miR-4495	CLIP-seq
MIRT1071283	hsa-miR-4496	CLIP-seq
MIRT1071237	hsa-miR-450b-3p	CLIP-seq
MIRT1071284	hsa-miR-4516	CLIP-seq
MIRT1071285	hsa-miR-4531	CLIP-seq
MIRT1071286	hsa-miR-4643	CLIP-seq
MIRT1071287	hsa-miR-466	CLIP-seq
MIRT1071288	hsa-miR-4662a-3p	CLIP-seq
MIRT1071289	hsa-miR-4666-3p	CLIP-seq
MIRT1071290	hsa-miR-4709-3p	CLIP-seq
MIRT1071291	hsa-miR-4716-3p	CLIP-seq
MIRT1071292	hsa-miR-4725-3p	CLIP-seq
MIRT1071293	hsa-miR-4728-3p	CLIP-seq
MIRT1071294	hsa-miR-4789-3p	CLIP-seq
MIRT1071295	hsa-miR-4793-3p	CLIP-seq
MIRT1071296	hsa-miR-4795-5p	CLIP-seq
MIRT1071297	hsa-miR-4800-5p	CLIP-seq
MIRT1071298	hsa-miR-501-3p	CLIP-seq
MIRT1071299	hsa-miR-501-5p	CLIP-seq
MIRT1071300	hsa-miR-502-3p	CLIP-seq
MIRT1071301	hsa-miR-508-5p	CLIP-seq
MIRT1071302	hsa-miR-576-3p	CLIP-seq
MIRT1071258	hsa-miR-592	CLIP-seq
MIRT1071259	hsa-miR-597	CLIP-seq
MIRT1071260	hsa-miR-599	CLIP-seq
MIRT1071303	hsa-miR-607	CLIP-seq
MIRT1071304	hsa-miR-620	CLIP-seq
MIRT1071305	hsa-miR-625	CLIP-seq
MIRT1071306	hsa-miR-642b	CLIP-seq
MIRT1071307	hsa-miR-661	CLIP-seq
MIRT1071262	hsa-miR-668	CLIP-seq
MIRT1071308	hsa-miR-711	CLIP-seq
MIRT1071309	hsa-miR-758	CLIP-seq
MIRT1071310	hsa-miR-766	CLIP-seq
MIRT1071263	hsa-miR-769-3p	CLIP-seq
MIRT1071311	hsa-miR-889	CLIP-seq
MIRT1071264	hsa-miR-9	CLIP-seq
MIRT2017523	hsa-miR-128	CLIP-seq
MIRT2017524	hsa-miR-214	CLIP-seq
MIRT2017525	hsa-miR-27a	CLIP-seq
MIRT2017526	hsa-miR-27b	CLIP-seq
MIRT2017527	hsa-miR-3120-3p	CLIP-seq
MIRT2017528	hsa-miR-3148	CLIP-seq
MIRT2017529	hsa-miR-3614-5p	CLIP-seq
MIRT2017530	hsa-miR-3619-5p	CLIP-seq
MIRT2017531	hsa-miR-4274	CLIP-seq
MIRT2017532	hsa-miR-4428	CLIP-seq
MIRT2017533	hsa-miR-4436b-5p	CLIP-seq
MIRT2017534	hsa-miR-4778-3p	CLIP-seq
MIRT2017535	hsa-miR-513a-5p	CLIP-seq
MIRT2017536	hsa-miR-579	CLIP-seq
MIRT2017537	hsa-miR-761	CLIP-seq
MIRT2249460	hsa-miR-1208	CLIP-seq
MIRT2017523	hsa-miR-128	CLIP-seq
MIRT2249461	hsa-miR-1321	CLIP-seq
MIRT2249462	hsa-miR-1323	CLIP-seq
MIRT2249463	hsa-miR-145	CLIP-seq
MIRT2249464	hsa-miR-1587	CLIP-seq
MIRT2249465	hsa-miR-1825	CLIP-seq
MIRT2249466	hsa-miR-1827	CLIP-seq
MIRT2249467	hsa-miR-199a-5p	CLIP-seq
MIRT2249468	hsa-miR-199b-5p	CLIP-seq
MIRT2249469	hsa-miR-204	CLIP-seq
MIRT2249470	hsa-miR-211	CLIP-seq
MIRT2249471	hsa-miR-2115	CLIP-seq
MIRT2017525	hsa-miR-27a	CLIP-seq
MIRT2017526	hsa-miR-27b	CLIP-seq
MIRT2017528	hsa-miR-3148	CLIP-seq
MIRT2249472	hsa-miR-3153	CLIP-seq
MIRT1071221	hsa-miR-3160-3p	CLIP-seq
MIRT2249473	hsa-miR-3180-5p	CLIP-seq
MIRT2249474	hsa-miR-3616-3p	CLIP-seq
MIRT2249475	hsa-miR-3647-3p	CLIP-seq
MIRT2249476	hsa-miR-3671	CLIP-seq
MIRT2249477	hsa-miR-370	CLIP-seq
MIRT2249478	hsa-miR-371b-5p	CLIP-seq
