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INPP5B (inositol polyphosphate-5-phosphatase B)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3633
Gene nameGene Name - the full gene name approved by the HGNC.
Inositol polyphosphate-5-phosphatase B
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
INPP5B
SynonymsGene synonyms aliases
5PTase
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p34.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and assoc
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030250 hsa-miR-26b-5p Microarray 19088304
MIRT692726 hsa-miR-1537-3p HITS-CLIP 23313552
MIRT692725 hsa-miR-187-3p HITS-CLIP 23313552
MIRT692724 hsa-miR-1284 HITS-CLIP 23313552
MIRT692723 hsa-miR-4796-5p HITS-CLIP 23313552
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001701 Process In utero embryonic development IEA
GO:0004439 Function Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA 21873635
GO:0004439 Function Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA 7721860
GO:0005515 Function Protein binding IPI 21233288, 25869668
GO:0005793 Component Endoplasmic reticulum-Golgi intermediate compartment IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P32019
Protein name Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)
Protein function Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.
PDB 3MTC , 3N9V , 4CML , 5A7I , 5A7J
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16776 INPP5B_PH
1 149
Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain
Domain
PF03372 Exo_endo_phos
350 629
Endonuclease/Exonuclease/phosphatase family
Domain
PF00620 RhoGAP
830 972
RhoGAP domain
Domain
Sequence
MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRM
AITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRM
FLHEVARACPGFDSATRDPEFLWLSRYRC
AELELEMPTPRGCNSALVTWPGYATIGGGRY
PSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEE
AGREMSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITD
MVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPK
ECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVK
LIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSH
LAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKV
KKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAP
AWCDRILWKGKNITQLSYQSHMALKTSDH
KPVSSVFDIGVRVVNDELYRKTLEEIVRSLD
KMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLN
ANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYL
PSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYL
YRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICY
STYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFG
SLLLRNPAGHQK
LDMTEKKKAQEFIHQFLCNPL
Sequence length 993
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
  Synthesis of IP2, IP, and Ins in the cytosol
Synthesis of IP3 and IP4 in the cytosol
Rho GTPase cycle
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Dent`s disease Dent Disease 2 rs137853262, rs137853263, rs151340620, rs151340621, rs151340622, rs151340623, rs151340625, rs151340626, rs151340630, rs1569540382, rs2124412922, rs2124388022, rs273585644, rs137853846, rs797044808, rs797044810, rs797044811, rs797044812, rs797044813, rs797044814, rs797044815, rs776743373, rs1057521742, rs1557194353, rs1557192084, rs1049618423, rs773387490, rs1556338810, rs1569540047, rs1569540369, rs1602819835 28018608
Hypothyroidism Hypothyroidism rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605 30595370

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