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AQP3 (aquaporin 3 (Gill blood group))

Gene

360

Aquaporin 3 (Gill blood group)

AQP3

AQP-3, GIL

9p13.3

This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting d

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1347380973	C>G,T	Affects	Splice donor variant, intron variant

Show/Hide all(227)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040256	hsa-miR-615-3p	CLASH	23622248
MIRT053376	hsa-miR-874-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23800944
MIRT053376	hsa-miR-874-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23800944
MIRT053376	hsa-miR-874-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23800944
MIRT053376	hsa-miR-874-3p	Luciferase reporter assay, qRT-PCR, Western blot	24462679
MIRT438336	hsa-miR-185-5p	Luciferase reporter assay, Western blot	24070899
MIRT438336	hsa-miR-185-5p	Luciferase reporter assay, Western blot	24070899
MIRT695357	hsa-miR-548n	HITS-CLIP	23313552
MIRT695356	hsa-miR-548az-5p	HITS-CLIP	23313552
MIRT695355	hsa-miR-548t-5p	HITS-CLIP	23313552
MIRT695354	hsa-miR-548a-5p	HITS-CLIP	23313552
MIRT695353	hsa-miR-548ab	HITS-CLIP	23313552
MIRT695352	hsa-miR-548ad-5p	HITS-CLIP	23313552
MIRT695351	hsa-miR-548ae-5p	HITS-CLIP	23313552
MIRT695350	hsa-miR-548ak	HITS-CLIP	23313552
MIRT695349	hsa-miR-548am-5p	HITS-CLIP	23313552
MIRT695348	hsa-miR-548ap-5p	HITS-CLIP	23313552
MIRT695347	hsa-miR-548aq-5p	HITS-CLIP	23313552
MIRT695346	hsa-miR-548ar-5p	HITS-CLIP	23313552
MIRT695345	hsa-miR-548as-5p	HITS-CLIP	23313552
MIRT695344	hsa-miR-548au-5p	HITS-CLIP	23313552
MIRT695343	hsa-miR-548ay-5p	HITS-CLIP	23313552
MIRT695342	hsa-miR-548b-5p	HITS-CLIP	23313552
MIRT695341	hsa-miR-548bb-5p	HITS-CLIP	23313552
MIRT695340	hsa-miR-548c-5p	HITS-CLIP	23313552
MIRT695339	hsa-miR-548d-5p	HITS-CLIP	23313552
MIRT695338	hsa-miR-548h-5p	HITS-CLIP	23313552
MIRT695337	hsa-miR-548i	HITS-CLIP	23313552
MIRT695336	hsa-miR-548j-5p	HITS-CLIP	23313552
MIRT695335	hsa-miR-548o-5p	HITS-CLIP	23313552
MIRT695334	hsa-miR-548w	HITS-CLIP	23313552
MIRT695333	hsa-miR-548y	HITS-CLIP	23313552
MIRT695332	hsa-miR-559	HITS-CLIP	23313552
MIRT695331	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT695330	hsa-miR-3125	HITS-CLIP	23313552
MIRT695329	hsa-miR-3916	HITS-CLIP	23313552
MIRT695328	hsa-miR-6859-5p	HITS-CLIP	23313552
MIRT695327	hsa-miR-3159	HITS-CLIP	23313552
MIRT695326	hsa-miR-3163	HITS-CLIP	23313552
MIRT695325	hsa-miR-889-3p	HITS-CLIP	23313552
MIRT695324	hsa-miR-877-5p	HITS-CLIP	23313552
MIRT695323	hsa-miR-6869-5p	HITS-CLIP	23313552
MIRT695322	hsa-miR-653-5p	HITS-CLIP	23313552
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT664406	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT664405	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT664404	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT664403	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT626527	hsa-miR-4643	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT695357	hsa-miR-548n	HITS-CLIP	23313552
MIRT695356	hsa-miR-548az-5p	HITS-CLIP	23313552
MIRT695355	hsa-miR-548t-5p	HITS-CLIP	23313552
MIRT695354	hsa-miR-548a-5p	HITS-CLIP	23313552
MIRT695353	hsa-miR-548ab	HITS-CLIP	23313552
MIRT695352	hsa-miR-548ad-5p	HITS-CLIP	23313552