MIRT2249479	hsa-miR-3929	CLIP-seq
MIRT2249480	hsa-miR-4270	CLIP-seq
MIRT2249481	hsa-miR-4324	CLIP-seq
MIRT2249482	hsa-miR-4419b	CLIP-seq
MIRT1071233	hsa-miR-4422	CLIP-seq
MIRT2017532	hsa-miR-4428	CLIP-seq
MIRT2249483	hsa-miR-4436b-3p	CLIP-seq
MIRT2249484	hsa-miR-4441	CLIP-seq
MIRT2249485	hsa-miR-4459	CLIP-seq
MIRT2249486	hsa-miR-4478	CLIP-seq
MIRT1071236	hsa-miR-4487	CLIP-seq
MIRT2249487	hsa-miR-4492	CLIP-seq
MIRT2249488	hsa-miR-4498	CLIP-seq
MIRT2249489	hsa-miR-4505	CLIP-seq
MIRT2249490	hsa-miR-4635	CLIP-seq
MIRT2249491	hsa-miR-4646-5p	CLIP-seq
MIRT2249492	hsa-miR-4649-3p	CLIP-seq
MIRT2249493	hsa-miR-4656	CLIP-seq
MIRT2249494	hsa-miR-4668-5p	CLIP-seq
MIRT2249495	hsa-miR-4674	CLIP-seq
MIRT2249496	hsa-miR-4675	CLIP-seq
MIRT2249497	hsa-miR-4695-5p	CLIP-seq
MIRT2249498	hsa-miR-4699-3p	CLIP-seq
MIRT2249499	hsa-miR-4722-5p	CLIP-seq
MIRT2249500	hsa-miR-4739	CLIP-seq
MIRT2249501	hsa-miR-4741	CLIP-seq
MIRT2249502	hsa-miR-4755-5p	CLIP-seq
MIRT2249503	hsa-miR-4756-5p	CLIP-seq
MIRT2249504	hsa-miR-4768-3p	CLIP-seq
MIRT1071295	hsa-miR-4793-3p	CLIP-seq
MIRT2249505	hsa-miR-4793-5p	CLIP-seq
MIRT2249506	hsa-miR-485-5p	CLIP-seq
MIRT1071301	hsa-miR-508-5p	CLIP-seq
MIRT1071247	hsa-miR-513a-3p	CLIP-seq
MIRT2249507	hsa-miR-516a-3p	CLIP-seq
MIRT2249508	hsa-miR-520a-5p	CLIP-seq
MIRT2249509	hsa-miR-525-5p	CLIP-seq
MIRT2249510	hsa-miR-541	CLIP-seq
MIRT2249511	hsa-miR-548an	CLIP-seq
MIRT2249512	hsa-miR-548o	CLIP-seq
MIRT1071256	hsa-miR-558	CLIP-seq
MIRT2249513	hsa-miR-590-3p	CLIP-seq
MIRT2249514	hsa-miR-623	CLIP-seq
MIRT2249515	hsa-miR-651	CLIP-seq
MIRT2249516	hsa-miR-654-5p	CLIP-seq
MIRT2249517	hsa-miR-658	CLIP-seq
MIRT2249518	hsa-miR-762	CLIP-seq
MIRT1071310	hsa-miR-766	CLIP-seq
MIRT2249519	hsa-miR-940	CLIP-seq
MIRT2249461	hsa-miR-1321	CLIP-seq
MIRT2249480	hsa-miR-4270	CLIP-seq
MIRT2249484	hsa-miR-4441	CLIP-seq
MIRT2249500	hsa-miR-4739	CLIP-seq
MIRT2249503	hsa-miR-4756-5p	CLIP-seq
MIRT2552980	hsa-miR-1207-3p	CLIP-seq
MIRT2552981	hsa-miR-1301	CLIP-seq
MIRT1071270	hsa-miR-3192	CLIP-seq
MIRT2552982	hsa-miR-3667-5p	CLIP-seq
MIRT2552983	hsa-miR-4432	CLIP-seq
MIRT2552984	hsa-miR-451b	CLIP-seq
MIRT2552985	hsa-miR-4660	CLIP-seq
MIRT2552986	hsa-miR-4696	CLIP-seq
MIRT2552987	hsa-miR-4701-5p	CLIP-seq
MIRT1071295	hsa-miR-4793-3p	CLIP-seq
MIRT2552988	hsa-miR-5047	CLIP-seq
MIRT1071301	hsa-miR-508-5p	CLIP-seq
MIRT2552989	hsa-miR-588	CLIP-seq
MIRT1071307	hsa-miR-661	CLIP-seq
MIRT1071262	hsa-miR-668	CLIP-seq
MIRT1071310	hsa-miR-766	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
BCL6	Repression	10601358
CEBPB	Activation	19717648
NFKB1	Activation	17018379
RELA	Activation	17018379
STAT6	Unknown	10601358

