ITGA6 (integrin subunit alpha 6)

Gene

• Entrez ID: 3655
• Gene name: Integrin subunit alpha 6
• Gene symbol: ITGA6
• Synonyms: CD49f, ITGA6A, ITGA6B, JEB6, VLA-6
• Chromosome: 2
• Chromosome location: 2q31.1
• Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs863223349	AGA>-	Likely-pathogenic	Coding sequence variant, 3 prime UTR variant, inframe deletion
rs1559159868	A>-	Pathogenic	Coding sequence variant, frameshift variant, intron variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023546	hsa-miR-1-3p	Proteomics	18668040
MIRT023546	hsa-miR-1-3p	Microarray	18668037
MIRT025291	hsa-miR-34a-5p	Proteomics	21566225
MIRT028271	hsa-miR-32-5p	Sequencing	20371350
MIRT028474	hsa-miR-30a-5p	Proteomics	18668040
MIRT046458	hsa-miR-15b-5p	CLASH	23622248
MIRT437371	hsa-miR-29c-3p	Luciferase reporter assay, qRT-PCR, Western blot	24091622
MIRT437371	hsa-miR-29c-3p	Luciferase reporter assay, qRT-PCR, Western blot	24091622
MIRT437371	hsa-miR-29c-3p	Luciferase reporter assay, qRT-PCR, Western blot	24091622
MIRT437371	hsa-miR-29c-3p	Luciferase reporter assay, qRT-PCR, Western blot	24091622
MIRT437372	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR, Western blot	24091622
MIRT437372	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR, Western blot	24091622
MIRT437372	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR, Western blot	24091622
MIRT437372	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR, Western blot	24091622
MIRT437373	hsa-miR-29a-3p	Luciferase reporter assay, qRT-PCR, Western blot	24091622
MIRT437373	hsa-miR-29a-3p	Luciferase reporter assay, qRT-PCR, Western blot	24091622
MIRT437373	hsa-miR-29a-3p	Luciferase reporter assay, qRT-PCR, Western blot	24091622
MIRT437373	hsa-miR-29a-3p	Luciferase reporter assay, qRT-PCR, Western blot	24091622
MIRT437372	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR	23354167
MIRT437372	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR	23354167
MIRT086118	hsa-miR-92b-3p	Luciferase reporter assay, Western blot	28036265
MIRT086118	hsa-miR-92b-3p	Luciferase reporter assay, Western blot	28036265
MIRT735096	hsa-miR-302b-3p	Western blotting, qRT-PCR	32806777
MIRT739675	hsa-miR-181a	CLIP-seq
MIRT739672	hsa-miR-181b	CLIP-seq
MIRT739671	hsa-miR-181c	CLIP-seq
MIRT739674	hsa-miR-181d	CLIP-seq
MIRT739673	hsa-miR-4262	CLIP-seq
MIRT739676	hsa-miR-4436a	CLIP-seq
MIRT1073653	hsa-miR-103a	CLIP-seq
