INHBA (inhibin subunit beta A)
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Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
3624 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Inhibin subunit beta A |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
INHBA |
SynonymsGene synonyms aliases
|
EDF, FRP |
ChromosomeChromosome number
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7 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
7p14.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activa |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
P08476 |
Protein name |
Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF) |
Protein function |
Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve |
PDB |
1NYS
,
1NYU
,
1S4Y
,
2ARP
,
2ARV
,
2B0U
,
2P6A
,
3B4V
,
4MID
,
5HLY
,
5HLZ
,
6Y6N
,
6Y6O
,
7OLY
,
7U5P
,
9I5W
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00688 |
TGFb_propeptide |
46 → 295 |
TGF-beta propeptide |
Family |
PF00019 |
TGF_beta |
320 → 425 |
Transforming growth factor beta like domain |
Domain |
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Sequence |
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Sequence length |
426 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Liver failure |
Liver Failure, Acute |
rs118203990, rs118203991, rs118203992, rs387907022, rs201861847, rs796065037, rs759315662, rs368196005, rs796052121, rs369437593, rs367683258, rs766314948, rs368085185, rs770446752, rs753039116, rs776797592, rs1490906786, rs1562849964, rs759960319, rs776597537, rs375350359, rs1573008071, rs1601977105, rs1174791046, rs1019313682 |
12560755 |
Ovarian papillary adenocarcinoma |
Ovarian papillary adenocarcinoma |
rs80357729, rs1593882341 |
|
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
26198764 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Adenocarcinoma of ovary |
Adenocarcinoma of ovary |
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Cervical lymphadenopathy |
Cervical lymphadenopathy |
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Endometrial neoplasms |
Uterine Neoplasms |
|
22228119 |
Endometrial cancer |
Uterine Cancer |
|
22228119 |
Endometriosis |
Endometriosis |
rs1800629, rs1143634 |
|
Intestinal obstruction |
Intestinal Obstruction |
|
|
Leiomyoma |
Fibroid Tumor |
|
22228119 |
Ovarian adenocarcinoma |
Ovarian adenocarcinoma |
|
24302632 |
Ovarian mucinous tumor |
Ovarian mucinous tumor |
|
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Pleural effusion |
Pleural effusion disorder |
|
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Uterine fibroids |
Uterine Fibroids |
|
22228119 |
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