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INHBA (inhibin subunit beta A)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3624
Gene nameGene Name - the full gene name approved by the HGNC.
Inhibin subunit beta A
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
INHBA
SynonymsGene synonyms aliases
EDF, FRP
ChromosomeChromosome number
7
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p14.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activa
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019457 hsa-miR-148b-3p Microarray 17612493
MIRT047412 hsa-miR-10b-5p CLASH 23622248
MIRT038928 hsa-miR-31-3p CLASH 23622248
MIRT484725 hsa-miR-548ac HITS-CLIP 21572407
MIRT484724 hsa-miR-548bb-3p HITS-CLIP 21572407
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle IDA 9884026
GO:0001541 Process Ovarian follicle development IGI 10932194
GO:0001541 Process Ovarian follicle development NAS 9166111
GO:0001942 Process Hair follicle development IGI 10932194
GO:0002244 Process Hematopoietic progenitor cell differentiation IDA 15451575
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P08476
Protein name Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF)
Protein function Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve
PDB 1NYS , 1NYU , 1S4Y , 2ARP , 2ARV , 2B0U , 2P6A , 3B4V , 4MID , 5HLY , 5HLZ , 6Y6N , 6Y6O , 7OLY , 7U5P , 9I5W
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00688 TGFb_propeptide
46 295
TGF-beta propeptide
Family
PF00019 TGF_beta
320 425
Transforming growth factor beta like domain
Domain
Sequence
Sequence length 426
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Cytokine-cytokine receptor interaction
TGF-beta signaling pathway
Signaling pathways regulating pluripotency of stem cells
  Signaling by Activin
Glycoprotein hormones
Antagonism of Activin by Follistatin
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Liver failure Liver Failure, Acute rs118203990, rs118203991, rs118203992, rs387907022, rs201861847, rs796065037, rs759315662, rs368196005, rs796052121, rs369437593, rs367683258, rs766314948, rs368085185, rs770446752, rs753039116, rs776797592, rs1490906786, rs1562849964, rs759960319, rs776597537, rs375350359, rs1573008071, rs1601977105, rs1174791046, rs1019313682 12560755
Ovarian papillary adenocarcinoma Ovarian papillary adenocarcinoma rs80357729, rs1593882341
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 26198764
Unknown
Disease name Disease term dbSNP ID References
Adenocarcinoma of ovary Adenocarcinoma of ovary
Cervical lymphadenopathy Cervical lymphadenopathy
Endometrial neoplasms Uterine Neoplasms 22228119
Endometrial cancer Uterine Cancer 22228119

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