IMPA2 (inositol monophosphatase 2)

Gene

• Entrez ID: 3613
• Gene name: Inositol monophosphatase 2
• Gene symbol: IMPA2
• Synonyms: -
• Chromosome: 18
• Chromosome location: 18p11.21
• Summary: This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disord

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT042179	hsa-miR-484	CLASH	23622248
MIRT649264	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT649263	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT649261	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT649262	hsa-miR-4421	HITS-CLIP	23824327
MIRT649260	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT649257	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT649256	hsa-miR-3672	HITS-CLIP	23824327
MIRT649255	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT664663	hsa-miR-8055	HITS-CLIP	23824327
MIRT649253	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT649264	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT649263	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT649261	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT649262	hsa-miR-4421	HITS-CLIP	23824327
MIRT649260	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT649259	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT649258	hsa-miR-1976	HITS-CLIP	23824327
MIRT649257	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT649256	hsa-miR-3672	HITS-CLIP	23824327
MIRT649255	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT649253	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT649264	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT649263	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT649261	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT649262	hsa-miR-4421	HITS-CLIP	23824327
MIRT649260	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT649257	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT649256	hsa-miR-3672	HITS-CLIP	23824327
MIRT649255	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT664663	hsa-miR-8055	HITS-CLIP	23824327
MIRT649253	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT649264	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT649263	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT649261	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT649262	hsa-miR-4421	HITS-CLIP	23824327
MIRT649260	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT649259	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT649258	hsa-miR-1976	HITS-CLIP	23824327
MIRT649257	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT649256	hsa-miR-3672	HITS-CLIP	23824327
MIRT649255	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT649253	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT1065793	hsa-miR-137	CLIP-seq
MIRT1065794	hsa-miR-146a	CLIP-seq
MIRT1065795	hsa-miR-146b-5p	CLIP-seq
MIRT1065796	hsa-miR-25	CLIP-seq
MIRT1065797	hsa-miR-27a	CLIP-seq
MIRT1065798	hsa-miR-27b	CLIP-seq
MIRT1065799	hsa-miR-2861	CLIP-seq