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000786	Component	Nucleosome	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	12374808
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	12374808
GO:0002376	Process	Immune system process	IBA	21873635
GO:0003700	Function	DNA-binding transcription factor activity	ISS
GO:0003700	Function	DNA-binding transcription factor activity	NAS	12374808
GO:0005515	Function	Protein binding	IPI	21903422, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IC	12374808
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0008134	Function	Transcription factor binding	NAS	12374808
GO:0016020	Component	Membrane	HDA	19946888
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0032733	Process	Positive regulation of interleukin-10 production	IDA	12374808
GO:0032736	Process	Positive regulation of interleukin-13 production	IDA	12374808
GO:0032743	Process	Positive regulation of interleukin-2 production	IDA	12374808
GO:0032753	Process	Positive regulation of interleukin-4 production	IDA	12374808
GO:0034122	Process	Negative regulation of toll-like receptor signaling pathway	IEA
GO:0042110	Process	T cell activation	NAS	12374808
GO:0042832	Process	Defense response to protozoan	ISS
GO:0043011	Process	Myeloid dendritic cell differentiation	IEA
GO:0043388	Process	Positive regulation of DNA binding	IEA
GO:0043565	Function	Sequence-specific DNA binding	ISS
GO:0043966	Process	Histone H3 acetylation	IEA
GO:0043967	Process	Histone H4 acetylation	IEA
GO:0045622	Process	Regulation of T-helper cell differentiation	NAS	12374808
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	12374808
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	12374808
GO:0060333	Process	Interferon-gamma-mediated signaling pathway	TAS
GO:0060337	Process	Type I interferon signaling pathway	TAS
GO:0072540	Process	T-helper 17 cell lineage commitment	ISS
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	24995979
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 601900
• HGNC: 6119
• e!Ensembl: ENSG00000137265

