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CXCL10 (C-X-C motif chemokine ligand 10)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3627
Gene nameGene Name - the full gene name approved by the HGNC.
C-X-C motif chemokine ligand 10
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CXCL10
SynonymsGene synonyms aliases
C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1
ChromosomeChromosome number
4
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q21.1
SummarySummary of gene provided in NCBI Entrez Gene.
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT438112 hsa-miR-21-5p qRT-PCR 24889251
MIRT438109 hsa-miR-21-5p qRT-PCR 24889251
MIRT438110 hsa-miR-21-5p qRT-PCR 24889251
MIRT438108 hsa-miR-21-5p qRT-PCR 24889251
MIRT438112 hsa-miR-21-5p qRT-PCR 24889251
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
IRF1 Activation 19342664
IRF3 Activation 18691624;24257594
IRF7 Activation 24701034
NFKB1 Activation 16982926;20164184;24701034
NFKB1 Unknown 16818736;19479051;24257594
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0005102 Function Signaling receptor binding TAS 10201891
GO:0005515 Function Protein binding IPI 18275857, 21314817, 28381538
GO:0005576 Component Extracellular region IDA 20041150
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P02778
Protein name C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) [Cleaved into: CXCL10(1-73)]
Protein function Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:11157474
PDB 1LV9 , 1O7Y , 1O7Z , 1O80 , 8K2X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8
28 → 89
Small cytokines (intecrine/chemokine), interleukin-8 like
 Domain
Sequence
Sequence length 98
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
IL-17 signaling pathway
TNF signaling pathway
Hepatitis C
Influenza A
Epstein-Barr virus infection
Coronavirus disease - COVID-19 		  Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Colonic neoplasms Malignant tumor of colon, Colonic Neoplasms rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 15059925
Dermatitis Dermatitis, Atopic rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 18249437
Unknown
Disease name Disease term dbSNP ID References
Alopecia areata Alopecia Areata 22358057
Biliary cirrhosis Biliary cirrhosis, Biliary Cirrhosis, Primary, 1, Primary biliary cirrhosis 18422935
Celiac disease Celiac Disease rs2305764, rs35218876 30097691
Cerebral ischemia Brain Ischemia 15829914

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