MIRT1065800	hsa-miR-32	CLIP-seq
MIRT1065801	hsa-miR-328	CLIP-seq
MIRT1065802	hsa-miR-33a	CLIP-seq
MIRT1065803	hsa-miR-33b	CLIP-seq
MIRT1065804	hsa-miR-3591-3p	CLIP-seq
MIRT1065805	hsa-miR-363	CLIP-seq
MIRT1065806	hsa-miR-367	CLIP-seq
MIRT1065807	hsa-miR-3918	CLIP-seq
MIRT1065808	hsa-miR-4251	CLIP-seq
MIRT1065809	hsa-miR-4324	CLIP-seq
MIRT1065810	hsa-miR-4512	CLIP-seq
MIRT1065811	hsa-miR-4723-5p	CLIP-seq
MIRT1065812	hsa-miR-4728-5p	CLIP-seq
MIRT1065813	hsa-miR-4768-3p	CLIP-seq
MIRT1065814	hsa-miR-513a-5p	CLIP-seq
MIRT1065815	hsa-miR-589	CLIP-seq
MIRT1065816	hsa-miR-92a	CLIP-seq
MIRT1065817	hsa-miR-92b	CLIP-seq
MIRT2015634	hsa-miR-3622b-5p	CLIP-seq
MIRT2015635	hsa-miR-4252	CLIP-seq
MIRT2015636	hsa-miR-4468	CLIP-seq
MIRT2015637	hsa-miR-4720-5p	CLIP-seq
MIRT2015638	hsa-miR-4799-3p	CLIP-seq
MIRT2247999	hsa-miR-214	CLIP-seq
MIRT1065797	hsa-miR-27a	CLIP-seq
MIRT1065798	hsa-miR-27b	CLIP-seq
MIRT2248000	hsa-miR-3168	CLIP-seq
MIRT1065804	hsa-miR-3591-3p	CLIP-seq
MIRT2248001	hsa-miR-361-5p	CLIP-seq
MIRT2248002	hsa-miR-3619-5p	CLIP-seq
MIRT2248003	hsa-miR-4277	CLIP-seq
MIRT2248004	hsa-miR-4291	CLIP-seq
MIRT2248005	hsa-miR-4299	CLIP-seq
MIRT2248006	hsa-miR-4314	CLIP-seq
MIRT1065809	hsa-miR-4324	CLIP-seq
MIRT2248007	hsa-miR-4509	CLIP-seq
MIRT2248008	hsa-miR-4667-5p	CLIP-seq
MIRT2248009	hsa-miR-4700-5p	CLIP-seq
MIRT2248010	hsa-miR-4710	CLIP-seq
MIRT2248011	hsa-miR-4744	CLIP-seq
MIRT1065813	hsa-miR-4768-3p	CLIP-seq
MIRT2248012	hsa-miR-4778-5p	CLIP-seq
MIRT2248013	hsa-miR-4792	CLIP-seq
MIRT2248014	hsa-miR-4799-5p	CLIP-seq
MIRT1065814	hsa-miR-513a-5p	CLIP-seq
MIRT2248015	hsa-miR-556-3p	CLIP-seq
MIRT2248016	hsa-miR-637	CLIP-seq
MIRT2248017	hsa-miR-761	CLIP-seq
MIRT2248018	hsa-miR-922	CLIP-seq
MIRT1065804	hsa-miR-3591-3p	CLIP-seq
MIRT2248005	hsa-miR-4299	CLIP-seq
MIRT2248010	hsa-miR-4710	CLIP-seq
MIRT2248013	hsa-miR-4792	CLIP-seq
MIRT2551748	hsa-miR-4637	CLIP-seq
MIRT2551749	hsa-miR-490-3p	CLIP-seq
MIRT2551750	hsa-miR-649	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IDA	17068342
GO:0005829	Component	Cytosol	TAS
GO:0006020	Process	Inositol metabolic process	IBA	21873635
GO:0006021	Process	Inositol biosynthetic process	IEA
GO:0006796	Process	Phosphate-containing compound metabolic process	TAS	9322233
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0008934	Function	Inositol monophosphate 1-phosphatase activity	IBA	21873635
GO:0008934	Function	Inositol monophosphate 1-phosphatase activity	IDA	17068342
GO:0042803	Function	Protein homodimerization activity	IDA	17068342
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0046854	Process	Phosphatidylinositol phosphorylation	IEA
GO:0046855	Process	Inositol phosphate dephosphorylation	IBA	21873635
GO:0046855	Process	Inositol phosphate dephosphorylation	IDA	17068342
GO:0046872	Function	Metal ion binding	IEA
GO:0052832	Function	Inositol monophosphate 3-phosphatase activity	IEA
GO:0052833	Function	Inositol monophosphate 4-phosphatase activity	IEA