MIRT695351	hsa-miR-548ae-5p	HITS-CLIP	23313552
MIRT695350	hsa-miR-548ak	HITS-CLIP	23313552
MIRT695349	hsa-miR-548am-5p	HITS-CLIP	23313552
MIRT695348	hsa-miR-548ap-5p	HITS-CLIP	23313552
MIRT695347	hsa-miR-548aq-5p	HITS-CLIP	23313552
MIRT695346	hsa-miR-548ar-5p	HITS-CLIP	23313552
MIRT695345	hsa-miR-548as-5p	HITS-CLIP	23313552
MIRT695344	hsa-miR-548au-5p	HITS-CLIP	23313552
MIRT695343	hsa-miR-548ay-5p	HITS-CLIP	23313552
MIRT695342	hsa-miR-548b-5p	HITS-CLIP	23313552
MIRT695341	hsa-miR-548bb-5p	HITS-CLIP	23313552
MIRT695340	hsa-miR-548c-5p	HITS-CLIP	23313552
MIRT695339	hsa-miR-548d-5p	HITS-CLIP	23313552
MIRT695338	hsa-miR-548h-5p	HITS-CLIP	23313552
MIRT695337	hsa-miR-548i	HITS-CLIP	23313552
MIRT695336	hsa-miR-548j-5p	HITS-CLIP	23313552
MIRT695335	hsa-miR-548o-5p	HITS-CLIP	23313552
MIRT695334	hsa-miR-548w	HITS-CLIP	23313552
MIRT695333	hsa-miR-548y	HITS-CLIP	23313552
MIRT695332	hsa-miR-559	HITS-CLIP	23313552
MIRT695331	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT695330	hsa-miR-3125	HITS-CLIP	23313552
MIRT695329	hsa-miR-3916	HITS-CLIP	23313552
MIRT695328	hsa-miR-6859-5p	HITS-CLIP	23313552
MIRT695327	hsa-miR-3159	HITS-CLIP	23313552
MIRT695326	hsa-miR-3163	HITS-CLIP	23313552
MIRT695325	hsa-miR-889-3p	HITS-CLIP	23313552
MIRT695324	hsa-miR-877-5p	HITS-CLIP	23313552
MIRT695323	hsa-miR-6869-5p	HITS-CLIP	23313552
MIRT695322	hsa-miR-653-5p	HITS-CLIP	23313552
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT664406	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT664405	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT664404	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT664403	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT626527	hsa-miR-4643	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT611611	hsa-miR-8485	HITS-CLIP	23824327
MIRT611610	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611609	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT611608	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT611607	hsa-miR-4641	HITS-CLIP	23824327
MIRT611606	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT756398	hsa-miR-551b-3p	Luciferase reporter assay, Western blotting, qRT-PCR	37000315
MIRT791492	hsa-miR-1291	CLIP-seq
MIRT791493	hsa-miR-297	CLIP-seq
MIRT791494	hsa-miR-328	CLIP-seq
MIRT791495	hsa-miR-3677-5p	CLIP-seq
MIRT791496	hsa-miR-3689a-3p	CLIP-seq
MIRT791497	hsa-miR-3689c	CLIP-seq
MIRT791498	hsa-miR-3924	CLIP-seq
MIRT791499	hsa-miR-4268	CLIP-seq
MIRT791500	hsa-miR-4448	CLIP-seq
MIRT791501	hsa-miR-4520a-3p	CLIP-seq
MIRT791502	hsa-miR-4520b-3p	CLIP-seq
MIRT791503	hsa-miR-4697-3p	CLIP-seq
MIRT791504	hsa-miR-567	CLIP-seq
MIRT791505	hsa-miR-635	CLIP-seq
MIRT791506	hsa-miR-663b	CLIP-seq
MIRT1933488	hsa-miR-127-3p	CLIP-seq
MIRT791493	hsa-miR-297	CLIP-seq
MIRT1933489	hsa-miR-3156-3p	CLIP-seq
MIRT791498	hsa-miR-3924	CLIP-seq
MIRT791499	hsa-miR-4268	CLIP-seq
MIRT1933490	hsa-miR-4301	CLIP-seq
MIRT1933491	hsa-miR-4432	CLIP-seq
MIRT791500	hsa-miR-4448	CLIP-seq
MIRT1933492	hsa-miR-499-5p	CLIP-seq
MIRT791504	hsa-miR-567	CLIP-seq
MIRT2173555	hsa-miR-4313	CLIP-seq
MIRT2173556	hsa-miR-466	CLIP-seq
MIRT2173557	hsa-miR-4667-3p	CLIP-seq
MIRT2173558	hsa-miR-4672	CLIP-seq
MIRT2173559	hsa-miR-4686	CLIP-seq
MIRT791506	hsa-miR-663b	CLIP-seq

