INPP5B (inositol polyphosphate-5-phosphatase B)
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Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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3633 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Inositol polyphosphate-5-phosphatase B |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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INPP5B |
SynonymsGene synonyms aliases
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5PTase |
ChromosomeChromosome number
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1 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1p34.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and assoc |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
P32019 |
Protein name |
Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase) |
Protein function |
Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. |
PDB |
3MTC
,
3N9V
,
4CML
,
5A7I
,
5A7J
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF16776 |
INPP5B_PH |
1 → 149 |
Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain |
Domain |
PF03372 |
Exo_endo_phos |
350 → 629 |
Endonuclease/Exonuclease/phosphatase family |
Domain |
PF00620 |
RhoGAP |
830 → 972 |
RhoGAP domain |
Domain |
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Sequence |
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Sequence length |
993 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Dent`s disease |
Dent Disease 2 |
rs137853262, rs137853263, rs151340620, rs151340621, rs151340622, rs151340623, rs151340625, rs151340626, rs151340630, rs1569540382, rs2124412922, rs2124388022, rs273585644, rs137853846, rs797044808, rs797044810, rs797044811, rs797044812, rs797044813, rs797044814, rs797044815, rs776743373, rs1057521742, rs1557194353, rs1557192084, rs1049618423, rs773387490, rs1556338810, rs1569540047, rs1569540369, rs1602819835 |
28018608 |
Hypothyroidism |
Hypothyroidism |
rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605 |
30595370 |
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