Protein

• UniProt ID: Q15306
• Protein name: Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5)
• Protein function: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transducti
• PDB: 2DLL, 6TD4, 7JM4, 7O56, 7OGS, 7OOT, 7RH2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00605	IRF	23 → 128	Interferon regulatory factor transcription factor	Domain
  PF10401	IRF-3	249 → 418	Interferon-regulatory factor 3	Family

• Sequence:

  MNLEGGGRGGEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQ
  DYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISD
  PYKVYRIVPEGAKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRD
  YVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIR
  SAEALAFSDCRLHICLYYREILVKELTTSSPEGCRISHGHTYDASNLDQVLFPYPEDNGQ
  RKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFD
  TQQFLSELQAFAHHGRSLPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQN
  SGHFLRGYDLPEHISNPEDYHRSIRHSSIQE

• Sequence length: 451

Pathways

KEGG:

Th17 cell differentiation

Reactome:

Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Interferon alpha/beta signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma, Childhood asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	30929738, 30929738, 31036433
Basal cell neoplasm	Basal Cell Neoplasm, Basal Cell Cancer	rs587776578, rs587776579, rs2117956624, rs2118419579, rs2118365442, rs2118041703, rs2136689212, rs2118336503, rs1587692888, rs267606984, rs878853849, rs1554695110, rs1064793921, rs1588605348, rs1588568813	31174203, 27539887
Carcinoma	Basal cell carcinoma, Squamous cell carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	31174203, 27539887, 26829030, 31174203
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605	30595370
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	28604730
Lymphoma	Lymphoma, T-Cell, Cutaneous	rs11540652, rs1592119138, rs1592123162, rs1599367044	26192916
Multiple myeloma	Multiple Myeloma	rs11540652, rs78311289, rs121913482, rs397507340, rs121913343, rs121913240, rs121913529, rs730882018, rs1057517992, rs121913527, rs756183569, rs746646631, rs1574706907, rs372078034, rs745380962, rs751524927, rs1575079076, rs1575446356, rs1478603808, rs1578264146, rs1578673280, rs1579484570, rs1579491104, rs1171390403, rs1582867955, rs764264135, rs951047896, rs890521687, rs1581495906, rs1587941402, rs1003155450, rs1588299621, rs1591100766, rs1591693095, rs1029296641, rs1593107841, rs1208575764, rs1593835248, rs1594406727, rs1594966387, rs1595889508, rs1159294530, rs1597073318, rs1135402871, rs1599413207, rs1418268495, rs1212577459, rs1600394490, rs1455074519, rs1603113792, rs1603415028, rs1602247047, rs1603452612	30213928, 18568025
Nasopharyngeal carcinoma	Nasopharyngeal carcinoma	rs200046052	20512145

Unknown
Disease name	Disease term	dbSNP ID	References
Alopecia	Alopecia		28196072
Alopecia, male pattern	Alopecia, Male Pattern		27182965, 29146897
Androgenetic alopecia	Androgenetic Alopecia, Alopecia, Androgenetic, 3, Alopecia, Androgenetic, 2, Alopecia, Androgenetic, 1		27182965, 29146897, 29146897, 27182965
Celiac disease	Celiac Disease	rs2305764, rs35218876	22057235
Erectile dysfunction	Erectile dysfunction		22704111
Granulomatous slack skin	Granulomatous Slack Skin		26192916
Lymphocytic leukemia	Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma		24292274, 26956414, 18758461, 22700719, 23770605, 26956414, 24292274, 18758461, 23770605, 22700719
Melanosis	Melanosis		20585627, 30166351
Progressive supranuclear palsy	Progressive supranuclear palsy		21685912
Skin carcinoma	Squamous cell carcinoma of skin, Skin carcinoma		27424798, 23548203
T-cell lymphoma/leukemia	Adult T-Cell Lymphoma/Leukemia		26437031
Vitiligo	Vitiligo		27723757