Other IDs

• MIM: 605922
• HGNC: 6051
• e!Ensembl: ENSG00000141401

Protein

• UniProt ID: O14732
• Protein name: Inositol monophosphatase 2 (IMP 2) (IMPase 2) (EC 3.1.3.25) (Inositol-1(or 4)-monophosphatase 2) (Myo-inositol monophosphatase A2)
• Protein function: Phosphatase that can use myo-inositol monophosphates, myo-inositol 1,4-diphosphate, scyllo-inositol-1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate and 2'-AMP as substrates in vitro (PubMed:17068342). It is likely that IMPA2 has an a
• PDB: 2CZH, 2CZI, 2CZK, 2DDK, 2FVZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00459	Inositol_P	16 → 282	Inositol monophosphatase family	Family

• Sequence:

  MKPSGEDQAALAAGPWEECFQAAVQLALRAGQIIRKALTEEKRVSTKTSAADLVTETDHL
  VEDLIISELRERFPSHRFIAEEAAASGAKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSI
  GFAVRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTEIGPKRDP
  ATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYYQFGLHCWDLAAATVIIR
  EAGGIVIDTSGGPLDLMACRVVAASTREMAMLIAQALQTINYGRDDEK

• Sequence length: 288

Pathways

KEGG:

Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system

Reactome:

Synthesis of IP2, IP, and Ins in the cytosol

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Febrile seizures	Febrile Convulsions	rs121909761, rs121909672, rs121909673, rs121909674, rs1561645243, rs267606837, rs796052510, rs1553553485, rs1554097890, rs1554101202, rs1554098226, rs765574676, rs1045493304	15557493
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	11317223
Seizure	Seizure, Febrile, Simple, Seizure, Febrile, Complex	rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061, rs121912707, rs118192249, rs118192251, rs118192217, rs118192218, rs118192219, rs118192222, rs118192226, rs118192228, rs118192234, rs118192236, rs118192235, rs118192241, rs118192242, rs118192185, rs118192188, rs118192245, rs118192246, rs118192186, rs118192194, rs118192197, rs118192199, rs118192201, rs118192202, rs118192203, rs118192204, rs118192205, rs118192206, rs118192208, rs118192211, rs118192216, rs118192239, rs387906684, rs387906686, rs387906687, rs1596893185, rs387907126, rs387907281, rs397515405, rs587778771, rs730882067, rs730882073, rs397514579, rs397514582, rs587776976, rs398122394, rs121918784, rs121918751, rs121918735, rs398123588, rs587780450, rs61749751, rs587777620, rs727503974, rs730882124, rs794726710, rs794726697, rs794726799, rs794727444, rs794727740, rs796053166, rs794726825, rs796052676, rs796053219, rs796053220, rs796053228, rs796052653, rs759584387, rs796052650, rs796052641, rs796052626, rs796052623, rs796052663, rs796052615, rs796052802, rs797044999, rs797045047, rs797045942, rs797045941, rs118192212, rs797044938, rs777257591, rs864321712, rs879255652, rs886039268, rs886039517, rs886039529, rs199497486, rs886039496, rs886039903, rs886041300, rs769827124, rs886041339, rs886041591, rs587783092, rs1555850151, rs1057516123, rs1057516121, rs1057516115, rs1057516111, rs1057516106, rs1057516105, rs756921902, rs1057516089, rs1057516087, rs1057516080, rs1057516076, rs1060499544, rs1555850512, rs1057517919, rs118192231, rs1057520413, rs1060503101, rs1064796294, rs1064794981, rs1064794632, rs1064797245, rs1131691830, rs1131692231, rs1131691936, rs1554626549, rs1553579225, rs1553531385, rs121918736, rs1554898088, rs1553579282, rs763353895, rs1553463119, rs1554093891, rs77838305, rs1555408401, rs1554627439, rs1554097873, rs1555850403, rs1064794719, rs1315483224, rs1567134495, rs770187706, rs1057518555, rs1576983339, rs1574192005, rs1459374430, rs1586800133, rs1574641522, rs1572096837, rs1572630269, rs1574554892, rs1574556643, rs1574571769, rs1574641605, rs1574697769, rs1574716524, rs1574746733, rs1574746935, rs1574752700, rs1574754680, rs863225030, rs1601545088, rs1600714727, rs1371059392, rs1600767259, rs1339542565, rs1600785769, rs2065899210, rs1600732174, rs1162306056, rs879255709, rs1900111672, rs2066910297, rs1554122080, rs796052941, rs1600789325, rs2082695884, rs1737677036, rs1737495759, rs868389022, rs1737685202, rs1737672350, rs762737130	15557493

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		20153384, 17251911, 16841073, 20800640, 17340635
Endometrioma	Endometrioma		20864642
Endometriosis	Endometriosis	rs1800629, rs1143634	20864642
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	16841073
Mood disorder	Mood Disorders		11673796, 16841073
Stroke	Cerebrovascular accident		17434096