MIRT1073654	hsa-miR-107	CLIP-seq
MIRT1073655	hsa-miR-1224-5p	CLIP-seq
MIRT1073656	hsa-miR-1252	CLIP-seq
MIRT1073657	hsa-miR-1265	CLIP-seq
MIRT1073658	hsa-miR-1267	CLIP-seq
MIRT1073659	hsa-miR-129-5p	CLIP-seq
MIRT1073660	hsa-miR-1301	CLIP-seq
MIRT1073661	hsa-miR-1468	CLIP-seq
MIRT1073662	hsa-miR-1537	CLIP-seq
MIRT1073663	hsa-miR-208a	CLIP-seq
MIRT1073664	hsa-miR-208b	CLIP-seq
MIRT1073665	hsa-miR-224	CLIP-seq
MIRT1073666	hsa-miR-2392	CLIP-seq
MIRT1073667	hsa-miR-25	CLIP-seq
MIRT1073668	hsa-miR-300	CLIP-seq
MIRT1073669	hsa-miR-3157-5p	CLIP-seq
MIRT1073670	hsa-miR-3171	CLIP-seq
MIRT1073671	hsa-miR-3174	CLIP-seq
MIRT1073672	hsa-miR-32	CLIP-seq
MIRT1073673	hsa-miR-3617	CLIP-seq
MIRT1073674	hsa-miR-363	CLIP-seq
MIRT1073675	hsa-miR-3646	CLIP-seq
MIRT1073676	hsa-miR-3658	CLIP-seq
MIRT1073677	hsa-miR-3662	CLIP-seq
MIRT1073678	hsa-miR-367	CLIP-seq
MIRT1073679	hsa-miR-377	CLIP-seq
MIRT1073680	hsa-miR-381	CLIP-seq
MIRT1073681	hsa-miR-3915	CLIP-seq
MIRT1073682	hsa-miR-3976	CLIP-seq
MIRT1073683	hsa-miR-4261	CLIP-seq
MIRT1073684	hsa-miR-4282	CLIP-seq
MIRT1073685	hsa-miR-4468	CLIP-seq
MIRT1073686	hsa-miR-4496	CLIP-seq
MIRT1073687	hsa-miR-450b-5p	CLIP-seq
MIRT1073688	hsa-miR-4519	CLIP-seq
MIRT1073689	hsa-miR-4640-3p	CLIP-seq
MIRT1073690	hsa-miR-4666-3p	CLIP-seq
MIRT1073691	hsa-miR-4678	CLIP-seq
MIRT1073692	hsa-miR-4689	CLIP-seq
MIRT1073693	hsa-miR-4691-3p	CLIP-seq
MIRT1073694	hsa-miR-4722-3p	CLIP-seq
MIRT1073695	hsa-miR-4769-3p	CLIP-seq
MIRT1073696	hsa-miR-4789-5p	CLIP-seq
MIRT1073697	hsa-miR-494	CLIP-seq
MIRT1073698	hsa-miR-499-3p	CLIP-seq
MIRT1073699	hsa-miR-499-5p	CLIP-seq
MIRT1073700	hsa-miR-499a-3p	CLIP-seq
MIRT1073701	hsa-miR-5047	CLIP-seq
MIRT1073702	hsa-miR-507	CLIP-seq
MIRT1073703	hsa-miR-548u	CLIP-seq
MIRT1073704	hsa-miR-557	CLIP-seq
MIRT1073705	hsa-miR-641	CLIP-seq
MIRT1073706	hsa-miR-653	CLIP-seq
MIRT1073707	hsa-miR-92a	CLIP-seq
MIRT1073708	hsa-miR-92b	CLIP-seq
MIRT2018199	hsa-miR-1283	CLIP-seq
MIRT2018200	hsa-miR-142-5p	CLIP-seq
MIRT2018201	hsa-miR-3140-5p	CLIP-seq
MIRT2018202	hsa-miR-340	CLIP-seq
MIRT1073685	hsa-miR-4468	CLIP-seq
MIRT2018203	hsa-miR-4729	CLIP-seq
MIRT2018204	hsa-miR-548g	CLIP-seq
MIRT2018205	hsa-miR-892a	CLIP-seq
MIRT1073657	hsa-miR-1265	CLIP-seq
MIRT2250078	hsa-miR-186	CLIP-seq
MIRT1073663	hsa-miR-208a	CLIP-seq
MIRT1073664	hsa-miR-208b	CLIP-seq
MIRT1073666	hsa-miR-2392	CLIP-seq
MIRT1073667	hsa-miR-25	CLIP-seq
MIRT2250079	hsa-miR-3133	CLIP-seq