Transcription factors

Show/Hide all(3)

Transcription factor	Regulation	Reference
CREB1	Unknown	18495115
TP53	Unknown	11231003
TP73	Unknown	11231003

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002684	Process	Positive regulation of immune system process	IDA	17943189
GO:0003091	Process	Renal water homeostasis	TAS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	18718702, 19545896
GO:0005886	Component	Plasma membrane	IDA	14521551, 18718702, 19545896
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	IDA	18718702
GO:0006833	Process	Water transport	IDA	30420639
GO:0006833	Process	Water transport	TAS	17943189
GO:0015204	Function	Urea transmembrane transporter activity	IBA	21873635
GO:0015250	Function	Water channel activity	EXP	9369468, 10510269, 16596446
GO:0015250	Function	Water channel activity	IDA	30420639
GO:0015250	Function	Water channel activity	TAS	17943189
GO:0015254	Function	Glycerol channel activity	IDA	17943189, 30420639
GO:0015793	Process	Glycerol transport	IDA	30420639
GO:0016021	Component	Integral component of membrane	IC	17943189
GO:0016323	Component	Basolateral plasma membrane	ISS
GO:0032526	Process	Response to retinoic acid	IDA	17943189
GO:0033280	Process	Response to vitamin D	TAS	17943189
GO:0042476	Process	Odontogenesis	IEP	12522663
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0045616	Process	Regulation of keratinocyte differentiation	TAS	17943189
GO:0051592	Process	Response to calcium ion	TAS	17943189
GO:0070295	Process	Renal water absorption	IEA
GO:0071456	Process	Cellular response to hypoxia	IDA	24462679
GO:0071918	Process	Urea transmembrane transport	IEA
GO:0090650	Process	Cellular response to oxygen-glucose deprivation	IEA

MIM	HGNC	e!Ensembl
600170	636	ENSG00000165272

Protein

UniProt ID

Q92482

Protein name

Aquaporin-3 (AQP-3) (Aquaglyceroporin-3)

Protein function

Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:12239222, PubMed:30420639). Could also be permea

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00230	MIP	16 → 261	Major intrinsic protein	Family

Sequence

MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTIN
LAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVF
GLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVD
PYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQ
HWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI

Sequence length

292

Interactions

View interactions

	KEGG		Reactome
	Vasopressin-regulated water reabsorption		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins

Associated diseases

Show/Hide Causal Diseases (3)

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma	Squamous cell carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	21401805
Esophagus neoplasm	Esophageal Neoplasms, Malignant neoplasm of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	21401805
Ovarian cancer	Malignant neoplasm of ovary	rs34424986, rs137853060, rs28934575, rs79658334, rs121913021, rs62625308, rs80356898, rs80357579, rs41293497, rs80356904, rs80357471, rs80357522, rs80357234, rs80357912, rs80357828, rs80357208, rs55770810, rs80358165, rs80358010, rs587780226, rs536907995, rs139414606, rs371638537, rs574552037, rs730881647, rs747993448, rs786202125, rs786202962, rs121913321, rs189261858, rs869320800, rs753023295, rs779466229, rs752411477, rs80357438, rs191486604, rs760874290, rs752780954, rs760782298, rs1555591361, rs1555578360, rs1555588460, rs1555587401, rs747427602, rs112675807, rs80357393	18214481

Show/Hide Unknown Diseases (8)

Unknown
Disease name	Disease term	dbSNP ID	References
Urinary bladder cancer	Malignant neoplasm of urinary bladder		22306368
Bladder neoplasm	Bladder Neoplasm		22306368
Lymphatic metastasis	Lymphatic Metastasis		21401805
Malignant neoplasm of tongue	Malignant neoplasm of tongue		21401805
Ovarian neoplasm	ovarian neoplasm		18214481
Skin cancer	Malignant neoplasm of skin		21401805
Skin neoplasms	Skin Neoplasms		21401805
Tongue neoplasms	Tongue Neoplasms		21401805

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