MIRT1073672	hsa-miR-32	CLIP-seq
MIRT1073673	hsa-miR-3617	CLIP-seq
MIRT1073674	hsa-miR-363	CLIP-seq
MIRT1073676	hsa-miR-3658	CLIP-seq
MIRT1073678	hsa-miR-367	CLIP-seq
MIRT1073691	hsa-miR-4678	CLIP-seq
MIRT1073698	hsa-miR-499-3p	CLIP-seq
MIRT1073699	hsa-miR-499-5p	CLIP-seq
MIRT1073700	hsa-miR-499a-3p	CLIP-seq
MIRT2250080	hsa-miR-548al	CLIP-seq
MIRT2250081	hsa-miR-548c-3p	CLIP-seq
MIRT1073705	hsa-miR-641	CLIP-seq
MIRT1073707	hsa-miR-92a	CLIP-seq
MIRT1073708	hsa-miR-92b	CLIP-seq
MIRT2389488	hsa-miR-101	CLIP-seq
MIRT2389489	hsa-miR-1243	CLIP-seq
MIRT2389490	hsa-miR-125a-3p	CLIP-seq
MIRT1073657	hsa-miR-1265	CLIP-seq
MIRT2389491	hsa-miR-1285	CLIP-seq
MIRT2389492	hsa-miR-130a	CLIP-seq
MIRT2389493	hsa-miR-130b	CLIP-seq
MIRT2389494	hsa-miR-144	CLIP-seq
MIRT1073663	hsa-miR-208a	CLIP-seq
MIRT1073664	hsa-miR-208b	CLIP-seq
MIRT2389495	hsa-miR-2355-5p	CLIP-seq
MIRT1073667	hsa-miR-25	CLIP-seq
MIRT2389496	hsa-miR-301a	CLIP-seq
MIRT2389497	hsa-miR-301b	CLIP-seq
MIRT2389498	hsa-miR-3126-3p	CLIP-seq
MIRT2018201	hsa-miR-3140-5p	CLIP-seq
MIRT2389499	hsa-miR-3187-5p	CLIP-seq
MIRT1073672	hsa-miR-32	CLIP-seq
MIRT1073673	hsa-miR-3617	CLIP-seq
MIRT2389500	hsa-miR-3622a-3p	CLIP-seq
MIRT2389501	hsa-miR-3622b-3p	CLIP-seq
MIRT1073674	hsa-miR-363	CLIP-seq
MIRT2389502	hsa-miR-3654	CLIP-seq
MIRT1073676	hsa-miR-3658	CLIP-seq
MIRT2389503	hsa-miR-3659	CLIP-seq
MIRT2389504	hsa-miR-3665	CLIP-seq
MIRT2389505	hsa-miR-3666	CLIP-seq
MIRT1073678	hsa-miR-367	CLIP-seq
MIRT2389506	hsa-miR-4280	CLIP-seq
MIRT2389507	hsa-miR-4295	CLIP-seq
MIRT2389508	hsa-miR-4328	CLIP-seq
MIRT1073688	hsa-miR-4519	CLIP-seq
MIRT2389509	hsa-miR-454	CLIP-seq
MIRT2389510	hsa-miR-4658	CLIP-seq
MIRT2389511	hsa-miR-4704-5p	CLIP-seq
MIRT2389512	hsa-miR-4738-3p	CLIP-seq
MIRT1073698	hsa-miR-499-3p	CLIP-seq
MIRT1073699	hsa-miR-499-5p	CLIP-seq
MIRT1073700	hsa-miR-499a-3p	CLIP-seq
MIRT2389513	hsa-miR-574-5p	CLIP-seq
MIRT2389514	hsa-miR-612	CLIP-seq
MIRT1073705	hsa-miR-641	CLIP-seq
MIRT2389515	hsa-miR-657	CLIP-seq
MIRT2389516	hsa-miR-891b	CLIP-seq
MIRT1073707	hsa-miR-92a	CLIP-seq
MIRT1073708	hsa-miR-92b	CLIP-seq
MIRT2553614	hsa-miR-297	CLIP-seq
MIRT2553615	hsa-miR-3149	CLIP-seq
MIRT1073685	hsa-miR-4468	CLIP-seq
MIRT1073691	hsa-miR-4678	CLIP-seq
MIRT2389512	hsa-miR-4738-3p	CLIP-seq
MIRT2553616	hsa-miR-586	CLIP-seq
MIRT2553617	hsa-miR-643	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
POU5F1	Activation	22311737
SOX2	Activation	22311737

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	2649503, 9360996, 15466886, 21880726
GO:0005886	Component	Plasma membrane	IDA	21310825
GO:0005886	Component	Plasma membrane	TAS
GO:0005912	Component	Adherens junction	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007044	Process	Cell-substrate junction assembly	TAS	9185503
GO:0007229	Process	Integrin-mediated signaling pathway	IEA
GO:0009986	Component	Cell surface	HDA	23658023
GO:0009986	Component	Cell surface	IDA	19933311, 20563599, 23154389
GO:0010668	Process	Ectodermal cell differentiation	IEP	23154389
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IEA
GO:0010976	Process	Positive regulation of neuron projection development	ISS
GO:0030175	Component	Filopodium	IEA
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0030335	Process	Positive regulation of cell migration	IMP	24091622
GO:0031581	Process	Hemidesmosome assembly	TAS
GO:0031589	Process	Cell-substrate adhesion	IMP	19933311
GO:0031994	Function	Insulin-like growth factor I binding	IDA	22351760
GO:0034676	Component	Integrin alpha6-beta4 complex	IEA
GO:0035878	Process	Nail development	IMP	23496044
GO:0038132	Function	Neuregulin binding	IDA	20682778
GO:0042327	Process	Positive regulation of phosphorylation	IMP	21310825
GO:0043065	Process	Positive regulation of apoptotic process	IGI	19364818
GO:0043236	Function	Laminin binding	IEA
GO:0043547	Process	Positive regulation of GTPase activity	IMP	25911094
GO:0043589	Process	Skin morphogenesis	IMP	23496044
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	21310825
GO:0046872	Function	Metal ion binding	IEA
GO:0050900	Process	Leukocyte migration	TAS
GO:0071407	Process	Cellular response to organic cyclic compound	IEA
GO:0098609	Process	Cell-cell adhesion	IEA
GO:2001237	Process	Negative regulation of extrinsic apoptotic signaling pathway	IMP	21310825

Other IDs

• MIM: 147556
• HGNC: 6142
• e!Ensembl: ENSG00000091409

Protein

• UniProt ID: P23229
• Protein name: Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)]
• Protein function: Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4)
• PDB: 7CEB, 7CEC
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01839	FG-GAP	355 → 393	FG-GAP repeat	Repeat
  PF08441	Integrin_alpha2	503 → 978	Integrin alpha	Family

• Sequence:

  MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKR
  LLLVGAPRAEALPLQRANRTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQ
  SQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLR
  GHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVG
  GETEHDESLVPVPANSYLGLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFS
  LDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVA
  VVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAV
  KNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMD
  LDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKS
  CFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKV
  CMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHF
  LKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNS
  PSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGN
  PFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSG
  VAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISN
  GKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAER
  KYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDV
  TAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLALLVFILWKCGF
  FKRSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKKQWITKWNENESYS

• Sequence length: 1130

Pathways

KEGG:

PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Cytoskeleton in muscle cells
Toxoplasmosis
Human papillomavirus infection
Pathways in cancer
Small cell lung cancer
Hypertrophic cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy
Dilated cardiomyopathy

Reactome:

Assembly of collagen fibrils and other multimeric structures
Basigin interactions
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
Type I hemidesmosome assembly

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Anonychia	ANONYCHIA	rs74315420, rs74315421, rs74315422, rs74315423, rs387907026, rs387907027, rs387907028, rs780261665, rs775644973, rs370554150
Aplasia cutis congenita	Aplasia Cutis Congenita	rs587777706
Arthrogryposis multiplex congenita	Arthrogryposis	rs1586285494, rs80358233, rs137853305, rs1559154278, rs398124167, rs398124172, rs587780399, rs786204576, rs786204430, rs769345284, rs749355583, rs793888524, rs793888525, rs878854368, rs555445835, rs758105619, rs886041851, rs794727136, rs755239192, rs760715690, rs773952935, rs112610938, rs1057516676, rs1057516996, rs780022652, rs1057517399, rs1057517360, rs1057518353, rs1057517977, rs1064796311, rs779232987, rs775997446, rs1064797093, rs1064797094, rs1064797095, rs755500591, rs754272530, rs758247804, rs200731870, rs747179265, rs1553740233, rs776569219, rs375628303, rs775631800, rs781667543, rs1553548666, rs928945364, rs763364977, rs1458048713, rs1553883480, rs1472403020, rs1336053002, rs202048855, rs1197561990, rs755531536, rs1554112524, rs762133567, rs1553555882, rs934111355, rs1255744452, rs1366269616, rs1555734932, rs1553548207, rs752582527, rs1257495033, rs113525641, rs755863625, rs374929094, rs539819851, rs1366853918, rs1218073575, rs1553537512, rs1553552384, rs747564597, rs776059611, rs756726488, rs1357811155, rs1553939600, rs772009599, rs1255445731, rs1011425121, rs1553561697, rs1553551748, rs1553552413, rs760935667, rs1553603400, rs1302373559, rs1389892619, rs1553710982, rs757157808, rs1180339426, rs761964375, rs1235589246, rs1443738549, rs1553934586, rs1553934597, rs1553603437, rs749452641, rs1553904694, rs754369875, rs112517981, rs774495973, rs1428597732, rs746999970, rs113091511, rs1553603958, rs1553469502, rs770797137, rs1553608621, rs1159756073, rs776167256, rs778593702, rs1553601066, rs1553689774, rs760768475, rs1559296376, rs201636991, rs1559039815, rs748922882, rs772366030, rs1207534366, rs1259297878, rs762780413, rs1559360386, rs1559940778, rs760200697, rs1344099907, rs750900690, rs1559168230, rs746177326, rs761067911, rs1323364980, rs537560378, rs1319778592, rs1340063197, rs1577833924, rs750585238, rs1600470099, rs1575714905, rs1576203853, rs779909544, rs760124743, rs2096362304, rs1212374733, rs1490309743, rs767709270, rs1374971806, rs2096491549, rs2097886912, rs2099021112, rs2097758221, rs1474341248, rs925947627
Epidermolysis bullosa	Epidermolysis bullosa with pyloric atresia	rs137852757, rs80356682, rs80356680, rs786205094, rs121912482, rs786205095, rs587776813, rs121912487, rs587776814, rs1558092501, rs80356683, rs118203899, rs118203900, rs1558095794, rs118203901, rs1558088792, rs121912466, rs2147483647, rs746056280, rs121912832, rs121912833, rs121912834, rs121912836, rs121912837, rs759990189, rs121912839, rs121912844, rs121912845, rs1575495784, rs121912848, rs121912849, rs121912851, rs121912852, rs121912853, rs121912854, rs121912855, rs121912769, rs1564673127, rs121912770, rs753898533, rs121912771, rs1589562891, rs2134563935, rs2134581672, rs121912772, rs121912773, rs121912774, rs121912856, rs201551805, rs769967565, rs786204774, rs797045084, rs886039330, rs886039412, rs1553277702, rs886041187, rs368007918, rs886041186, rs766902987, rs886041555, rs752657203, rs757415879, rs886058642, rs752317971, rs201307156, rs1057517096, rs774133746, rs772421306, rs758886532, rs144023803, rs1057517723, rs760063197, rs916512411, rs772381373, rs768128088, rs374718902, rs762162799, rs1064793916, rs780623622, rs747522386, rs1064793760, rs775196743, rs1131691385, rs201940939, rs200972872, rs139318843, rs1368134215, rs1203706188, rs772038362, rs1553281335, rs1181742615, rs1553853022, rs1553612928, rs1055680335, rs1057517023, rs760094345, rs1560241522, rs199527325, rs751535193, rs767539005, rs775244527, rs769808745, rs1032335328, rs1478395810, rs777672897, rs1575466699, rs776841521, rs1589572214, rs761388039, rs769294243, rs761927109, rs754621187	9185503, 26817667
Junctional epidermolysis bullosa with pyloric atresia	Junctional epidermolysis bullosa with pyloric atresia	rs794726676, rs121912461, rs121912462, rs80338755, rs121912463, rs147222357, rs121912464, rs121912465, rs1434530468, rs121912467, rs121912468, rs758551913, rs879255260, rs886041205, rs752657203, rs772142634, rs551348450, rs545619665
Renal dysplasia	Renal Cell Dysplasia, Renal dysplasia	rs387907123
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	17379860

Unknown
Disease name	Disease term	dbSNP ID	References
Accessory kidney	Accessory kidney
Congenital pyloric atresia	Congenital pyloric atresia
Cystitis	Cystitis
Dental enamel hypoplasia	Dental Enamel Hypoplasia
Ectropion	Ectropion
Esophageal atresia	Esophageal Atresia
Hydronephrosis	Hydronephrosis
Intestinal atresia	Intestinal Atresia
Junctional split	Junctional split
Nail diseases	NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9
Nail dysplasia	Nail dysplasia
Nail dystrophy	Dystrophia unguium
Pterygium	Pterygium
Ureterocele	Ureterocele
Urogenital abnormalities	Urogenital Abnormalities